Esophageal cancer

This phase 2 trial is testing an experimental drug called patritumab deruxtecan (HER3-DXd) in 740 people with advanced solid tumors, including melanoma, lung, breast, and other cancers. The drug is given by IV every three weeks. The main goal is to see if the drug shrinks tumors.…

This early-stage trial is testing a new drug called IM-1617 in people with advanced solid tumors (cancers that have spread or can't be removed by surgery). The study has two parts: first, finding a safe dose, then testing that dose in more people to see how well it works and how …

This study tests whether two common heart medications—atorvastatin (a statin) and lisinopril (an ACE inhibitor)—can prevent or reduce heart damage caused by radiation therapy for chest cancers like breast, lung, and esophageal cancer. About 60 adults receiving chest radiation wil…

This phase 2 trial tests whether specially selected immune cells taken from a patient's own tumor, grown in large numbers in the lab, and given back along with the drug pembrolizumab (Keytruda) can shrink tumors in people with metastatic colorectal, pancreatic, ovarian, breast, o…

This study tests an oral drug called NEO212 in people with specific brain tumors (astrocytoma, glioblastoma) or cancers that have spread to the brain. The goal is to find the safest dose and see if it helps control tumor growth. About 134 adults will take NEO212 alone or with sta…

This study tests a new drug called TQB6411 in people with advanced esophageal cancer that has worsened after standard treatments. The drug is designed to target and attack cancer cells. The trial has two parts: first to find a safe dose, then to see if it shrinks tumors. About 10…

This early-phase trial tests SL-28, a cell therapy made from donor immune cells, in 60 people with advanced solid tumors (like lung, pancreatic, or breast cancer) that haven't responded to standard treatments. The study aims to find a safe dose and see if the therapy can shrink t…

Researchers are testing whether adding an experimental drug called 2141-V11 to standard immunotherapy is safe for people with advanced esophageal, gastric, or gastroesophageal junction adenocarcinoma. Participants receive injections of 2141-V11 directly into their tumors along wi…

This Phase 1 trial tests a new drug called BL-M07D1 in 280 adults with advanced HER2-positive cancers, including breast, lung, and stomach cancers. The study aims to find safe doses and check for early signs of tumor shrinkage. Participants must have tried at least two prior trea…

This clinical trial is looking at the best timing for local treatments like surgery or radiation in people with esophageal or stomach cancer that has spread to only a few spots. All participants first get 4 months of standard drug therapy. Then, depending on their response, they …

Researchers are testing two investigational radiopharmaceuticals in adults with advanced solid tumors, including colorectal, pancreatic, biliary tract, gastric, esophageal, and head and neck cancers. First, participants receive SKL35502, an imaging agent that highlights tumors ca…

This Phase 3 trial is testing whether a new targeted drug called sonesitatug vedotin, combined with chemotherapy (capecitabine) and possibly an immunotherapy (rilvegostomig), can help people with advanced stomach, gastroesophageal junction, or esophageal cancer that has a specifi…

This trial tests whether the type of anesthesia given during esophageal cancer surgery affects how long patients stay free of cancer recurrence. Researchers will randomly assign about 1,600 adults with stage 1 to 3 esophageal cancer to receive either propofol-based total intraven…

This early-stage trial tests a new drug called LY4052031, which is designed to deliver a cancer-killing agent directly to tumor cells that have a protein called Nectin-4. The study includes 420 adults with advanced or metastatic solid tumors such as bladder, breast, lung, and oth…

This early-phase study tests a new radioactive drug, LY4337713, in people with advanced cancers that have high levels of a protein called FAP. The cancers include certain types of ovarian, breast, pancreatic, colorectal, esophageal, stomach, and bile duct cancers. The study aims …

This early-stage study tests a new medicine called PF-08046033 in adults with advanced lung, esophageal, or skin cancers that have spread or can't be removed. The main goal is to check safety and find the right dose. Researchers will also look for early signs that the drug may he…

This early-phase study tests an experimental drug called PF-08046876 in about 310 adults with advanced cancers of the bladder, lung, head and neck, esophagus, or pancreas that have not responded to standard treatments. The drug is a type of 'antibody drug conjugate' designed to s…

This study tests two new drug combinations for people with advanced stomach, gastroesophageal junction, or esophageal cancer that has worsened after initial treatment. About 210 participants will receive either an experimental antibody-drug conjugate plus chemotherapy, or a stand…

This trial tests whether adding a personalized, ultra-precise radiation technique called PULSAR to standard chemotherapy and immunotherapy is safe for people with esophageal or gastro-esophageal junction cancer. The study aims to find the best radiation dose that can be given wit…

This study tests new experimental drugs combined with standard chemotherapy and immunotherapy for people with advanced stomach, gastroesophageal junction, or esophageal cancer that cannot be removed by surgery or has spread. About 160 participants will receive the combination to …

This study tests a new drug called ivonescimab combined with standard chemotherapy (FOLFOX) in people with advanced HER2-negative stomach or esophagus cancer that has not been treated before. The goal is to see if the combination can keep the cancer from growing for at least 6 mo…

This early-phase study tests a new drug called STRO-004 in adults with advanced solid tumors that have not responded to standard treatments. The study has three parts: finding a safe dose of STRO-004 alone, testing that dose in more patients, and combining STRO-004 with another d…

This phase 1 trial tests a vaccine made from two HER2 protein fragments in people with advanced breast or esophageal cancers that have spread or cannot be removed. The vaccine aims to train the immune system to recognize and attack HER2-positive tumor cells. Participants receive …

This study is testing the drug T-DXd (Enhertu) in 100 adults with advanced HER2-positive solid tumors who have already tried other treatments and have no good options left. The goal is to see how well the drug works in real-world settings, including how many patients respond and …

This study tests a new drug combination for people with metastatic solid tumors that lack a gene called MTAP. The drugs, BMS-986504 and pemetrexed, aim to stop cancer cells from growing. The trial will check safety and how well the combo works in 72 participants.

