University Hospital, Rouen

This study tests whether domperidone, a drug that speeds up stomach emptying, can help adults with type 1 diabetes keep their blood sugar in a healthy range. About 70 participants with slow stomach emptying but no digestive symptoms will take either domperidone or a placebo for 2…

This study compares two ways of giving antibiotics after pancreatic surgery in patients who had a biliary stent placed before surgery. The goal is to see if a 5-day course of broad-spectrum antibiotics is better than a single preventive dose at reducing surgical site infections. …

This study tests whether fosfomycin-trometamol, an antibiotic already used for women, works well for men with urinary tract infections (UTIs). The goal is to find a safer option than current antibiotics, which can cause rare but serious side effects. About 138 men will take the d…

This study tests a brain implant called deep brain stimulation (DBS) in 6 adults with severe aggression from autism or schizophrenia who haven't improved with standard care. The implant targets a brain area called the Sano triangle to try to control aggressive outbursts. The goal…

This study tests a technique called ischemic preconditioning (IPC) to prevent acute kidney injury in people undergoing open surgery for a type of abdominal aortic aneurysm near the kidneys. About 206 adults aged 18-85 will be randomly assigned to receive IPC or standard care. The…

This study tests baricitinib, a pill that blocks certain immune signals, in 33 adults with a type of eye inflammation (non-anterior uveitis) that hasn't improved with other treatments. Participants stop their current medications before starting baricitinib for 6 months. The main …

This study tests the safety of a skin patch called rotigotine (a dopamine agonist) in 120 adults aged 18-60 with autosomal dominant polycystic kidney disease (ADPKD), a common inherited condition that causes kidney cysts and can lead to kidney failure. Participants will wear the …

This study tests whether a simple blood test (ctDNA) can help doctors decide when to reduce or change chemotherapy for people with advanced colorectal cancer that has spread. About 408 participants will be randomly assigned to either standard care or a strategy where the blood te…

This study looks at a new way to treat early signs of rejection in kidney transplant patients who develop antibodies against their donor kidney. About 290 adults will be randomly assigned to either switch to belatacept plus standard care or stay on their current medication. The g…

This study looks at kidney transplant patients who take drugs to prevent organ rejection. Some take standard anticalcineurin drugs, which can harm blood vessels and raise heart risks. Others switch to a newer drug called belatacept. The goal is to see if belatacept improves blood…

This study tests a new ultrasound technique called VEXUS to detect acute kidney injury after heart surgery. About 250 adults having valve or bypass surgery will be checked with this non-invasive method. The goal is to see if VEXUS can spot kidney problems earlier than current too…

This study tests a computer program that looks at young children's medical records to help doctors find asthma earlier. About 300 children aged 2 to 5 will take part. The goal is to see if the program can correctly identify kids with asthma, so they can get treatment sooner and a…

This study tests whether doing balance exercises with eyes closed soon after total knee replacement helps patients recover better. About 66 adults aged 60-85 with knee osteoarthritis will be split into two groups: one doing standard rehab plus eyes-closed balance training, the ot…

This study tests a drug called iloprost to see if it can reduce pain and the need for strong painkillers in adults with sickle cell disease who are hospitalized for a painful crisis. Iloprost helps open blood vessels and reduce inflammation. About 144 participants will receive ei…

This study tests whether a handheld device called AccuVein helps nurses insert an IV on the first try in patients with hard-to-find veins. About 100 adults who are difficult to infuse will be randomly assigned to have their IV placed with or without the device. The main goal is t…

This study looks at how a common antibiotic combination (piperacillin-tazobactam) is removed from the blood by continuous kidney replacement therapy in intensive care patients with severe infections. The goal is to find the right dose to avoid underdosing (which can lead to treat…

This study looks at adults with a rare condition called idiopathic megarectum, where the rectum is abnormally large and causes severe constipation. Researchers want to find out if these patients had more constipation or digestive issues as children compared to constipated adults …

This study looks at whether monitoring the lung's air volume during surgery that uses only one lung can help doctors perform breathing maneuvers to prevent lung collapse. About 44 adults having lung surgery will be randomly assigned to either have these maneuvers or not. The goal…

This study looks at how the non-opioid painkiller nefopam is processed by the body in adults with sudden rheumatic pain. Researchers will measure drug levels in the blood and how long it stays in the system. 24 hospitalized patients will take nefopam tablets to help understand it…

This study looks at how a liquid form of a blood pressure drug called nicardipine works in children aged 1 to 15 who have cancer and high blood pressure. The medicine is specially made by the hospital pharmacy because the adult version isn't right for kids. Researchers will take …

This study looks at why some people with irritable bowel syndrome (IBS) feel more pain after eating fructose (a sugar found in fruit). Researchers think gut bacteria might play a role. They will study 60 adults with IBS, comparing those with and without fructose malabsorption and…

This study looks at whether a personalized health plan can help frail adults aged 70 and older maintain a better quality of life. Researchers will compare two groups over two years, measuring changes in physical and mental well-being. The goal is to see if tailored support in a h…

This study follows 60 adults with pulmonary hypertension to see how sleep-related breathing problems and heart rate changes evolve over two years. Participants will have overnight sleep tests at the start, 12 months, and 24 months. The goal is to find better ways to predict and m…

This study looks at a new phone service in Le Havre that helps people find the right healthcare quickly. When you call, a trained assistant decides if you need emergency help or can see a regular doctor, often within 48 hours. The goal is to see if this service reduces unnecessar…

This study looks at 16 adults with brain arteriovenous malformations (AVMs) to see if a liquid biopsy from the drainage vein can detect gene changes that may cause the condition. Researchers hope to better understand these abnormal blood vessels, which can rupture and cause serio…

This study looks at 350 people having lung surgery for cancer. During surgery, one lung is deflated. At the end, doctors re-inflate it using one of two methods: manual bagging or a machine that controls pressure and volume. The goal is to see which method leads to fewer lung prob…

This study looks at whether a simple blood test before chest surgery can predict serious lung problems afterward. About 100 adults having lung surgery will give blood samples, which will be analyzed for immune system markers. The goal is to find a way to identify high-risk patien…

This study will follow 200 cancer patients starting immune checkpoint inhibitors to see if these drugs cause blood vessel problems. Researchers will measure artery stiffness before treatment and again after 6-8 weeks and one year. The goal is to better understand side effects lik…

This study tests whether a brief question from a nurse can reduce the number of unnecessary IV catheters placed in emergency department patients. About 1,680 adults who need a blood draw and IV line will take part. The goal is to see if this simple check lowers patient pain, save…

This study aims to find out if women with Ehlers-Danlos syndrome (EDS) experience more severe period pain than those without the condition. Researchers will compare pain scores and other gynecological issues between 156 women with EDS and a control group using online questionnair…