University Hospital, Rouen

This study looked at whether adding hydroxychloroquine to standard treatment could improve blood vessel function in people with antiphospholipid syndrome, a condition that raises the risk of blood clots. About 25 adults were planned to take either hydroxychloroquine or a placebo …

This study tested whether using three pacing sites instead of the usual two could help more people with heart failure benefit from cardiac resynchronization therapy (CRT). About 25-30% of patients do not respond to standard CRT. The trial planned to enroll adults with severe hear…

This study looked at whether switching kidney transplant patients from tacrolimus to sirolimus (both with mycophenolate mofetil) could lower the risk of kidney damage, new diabetes, and cancer. It involved 65 stable transplant recipients between 12 and 36 months after surgery. Th…

This study tested a personalized approach to treating acquired thrombotic thrombocytopenic purpura (aTTP), a rare and serious blood clotting disorder. Researchers gave 58 adults a drug called caplacizumab, with the dose adjusted based on regular monitoring of a key blood enzyme (…

This study tested a new, less invasive imaging technique called probe-based confocal laser endomicroscopy (pCLE) to help diagnose diffuse parenchymal lung diseases. The goal was to see if this method could provide clear images of lung tissue during a routine bronchoscopy, potenti…

This study looked at whether a special CT scan (dual-energy cardiac CT) can check heart muscle damage as well as an MRI in people who had a heart attack more than 24 hours earlier. The goal was to see if the CT scan could give doctors enough information to decide on treatment, av…

This study looked at whether a blood test could detect pancreatic cancer by finding circulating tumor cells (CTCs). The goal was to see if this test could be a less invasive alternative to the standard endoscopic biopsy, which requires anesthesia and carries some risks. The study…

This study looked at whether giving a continuous local anesthetic (ropivacaine) near the surgical cut after upper abdominal surgery could improve diaphragm function and reduce lung complications. It planned to include 88 adults having liver surgery, but was terminated early after…

This study tested whether adding a smartphone app to the usual pre-surgery talk could lower anxiety in children aged 4 to 10. About 182 kids scheduled for surgery at a French hospital were to take part. The study was stopped early, so results are limited.

This study aimed to see if regular moderate physical activity could reduce chronic fatigue and improve quality of life in people with inflammatory bowel disease (IBD). The researchers planned to enroll adults with IBD in remission who experienced significant fatigue. However, the…

This study compared two types of non-invasive breathing machines (AVAPS-AE vs. S/T mode) for patients with acute respiratory failure who also had obesity or were at risk for sleep apnea. The goal was to see which machine helped resolve high carbon dioxide levels faster. The study…

This study tested whether a gas sedative (isoflurane) helps patients with septic shock wake up and get off a breathing machine faster than standard IV sedation (midazolam). The trial was planned for adults in the ICU needing sedation for 3-28 days. However, the study was stopped …

This study explored whether measuring the thickness of a thin layer inside blood vessels (glycocalyx) before heart surgery could predict serious problems like shock, kidney failure, or death. Researchers planned to enroll 130 adults undergoing heart surgery with a heart-lung mach…

This study aimed to see if a carefully designed exercise program could help women with anorexia nervosa during refeeding by affecting a specific metabolic pathway (kynurenine). The study planned to include 9 adult women with a BMI between 15 and 18.5. However, the study was termi…

This study looked at whether pain medicine (ropivacaine and sufentanil) given to mothers during labor can affect the baby's heart rate. Researchers planned to measure medicine levels in the mother's blood and compare them to any heart rate changes in the baby. The study was stopp…

This study aimed to find out if the amount of sunitinib (a targeted therapy) in the blood of people with metastatic kidney cancer is linked to severe side effects or how well the treatment works. Researchers planned to collect extra blood samples during routine tests from 6 patie…

This study tested a website designed to help parents and children better understand how to use painkillers after outpatient surgery. The goal was to improve pain management at home by addressing common fears and knowledge gaps. The study involved 200 children aged 2-12 undergoing…

This study looks at children born very premature (before 32 weeks) who received language therapy at age 3-4. Researchers want to see if that early help improves their reading skills by age 8. The goal is to understand how early language support can shape long-term learning.

This study looked at whether giving patients extra guidance on showering before planned surgery could make their skin cleaner when they arrive at the operating room. It included 22 adults scheduled for various surgeries. The study was stopped early, so results are limited.

This study aimed to see if using a heart-lung machine during heart surgery changes blood flow in the gut. Researchers checked blood flow under the tongue in 21 adults having aortic valve replacement. The study was stopped early, so results are limited.

This study looked at 289 people with early-onset breast, ovarian, colorectal, or pediatric cancers, plus those with multiple tumors. Researchers used a special test to check 200 genes for inherited mutations that standard tests might miss. The goal was to better understand why th…

This study aimed to see how accurate different COVID-19 antibody tests are. Researchers used blood samples from 101 adults, including some taken before the pandemic and some from people with other infections. The goal was to find which tests best detect past COVID-19 infection.

This study aimed to find brain wave and movement patterns that could identify a specific type of depression where people lose interest in activities (anhedonia) and don't respond to standard antidepressants. Researchers compared 36 people with this condition to healthy volunteers…

This study aimed to describe the tiny blood vessels in the lungs of people with scleroderma or emphysema using a special microscope during a bronchoscopy. Researchers wanted to see how these vessels are damaged in each disease to better understand what causes the damage. Only 9 p…

This study looked at whether a simple sit-to-stand test could help emergency doctors decide which COVID-19 patients need to stay in the hospital. The test measures how many times a person can stand up from a chair in 30 seconds. The goal was to see if using this test, along with …