Spray before biopsy may curb bleeding and boost cancer diagnosis
NCT ID NCT02970175
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested whether spraying a drug called terlipressin into the airways before taking biopsy samples can reduce bleeding. The goal was to allow doctors to safely take more tissue samples, which could improve the chances of diagnosing lung cancer. The trial involved 130 adults scheduled for a bronchoscopy who had a suspicious lung lesion. Results will show if this approach leads to more biopsies and better diagnostic yield.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Phase 3
Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.
- Participants
-
130 people
The number who actually took part.
- Started
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Jun 2017
- Finished
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Apr 2024
- Lead sponsor
-
Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Patients ≥18 years old * Patients scheduled to undergo bronchoscopy, presenting a suspicious radiographic lesion and a lesion proximal tumor pace viewable in white light endoscopy and without pathologic diagnosis * Patient having read and understood the information letter and signed the consent form * Effective contraception in women of childbearing age Exclusion Criteria: * Patients with contraindication to the use of terlipressin: * septic shock , * Hypersensitivity to terlipressin or the excipients or by whom use the product is not recommended: * Recent history (\<3 months) of acute coronary syndrome (including myocardial infarction) or unbalanced coronary insufficiency, or disorders of the ventricular heart rate. * severe uncontrolled hypertension, * cerebrovascular insufficiency and ischemic stroke of recent origin (\<3 months). * severe arterial occlusive lower extremities, * severe chronic renal impairment (GFR \<20 ml / min). * Patients receiving uninterrupted antiplatelet therapy during 5 days before endoscopy (7 days for Clopidogrel Related), including low dose aspirin (≤ 75 mg / day). * Patients receiving anticoagulant therapy: * Unfractionated heparin within 12 hours before endoscopy. * low molecular weight heparin within 24 hours before endoscopy. * Patients with bleeding disorders defined by TP below 70% or TCA ratio patient / control greater than 1.3. * Patients with thrombocytopenia less than 100 g / L. * Subjects misunderstanding of spoken and written French * Person under guardianship or deprived of liberty by judicial or administrative decision (under Article L1121-6 and L1121-8 of Public Health Code * Pregnant or lactating women, premenopausal women without adequate contraception * Patient participating in other drug testing or participating in another drug test in the previous month
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Rouen University Hospital
Rouen, France
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Other studies related to the condition(s) this trial covers.
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