Eye adnexa disorder

This study tested a new gel called IVIEW 1201 against standard antibiotic eye drops for treating bacterial pink eye. 129 people with acute bacterial conjunctivitis took part. The goal was to see if the gel works better at clearing up redness and discharge by day 8 and day 14.

This study tests whether transplanting healthy bacteria from the eye's surface can help people with moderate to severe dry eye. Forty participants will either receive the bacteria transplant or a fake procedure. Researchers will measure changes in eye discomfort and surface damag…

This Phase 3 trial tests dazodalibep, a drug given by IV, in 651 people with moderate-to-severe Sjögren's syndrome. The goal is to see if it reduces disease activity and improves symptoms like dryness and fatigue. Participants receive either the drug or a placebo, and researchers…

This trial tests a new dissolvable plug placed in the tear duct that releases tacrolimus, an anti-inflammatory drug, to treat moderate to severe dry eye. Adults aged 18 to 75 with dry eye will receive either the tacrolimus plug in one of two sizes or an approved dissolvable plug …

This trial compares two versions of a surgery called external dacryocystorhinostomy, which creates a new drainage path for a blocked tear duct. Half of the participants receive the standard surgery, while the other half receive the surgery plus a piece of amniotic membrane placed…

This Phase 3 trial tests whether RGN-259, an eye drop containing thymosin beta 4, can reduce the signs and symptoms of dry eye. About 700 adults with a history of dry eye will use the drops four times a day for two weeks, or a placebo. Researchers will measure changes in corneal …

This trial tests whether an experimental eye drop made of tiny fat bubbles, called liposomes, can improve the health of the eye surface and tear film in adults with dry eye disease. Participants will use one drop in each eye three times a day for four weeks. Researchers will meas…

This trial tests whether adding insulin to autologous serum eye drops (made from a patient's own blood) improves symptoms and signs of moderate to severe dry eye in people with autoimmune conditions like Sjögren's syndrome. Researchers will compare standard serum drops against se…

This trial tests whether an oral medication called linsitinib can help people with active, moderate to severe thyroid eye disease, a condition that causes eye bulging and inflammation. Participants take either linsitinib or a placebo twice daily for 24 weeks. The main goal is to …

This study looked at how safe and tolerable different lengths of treatment with teprotumumab are for adults with thyroid eye disease (TED). About 313 participants received the drug for varying durations to see if shorter treatment works as well and reduces side effects. The goal …

This trial tests whether cyclosporine eye drops, a treatment for dry eye disease, can help maintain the health of corneal endothelial cells—the cells that keep the cornea clear. About 204 adults with dry eye will receive either cyclosporine drops or a saline solution for 12 month…

This trial compares two surgical techniques for removing a pterygium, a fleshy growth on the eye's surface that can distort vision. Researchers are testing whether using a piece of the patient's own conjunctiva (the clear tissue covering the eye) or a preserved amniotic membrane …

This trial tests whether insulin eye drops can improve the ocular surface in people with moderate-to-severe dry eye disease. Participants will receive either insulin eye drops or artificial tears for up to a year. The study measures changes in dry eye symptoms and tear production…

This study tested an investigational drug called VRDN-001 in 143 people with thyroid eye disease who did not improve in earlier studies. The drug aims to reduce inflammation and eye bulging by blocking a specific receptor. Researchers measured how many participants had at least a…

This study tested cyclosporin 0.1% eye drops in 25 adults with moderate to severe dry eye disease that didn't get better with artificial tears. The goal was to see if the drops reduce eye dryness and redness. Participants used the drops alongside their usual tear substitutes for …

This Phase 3 trial tested an investigational drug called veligrotug (VRDN-001) in 188 people with chronic thyroid eye disease. The drug is an antibody that blocks a protein involved in the disease. The main goal was to see if it could reduce eye bulging (proptosis) compared to a …

This completed Phase 3 trial tested a drug called VRDN-001 in 231 people with thyroid eye disease (TED). The drug works by blocking a receptor involved in inflammation and swelling. The main goal was to check safety and tolerability, with secondary goals including measuring chang…

This trial tests whether veligrotug, an antibody that blocks a receptor involved in inflammation, can reduce eye bulging and swelling in people with active thyroid eye disease. Participants receive five infusions of the drug or a placebo. The study measures how many people see a …

This trial investigates whether a sterile gauze infused with natural plant extracts can reduce bacteria on the eyelid margin in people with bilateral anterior blepharitis. Each participant receives the plant-based gauze on one eye and a standard gauze on the other, allowing direc…

This study tests a drug called satralizumab in 127 people with moderate-to-severe thyroid eye disease, a condition that causes eye bulging and discomfort. Participants receive either the drug or a placebo to see if it reduces eye bulging by at least 2 millimeters over 24 weeks. T…

This trial compares two operations for primary acquired nasolacrimal duct obstruction, a condition where tears cannot drain normally from the eye into the nose, causing persistent tearing. One surgery uses a small skin incision near the inner corner of the eye, while the other go…

This Phase 3 trial tests satralizumab, a drug that blocks IL-6, in 131 people with moderate-to-severe thyroid eye disease. The main goal is to see if it reduces eye bulging by at least 2 mm after 24 weeks. Participants receive either satralizumab or placebo injections, and resear…

This study tests two types of light therapy—low-level light and intense pulse light—to kill Demodex mites that cause eyelid inflammation (blepharitis). 88 adults with confirmed mite infections will receive one of four treatments: sham, blue light alone, IPL alone, or both. All wi…

This study tested whether cleaning the eyelids with wipes containing chlorhexidine can treat blepharitis caused by Demodex mites. 106 adults with the condition used the wipes twice daily for four weeks. Researchers measured mite counts and eyelash debris before and after treatmen…

This phase 3 study tests whether the drug ianalumab can reduce disease activity in people with active Sjogren's syndrome. About 275 adults with the condition will receive either ianalumab or a placebo shot under the skin. The main goal is to see if the drug improves symptoms and …

This study tests whether Miebo eye drops, used before and after cataract surgery, can improve the accuracy of lens measurements and final vision in people with dry eye. Participants apply the drops four times daily for about 30 days before surgery and again for 30 days after. The…

This study tested a new drug called VRDN-003 in 87 people with thyroid eye disease (TED). The drug is given as a shot under the skin and targets a protein linked to the disease. The main goal was to check safety and how the drug moves through the body, not yet to measure how well…