This phase 3 trial is testing whether an experimental drug called lerotinib can help people with advanced esophageal cancer that has progressed after at least two prior treatments. Participants are randomly assigned to receive either lerotinib or a standard chemotherapy chosen by…

This study looks at whether supervised exercise can improve recovery in people who have had surgery for esophageal or gastric cancer. About 171 participants will be assigned to high-intensity interval training, low-intensity continuous training, or usual care for 8 weeks. The goa…

This study tests whether freezing cancer cells with liquid nitrogen before chemotherapy can improve outcomes for people with advanced esophageal cancer. About 40 adults will be randomly assigned to receive either the freezing treatment plus chemotherapy or chemotherapy alone. The…

This early study tests a new device that uses heat to remove abnormal cells in the esophagus of people with Barrett's esophagus, a condition that can lead to cancer. The study has two parts: first, a small group of people scheduled for esophagus removal surgery will help find the…

This study is for people with advanced gastrointestinal cancers that are growing despite immunotherapy. Researchers want to see if adding targeted radiation to one tumor can help the immune system attack other tumors throughout the body. About 28 participants will receive radiati…

This early-stage trial is testing an experimental immunotherapy called AB122, given alone or combined with other investigational drugs, in people with advanced solid tumors such as pancreatic, colorectal, lung, and stomach cancers. The goal is to find out which combinations are s…

This Phase 1 trial tests IDOV-Immune, a genetically engineered virus designed to infect and destroy cancer cells while boosting the immune system. It is for adults with advanced solid tumors (like colorectal, pancreatic, or lung cancer) that have not responded to standard treatme…

This trial is investigating the best time to give immunotherapy for people with advanced esophageal cancer that cannot be removed by surgery. Participants will receive either immunotherapy before chemoradiation or after, to see which sequence helps control the cancer longer. The …

This trial is testing an experimental drug called petosemtamab (MCLA-158) in people with advanced solid tumors, including colorectal, head and neck, and lung cancers. The drug is a bispecific antibody designed to block two cancer-related proteins, EGFR and LGR5. Researchers want …

This Phase 1 trial tests whether HLX18, a biosimilar of the cancer drug OPDIVO, works similarly in people with esophageal, melanoma, or bladder cancer after their tumors have been surgically removed. About 174 participants will receive either HLX18 or OPDIVO to compare how the dr…

This early-phase trial is testing an experimental oral drug called APG-2449 in people with advanced solid tumors, including certain lung cancers, mesothelioma, esophageal cancer, and ovarian cancer. APG-2449 is designed to block several proteins (FAK, ALK, and ROS1) that help can…

This early-phase trial tests a new drug called TPD3310 in 112 people with advanced solid tumors that have not responded to standard treatments. The study aims to find a safe dose and check for early signs of tumor shrinkage. Participants receive weekly injections over 28-day cycl…

This phase 2 trial tests a drug called zanidatamab in about 200 adults with advanced HER2-positive cancers, including breast, lung, stomach, and others. Participants have already tried at least one standard treatment. The study measures how many tumors shrink or disappear. Zanida…

This phase 2 study is testing whether adding two newer drugs—pembrolizumab (an immunotherapy) and trastuzumab (a targeted therapy)—to standard chemotherapy can help people with HER2-positive esophageal or stomach cancer that can be surgically removed. About 49 adults will receive…

This study tests a new drug that delivers a tiny dose of radiation directly to cancer cells that have a specific marker called FAP. The trial involves 112 adults with advanced cancers of the pancreas, stomach, esophagus, colon, ovary, head/neck, sarcoma, or mesothelioma. First, a…

This trial compares two endoscopic procedures—endoscopic mucosal resection (EMR) and endoscopic submucosal dissection (ESD)—for removing visible precancerous lesions in people with Barrett's esophagus. About 331 adults with Barrett's esophagus and early-stage abnormal tissue will…

This study tests a new way to give chemotherapy for gastrointestinal cancers like colorectal and stomach cancer. Doctors will adjust the dose of one chemo drug (5-FU) based on how well each patient tolerates it, aiming to give higher doses to those who can handle it without sever…

This study tests a shorter, more intense radiation schedule combined with chemotherapy for people with locally advanced esophageal cancer. The goal is to see if this approach is safe and feasible, and to reduce side effects like low white blood cell counts. About 60 adults will r…

This program provides the experimental drug ulixertinib to people with advanced solid tumors that have certain gene mutations (MAPK pathway). It is for patients who have not responded well to or have run out of standard treatments. The goal is to control the disease and possibly …

This phase II trial is testing a combination of proton radiation and chemotherapy (carboplatin and paclitaxel) before surgery for patients with resectable esophageal or esophagogastric junction cancer. The goal is to see if this approach is safe, tolerable, and effective at impro…

This study looks at two approaches for people with a type of esophageal cancer that shrank after initial chemo-immunotherapy. One group will have surgery to remove the tumor, while the other will get a combination of radiation and chemotherapy instead. Both groups will also recei…

