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Simple Pre-Surgery trick may shield kidneys from damage

NCT ID NCT07441564

Disease control Sponsor: University Hospital, Rouen Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study tests whether a short, controlled clamping of the aorta before aneurysm surgery can prevent acute kidney injury. About 206 patients will be randomly assigned to receive this preconditioning or standard care. The goal is to see if this simple procedure lowers the risk of kidney damage after surgery.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
ischemic preconditioning (brief clamping of the aorta before surgery)
What this could lead to
If it works, this could offer a simple way to protect kidneys during high-risk aneurysm surgery, reducing complications and improving recovery.
What could go wrong
This is an early human test of a technique never tried in people before. It may not reduce kidney injury, and the clamping itself carries some risk.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 206 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Sep 2026

An estimate. Start dates often move.

Expected to finish

Dec 2029

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 85 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients aged 18-85 years * Patients with juxtarenal abdominal aortic aneurysms scheduled for open surgery * Patients with juxtarenal abdominal aortic aneurysms, which require suprarenal aortic cross clamping * Patients with juxtarenal abdominal aortic aneurysms, which are of atheromatous etiology or which developed after aortic dissection * Affiliation with, or beneficiary of a Social security (national health insurance) scheme * Adult having read and understood the information letter and signed the consent form * Women of childbearing potential with effective contraception according WHO definition (estrogen-progestin contraception or intrauterine device or male condom) since at least 1 month with a negative blood pregnancy test by b-HCG at inclusion. * Women surgically sterile (absence of ovaries and/or uterus or tubal ligation) * Postmenopausal women: confirmation of non-medically induced amenorrhea since at least 12 months prior to the inclusion visit Exclusion Criteria: * Patients dependent from dialysis * Patients with aortic aneurysms, which require reconstruction of the visceral arteries * Patients with aortic aneurysms, which require supra-visceral aortic cross clamping * Patients with wall thrombus or calcification of inter- and suprarenal aorta * Patients with septic aortitis * Patients with aneurysm requiring stent graft (EVAR) explantation * Patients requiring emergency surgery * Patients receiving treatments that may interact with preconditioning: Nicorandil and Glibenclamide * Pregnant or parturient or breastfeeding woman or absence of proven contraception * Person deprived of liberty by an administrative or judiciary decision or person placed under judicial protection, under guardianship or curatorship * Person participating to another trial during the month before randomization * Medical history or psychological or sensorial abnormality prone to inhibit the subject to understand the conditions required for his/her participation to the protocol or unable to give an informed consent

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Conditions

The condition(s) this trial relates to.

abdominal aortic aneurysm aortic aneurysm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Aneurysm aortic

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    7 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Ap-Hp La Pitie

    Paris, 75013, France

  • CHU de DIJON

    Dijon, 21000, France

  • CHU de LILLE

    Lille, 59000, France

  • CHU de NANCY

    Nancy, 54511, France

  • CHU de NANTES

    Nantes, 44093, France

  • CHU de ROUEN

    Rouen, 76031, France

  • CHU de TOULOUSE

    Toulouse, 31400, France

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