This study tests whether a graft made from a patient's own or donor stem cells can repair the cornea's surface in people with limbal stem cell deficiency, a condition that causes pain, scarring, and vision loss. A small biopsy of limbal tissue is taken from a healthy eye or donor…

This study tested an eye drop called RMP-A03 in 77 healthy volunteers and people with pterygium, a fleshy growth on the eye. The goal was to see if it safely reduces redness and controls the condition. Participants received either a low dose, high dose, or placebo drops, and rese…

This study looked at whether tocilizumab, a drug that calms the immune system, can help people with active moderate-to-severe thyroid eye disease that did not get better with steroids. Thirty-two adults received the drug every four weeks. Researchers measured improvements in eye …

This study tested whether using 3D-printed, custom models to plan and guide orbital decompression surgery leads to fewer complications and better outcomes for people with thyroid eye disease. Twelve adults with inactive, moderate-to-severe disease were randomly assigned to receiv…

This phase 2 trial tested a biologic drug called RC18 in 42 people with primary Sjögren's syndrome, an autoimmune disease that causes dry eyes and mouth. Participants received weekly injections of either RC18 (at 160 mg or 240 mg) or a placebo for 24 weeks. The goal was to see if…

This Phase 2 trial tested a drug called CFZ533 (iscalimab) in 273 adults with Sjögren's syndrome, an autoimmune disease causing dryness, pain, and fatigue. Participants received either the drug or a placebo for 24 weeks. The study measured changes in disease activity and symptoms…

This study tested a drug called IBI311 in 91 adults with thyroid eye disease, a condition that can cause bulging eyes and discomfort. Participants received an initial high dose followed by several maintenance doses every three weeks. The main goal was to see if the drug could red…

This study tested whether eye drops made from a patient's own blood or from donated umbilical cord blood can improve dry eye disease. Eighty adults with dry eye from conditions like Sjogren's syndrome or after using glaucoma drops were randomly assigned to one of the two types of…

This phase 2 trial tested the antibiotic doxycycline as a first treatment for a rare type of eye lymphoma (OAMZL) that may be linked to a bacterial infection. 44 newly diagnosed patients took doxycycline for several months. The goal was to see if eradicating the infection could c…

This study tested a new anti-infective eyedrop called SCH1 in 30 adults with acute infectious conjunctivitis (pink eye). Participants received either the active eyedrop or a placebo. The goal was to see if the drug could completely clear redness and discharge. The trial is comple…

This early-phase trial tested a new personalized therapy called TBio-4101 for people with advanced melanoma that had stopped responding to standard treatments. The therapy uses a patient's own tumor-fighting immune cells, which are collected, multiplied in the lab, and then infus…

This Phase 3 trial tested whether batoclimab, an injected antibody, can reduce eye bulging (proptosis) in people with active, moderate-to-severe thyroid eye disease. 86 participants received weekly injections of batoclimab or a placebo for 24 weeks. The main goal was to see how m…

This study tested whether a new eye drop called AR-15512 can improve the health of the eye surface in people with dry eye disease. 80 participants received either the new drops or artificial tears. The main goal was to see if the drops increased the number of goblet cells, which …

This study tested whether a steroid eye drop (fluorometholone) given for four weeks after trachoma surgery could stop eyelashes from growing back and rubbing against the eye. Over 2,400 people aged 15 and older took part. The goal was to see if this simple, low-cost addition to s…

This study tested a drug called IBI311 in 53 people with thyroid eye disease that did not get better with steroids. The drug is a modified antibody that blocks a specific receptor. The main goal was to see if it could reduce eye bulging. The trial was completed and compared IBI31…

This study tested whether baricitinib, a drug already used for rheumatoid arthritis, can help people with active Sjogren's syndrome. 87 participants were randomly assigned to receive either hydroxychloroquine alone or baricitinib plus hydroxychloroquine for 24 weeks. The goal was…

This study tested a new medicine called LASN01 in 41 adults with thyroid eye disease, a condition that causes eye bulging and discomfort. The goal was to see if LASN01 could safely reduce eye bulging compared to a placebo. Participants received either LASN01 or a dummy treatment …

This study looked at the long-term safety of efgartigimod in 24 adults with primary Sjögren's syndrome who had already completed a prior trial. Efgartigimod works by lowering certain antibodies that may drive the disease. The main goal was to track side effects over 48 weeks, wit…

This study tested a drug called ianalumab in 21 adults with Sjögren's syndrome, an autoimmune disease that causes dry eyes and mouth. The goal was to understand how the drug works in the salivary glands and check its safety. Participants received injections of ianalumab and had b…

This study tested whether a drug called moxidectin, combined with other medicines, works better than the standard treatment (ivermectin combinations) for lymphatic filariasis, a parasitic disease that can cause severe swelling. 164 adults with the infection received a single dose…

This massive study tested whether giving deworming medicine (albendazole) to everyone in a community, not just children, can break the cycle of soil-transmitted worm infections. Over 350,000 people in India, Malawi, and Benin took part. The goal was to see if treating entire vill…

This study tested whether tocilizumab, a drug that blocks inflammation, can help people with primary Sjögren's syndrome—an autoimmune disease causing dry eyes, dry mouth, pain, and fatigue. Researchers gave 110 participants either tocilizumab or a placebo to see if it could reduc…

This Phase 2 trial tested whether injections of aflibercept, a drug that blocks abnormal blood vessel growth, are safe for people with active thyroid eye disease. Eleven adults received three injections over a month, with or without hyaluronidase to help spread the drug. The main…

This Phase 3 trial tested a drug called batoclimab in 114 adults with active, moderate-to-severe thyroid eye disease (TED). Participants received weekly injections of batoclimab or a placebo for 24 weeks. The main goal was to see if the drug could reduce eye bulging (proptosis) b…

This study looked at how well flu vaccines (seasonal and H1N1) work in 234 adults with autoimmune diseases like lupus or vasculitis, some of whom were on steroids or immunosuppressants. Researchers measured antibody levels three weeks after each shot to see if the vaccine provide…

This study tested whether low-level light therapy (LLLT) plus non-steroidal immunosuppressant eye drops can help people with dry eye disease. 160 participants received three weekly light sessions along with either cyclosporine or tacrolimus drops. The goal was to see if the combi…