This study tests whether adding the immunotherapy drug iparomlimab after standard chemoradiation can help older adults (70+) with inoperable esophageal cancer live longer without the disease getting worse. About 52 participants will receive the drug for one year after chemoradiat…

This phase 2 trial tests a drug called HLX43 in 102 people with advanced esophageal cancer that did not respond to or could not tolerate standard first-line therapy. HLX43 is an antibody-drug conjugate designed to deliver a chemotherapy agent directly to cancer cells. The study a…

This phase II trial is testing whether adding a targeted radiation dose and the immunotherapy drug durvalumab to standard chemotherapy and radiation can help people with advanced esophageal cancer who have trouble swallowing. The study will enroll 54 adults whose cancer has sprea…

This study tests a new drug called MDX2001 in people with advanced solid tumors that have spread. The main goals are to check the drug's safety and see if it can shrink tumors. About 285 adults with various cancers like lung, breast, or colon cancer will take part. This is an ear…

This study tests whether adding an immunotherapy drug (PD-1 inhibitor) to standard chemotherapy and radiation before surgery helps people with a certain type of esophageal cancer live longer. About 422 adults with stage T1-4aN1-3M0 or T3-4aN0M0 squamous cell esophageal cancer who…

This early-phase trial is testing a new targeted drug called CA-4948 combined with standard chemotherapy and immunotherapy for people with advanced stomach, esophageal, or gastroesophageal junction cancer that cannot be removed by surgery. The study will enroll 42 participants an…

This phase 3 trial tests whether adding two drugs—toripalimab and capecitabine—after standard chemoradiation can prevent esophageal cancer from coming back. About 242 adults with advanced esophageal cancer who finished chemoradiation without progression will be enrolled. The goal…

This Phase 1 trial is testing an oral drug called AUR107 in 50 adults with advanced solid tumors that have come back after prior treatment. The study aims to find a safe dose and understand how the drug moves through the body. It is the first time AUR107 is being tested in humans…

This study is for people with esophageal or stomach cancer that has spread to 3 or fewer places in the body. It compares standard chemotherapy alone to chemotherapy plus radiation or surgery to the main tumor and those spots. The goal is to see if adding local treatment helps peo…

This study explores whether monitoring tumor DNA in the blood (ctDNA) can help guide treatment for esophageal cancer. Researchers will give patients immunotherapy and chemotherapy, followed by chemoradiotherapy, and track ctDNA levels to see if they predict outcomes. The goal is …

This study is testing whether a procedure called gastric preconditioning—done before esophageal cancer surgery—can lower the risk of a serious complication called an anastomotic leak. The procedure uses a tiny tube to redirect blood flow in the stomach, which may help the surgica…

This phase 2 trial is testing whether a combination of the immunotherapy drug bemosubaiabimab, the targeted pill anlotinib, plus radiation and chemotherapy can help people with oligometastatic esophageal cancer—cancer that has spread to a few spots. About 28 participants will rec…

This Phase 2 trial is testing whether adding the immunotherapy drug tislelizumab to standard chemoradiotherapy can shrink advanced esophageal tumors enough to allow surgery. About 45 people with unresectable esophageal squamous cell carcinoma will receive the combination, followe…

This study tests a two-step approach for people with advanced esophageal cancer that cannot be removed by surgery. First, patients receive a combination of immunotherapy and chemotherapy. Then, based on how well the tumor responds, they get either the same drugs plus radiation or…

This pilot study tests whether closing the diaphragm and securing the stomach tube during robotic esophageal cancer surgery can prevent a type of hernia that sometimes occurs afterward. Forty adults with esophageal cancer will be randomly assigned to either the standard approach …

This study tests a new treatment called EBNK-001, made from donor immune cells (natural killer cells), in people with advanced solid tumors that have not responded to standard therapies. Participants receive the cells after chemotherapy to prepare the body, along with low-dose in…

This early-stage trial tests a new combination treatment for people with advanced HER2-positive solid tumors (like breast, lung, or stomach cancer). Participants receive an injection of a special virus directly into one tumor to help the immune system attack cancer, followed by a…

This early-phase study tests a new drug called SH009 in people with advanced solid tumors (like liver, lung, breast, or stomach cancer) that have not responded to standard treatments. The main goals are to see if the drug shrinks tumors and to check its safety. About 150 adults w…

This phase 3 trial is testing whether a personalized program of supplements (vitamin D, mushroom extract, fish oil, probiotics, and whey protein) plus lifestyle coaching can improve recovery and quality of life for people undergoing surgery for lung, stomach, or esophageal cancer…

This early-phase study tests a new drug called BL-B01D1 in people with advanced lung cancer or other solid tumors that have spread or cannot be removed. The main goals are to check the drug's safety, find the best dose, and see if it helps shrink tumors. About 470 adults will tak…

This early-phase study tests a new treatment called PTC13, which uses specially engineered immune cells (CAR-T cells) to attack cancer cells that have a protein called CEA. The study includes 18 adults with advanced colorectal, stomach, pancreatic, or other solid tumors that have…

This study is looking at the best way to treat esophageal cancer that cannot be removed by surgery. It will follow 2,000 patients who receive chemoradiotherapy (radiation plus chemotherapy) along with possible immunotherapy or targeted drugs. The goal is to see which combinations…

This large phase 3 study is testing different combinations of chemotherapy, radiation, immunotherapy, and targeted drugs given before surgery for esophageal cancer. The goal is to find which approach works best to improve survival. The trial will enroll 2,000 adults with stage I …

