University Hospital, Rouen

This study tests whether taking Sildenafil (Viagra) soon after rectal cancer surgery and radiation can prevent long-term erectile problems. About 188 men aged 18 to 70 with normal erectile function before treatment will take part. The goal is to see if early rehabilitation helps …

This study tests whether using high-flow oxygen at home can reduce the number of severe COPD flare-ups or deaths compared to standard oxygen. About 406 people who have been hospitalized for a serious COPD attack will take part. The goal is to see if this approach keeps them healt…

This study tests whether a single injection of a patient's own stem cells (from fat tissue) into the thumb joint can safely treat painful thumb arthritis when standard treatments have failed. The trial involves 12 adults who are candidates for surgery. The main goal is to check f…

This study tests whether a drug that blocks endothelin-1 receptors can improve blood vessel function and lower blood pressure in people with resistant hypertension (high blood pressure that doesn't respond to standard treatments). About 24 adults aged 30-80 will take the drug for…

This study tests whether rituximab is safer and more effective than the current standard drug, cyclophosphamide, for people with severe mucous membrane pemphigoid (MMP). MMP is a rare autoimmune disease that causes painful blisters and scarring on mucous membranes, which can lead…

This study looks at two surgical options for people with a serious belly infection caused by a burst diverticulitis pocket. About 204 adults will be randomly assigned to have the infected part removed and the colon reconnected either with or without a temporary stoma (a bag outsi…

This study tests a personalized approach to treating pemphigus, a serious autoimmune blistering disease. Instead of waiting for a relapse to retreat, doctors will use blood levels of anti-desmoglein antibodies to decide when to give additional rituximab infusions. The goal is to …

This study tests whether giving hospitalized patients a personalized medication plan helps them stop using strong opioids sooner, lowering the risk of dependence. About 200 adults with acute non-cancer musculoskeletal pain will be randomly assigned to usual care or the personaliz…

This study looks at whether giving gout medication (febuxostat) right after an attack is better than waiting the usual 6 weeks. Gout is a painful joint condition caused by high uric acid. The goal is to see if early treatment reduces the number of days with gout symptoms. About 1…

This study tests whether the drug apremilast can completely heal painful mouth ulcers in people with severe recurrent aphthous stomatitis who haven't been helped by standard treatment. About 134 adults will receive either apremilast or a placebo for 12 weeks. The goal is to see i…

This study tests whether a simpler treatment can replace the standard plasma exchange procedure for people with immune thrombotic thrombocytopenic purpura (iTTP), a rare blood clotting disorder. Instead of plasma exchange, patients will receive plasma infusions, along with medica…

This study looks at 60 adults with rapid atrial fibrillation who already have a pacemaker and recently had a heart ablation. Researchers want to see if pacing the heart's natural electrical system (left bundle branch) helps them exercise better compared to standard right ventricu…

This study compares two ways to prevent cytomegalovirus (CMV) infection in kidney transplant patients who already carry the virus. One approach gives antiviral drugs to everyone for three months, while the other uses immune system tests to decide who needs treatment. The goal is …

This study tests whether taking glutamine, a natural amino acid, for 8 weeks can improve insulin resistance and reduce irritable bowel syndrome (IBS) symptoms in people with severe obesity. About 110 participants will receive either glutamine or a placebo powder. The goal is to s…

This study is for people who had surgery for stage II or III colon cancer with a PI3K mutation. It tests whether taking a low-dose aspirin daily can lower the chance of the cancer returning or a new cancer developing. Half the participants will get aspirin, the other half a place…

This study tests if giving chemotherapy before surgery (instead of only after) helps people with blocked colon cancer get the full planned treatment. About 232 adults with stable tumor genetics will be randomly assigned to standard care or the new approach. The goal is to see if …

This study tests whether giving different types of chemotherapy after surgery, based on how much the tumor shrank with initial chemo, can help prevent pancreatic cancer from coming back. About 390 adults who had surgery after 3 months of a specific chemo (mFOLFIRINOX) will be ass…