This study tested an experimental drug called nipocalimab in 163 adults with primary Sjogren's syndrome, an autoimmune disease causing dryness and fatigue. Participants received either the drug or a placebo for 24 weeks. The goal was to see if nipocalimab could reduce overall dis…

This extension study tested the safety and tolerability of two doses of iscalimab in 206 people with Sjögren's syndrome who had already completed a prior study. Participants received weekly injections for three weeks, then bi-weekly doses. The goal was to see if the drug is safe …

This study tested a new eye gel called IVIEW-1201 in 135 people with acute adenoviral conjunctivitis (pink eye caused by a virus). The goal was to see if the gel could clear symptoms like redness and discharge faster than a placebo. The gel contains povidone-iodine, an antiseptic…

This Phase 2 study tested an experimental drug called SAR441344 in 84 adults with primary Sjögren's syndrome, a condition causing dry eyes, dry mouth, and fatigue. Participants received either the drug or a placebo by injection over 12 weeks. The goal was to see if the drug could…

This Phase II study tested a new biologic drug called IBI311 in 38 people with thyroid eye disease, a condition that causes eye bulging and discomfort. Participants received different doses of the drug to see if it could safely reduce eye protrusion. The trial is completed, and r…

This study tested an eyedrop called TP-03 in 39 people with meibomian gland dysfunction (a common cause of dry eye) linked to Demodex mites. The goal was to compare two dosing schedules (twice vs. three times daily) for safety and effectiveness. The results could lead to a new tr…

This study tested a drug called telitacicept in 381 adults with active primary Sjogren's syndrome, an autoimmune disease causing dry eyes and mouth. Participants received either the drug or a placebo to see if it safely reduces disease activity. The goal is to control the conditi…

This early-stage trial tests an experimental drug called IBI355 in 30 adults with primary Sjögren's syndrome, an autoimmune disease that causes dry eyes and mouth. The main goal is to check the drug's safety and how the body processes it at different doses. Participants receive e…

This completed study looked at how well teprotumumab (TEPEZZA) works in real-world use for 5 Chinese patients with thyroid eye disease. The main goal was to see how many patients had a reduction in eye bulging (proptosis) after their last IV infusion. The study also collected bas…

Researchers are studying whether cell-free RNA in saliva can work as a non-invasive liquid biopsy to help diagnose Sjögren's disease. The trial compares saliva from people with Sjögren's disease against saliva from people with dry-eye and dry-mouth symptoms who do not have the di…

Researchers are testing whether dry eye symptoms and signs can serve as a predictive marker in people with hand osteoarthritis. Participants complete the Ocular Surface Disease Index questionnaire and undergo tear tests, including Schirmer tests, tear break-up time, and optical c…

This study tests whether a modified action camera can take clear images inside the nose, compared to the standard large camera system. Forty adults with tearing or sinus issues will have both types of images taken during their routine exam. Doctors will rate the image quality to …

This study tested a non-invasive imaging device called dermal optical coherence tomography (D-OCT) to diagnose basal cell carcinoma (a common skin cancer) around the eye area. Researchers compared its accuracy to standard biopsy results in 210 adults with suspected lesions. The g…

This study tested an artificial intelligence (AI) algorithm designed to analyze images of minor salivary gland biopsies to help diagnose Sjogren's syndrome. Researchers used 1,000 biopsy samples from patients with suspected Sjogren's to see if the AI could accurately count immune…

This study tested a device called SUDOSCAN, which measures sweat function in just two minutes, to see if it can detect small fiber nerve damage in people with autoimmune diseases (like lupus or rheumatoid arthritis) or unexplained pain. Researchers enrolled 139 adults and compare…

This completed study looked at whether lupus patients already taking hydroxychloroquine long-term had a lower risk of catching COVID-19 or developing severe symptoms. Researchers compared 552 patients who either took the drug or did not, using blood tests and questionnaires. The …

This study tested whether a new dynamic color temperature mode on screens can prevent dry eye and visual fatigue. Thirty adults read text on a screen for 50 minutes under different color settings. Researchers measured eye fatigue and dryness before and after to see if the new mod…

This early-stage trial tested an experimental eyedrop called INV-102 in 84 adults with moderate dry eye disease. The study had two parts: first, checking safety at different doses, and second, seeing if the drops improve eye dryness symptoms after two weeks. Participants used the…

Researchers are testing an experimental eyedrop called INV-102 in adults with acute infectious keratoconjunctivitis, a common eye infection that causes redness and discharge. The Phase 2 trial randomly assigns participants to receive either INV-102 or a vehicle drop for one week,…

Researchers are testing an experimental eyedrop called INV-102 in adults with moderate to severe dry eye disease. The trial compares INV-102 with a vehicle drop over four weeks of repeated dosing. The main goal is to see whether INV-102 reduces corneal damage, measured by a stand…

Researchers are testing two eye drops that contain hyaluronic acid and amino acids in people with dry eye syndrome. Adults with moderate to severe dry eye receive the 0.30% drop, while those with mild dry eye receive the 0.15% drop. The study measures changes in eye surface stain…

This study tests a new artificial tear called ABBV-444 against an existing brand, Refresh Optive, in 250 adults with dry eye disease. Participants use the assigned eye drops for 90 days. The goal is to see if the new formula improves eye comfort and surface health better than the…

This study tests a device called Rexon-Eye that uses low-level electrical current to treat dry eye disease. Researchers will also analyze tear proteins to see how they change with treatment. The trial involves 75 adults with dry eye and aims to understand both the device's effect…

Researchers at King Saud University tested whether a four-week yogic eye exercise program reduces symptoms of computer vision syndrome in female university students. All 36 participants performed a 13-minute sequence of relaxation and eye-strengthening exercises three days a week…

This trial tests whether low-dose atropine eye drops can reduce excessive tearing (epiphora) in adults. Participants use one of two strengths (0.005% or 0.01%) in their affected eye(s) for one week. The study compares how well each dose works and monitors for any side effects.