This study tests whether adding low-dose or standard radiotherapy to the usual combination of immunotherapy (anti-PD-1) and chemotherapy can help people with metastatic esophageal squamous cell carcinoma. About 100 adults who have not had prior treatment will participate. The goa…

This Phase 1 trial is testing TJ101, an experimental antibody-drug conjugate that delivers chemotherapy directly to cancer cells. It is for adults with advanced or metastatic solid tumors (lung, prostate, esophageal, and others) who have run out of standard options. The study aim…

This study tests a new tablet called ABP1011T in people with advanced solid tumors, including small cell lung cancer and others like esophageal or bladder cancer. Participants take one pill daily in 21-day cycles. The goal is to see if the drug can shrink tumors and how safe it i…

This study tests whether giving two different chemotherapy regimens one after the other before surgery can help people with esophageal cancer that has spread to nearby lymph nodes. About 216 adults with resectable cancer will receive either FLOT followed by CROSS or CROSS followe…

This early-phase trial tests an oncolytic virus (IDOV-SAFE) in about 89 people with advanced digestive cancers, like colorectal or stomach cancer, that have not responded to standard treatments. The virus is designed to infect and kill cancer cells. Some participants may also rec…

This early-stage study tests whether combining two drugs (sacituzumab govitecan and capecitabine) is safe for people with advanced gastrointestinal cancers that have stopped responding to standard treatments. About 20 adults with stomach, colorectal, or pancreatic cancer will tak…

This study tests whether adding omega-3 fatty acids (EPA and DHA) to standard PD-1 inhibitor therapy helps patients with advanced esophageal cancer. About 142 adults will receive either omega-3 or placebo drops daily for 6 months alongside their cancer treatment. The main goal is…

This study tests an experimental drug called VMD-928, taken as a pill, either alone or with another cancer drug (pembrolizumab). It is for adults with advanced solid tumors or lymphoma that have not responded to or are no longer controlled by available treatments. The goal is to …

This early-phase trial tests a new drug called MT-4561 in about 27 people with advanced solid tumors (like lung, breast, or pancreatic cancer) who have no standard options left. The main goals are to find a safe dose and see if the drug can shrink tumors. It is a first-in-human s…

This study tests whether injecting a cancer-killing virus directly into tumors, combined with standard chemotherapy and an immunotherapy drug, can shrink advanced esophageal cancer enough to allow surgery. About 40 adults with unresectable locally advanced esophageal squamous cel…

This study tests a combination of two drugs, afatinib and palbociclib, in people with advanced esophageal cancer that has come back or spread after prior treatment. The goal is to find a safe dose and see if the combo can shrink tumors. About 45 adults aged 18 to 75 with a specif…

This study tests whether a low dose of radiation to the small intestine can help the immune system fight cancers that have stopped responding to immunotherapy. About 48 adults with advanced lung, esophageal, or other solid tumors will receive one radiation session followed by con…

This study is testing whether adding the immunotherapy drug adebrelimab to standard chemotherapy before and after surgery can help patients with locally advanced esophageal cancer. About 30 participants will receive three cycles of the combination before surgery, then continue ad…

This early-stage study is testing a new treatment called CEA-targeted CAR-T cells for people with advanced solid tumors like lung, stomach, colon, rectal, esophageal, or pancreatic cancer that have not responded to standard therapies. The treatment uses a patient's own immune cel…

This study tests whether combining the drug camrelizumab with chemotherapy before surgery can help people with esophageal cancer keep their esophagus instead of having it removed. About 283 adults with early-stage esophageal cancer will receive the treatment and be monitored for …

This phase II study is testing whether a new drug called SI-B003, alone or combined with BL-B01D1 or a PD-1 antibody, can shrink tumors in people with advanced esophageal, gastric, or colorectal cancer. About 376 participants will receive the treatments intravenously every three …

This pilot study tests a two-step treatment for T4 esophageal cancer, where the tumor has spread to nearby organs. First, patients receive up to 8 cycles of chemotherapy with docetaxel, cisplatin, and fluorouracil. If the tumor shrinks enough, they then get a lower dose of radiat…

This early-phase study tests a new drug called BL-M17D1 in 20 people with advanced HER2-positive gastrointestinal cancers (like stomach, pancreas, or colon cancer) or other solid tumors. The main goals are to check safety, find the right dose, and get a first look at whether the …

This phase 2 trial tests whether adding high-dose-rate brachytherapy (internal radiation) to the immune therapy drug nivolumab can improve outcomes for people with advanced esophageal cancer that has not been fully controlled by standard chemoradiation. About 60 participants will…

This study is testing a new type of PET/CT scan called [¹⁸F]FAPI-74 to see if it can better detect when stomach or esophageal cancer has spread to other parts of the body. About 200 adults with these cancers will receive one dose of the scan tracer and be followed for up to 3 mon…

This study tests whether taking multiple MRI scans before, during, and after standard radiation therapy can help doctors see how tumors change. Researchers will enroll people with advanced esophageal cancer, glioblastoma, prostate cancer, vulvar cancer, or pediatric glioma. The g…

This study explores whether a common blood test that measures how well blood clots (called TEG) can also act as a biomarker for cancer. Researchers will compare TEG results from patients with several types of cancer (liver, pancreas, bile duct, esophagus, colorectal, and lung) ag…

This study tests a dye called CYTALUX (pafolacianine) that attaches to cancer cells and glows under a special camera during surgery. About 50 adults with certain cancers (like esophageal, pancreatic, or gynecologic) will get the dye before surgery. The goal is to see if the glowi…

