Heart rate drug may keep arteries young, study suggests

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Healthy volunteers * Caucasian * Resting heart rate ≥70 bpm (mean of 3 measures after 15 minutes of rest) * No significant EKG abnormality * No significant biological abnormalities at inclusion * Healthy volunteers able to read and understand information letter and to give written informed consent * Healthy volunteers with medical insurance * Contraception for two months for women of childbearing age (Estrogen contraceptive or intrauterine device or tubal ligation) (NB : women with amenorrhea for more than 2 years will be considered postmenopausal) Exclusion Criteria: * Subjects who don't understand french language * Person deprived of liberty by an administrative or judicial decision or protected adult subject (under guardianship) * Pregnant women, nursing mother or women without contraception * Healthy volunteers who participate to an other trial / participated to an other trial without drugs during the last month or a trial with drugs during the last 3 months * Hypersensitivity to the active substance or to any of the excipients * Congenital galactosemia, lactase deficiency, or glucose-galactose malabsorption * Body mass index (BMI) \< 18 kg/m² or \> 30 kg/m² * Severe hypotension (\< 90/50 mmHg) (3 measures after 15 minutes of rest) * Essential or secondary Hypertension (SBP ≥140 mmHg and/or DBP ≥90 mmHg) (3 measures after 15 minutes of rest) * Active smoking at the day of inclusion (\>5 cigarettes/day) * Severe hypercholesterolemia (Total cholesterol \>2,5 g/L) * Practice sports intensively (≥ 1 hour/day) * Renal insufficiency (creatinine clearance ≤ 60 ml/min/1,73 m² Cockroft and Gault formula) * Known liver failure * Known heart failure or suspected heart failure (congestive episode) * Atrial fibrillation * High-grade conduction block (Sick sinus syndrome, sino-atrial block or grade 2 or 3 atrio-ventricular block) * Abnormal corrected QT with Bazett formula (cQT \> 450 ms (men) or \> 470 ms (women)). * Pacemaker * All cardiac or extra cardiac diseases, active or with sequelae, which, in the opinion of the investigator, is accompanied by a risk of cardiac or vascular consequences * Retinal disease * Taking any medication is prohibited during the study except oral contraceptive, acetaminophene or decision of the investigator. In addition, the administration of drugs listed in schedule 2 during the previous 4 weeks prohibits inclusion.