This study compares a clinic-based thermal device (MiBo Thermoflo) to standard warm compresses for treating dry eye caused by meibomian gland dysfunction. About 42 adults who haven't improved with warm compresses will be randomly assigned to either three sessions of MiBo therapy …

Researchers are testing tivanisiran sodium eye drops in adults with dry eye disease to see if the drops are safe when used once daily for a year. About 300 participants will receive either the tivanisiran drops or a vehicle drop, which is a solution without the active ingredient.…

This study compares two lubricating eye drops—Systane PRO PF and Thealoz Duo—to see which one better relieves dry eye symptoms. About 100 adults with dry eye will use each drop for 4 weeks, one twice a day and the other four times a day. The goal is to find out if they work equal…

This study tests whether a lower dose (6%) or a higher dose (8%) of sevoflurane gas works better and causes fewer side effects when putting children aged 1 to 6 years to sleep for minor eye surgery. The main goal is to see which dose leads to less agitation and confusion when the…

This study tested whether a numbing gel (lidocaine) works as well as a needle injection for pain relief during pterygium surgery. 41 adults having pterygium removal took part. The goal was to see if the gel causes less pain and eye dryness after surgery.

This trial tests whether a cosmetic eyelash serum called Dallixa® can safely improve eyelash fullness and length in adults who have naturally sparse eyelashes (idiopathic eyelash hypotrichosis). Participants will apply the serum and be evaluated over four months using a standard …

This study compares two eye drops—SYSTANE PRO and MIEBO—to see if SYSTANE PRO works as well as MIEBO for treating dry eye disease. About 260 adults with moderate dry eye will use one of the two drops for one month. The main goal is to measure changes in dry eye symptoms using a s…

This study is testing a new eye drop that combines trehalose, sodium hyaluronate, and NAAGA without preservatives. It will enroll 30 adults with dry eye disease who are either new to treatment or unhappy with their current drops. Over 6 months, researchers will track changes in s…

This study is testing two new artificial tear formulas to see if they are safe and well-tolerated in people with moderate dry eye disease. Researchers will monitor for side effects and eye health in 148 participants who already use artificial tears. The goal is to find better opt…

This trial investigates whether using Systane Complete eye drops twice a day works as well as using Thealoz Duo eye drops four times a day for adults with mild to moderate dry eye disease. Over 30 days, participants will use one of the two regimens and report symptom changes thro…

This trial tests whether a telemedicine follow-up — a simple online survey with photos and a vision check — can safely replace the first in-person visit after low-risk eyelid procedures like droopy eyelid repair or skin cancer removal. Adults undergoing these surgeries will eithe…

This study tests whether wearing a compression dressing for 24 hours after upper eyelid blepharoplasty (eyelid lift) reduces swelling, bruising, and pain. Each participant has both eyelids operated on; one eye gets the dressing, the other does not. Masked observers assess recover…

This Phase 2 trial tests a new eye drop that combines two active ingredients—lifitegrast and perfluorohexyloctane—for people with dry eye disease. About 423 adults will use the drops twice daily for 4 weeks. Researchers will measure changes in eye surface staining and symptom sco…

This study is testing whether eye drops made from cord blood plasma can relieve symptoms of moderate to severe dry eye disease better than standard artificial tears. Researchers will compare the cord blood drops combined with cyclosporine to a control treatment of hyaluronic acid…

This Phase 3 trial tested rebamipide eye drops in 762 people with dry eye lasting at least 6 months. Participants received either rebamipide or placebo drops for 26 weeks. The goal was to see if the drops could reduce eye surface damage and discomfort better than placebo.

This early study tested a dexamethasone eye insert placed by a doctor against a standard steroid gel for treating allergy and dry eye symptoms in 36 people with keratoconus who wear gas permeable contact lenses. The goal was to see if the insert improves signs like eyelid bumps a…

This study tested whether using Systane PRO eye drops consistently for 30 days can relieve symptoms of dry eye disease and improve daily functioning. Thirty-three adults with mild to moderate dry eye took part. The main goal was to see if their eye comfort scores improved from th…

This Phase 3 trial tested rebamipide eye drops in 755 people with dry eye for at least 6 months. Participants received either rebamipide or placebo drops for up to 52 weeks. The goal was to see if the drops could reduce eye surface damage and ease discomfort.

This study tests an experimental eye drop called GRF312 5% in 100 adults with dry eye disease. The goal is to see if it is safe and helps relieve symptoms. Participants will use the drops at home and attend clinic visits for check-ups.

This pilot study tested whether a TENS device, placed on the forehead, is safe and practical for treating chronic eye pain in 39 veterans. Participants used the device at home for 6 months. The goal was to see if it reduces pain and to prepare for a larger trial.

This early study tests whether RCI001 eye drops are safe and tolerable in 40 healthy adult men. Participants receive either the active eye drops or a placebo, and researchers monitor for side effects and how the drug behaves in the body. This is a first step toward possibly devel…

This study tested whether CAM-101 eye drops are safe and can help relieve dry eye in people who developed the condition after a bone marrow transplant (graft-versus-host disease). 64 adults received either a low or high dose of CAM-101 or a placebo drop four times a day for six w…

This study tested whether a dietary supplement called Nutritears, containing lutein, zeaxanthin, curcuminoids, and vitamin D3, can improve dry eye symptoms. 131 adults with dry eye syndrome took either the supplement or a placebo daily for 8 weeks. Researchers measured tear produ…

This study tested the TearCare MGX system, a device that applies heat to the eyelids, for treating dry eye caused by meibomian gland dysfunction. 21 adults with dry eye symptoms received the treatment, comparing a standard version with one that includes an extended warming hold. …

This study tested two ways to warm the eyelids for people with dry eyes caused by meibomian gland dysfunction. Fifteen adults used a USB-powered warm compress and a self-heating eye mask for two weeks each. Both devices improved tear stability and comfort, but the USB-powered ver…

This completed Phase 3 trial tested a new eye drop containing brimonidine and sodium hyaluronate against Lumify for reducing eye redness in 578 adults. Participants used the drops four times daily, and redness was measured over several hours. The goal was to see if the new drop w…

This study tested how comfortable two prescription steroid eye drops feel right after use. Forty adults with eye inflammation or dry eye received one drop of Flarex in one eye and one drop of Lotemax SM in the other. They rated comfort and vision impact at 30 seconds, 5 minutes, …

This study tested whether using the Systane iLux device—which applies heat and pressure to the eyelids—before cataract surgery could improve dry eye symptoms. Thirty adults scheduled for cataract surgery received the treatment in one eye. Researchers measured changes in tear film…

This study tested an eye drop called reproxalap in 131 adults with moderate-to-severe seasonal eye allergies. Participants were exposed to ragweed pollen in a special chamber to trigger symptoms. The eye drop was compared to a placebo (no active ingredient) to see if it reduced i…