This early-phase study tests whether a special PET scan using a radioactive tracer called 18F-AraG can find tumors in people with esophageal cancer and predict how well they respond to chemoradiation. About 60 adults with untreated, locally advanced esophageal cancer will receive…

This study explores whether a magnetic resonance spectroscopy (MRS) scan of the thigh can predict a patient's fitness for major cancer surgery, as an alternative to the standard cardiopulmonary exercise test (CPET). Researchers will compare fat levels in thigh muscles from the MR…

This study looks at whether the things people buy at stores—like pain relievers or digestive aids—could be early warning signs of cancer. Researchers will compare the shopping habits of 2900 people, some diagnosed with cancer and some not, to see if certain purchases happen more …

This study tests how well PET/CT scans, along with other imaging, can define the exact edges of esophageal cancer before and after treatment. Researchers will compare these images to the actual tumor removed during surgery. The goal is to improve surgical planning and ensure all …

This study aims to see if certain chemicals (oncometabolites) in a person's breath and blood can spot early-stage gastro-esophageal cancer. Researchers will compare samples from 1,000 people, including those with cancer, those with Barrett's esophagus (a precancerous condition), …

This study is testing a blood test that looks for DNA signals from 20 different cancers, including lung, breast, and colon cancer. Researchers will see if the test can find cancer early, detect any cancer left after treatment, and catch a relapse before it shows up on scans. The …

This study tests a special dye and imaging system to help surgeons see colorectal, pancreatic, esophageal, and stomach cancers during surgery. About 66 adults scheduled for cancer surgery will receive the dye, and the imaging system will check if it lights up cancer tissue. The g…

This study is testing a new type of PET scan that uses special probes to highlight digestive system cancers, such as stomach, liver, colon, and pancreatic cancers. Researchers will enroll 400 adults to see how well this imaging method finds tumors and tracks their response to tre…

This study tests a new PET imaging probe that targets a protein called CLDN18.2, found in some stomach, pancreatic, bile duct, and esophageal cancers. Researchers will scan 56 people (patients and healthy volunteers) to see if the scan can accurately detect tumors and guide treat…

This study is testing a simple, less invasive way to detect early signs of Barrett's esophagus, esophageal cancer, and stomach cancer. Participants swallow a capsule attached to a string, which expands into a sponge in the stomach to collect cell samples. Researchers then look fo…

This study tests an artificial intelligence system that assists doctors in determining how deep early esophageal cancer has spread, using endoscopic ultrasound images. The goal is to improve the accuracy of preoperative staging, which helps guide treatment decisions. Researchers …

This study tests whether a dye called pafolacianine (CYTALUX™) can make cancer cells glow under near-infrared light during surgery. Fifteen adults with gastric, esophageal, or appendiceal cancer will receive the dye before standard surgery. Surgeons will use a special camera to l…

This study tests whether adding the antifungal drug itraconazole to standard ablation therapy can prevent esophageal cancer in people with high-risk Barrett's esophagus. About 64 participants will receive either itraconazole or a placebo alongside their usual endoscopic ablation.…

This study tests whether using a special formula (MCT) for tube feeding right after esophageal cancer surgery can prevent chyle leak, a complication where lymph fluid leaks into the chest. About 160 adults having minimally invasive surgery for esophageal cancer will be randomly a…

This study tests whether giving the drug amiodarone after minimally invasive esophageal cancer surgery can prevent a common complication called atrial fibrillation (an irregular, often rapid heart rhythm). About 90 adults having this surgery will be randomly assigned to receive e…

This study tests an 8-week program of nutrition advice, exercise, and psychological support for people with pancreatic or esophageal cancer before they have surgery. The goal is to see if patients can complete the program and if it helps them prepare for surgery. Only 9 patients …

This study compares two ways to manage pain after minimally invasive surgery for esophageal cancer: a paravertebral catheter versus the standard epidural. The goal is to see if the paravertebral approach provides similar or better recovery quality by day three. About 506 adults h…

This phase II trial tests whether a standardized acupuncture protocol can reduce peripheral neuropathy, a common and often lasting side effect of oxaliplatin chemotherapy. Participants are adults with gastrointestinal solid tumors who stopped oxaliplatin-based treatment and still…

This study tests whether cancer patients can complete a supervised exercise program from home using video calls. The program includes resistance training with dumbbells and aerobic exercise. Researchers want to see if this approach is practical and helps patients maintain functio…

This trial tests whether giving radiation in tiny pulses (pulsed low-dose-rate) instead of the standard continuous dose can lower the risk of severe esophagitis—painful inflammation of the swallowing tube—during chemoradiation for esophageal cancer. About 50 people with stage II …

This trial compares two types of esophageal stents—fully covered and partially covered—for people with advanced esophageal cancer who have trouble swallowing. The goal is to see which stent requires fewer repeat procedures and has fewer complications. Participants receive one of …

This study tests whether olanzapine, a drug already used for other conditions, can help cancer patients who are losing weight and appetite. About 66 adults with advanced lung, stomach, or bowel cancers will receive either olanzapine or a placebo. The goal is to see if olanzapine …

This study tests whether a program of physical therapy, nutritional planning, and psychological support before and after surgery can help patients with locally advanced esophageal, gastroesophageal junction, or stomach cancer recover better. Sixty participants will follow the pro…

