Can a herbal mist soothe dry eyes? new study investigates
NCT ID NCT06089317
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested whether a fine mist made from traditional Chinese herbs can help people with dry eye disease. 200 adults received either the herbal mist, a placebo mist, or standard eye drops for 4 months. Researchers measured symptom scores and tear film stability to see if the TCM mist offers extra relief beyond artificial tears.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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200 people
The number who actually took part.
- Started
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Jul 2024
- Finished
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Jun 2025
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 80 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion criteria: 1. At least one eye of subjects meets DED diagnostic criteria as the Tear Film and Ocular Surface Society (TFOS) Dry Eye Workshop (DEWS II); and 2. Ocular Surface Disease Index (OSDI)≥13 and \<33; and 3. The age range between years 18-80, no sex limitation; and 4. Symptoms of dry eye for at least 6 months; and 5. Can complete the questionnaires independently and understand Chinese or English. Exclusion criteria: 1. Had or currently suffering from other concomitant ocular surface diseases, including chronic conjunctivitis, ocular rosacea, cicatricial pemphigoid, graft-versus-host disease, limbal stem cell deficiency, and severe ocular allergy; 2. Received any refractive surgery and corneal surgery before, including corneal transplant; or any eye surgery in the past 6 months; 3. Receiving DED-related medications, including topical steroid eyedrops, topical antibiotics, topical cyclosporin A, and topical diquafosol; 4. Received intense pulsed laser (IPL) or vectored thermal pulsation (VTP) therapy in the past 12 months; 5. Received topical antiglaucomatous treatment in the past 12 months 6. Plans to use contact lenses during treatment and follow-up periods or used contact lenses 2 weeks before the baseline measurement and recruitment; 7. Had or currently suffering from severe cardiopulmonary disease, liver and kidney dysfunction, and severe blood system diseases; 8. Suffering from glucose-6-phosphate dehydrogenase deficiency (G6PD); 9. Had or currently suffering from specific respiratory diseases, e.g. emphysema, bronchitis, asthma, chronic obstructive pulmonary disease, bronchial dilatation; 10. Has adverse reaction history to herbs used in this study before; 11. Whose TCM constitution is manifested as "yang-deficiency" or diagnosed by TCM practitioners that their TCM syndrome is not suitable for the atomization treatment; 12. Pregnancy, preparation for pregnancy, or lactation;
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Hong Kong Eye Hospital
Kowloon, Hong Kong, Hong Kong
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Prince of Wales Hospital
Shatin, 000000, Hong Kong
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The CUHK Medical Centre (CUHKMC)
Shatin, 000 000, Hong Kong
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The Chinese University of Hong Kong Eye Centre (CUHKEC)
Kowloon, 000000, Hong Kong
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