Could a simple antibiotic replace chemo for this eye cancer?

NCT ID NCT01820910

Completed Disease control Sponsor: International Extranodal Lymphoma Study Group (IELSG) Source: ClinicalTrials.gov ↗

First seen Jan 27, 2026 · Last updated May 22, 2026 · Updated 19 times

Summary

This study tested whether a long course of the antibiotic doxycycline can control a rare lymphoma of the eye (OAMZL) that is linked to a bacterial infection. 44 newly diagnosed patients received the antibiotic and were monitored for 2 years; if the infection returned, they were retreated. The goal was to see if this approach could delay or avoid the need for chemotherapy or radiation.

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Contacts and locations

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Locations

AO Ospedali Riuniti Papardo Piemonte

Messina, Italy
Ematologia

Parma, Italy
Molinette 1

Torino, Italy
Ospedale Civile

Piacenza, Italy
Ospedale San Raffaele

Milan, Italy
Ospedale dell'Angelo

Venezia, Italy
Spedali Civili Di Brescia

Brescia, Italy
Università La Sapienza

Rome, Italy

Conditions

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MARGINAL ZONE LYMPHOMA OF OCULAR ADNEXAL MARGINAL ZONE LYMPHOMA OF OCULAR ADNEXAL