This study aims to screen about 100,000 newborns in Normandy, France, for two rare lysosomal storage diseases: MPS1 and Pompe disease. Using a blood spot test (tandem mass spectrometry), researchers want to see how common these conditions are and improve early detection. Parents …

This study is testing whether a dried blood spot (a drop of blood on a card) can effectively screen for hepatitis B, hepatitis C, and AIDS in people who use drugs. The goal is to make screening easier and more accessible for this group. Researchers will enroll 500 current or form…

This study tests whether taking glutamine, a natural amino acid, can reduce symptoms in people with diarrhea-predominant irritable bowel syndrome (IBS-D) who also have a 'leaky gut.' Researchers will give 60 adults either glutamine or a placebo daily for 8 weeks and measure chang…

This study tests whether electrical spinal cord stimulation is safe for people with Parkinson's disease who have a painful bent spine (camptocormia). Six participants will receive the stimulation and be monitored for side effects for about 10-11 months. The goal is to see if this…

This study tests whether a dietary supplement called DIELEN Protect, which contains glutamine and marine peptides, can improve symptoms in people with moderate to severe irritable bowel syndrome (IBS). About 100 adults with IBS will take either the supplement or a placebo daily f…

This study tests botulinum toxin (Botox) injections into the rectum to help people with fecal incontinence who haven't improved with standard treatments. Researchers want to understand how the injections affect bowel muscle contractions and identify which patients benefit most. T…

This study tests whether injecting a local anesthetic (ropivacaine) into the vagina before making the first cut for a hysterectomy can lower pain after surgery. About 108 adults having a hysterectomy for non-cancer reasons will be randomly assigned to get either the anesthetic or…

This study tests whether playing a special video game at home can improve walking and balance in people with Parkinson's disease. 80 participants will either continue their usual care or also play the "TOAP RUN" game using a Kinect sensor for 12 months. Researchers will measure c…

This study tests whether adding hip abductor exercises to standard pelvic floor muscle training can better reduce urine leaks in women with stress urinary incontinence. About 78 women will be split into two groups: one doing only pelvic floor exercises at home, the other adding h…

This study looks at whether a respiratory rehabilitation program (exercise and breathing training) can improve sleep quality in people with stable COPD. About 90 adults aged 50 and older with COPD will be randomly assigned to either the rehab program or their usual care. The main…

This study tests whether aromatherapy (using calming scents) and music therapy can help lower stress in patients having a cerebral arteriography, a brain artery scan. About 224 adults will be randomly assigned to receive one or both therapies or standard care. The goal is to see …

This study looks at whether adding endurance training (like cycling) to standard physical therapy helps people recover better after minimally invasive lung cancer surgery. About 184 adults having lung surgery will be randomly assigned to standard rehab or standard rehab plus extr…

This study looks at whether a quick swallowing test done by a physical therapist can reliably detect vocal cord paralysis after major lung cancer surgery, compared to the standard scope exam. About 72 adults having lung surgery will be tested with both methods shortly after surge…

This study looks at how a specific nerve-sliding exercise (called neurodynamic sliding mobilisation in the slump position) affects pain perception in healthy adults aged 30 to 64. Researchers will measure the pressure point where a sensation becomes painful, comparing the nerve-s…

This study tests a new, high-resolution probe to measure colon muscle activity in people with severe constipation that doesn't get better with standard laxatives. Researchers will compare results from 76 patients and healthy volunteers to see if the probe can better identify colo…

This study is testing whether a simple blood test that looks for tiny bits of tumor DNA (ctDNA) can predict if liver cancer will come back after surgery. Researchers will take blood samples before and after surgery, and at 3 and 6 months, from 150 adults with liver cancer. The go…

This study tests a new way to measure how much blood the heart pumps (cardiac output) using ultrasound from under the ribs. It involves 50 adults in the intensive care unit who already need an ultrasound. The goal is to see if this new method works as well as the standard one, po…

This study looks at how two breathing treatments—high-flow oxygen therapy and non-invasive ventilation—affect heart function in people with chronic heart failure. Researchers want to see if high-flow oxygen can lower pressure in the heart's blood vessels. The study involves 30 ad…