This study tested two experimental drugs, REGN1908 and REGN1909, mixed together to reduce eye allergy signs and symptoms in people with cat allergies. The goal was to see how safe and effective the drug is compared to a placebo. The study included 64 participants with a history o…

This pilot study tested whether a wheat-free and milk-free diet could reduce symptoms in people with Sjogren's syndrome, an autoimmune disease. Thirty participants were randomly assigned to either the special diet or a control diet. After two months, those on the wheat-free diet …

This study tested whether a nasal spray containing varenicline (OC-01) can improve tear film quality and reduce dryness in people with dry eye disease. Fifty adults used either the active spray or a placebo. Researchers measured tear film changes and symptom scores shortly after …

This study tested whether electroacupuncture (a type of acupuncture with mild electric pulses) can improve symptoms of mild-to-moderate dry eye. 168 adults received either real or sham electroacupuncture. Researchers measured tear film stability and other eye health markers to se…

This study tested whether BRM421 eye drops can safely reduce the signs and symptoms of dry eye compared to a placebo. 220 adults with dry eye for at least 6 months received either the active drops or a placebo. The main outcomes were changes in corneal staining (eye surface damag…

This study tested whether BRM421 eye drops can safely ease the signs and symptoms of dry eye. 157 adults with dry eye for at least 6 months received either the active drops or a placebo. The trial measured changes in corneal staining and discomfort scores. Results suggest the dro…

This study tested whether far infrared eye masks placed on acupoints around the eyes could improve dry eye symptoms. Thirty-one adults with dry eye disease used the masks, and researchers measured tear film stability, gland health, and symptom scores before and after one month of…

This study tested an eye drop called HBM9036 in 577 Chinese adults with moderate to severe dry eye. The goal was to see if it reduces eye surface damage and improves symptoms better than a placebo. Participants used the drops for about two months, and doctors measured changes in …

This study tested two experimental drugs, REGN5713 and REGN5715, given together to reduce eye allergy symptoms caused by birch pollen. Fifty-four adults with a history of moderate to severe birch pollen allergy received the drug combo or a placebo. The main goal was to see if the…

This study tested whether scleral lenses treated with a special coating called Hydra-PEG can improve comfort and reduce dryness in people with dry eye. 46 participants wore two types of lenses over several weeks and rated their comfort on a scale. The goal was to see if the coate…

This study tested three ways to use an eyelid wipe soaked with IVW-1001, a dry eye treatment, in 30 people with dry eye disease. Researchers measured changes in tear production and checked for any vision changes. The goal was to find the best wiping technique for safety and sympt…

This pilot study tested whether Tixel, a device used to treat wrinkles around the eyes, could also improve dry eye symptoms. 75 adults with mild to moderate wrinkles and dry eye received the standard Tixel treatment. Researchers measured tear film stability and dry eye questionna…

This study tested three different ways to use a medicated eyelid wipe (IVW-1001) for people with dry eye disease. Fifteen adults with dry eye took part. The main goal was to see how safe and tolerable the different dosing techniques were, and how well they improved tear productio…

This study looked at whether regular aerobic exercise, like walking, can reduce fatigue in women with primary Sjögren's syndrome. Forty-five women participated in a 16-week program. Researchers measured changes in fatigue, mood, and physical fitness.

This study tested three treatments for meibomian gland dysfunction, a common cause of dry eye. 374 adults with mild-to-moderate dry eye were randomly assigned to receive either vectored thermal pulsation (a device that heats and massages the eyelids), intense pulsed light therapy…

This study tested the safety of AR-15512 eye drops in 55 people with dry eye disease. Participants received the drops at different temperatures and with eyes open or closed to see if these factors affect side effects. The goal was to measure how many people had eye-related side e…

This study tested whether a fine mist made from traditional Chinese herbs can help people with dry eye disease. 200 adults received either the herbal mist, a placebo mist, or standard eye drops for 4 months. Researchers measured symptom scores and tear film stability to see if th…

This study tested whether injecting triamcinolone acetonide into the eyelid could help people with thyroid eye disease who have a retracted upper eyelid. Fifteen adults received a combination of two injections and were measured one month later. The goal was to see if the eyelid p…

This early-phase trial tested YM-101 eye drops in 30 adults with dry eye syndrome. Participants received either high or low dose YM-101 plus artificial tears, then switched to placebo after a washout period. The study measured changes in corneal staining, tear break-up time, and …

This study tested whether eye drops made from a patient's own blood (autologous serum) can relieve severe dry eye better than standard artificial tears. 46 adults with severe dry eye tried both diluted (20%) and full-strength (100%) serum drops, as well as artificial tears. The m…

This study tested if insulin eye drops can safely and effectively treat moderate to severe dry eye disease. 116 adults received either insulin drops, standard cyclosporin drops, or artificial tears (placebo) for 6 months. The main goal was to see if insulin drops improved corneal…

This phase 3 trial tested whether a new eye drop called HUC3-053 works as well as an existing drop (Hyalein) for dry eye. 297 adults used the drops 5-6 times daily for 12 weeks. The study measured changes in eye surface staining and other signs of dry eye.

This study tested whether a special yellow-light, anti-glare phone screen could reduce eye strain and dryness caused by using a phone for 2 hours in a dim room. 70 adults with mild nearsightedness took part. Researchers measured tear quality, eye redness, and other signs of eye f…

This Phase 2 study tested three different dosing schedules of Lagricel Ofteno eye drops (sodium hyaluronate 0.4%) in 141 people with mild to moderate dry eye. Participants used the drops either twice, four times, or six times a day. The main goal was to see which schedule best im…

This study tested three different eye drops (Humylub Ofteno PF, Hyabak, and Lagricel Ofteno PF) in 182 people with mild to moderate dry eye. Participants used the drops four times a day for 30 days. The main goal was to see if Humylub was as good as the others at reducing dry eye…

This study tested whether a dietary supplement could improve dry eye symptoms by changing the bacteria in the gut. Twenty adults with dry eye disease took the supplement for 8 weeks. Researchers measured tear production and eye surface health before and after treatment. The goal …

This completed study tested whether Reinnerva/Lubristil+G eye drops work better than Vismed for people with dry eyes. Forty adults with dry eye symptoms used one drop in each eye twice daily (Reinnerva/Lubristil+G) or four times daily (Vismed) for 60 days. Researchers measured te…

This study tested a new eye drop formula in 188 adults with mild to moderate dry eye disease. Participants used the drops for 30 days and reported how much their symptoms bothered them. The goal was to see if the drops safely improve comfort.

