Starving the gut: anorexia may damage intestinal barrier

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: Patients with anorexia nervosa : * female, * living in Upper Normandy since 1 year at least, * between 18 and 50 years of age * with a BMI between 14 and 16 kg/m², * diagnosed as anorexia nervosa according to the DSM IV criteria * hospitalised for the first time in the Nutrition Unit * not being pregnant (effective contraception and negative pregnancy test) * not breast-feeding, * HIV-1 negative , * HIV-2 negative, * HBV negative (hépatitis B virus), * HCV negative (hépatitis C virus), * Affiliated to the National Health Service, * Giving a filled informed consent, * Not included in other studies Controls : * female, * living in Upper Normandy since 1 year at least, * between 18 and 50 years of age, * with a BMI between 20 and 24,9 kg/m², * without antecedent or current diagnosis of eating disorders (DSM IV criteria), * without dyspepsia or irritable bowel syndrom for 6 month, * not being pregnant (effective contraception and negative pregnancy test) * not breast-feeding, * HIV-1 negative , * HIV-2 negative, * HBV negative (hépatitis B virus), * HCV negative (hépatitis C virus), * Affiliated to the National Health Service, * Giving a filled informed consent, * Not included in other studies Exclusion Criteria: Patients with anorexia nervosa : * Adult under guardianship, * Patient with inflammatory bowel disease and/or psychotic disorders, * Antecedent of digestive surgery, * Drug addiction for the last 6 month, * Alcohol and/or other substance use disorder, * Current immunological treatment, and/or non steroidal anti inflamatory and/or corticosteroids and/or anticoagulants and/or platelet antiaggregants * galactosemia * Lactulose intolerance, * Laxatives intake in the last 3 days * Antecedent of digestive surgery, Controls : * Adult under guardianship, * Patient with inflammatory bowel disease and/or psychotic disorders, * Antecedent of digestive surgery, * Drug addiction for the last 6 month, * Alcohol and/or other substance use disorder, * Current immunological treatment, and/or non steroidal anti inflamatory and/or corticosteroids and/or anticoagulants and/or platelet antiaggregants * galactosemia * Lactulose intolerance, * Laxatives intake in the last 3 days * Antecedent of digestive surgery,