This study looks at how the walls of the carotid artery (the main artery in the neck) behave in people with different types of memory loss. Researchers will measure artery viscosity in 140 volunteers over age 70, comparing those with Alzheimer's disease, vascular dementia, and th…

This study looks at specific immune cells in people with thrombotic thrombocytopenic purpura (TTP), a rare blood disorder. Researchers want to understand how these cells cause the disease and change with treatment. By studying 44 patients, they hope to find early warning signs of…

This study aims to collect medical information and biological samples (blood, urine, stool, and gut biopsies) from 2000 adults with functional digestive disorders like irritable bowel syndrome, indigestion, and constipation. The goal is to identify markers that could help diagnos…

This study looks at whether a one-minute chair lift test can help doctors predict how well patients with a non-severe pulmonary embolism (a blood clot in the lungs) will recover. Researchers will compare the test results with standard risk scores and heart markers. The goal is to…

This study looks at whether using an EEG (a device that tracks brain activity) can give a more accurate picture of sleep quality in intensive care patients with acute respiratory failure. About 47 adults will have their sleep assessed by both EEG and nurse observation. The goal i…

This study looks at whether a substance called PLGF in the umbilical cord can act as an early warning sign for brain damage caused by drinking alcohol during pregnancy. Researchers will compare PLGF levels in 60 mothers and their babies—half exposed to alcohol, half not—and then …

This study compares two ways to pick the best embryo for IVF: the standard method (looking at shape) versus a newer method that also tracks how fast the embryo grows. Researchers want to see which approach leads to more live births. About 520 couples doing their first or second I…

This study is following 600 people with Irritable Bowel Syndrome (IBS) over time to learn more about how the condition changes and what factors affect it. Researchers will collect information on symptoms, lifestyle, diet, stress, and gut bacteria. No new treatments are being test…

This study aims to improve genetic counseling for spinal muscular atrophy (SMA), a severe nerve disease. Some carriers of the disease have a hidden gene duplication that current tests miss. Researchers will use advanced long-read DNA analysis to detect these hidden duplications i…

This study aims to find out how often patients on immunotherapy (cancer treatments like pembrolizumab or nivolumab) who have chronic itching also have certain antibodies (BP180 and BP230) in their blood. Researchers will enroll 100 adults with itching that started after immunothe…

This study looks at the bacteria living in the airways of infants under 2 years old with severe asthma. Researchers want to understand how these bacteria differ from normal and how they relate to the immune system. The goal is to find new ways to treat severe asthma in babies. Th…

This study takes stool samples from women with eating disorders (anorexia, bulimia, or binge eating) and from healthy women, then transplants the bacteria into mice. Researchers will track the mice's weight and eating habits to see if the gut microbes play a role in these conditi…

This study looks at a new method to deliver fentanyl, a strong painkiller, by breathing it in through the nose or a face mask. It involves 20 healthy adults to see how well the medicine is absorbed and how comfortable the method is. The goal is to find a faster, needle-free way t…

This study aims to understand the sexual and gynecological problems women may face after treatment for rectal cancer. Researchers will ask 15 women who are in remission to fill out questionnaires about their symptoms. The goal is to learn how common these issues are and what fact…

This study looks at how the antibiotic ceftriaxone works in adults treated in the emergency department for urinary tract infections. Researchers want to find out if the standard 1-gram dose is enough to kill the bacteria. About 300 patients will have their blood tested to measure…

This pilot study tests whether a drug called aprepitant (an NK1 receptor antagonist) can lower aldosterone levels in people with severe obstructive sleep apnea and high blood pressure. Researchers believe that sleep apnea may overstimulate aldosterone through nerve signals involv…

This study looks at the nutritional effects of a low-calorie, high-protein diet given to people before they have weight-loss (bariatric) surgery. The goal is to see if this diet causes any health problems like low blood cell counts, vitamin deficiency, or muscle weakness. About 2…

This study follows 200 adults with antiphospholipid syndrome (APS), a rare condition that increases blood clot risk. Researchers will track how often clots return and look at side effects from current treatments. The goal is to update old data and better understand real-world out…