This study tested a new eye treatment called TTAX03 in 74 people with mild to moderate dry eye disease. The goal was to see if it is safe and if it can reduce eye dryness and damage. Participants received either a single dose of TTAX03 or a saline (salt water) control and were ch…

This phase 2 trial tested two strengths of rhNGF eye drops against a placebo in 317 adults with moderate-to-severe dry eye disease. Participants used the drops three times a day for 4 weeks, followed by 4 weeks of monitoring. The goal was to see if the drops could improve dry eye…

This study tested a new medicated eyelid wipe called IVW-1001 in 150 adults with dry eye disease. Participants used either a low dose, a higher dose, or a placebo wipe. The goal was to see if the wipe is safe and can improve tear production and eye comfort.

This study tested two different eye drop treatments for people with dry eye disease who were having cataract surgery. One group used a single medication (rebamipide), while the other used a combination of two medications (diquafosol and cyclosporine). The goal was to see which ap…

This completed Phase 3b trial tested AR-15512 eye drops in 81 adults with dry eye disease. The goal was to see if a single dose could quickly increase tear production, measured by tear meniscus height. The study was open-label, meaning everyone knew they were getting the active d…

This study looked at how two light-based treatments—intense pulsed light (IPL) and low-level light therapy (LLLT)—work for dry eye disease caused by clogged oil glands. Twenty-six participants received four treatment sessions, with one eye getting IPL plus LLLT and the other gett…

This study tested whether Ectoin allergy nasal spray and eye drops can relieve symptoms of hay fever (runny nose, sneezing, itchy eyes) better than a placebo. 46 adults with ragweed allergies were exposed to pollen in a special chamber. Researchers measured symptom scores and nas…

This study compared two types of eye drops—ectoin (BAT04) and hyaluronic acid—for treating dry eye disease. 64 adults with mild to moderate dry eye used the drops six times daily in both eyes for 28 days. The main goal was to see how well each drop improved tear film stability, m…

This study tested whether a new eye drop called T2769 works as well as a commonly used one (Vismed Multi) for people with moderate to severe dry eye. 251 adults used the drops for 35 days. The main goal was to see if T2769 could reduce eye surface damage as effectively as Vismed …

This completed Phase 3 trial tested whether FID 123320 eye drops can safely reduce eye redness caused by minor irritations. The study involved 283 children and adults who used either the active drops or a placebo. Researchers measured redness at several time points, from 1 minute…

This Phase 3 trial tested SI-614 eye drops, a modified form of sodium hyaluronate, against placebo in 232 adults with dry eye disease. Participants used the drops four times daily for 84 days. The study measured changes in eye surface staining (a sign of damage) and daily symptom…

This early-stage study tested a new eye gel called PRO-165 to see if it is safe and tolerable for people with dry eyes. 32 healthy adults used either the new gel or a standard lubricating gel. The goal was to check for side effects and comfort, not to cure dry eye.

This study tested whether giving two types of light therapy (intense pulsed light and low-level light therapy) before laser eye surgery can help prevent dry eyes afterward. 62 people who were already scheduled for laser vision correction took part. The goal was to see if these tr…

This study tested a single-dose eye drop containing hyaluronate and sodium phosphate to relieve eye discomfort, especially dryness. Twenty-eight adults with mild to moderate dry eye participated. Researchers measured how long tears stayed on the eye and checked eye surface health…

This study tested whether a new eye drop called T2769 works as well as a standard treatment (Hylo-Forte) for people with moderate to severe dry eye. 74 adults who still had dry eye symptoms despite using artificial tears took part. The main goal was to see if T2769 could reduce e…

This study tested a low-level light therapy mask on 98 adults having cataract surgery. The mask was used one week before and one week after surgery to see if it could prevent or reduce dry eye symptoms. Researchers measured dry eye symptoms, tear stability, and eye surface health…

This study tested a gentle laser (micropulse) on 30 people with dry eye from meibomian gland dysfunction. The laser targets tiny blood vessels on the eyelid edge to reduce inflammation and improve tear quality. Researchers measured tear stability and symptom scores to see if the …

This study tested two different eye drops—diquafosol and rebamipide—to see which one provides faster relief for dry eye disease. Thirty adults with dry eye received one drop of each, and their symptoms and tear quality were checked 30 minutes later. The goal was to find out which…

This completed Phase 3 trial tested whether 0.25% reproxalap eye drops can reduce discomfort from dry eye disease better than a placebo. 116 adults with dry eye for at least 6 months used the drops six times over two days. The main goal was to measure changes in eye discomfort us…

This study tested whether Miebo eye drops (perfluorohexyloctane) can safely and effectively relieve dry eye symptoms in people who wear soft contact lenses. 104 adults used the drops up to four times daily, both before and while wearing their lenses. Researchers measured changes …

This study tested a cognitive exercise therapy approach (BETY) in 60 adults with primary Sjögren's syndrome. Participants were randomly assigned to group sessions, individual sessions, or a home exercise program for 12 weeks. The therapy combines physical exercises with strategie…

This small study tested whether levocarnitine, a natural substance, can help treat dry eye in adults with Sjogren's syndrome. Fifteen participants received both the drug and a placebo in a crossover design. The goal was to see if levocarnitine reduces eye inflammation and improve…

This study tested whether Total 30 contact lenses can help people who previously stopped wearing contact lenses because of discomfort or dryness. Sixty adults aged 18 to 40 who had worn reusable lenses for at least a year but quit within the past two years were refitted with Tota…

This study tested the safety of reproxalap eye drops in 757 adults with dry eye disease. Participants used the drops for up to one year. The main goal was to check for serious side effects like vision changes or eye pressure increases. Results will show whether the drops are safe…

This Phase 3 study tested SJP-0132 eye drops against placebo in 427 Chinese adults with dry eye disease. Participants used the drops four times daily for 8 weeks. The goal was to see if the drops improve eye surface damage and reduce dryness symptoms.