This study tests a symptom management program for 300 esophageal cancer patients after surgery. The program uses patient feedback to guide care and aims to reduce common problems like reflux, trouble swallowing, and eating difficulties. Participants use a smartphone app to report…

This study tests whether taking omega-3 fish oil capsules and doing simple resistance exercises with elastic bands can help cancer patients maintain muscle mass and strength. It involves 288 adults with various cancers who are at risk of muscle wasting. The goal is to improve phy…

This early-stage trial tests a new drug called GB18 in 18-36 cancer patients who are losing weight and appetite due to their illness (cachexia). The drug is given as a shot under the skin. The main goal is to check safety, but researchers will also see if it helps patients gain w…

This study tests whether a combination of two drugs, fosrolapitant and palonosetron, plus a steroid, can prevent nausea and vomiting caused by chemotherapy and immunotherapy in people with esophageal or lung cancer. About 120 participants will receive the drug before each chemo c…

This study tests whether a program of exercise and nutrition supplements before esophageal cancer surgery is practical and helpful. About 20 adults scheduled for surgery will either receive the program or standard care. Researchers will track how many people stick with the progra…

This pilot study tests whether brodalumab, a drug used for autoimmune conditions like psoriasis, can safely reduce immune-related side effects caused by cancer immunotherapy. About 11 adults with advanced solid tumors who developed these side effects will receive brodalumab injec…

This study tests a personalized rehabilitation program for people recovering from surgery for esophageal or gastric cancer. Participants will receive a structured assessment of their physical, psychological, and social needs, followed by evidence-based support. The goal is to imp…

This study tests whether using CPAP or BiPAP breathing machines can reduce tumor movement during radiation therapy for lung cancer, esophageal cancer, or lymphoma. About 31 adults with advanced but treatable cancers will try these machines during treatment. The goal is to see if …

This study tests whether a high-flow nasal cannula (a device that delivers warm, moist oxygen) can prevent low oxygen levels during sedated gastrointestinal endoscopy in people at high risk for obstructive sleep apnea. About 600 adults with a STOP-Bang score of 5 or higher will b…

This study tests whether a yoga program designed for both patients and their family caregivers can improve physical function, fatigue, sleep, mood, and quality of life. It includes 400 people with lung or esophageal cancer who are getting radiation therapy, plus their caregivers.…

This study looks at whether people with certain cancers prefer getting their immune therapy as a shot under the skin (subcutaneous) or through a needle in a vein (intravenous). About 880 adults who are already eligible for standard treatments like nivolumab or pembrolizumab will …

This study tests whether a new device that combines a bite block, oxygen tube, and airway support can prevent dangerously low oxygen levels in severely obese patients during sedated endoscopy. About 410 adults with a BMI of 35 or higher will be randomly assigned to receive either…

This study tests whether using virtual reality (VR) can reduce severe belly pain and improve quality of life in people with digestive tract cancers. 360 participants will be split into three groups: one using a skills-based VR program, one using distracting VR videos, and a contr…

This study tests whether combining virtual reality with pleasant smells can lower pain and anxiety in people recovering from heart or lung surgery. About 80 adults scheduled for cardiothoracic surgery will either receive the VR-and-scent therapy or standard care. The goal is to s…

This study tests a six-week program of morning bright light exposure combined with moderate walking for people with lung or esophageal cancer. The goal is to see if it can improve sleep-wake rhythms, reduce physical and emotional symptoms, and boost quality of life. Two hundred p…

This study tests whether a personalized comfort care plan can help people with advanced esophageal cancer live longer and feel better. About 624 adults whose cancer has spread or returned will receive either standard comfort care or a tailored version that adjusts to their needs.…

This study is testing whether a mobile app that guides users through yoga poses is practical and safe for people with lung cancer who are getting radiation therapy, and for their family caregivers. About 60 patient-caregiver pairs will try the app at home. The goal is to see if p…

This study tests whether fecal microbiota transplantation (FMT) – taking donor gut bacteria in capsules – can prevent or reduce gastrointestinal symptoms like nausea, vomiting, and diarrhea caused by chemotherapy or targeted therapy. It involves 90 adults with advanced (Stage IV)…

This phase 2 trial is testing whether adding two chemotherapy drugs (carboplatin and paclitaxel) to standard palliative radiation can better relieve difficulty swallowing in people with incurable esophageal cancer. The study enrolls 50 patients who have trouble swallowing solid f…

This study looks at whether a short exercise program before surgery is practical and helpful for people with esophageal cancer. About 20 patients will take part. The goal is to see if patients can stick with the program and if it improves their recovery.

This study tests a new device called the COMBO Endoscopy Oropharyngeal Airway in 580 obese patients undergoing sedated gastrointestinal endoscopy. The device combines oxygen delivery, breathing monitoring, and a bite block to prevent low oxygen levels. Researchers will compare it…

This study is for Black adults newly diagnosed with gastrointestinal cancer. It focuses on ensuring patients receive proper biomarker testing and evidence-based care, helping them find and join clinical trials if they choose, and providing easy-to-understand information about the…

This study tests whether a newer, MRI-guided radiation method (MRgART) is gentler on the heart than standard radiation (LINAC) for people with lung, esophageal, or other chest cancers. About 60 adults will receive radiation and have their heart function checked via MRI and blood …

This study tests a small device called Seismofit that sticks to the chest and measures heart vibrations to estimate fitness in under three minutes. Researchers want to see if it can predict complications like pneumonia and hospital stay length in 164 oesophageal cancer patients u…

