New combo therapy may replace painful plasma exchange for rare blood disease
NCT ID NCT06291025
First seen Feb 28, 2026 · Last updated May 20, 2026 · Updated 16 times
Summary
This study tests whether a simpler treatment can replace the standard plasma exchange procedure for people with immune thrombotic thrombocytopenic purpura (iTTP), a rare blood clotting disorder. Instead of plasma exchange, patients will receive plasma infusions, along with medications to suppress the immune system and a drug called caplacizumab to prevent clotting. The goal is to see if this approach is as effective and safer, reducing the need for invasive procedures. About 131 adults will take part.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Ap-Hm La Conception
RECRUITINGMarseille, 13005, France
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Ap-Hp Pitie Salpetriere
NOT_YET_RECRUITINGParis, 75651, France
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Ap-Hp Saint Louis
RECRUITINGParis, 75010, France
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Ap-Hp St Antoine
RECRUITINGParis, 75571, France
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CH PAU
NOT_YET_RECRUITINGPau, 64046, France
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CHU NICE
RECRUITINGNice, 06200, France
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Ch Saint-Nazaire
NOT_YET_RECRUITINGSaint-Nazaire, 44606, France
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Ch Valenciennes
RECRUITINGValenciennes, 59322, France
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Chru Besanon
RECRUITINGBesançon, 25030, France
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Chu Amiens
RECRUITINGAmiens, 80054, France
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Chu Angers
RECRUITINGAngers, 49933, France
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Chu Bobigny
RECRUITINGBobigny, 93000, France
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Chu Bordeaux
RECRUITINGBordeaux, 33076, France
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Chu Clermont-Ferrand
RECRUITINGClermont-Ferrand, 63003, France
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Chu Edouard Herriot
RECRUITINGLyon, 69003, France
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Chu Lille
RECRUITINGLille, 59037, France
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Chu Limoges
NOT_YET_RECRUITINGLimoges, 87042, France
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Chu Martinique
NOT_YET_RECRUITINGFort-de-France, 97261, Martinique
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Chu Montpellier
RECRUITINGMontpellier, 34295, France
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Chu Nancy
RECRUITINGNancy, 54500, France
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Chu Nantes
RECRUITINGNantes, 44093, France
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Chu Nimes
RECRUITINGNîmes, 30029, France
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Chu Reims
RECRUITINGReims, 51092, France
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Chu Reunion Sud
RECRUITINGSaint-Pierre, 97448, Reunion
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Chu Rouen
RECRUITINGRouen, 76031, France
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Chu Strasbourg
RECRUITINGStrasbourg, 67091, France
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Chu Toulouse
RECRUITINGToulouse, 31000, France
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Chu Tours
NOT_YET_RECRUITINGTours, 37044, France
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Hopital Jean Verdie
RECRUITINGBondy, 93140, France
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Reunion Nord
RECRUITINGSaint-Denis, 97400, Reunion
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Conditions
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