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Spray before biopsy may curb bleeding and boost cancer diagnosis

NCT ID NCT02970175

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether spraying a drug called terlipressin into the airways before taking biopsy samples can reduce bleeding. The goal was to allow doctors to safely take more tissue samples, which could improve the chances of diagnosing lung cancer. The trial involved 130 adults scheduled for a bronchoscopy who had a suspicious lung lesion. Results will show if this approach leads to more biopsies and better diagnostic yield.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

130 people

The number who actually took part.

Started

Jun 2017

Finished

Apr 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients ≥18 years old * Patients scheduled to undergo bronchoscopy, presenting a suspicious radiographic lesion and a lesion proximal tumor pace viewable in white light endoscopy and without pathologic diagnosis * Patient having read and understood the information letter and signed the consent form * Effective contraception in women of childbearing age Exclusion Criteria: * Patients with contraindication to the use of terlipressin: * septic shock , * Hypersensitivity to terlipressin or the excipients or by whom use the product is not recommended: * Recent history (\<3 months) of acute coronary syndrome (including myocardial infarction) or unbalanced coronary insufficiency, or disorders of the ventricular heart rate. * severe uncontrolled hypertension, * cerebrovascular insufficiency and ischemic stroke of recent origin (\<3 months). * severe arterial occlusive lower extremities, * severe chronic renal impairment (GFR \<20 ml / min). * Patients receiving uninterrupted antiplatelet therapy during 5 days before endoscopy (7 days for Clopidogrel Related), including low dose aspirin (≤ 75 mg / day). * Patients receiving anticoagulant therapy: * Unfractionated heparin within 12 hours before endoscopy. * low molecular weight heparin within 24 hours before endoscopy. * Patients with bleeding disorders defined by TP below 70% or TCA ratio patient / control greater than 1.3. * Patients with thrombocytopenia less than 100 g / L. * Subjects misunderstanding of spoken and written French * Person under guardianship or deprived of liberty by judicial or administrative decision (under Article L1121-6 and L1121-8 of Public Health Code * Pregnant or lactating women, premenopausal women without adequate contraception * Patient participating in other drug testing or participating in another drug test in the previous month

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Rouen University Hospital

    Rouen, France

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Other studies related to the condition(s) this trial covers.