This study looks at whether adding a geriatrician (a doctor who specializes in care for older adults) to cancer treatment can improve outcomes for people aged 70 and older with gastrointestinal cancers like stomach, colon, or pancreatic cancer. Researchers will test if an online …

This study reviews the medical records of about 4000 people who had surgery for esophageal cancer. The goal is to see how the amount of cancer left at the edges of the removed tissue affects how long people live. No new treatments are given; the study only looks at past informati…

This study aims to collect tumor, normal tissue, and blood samples from up to 1559 people with cancers of the lung, esophagus, or pleura. Researchers will analyze genetic and epigenetic changes to better understand these diseases and identify potential markers for future treatmen…

This study looks at whether changes in DNA markers in the blood can show how well esophageal cancer treatment is working. Researchers will compare these markers with standard CT/MRI scans and tumor markers. The goal is to find a simpler, less invasive way to track treatment respo…

This study follows 130 adults undergoing surgery for stomach or esophageal cancer to see how often they experience postoperative delirium—a state of confusion and disorientation after anesthesia. Researchers will also check whether depression, frailty, poor nutrition, or muscle l…

This observational study follows over 2,400 people with esophageal cancer across multiple African hospitals to see which treatments they receive and how they fare. Researchers will track symptoms, quality of life, and survival over time. The goal is to understand what works best …

This study looks at whether measuring a patient's energy reserve (fitness) before major cancer surgery can help predict how well they recover. Researchers will use a special exercise test to measure gas exchange and see if it relates to complications after surgery. The goal is to…

This study looks at whether changes in DNA methylation—a type of epigenetic marker—can help predict if esophageal cancer will come back soon after surgery. Researchers will analyze tumor tissue from 150 patients who had their cancer removed and track who experiences a recurrence …

This study uses artificial intelligence to analyze patient data—like medical history, scans, and lab results—to predict how well esophageal cancer patients respond to chemoimmunotherapy before surgery. Researchers aim to build a model that identifies who achieves a complete respo…

This study looks at whether giving the chemotherapy drug paclitaxel over a longer period (2-3 hours instead of 1 hour) can help cancer patients with low muscle mass achieve safer drug levels. Researchers will compare drug concentrations in 22 women with breast, stomach, or esopha…

This study investigates clonal hematopoiesis (CH) — small mutations in blood cells that can arise naturally or after cancer treatment — in adults receiving chemotherapy or radiation for solid tumors like breast, lung, or colorectal cancer. Researchers will collect blood, saliva, …

This study is building a huge registry of information and biological samples from adults with or at risk for many types of cancer, as well as healthy volunteers. Researchers will use this resource to study what causes cancer and how to better prevent, detect, and treat it. The re…

This study watches for heart changes in 150 adults receiving chest radiation for lung, esophageal, breast, or thymus cancer. Researchers will check heart markers, electrical activity, and immune cells at the end of treatment and up to 3 months later. The goal is to find early sig…

This study investigates whether the unique bacteria found inside digestive system tumors can help predict how well a patient will respond to neoadjuvant therapy (chemotherapy before surgery). Researchers will analyze tumor samples from 90 adults with pancreatic, gastric, colorect…

This study is looking at whether a blood test (liquid biopsy) can find tiny bits of cancer DNA left behind after treatment for esophageal cancer. Researchers will collect blood samples from 248 patients before, during, and after standard treatment. The goal is to see if this test…

This study is creating a database to track how people with esophageal or gastroesophageal junction cancer that has spread to only a few places (like the liver or lymph nodes) are treated in real-world settings. Researchers will collect information from 50 participants to see whic…

This early-stage trial tests whether a special PET scan (FMISO-PET) can identify oxygen-deprived (hypoxic) areas in esophageal tumors, which are harder to treat. Patients with hypoxic tumors receive a higher radiation dose, while others get standard care. The study aims to see if…

This study looks at how radiation treatment for esophageal cancer affects the body's ability to respond to the pneumonia vaccine. Researchers will give the vaccine to 80 patients who have low white blood cell counts after chemoradiation. They want to see if the vaccine still work…

This study is building a large database of 15,000 patients with esophageal or gastric cancers in France. Researchers will look back at medical records to see how patients fared after surgery, focusing on how long they stayed cancer-free. The goal is to learn more about survival, …

This study looks at whether giving extra nutrition through a feeding tube before surgery can lower the chance of complications in malnourished people with esophageal or stomach cancer. About 670 participants will be followed to compare those who get nutritional support with those…

This study is testing whether a quick, non-invasive test that measures heart rate and breathing patterns before thoracic surgery can help predict which patients are more likely to have complications after the operation. Researchers will enroll 130 adults undergoing major chest su…

This study collects blood, urine, and bone marrow samples from 620 people with solid cancers like lung, colorectal, and pancreatic cancer. Researchers will look for tumor cells and DNA in these samples to understand how cancer spreads and why it sometimes comes back after surgery…

This study observes 160 adults with oesophageal cancer to see if an endoscopic ultrasound (EUS) changes their treatment plan after standard scans. Researchers will also interview patients and doctors to understand their views on using EUS. The goal is to learn when this test is m…

This study follows 100 people newly diagnosed with esophageal cancer in Hungary. Researchers will track heart function, nutrition, physical ability, and mental health before and after surgery. The goal is to find which factors are linked to better survival and quality of life, so…

This study compares how patients recover and feel after two types of surgery for esophageal cancer: minimally invasive (smaller cuts) versus open surgery. Researchers will track quality of life, pain, and daily function for up to three years in 3,500 participants. The goal is to …