This Phase 3 study tested cenegermin (Oxervate) eye drops against a placebo in 85 adults with severe dry eye caused by Sjogren's syndrome, who were already using cyclosporine drops. The goal was to see if cenegermin could increase tear production and reduce eye discomfort over 4 …

This study tested whether a device that warms and massages the eyelids (TearCare) works better than prescription eye drops (Restasis) for dry eye disease. 345 adults with dry eye and blocked eyelid glands were randomly assigned to either an in-office TearCare procedure or twice-d…

This study tested whether special anti-reflection and circularly polarized films placed on smartphone screens can reduce dry eyes and eye strain caused by close-up screen use. 120 adults with mild nearsightedness used phones for 45 minutes in light or dark settings. Researchers m…

This study tested whether 0.05% cyclosporine eye drops can improve symptoms of mild to moderate dry eye. Researchers enrolled 60 adults and compared the drops to standard artificial tears. The goal was to see if the drops reduce eye inflammation and ease discomfort like tired eye…

This study tested the TearCare device, which warms the eyelids to melt clogged oil glands and improve tear quality. Twelve adults who had used the device before received another treatment. Researchers measured how long tears stayed on the eye and checked gland function. The goal …

This study tested a radio frequency device (Forma Eye) for dry eye caused by meibomian gland dysfunction. 47 adults received up to 3 treatments and were followed for 24 weeks. Researchers measured symptom scores, tear break-up time, and gland function to see if the treatment is s…

This study tested whether a special eye drop (apraclonidine) can safely reduce eye redness caused by minor irritations. 159 adults who often use redness-relief drops took part. Researchers measured redness before and after using the drops, checking at 15 minutes and 10 hours late…

This study tested Miebo eye drops in 99 adults with dry eye disease. Participants used one drop in each eye four times daily for 14 days. The main goal was to see how much dry eye symptoms improved after one week, measured on a 0-to-100 scale. The study is complete, but results a…

This small pilot study tested the TearCare system, a device that applies heat to the eyelids, in 24 adults with dry eye disease. The goal was to see if it safely improves tear stability and oil gland function compared to a warm compress. Results were measured after one month.

This Phase 2 trial tested an experimental eye drop called SHJ002 in 85 adults with dry eye disease. The drops are designed to block a specific microRNA linked to inflammation. Researchers measured changes in corneal staining and symptom scores over 84 days to see if the drops are…

This study tested a device called TearCare against another device, LipiFlow, in 235 adults with dry eye disease caused by blocked oil glands. The goal was to see if TearCare safely improves tear quality and eye comfort. Participants received one treatment session, and researchers…

This Phase 3 trial tested whether reproxalap eye drops can safely reduce discomfort in people with dry eye disease. 421 adults used the drops or a placebo for up to 6 weeks. The main goal was to measure changes in eye discomfort scores over time.

This study tested a new preservative-free eye drop (Thealoz Total) in 30 adults with chronic dry eye and eye redness. Participants used the drops daily for 12 weeks. Researchers measured changes in redness and how satisfied patients felt. The goal was to see if the drops improve …

This study tested whether taking a daily probiotic capsule for 35 days can reduce dry eye symptoms in adults aged 20 to 65 with confirmed dry eye. Researchers measured tear production, tear quality, and eye surface health before and after the treatment. The goal was to see if pro…

This study tested whether auricular acupuncture (tiny needles on the ear) can relieve dry eye symptoms in university students. Fifty students with dry eyes received either real ear acupuncture or a sham version, plus artificial tears, for four weeks. Researchers measured symptom …

This study tested a gentle light treatment (low-level light therapy) given before and after Femto-LASIK eye surgery. 61 adults without prior dry eye received either real light therapy or a sham treatment. Those who got the real treatment had more stable tears and fewer dry eye sy…

This study tested whether adding acupuncture to standard artificial tears helps people with moderate dry eye more than drops alone. 90 adults were randomly assigned to get either artificial tears only or tears plus acupuncture twice a week for five weeks. Researchers measured sym…

This study tested the TearCare system, a device that gently heats the eyelids for 15 minutes followed by manual expression, in 29 adults with dry eye disease. The goal was to see if a single treatment could improve tear film stability and reduce dry eye symptoms over one month. T…

This phase 2 trial tested whether VSJ-110 eye drops can reduce itching and redness caused by allergic conjunctivitis (eye allergies). 47 adults received either the active eye drop or a placebo, then were exposed to an allergen. The study measured how much their eyes itched and re…

This pilot study tested a device that gently stimulates the inside of the nose to see if it can improve tear production in people with Sjogren's syndrome. 26 participants used either the active device or a sham (fake) device for 6 weeks, then everyone used the active device for a…

This study followed 293 people with autoimmune diseases and healthy volunteers to see how COVID-19 infection or vaccination affects their immune system, inflammation, and blood vessels. Participants were grouped based on their COVID-19 history and had up to 5 visits over 12-18 mo…

This study looks at how oral isotretinoin, a common acne treatment, affects the surface of the eye and the meibomian glands, which produce the oily layer of tears. Researchers will measure tear film stability, gland structure, and dry eye symptoms in 60 acne patients before and a…

This study follows nearly 90,000 farmers and their spouses to track long-term health effects of pesticides, crops, and animals. Participants report new medical conditions, which researchers then confirm through medical records and genetic samples. The goal is to better understand…

This study examined whether women with autoimmune diseases or inflammatory rheumatism receive proper gynecological follow-up, including cervical cancer screening and contraception advice. Researchers surveyed 318 women with conditions like lupus, rheumatoid arthritis, and Sjögren…

This study investigates why people with loiasis, a parasitic infection, may test positive on rapid diagnostic tests for lymphatic filariasis. Researchers will follow 60 individuals with high loiasis worm burdens to monitor the release of filarial antigens in their blood. By ident…

This study looks at how different doses of the antibiotic doxycycline affect antibiotic resistance in people with ocular rosacea, an inflammatory eye condition. Researchers will compare a low anti-inflammatory dose (40 mg daily) with a standard antibiotic dose (200 mg daily) and …

This study tracks 378 people with moderate to severe dry eye disease and healthy volunteers to see how signs, symptoms, and biomarkers change after treatment with either Vevye or Xiidra eye drops. The goal is to find better ways to measure the disease and its response to therapy.…

This study looks at how isotretinoin, a vitamin A-based acne medication, affects eye structures and tear production in people with severe cystic acne. Participants receive standard treatment and undergo eye exams, including dry eye tests and advanced imaging, before and during th…

This study looked at 54 people with primary Sjögren's syndrome who also had muscle inflammation. Researchers wanted to see how many met the official criteria for inflammatory myopathies. The goal was to better understand and classify muscle disease in Sjögren's patients.

