Gut health hack: supplement shows promise for dry eyes

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: Adults aged 18-65 years. Clinical diagnosis of dry eye disease with clinically significant symptoms, defined as Ocular Surface Disease Index (OSDI) score ≥23 at screening and/or baseline. Evidence of tear film instability consistent with dry eye disease, defined as fluorescein tear break-up time (TBUT) ≤10 seconds in at least one eye at screening and/or baseline. Willing and able to provide written informed consent. Willing to maintain habitual diet and lifestyle during the study period and to avoid initiating new microbiome-active products (e.g., probiotic/prebiotic/synbiotic supplements) during the intervention. Exclusion Criteria: Current restrictive dietary pattern likely to materially alter gut microbiota (e.g., ketogenic diet, elimination diets, prolonged fasting) or planned major dietary change during the study period. Colonoscopy within the past 4 weeks. Systemic antibiotic use within the past 4 weeks. Use of probiotic, prebiotic, synbiotic, postbiotic, or fecal microbiota-related products within the past 4 weeks. Active ocular infection or acute ocular inflammation requiring treatment escalation (e.g., acute blepharitis flare, active allergic conjunctivitis requiring escalation), at screening/baseline. Sjögren syndrome or other active systemic autoimmune disease with clinically significant ocular involvement, in the investigator's judgment. Ocular surgery (including refractive surgery) or significant ocular trauma within the past 6 months. Contact lens wear within 30 days prior to baseline or planned contact lens use during the study. Topical cyclosporine, lifitegrast, or topical ocular corticosteroid use within 8-12 weeks prior to baseline, or planned initiation during the study. Punctal plug placement within the past 3 months or planned during the study. Known hypersensitivity to any component of the study product. Any other systemic or ocular condition that, in the investigator's judgment, could compromise participant safety or interfere with study outcomes.