This study is collecting medical history, blood, and tissue samples from 7,000 people with esophageal disorders like GERD or Barrett's esophagus. Researchers hope to find genetic or protein markers that signal a higher risk of developing esophageal cancer. The goal is to enable e…

This study aims to understand why many cancer patients lose muscle and fat (cachexia), a condition that worsens their health. Researchers will use advanced techniques to analyze samples from 1000 adults with certain cancers. The goal is to find early warning signs and new targets…

This study is collecting survey responses from 1,000 people who have had or will have surgery on their esophagus. The goal is to validate new questionnaires that measure recovery and symptoms. The information will help doctors set expected recovery scores and improve treatment pl…

This study reviews past medical records to see if people with esophageal cancer have better survival when treated at hospitals that perform many surgeries (more than 5 per year) compared to those that do fewer. The goal is to understand whether hospital experience and additional …

This study looks at tissue samples from 30 adults with stomach or esophageal cancer that spread to the brain. Researchers compare the genetic markers of the original tumor and the brain tumor to see if they differ. The goal is to better understand how these cancers change when th…

This study collects tissue samples from people with various advanced or early-stage cancers to train a diagnostic platform called Elephas. The goal is to see how accurately it can predict whether a patient will respond to immunotherapy or chemoimmunotherapy. About 324 participant…

This study aims to develop a simple tool to predict whether a person's stomach will still have food or liquid in it before a sedated endoscopy. Having a full stomach during sedation raises the risk of serious complications like choking. Researchers will study 5,000 adults to iden…

This study is testing whether an artificial intelligence (AI) system can predict how well esophageal cancer will respond to treatment and estimate a patient's long-term outlook. Researchers will collect medical images, genetic data, and other health information from 1,500 partici…

This study is a large registry that will follow about 8,000 cancer patients who receive radiation therapy using a special machine called an MR-Linac, which combines an MRI scanner with a radiation beam. The goal is to learn how well this technology works for different cancers, in…

This study collects tissue, blood, urine, and stool samples from 5000 people undergoing colonoscopy or endoscopy, including those with cancer, polyps, or inflammatory bowel disease, as well as healthy volunteers. The goal is to find new biomarkers that could improve early detecti…

This study is testing whether a combined PET-MRI scan can help doctors plan radiation treatment more precisely for people with esophagogastric cancer. Fifteen participants will receive PET-MRI scans before, during, and after radiation therapy. The images will not be used for thei…

This study looks at how well patients understand the information they get before major abdominal cancer surgery and whether that affects regret afterward. Researchers will survey 90 adults before surgery, then one month and three months after. The goal is to improve how doctors c…

This study is testing whether a blood test that looks for tumor DNA (ctDNA) can find cancer returning earlier than standard scans. About 100 people with different solid tumors will give blood samples after treatment. The goal is to see if early detection can lead to better treatm…

This study uses a 20-25 minute survey to find out which features of diagnostic tests for gastro-esophageal cancer matter most to patients and the general public. Researchers aim to understand preferences and regional differences to improve screening decisions. About 2,200 adults …

This study looks at whether a specific gene, ALDH2, which helps break down alcohol, is linked to how long people with esophageal cancer live. Researchers will follow 700 patients for up to 12.5 years to see if gene variations affect survival. The goal is to better understand why …

This study at Stanford University collects tissue and blood samples from 100 adults with or at high inherited risk for stomach, esophageal, or related cancers. Researchers aim to understand how genes and proteins contribute to cancer development. The study does not test any treat…

This study follows 200 people with cancers of the esophagus, stomach, pancreas, colon, or rectum who are scheduled for surgery, along with some healthy controls. Researchers will track weight, muscle mass, physical activity, quality of life, and immune markers over a year to bett…

This study is testing whether an artificial intelligence (AI) tool can help match cancer patients with the right clinical trials. Researchers will enroll up to 50,000 people with various cancers to see if the AI improves trial enrollment rates and patient outcomes. The goal is to…

This study collects samples from 320 people, including those with solid cancers (like lung, colon, or pancreatic cancer) and those undergoing lung cancer screening, to look for cancer cells and DNA in blood, urine, and bone marrow. The goal is to learn how cancer spreads and find…

This study collects and stores tissue and blood samples from people with stomach, esophageal, pancreatic, liver, and other gastrointestinal cancers. The goal is to build a large database of samples and medical information to help researchers understand these cancers better. Parti…

This research study collects sputum and tissue samples from 700 people with precancerous changes or certain cancers (lung, head and neck, esophageal). The goal is to find biomarkers—biological signs—that could help understand or detect these cancers earlier. Participants include …

This observational study is collecting blood samples and medical images from 200 people with several types of solid tumors (like lung, head and neck, and esophageal cancers) who are receiving immunotherapy and radiation as part of their standard care. Researchers want to see if c…

This study follows 1,100 people with esophageal cancer to see how often the cancer spreads to a specific lymph node near the windpipe (subcarinal node). Researchers will also look for factors that make spread more likely. The goal is to help doctors decide whether to remove these…

This study observes 1,852 people with esophageal cancer to see how often the cancer spreads to a specific lymph node in the chest (left tracheobronchial lymph node). Researchers will track who develops this spread and look for risk factors. The goal is to better understand the di…

This study is testing whether measuring ctDNA (bits of tumor DNA) in blood or stool can help doctors manage patients with cancers of the digestive tract, including pancreas, colon, and bile duct cancers. Researchers will track survival and see how these markers relate to outcomes…