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Heart surgery study probes hidden cell stress signals

NCT ID NCT03722979

Knowledge-focused Sponsor: University Hospital, Rouen Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looked at a type of cell stress called endoplasmic reticulum (ER) stress in 53 adults having planned heart surgery with a heart-lung machine. The goal was to measure changes in ER stress markers before and after the machine was used. By studying these markers, researchers hope to better understand how the body's cells react to severe inflammation during surgery.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could help researchers understand how cells respond to severe inflammation, potentially pointing toward new targets for treatment.
What could go wrong
This is a small, early observational study with only 53 participants. It measures biological markers, not patient outcomes, so it may not lead directly to any treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

53 people

The number who actually took part.

Started

Jul 2018

Finished

Mar 2019

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Major patient (age ≥ 18 years) * Patient undergoing cardiac surgery under extracorporeal circulation (duration of planned CEC \> 1h) * Informed person, having read and signed his consent preoperatively no later than the day before the procedure. * Person affiliated with a social security scheme * Effective contraception in women of childbearing potential. For menopausal women, the diagnosis of menopause will be based on the gynecological history of the patient (age\> 50 years + amenorrhea for more than 12 months). Exclusion Criteria: * Patient with urgent cardiac surgery * Patient with cardiac surgery without extracorporeal circulation * Patient with surgery under "mini-CEC" * Patient with simple aortic valve replacement or single / double coronary artery bypass (CEC duration typically \<1h) * Patient with chronic autoimmune inflammatory disease, eg lupus, rheumatoid arthritis, inflammatory bowel disease ... * Patient with progressive neoplastic disease * Patient with underlying heart disease with left ventricular ejection fraction \<30% * Pregnant or lactating woman * Person deprived of liberty by an administrative or judicial decision or protected major subject (under tutorship or curatorship) * Patient participating in another interventional clinical trial

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cardiac surgery

Contacts and locations

Locations

  • ROUEN Hospital University

    Rouen, 76000, France

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