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Eye scans reveal hidden blood vessel changes in thyroid disease patients

NCT ID NCT07341347

Knowledge-focused Sponsor: Osijek University Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This completed study looked at 68 adults with thyroid-associated orbitopathy (thyroid eye disease) to see how changes in the eye socket affect blood vessels in the retina. Using a special imaging technique called OCTA, researchers measured vessel density in different layers of the retina. The goal was to understand the link between eye muscle or fat enlargement and retinal blood flow, which could help doctors monitor the disease better.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this research could help doctors better understand how thyroid eye disease affects the eye's blood vessels, potentially leading to earlier detection or monitoring of eye damage.
What could go wrong
This is a small, observational study that does not test any treatment. It only looks for patterns in blood vessel changes, so it cannot directly lead to new therapies or cures.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

68 people

The number who actually took part.

Started

Dec 2024

Finished

Jul 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Patients with TED followed at Department of Ophthalmology, University Hospital Osijek, Department of Ophthalmology, Croatia.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * adult patients (≥18 years) of both sexes with a confirmed diagnosis of TAO treated at University Hospital Osijek. Exclusion Criteria: * anterior segment pathology (e.g., central keratopathy), * primary open- or closed-angle glaucoma, * posterior segment disorders (e.g., diabetic retinopathy, age-related macular degeneration, retinal vascular occlusion), * previous ocular trauma or uveitis, * refractive errors exceeding ±6.0 Diopter sphere or ±3.0 Diopter cylinder * media opacities that compromised angio optical OCTA image quality, * contraindication for orbital MRI

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Conditions

The condition(s) this trial relates to.

endocrine exophthalmos

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Thyroid associated orbitopathy

Contacts and locations

Locations

  • University Hospital Osijek

    Osijek, 31000, Croatia

More trials for these conditions

Other studies related to the condition(s) this trial covers.