This study tested whether surgeons can safely use an Apple Vision Pro headset to view a microscope during cataract and other eye surgeries. 45 adults having elective eye surgery took part. The goal was to see if the headset is safe and comfortable for the surgeon, not to change h…

This study looked at 100 people with primary Sjögren's syndrome to understand how the disease affects their physical, emotional, and social well-being. Researchers used questionnaires and simple tests to measure symptoms like fatigue, pain, swallowing problems, and mood. A health…

This study looked at 20 adults who wear an artificial eye to see if it causes more dry eye symptoms and damage to the tiny oil glands in the eyelids. Researchers compared the artificial eye side with the healthy eye side using special imaging and questionnaires. The goal was to u…

This study involved 10 adults with severe dry eye disease who did not respond to standard treatments. Researchers measured levels of growth factors and vitamins in autologous serum eye drops before and after filtration, to see if filtering reduces their concentration. The goal is…

This study looked at 235 people to understand how certain immune cells, called innate T cells, might be involved in systemic sclerosis (a rare disease that causes hardening of the skin and organs). Researchers compared patients with systemic sclerosis to those with other autoimmu…

This study looked at whether immune cells from the intestine play a role in Sjogren's syndrome, an autoimmune disease that causes dry eyes and mouth. Researchers examined saliva gland samples from 57 adults suspected of having Sjogren's. The goal was to better understand the dise…

This study looked at a rare disease called IgG4-related disease, which causes swelling and scarring in organs. Researchers compared immune cells in the blood of 75 people: those with the disease, those with Sjogren syndrome, and healthy volunteers. The goal was to better understa…

This study looked at whether a food safety training program helps food service employees improve their knowledge, attitudes, and practices around safe food handling. About 200 adult workers took part, and the training covered personal hygiene and safe food preparation. The goal w…

This study looked at 100 adults with atopic dermatitis (eczema) who were prescribed tralokinumab. Researchers tracked how many developed eye problems like conjunctivitis within 4 months of starting the drug. The goal was to better understand these side effects in real-world use, …

This study looked at how often people with primary Sjögren's syndrome have digestive issues. Researchers asked 151 patients about 10 different digestive symptoms using a simple questionnaire. The goal was to understand which symptoms are most common and how they relate to how lon…

This study looked at the DNA changes (mutations) in eye cancers called ocular melanoma. Researchers analyzed tumor samples from 58 patients to understand how these cancers develop and spread. The goal was to identify key mutations that could lead to better treatments in the futur…

This completed study looked at 31 people with dry eye to see if measuring corneal sensitivity (how well the eye feels touch) can detect early-stage neurotrophic keratopathy, a condition where the cornea loses sensation. Researchers aimed to find out which dry eye patients might l…

This completed study looked at how the immune system might affect the outlook for people with pulmonary arterial hypertension (PAH). Researchers took blood and skin samples from 629 participants with different types of PAH to search for specific antibodies. The goal was to better…

This completed study surveyed 121 adults with autoimmune diseases like lupus, Sjögren's syndrome, or scleroderma. Participants filled out a questionnaire about their use of alternative medicines. The goal was to find out how common these practices are in this patient group.

This study tested a digital color scale to objectively measure scarring of the eye's surface in people with recurrent pterygium, a growth that can come back after surgery. Researchers took photos of 25 patients' eyes and used software to analyze the scar tissue. The goal was to s…

This completed study from Thomas Jefferson University involved 20 adults with thyroid eye disease and their caregivers. Researchers conducted focus groups and interviews to understand how the condition affects mood, relationships, work, and daily life. Participants also completed…

This study examined how common PCOS treatments (birth control pills and clomiphene citrate) affect the eyes. Researchers measured dry eye signs and retinal blood vessels in 60 women with PCOS and compared them to 30 healthy women. The goal was to see if these treatments cause cha…

This study looked at how a surgery called balanced orbital decompression affects blood flow in the eyes of people with inactive thyroid-associated orbitopathy (thyroid eye disease). Researchers measured blood vessel changes in the eye before and after surgery using special imagin…

This completed study looked at 68 adults with thyroid-associated orbitopathy (thyroid eye disease) to see how changes in the eye socket affect blood vessels in the retina. Using a special imaging technique called OCTA, researchers measured vessel density in different layers of th…

This study looked at whether a central monitoring station outside the operating room could safely replace having an anesthesia nurse in each room during eye surgeries like cataract removal. Researchers compared the rate of complications (like high blood pressure or low oxygen) be…

This study looked at two methods for fixing a tissue graft after removing a pterygium, a growth on the eye's surface. In 30 patients with pterygium in both eyes, one eye received stitches and the other did not. Researchers used special imaging to compare healing, comfort, and gra…

This study looked at how a special exercise approach called BETY affects people with rheumatic diseases (like arthritis) who have chronic pain. Researchers reviewed past records of 300 participants to see if BETY improved their physical function, mood, and quality of life compare…

This study looked at whether a pelvic floor symptom questionnaire (PFDI-20) is valid and reliable for people with primary Sjögren's syndrome. Ten adults with the condition completed the survey along with other health assessments. The goal was to see if the questionnaire accuratel…

This study looked at 27 adults with Sjögren's syndrome to find out how common jaw joint problems (TMD) are and if they relate to disease activity. Researchers measured jaw function, mouth opening, head posture, and oral health. The goal was to better understand the link between S…

This study looked at whether whole genome sequencing (a complete read of a person's DNA) can help diagnose leukodystrophies, a group of rare brain diseases that are hard to identify. Researchers enrolled 236 children with white matter abnormalities on brain scans but no known gen…

This completed study looked at 1,000 women with autoimmune diseases (like lupus) who had a C-section. Researchers wanted to find out how many had severe bleeding (postpartum hemorrhage) and what factors increased that risk. By analyzing medical records, they hope to identify high…

This study looked at specific cells in the blood of 40 women with either Sjögren's syndrome or systemic sclerosis. The goal was to see if counting these cells could help understand the diseases better. No treatment was given; it was purely an observational study to explore potent…

This completed study looked at how two types of eye drops—cyclosporine A and hyaluronic acid—change the community of bacteria living on the eye's surface in people with dry eye syndrome. Fifty adults were randomly assigned to receive either cyclosporine plus hyaluronic acid or hy…