New chemo combo aims to boost survival in tough esophageal cancer
NCT ID NCT06161818
First seen Dec 26, 2025
Summary
This study tests whether giving two different chemotherapy regimens one after the other before surgery can help people with esophageal cancer that has spread to nearby lymph nodes. About 216 adults with resectable cancer will receive either FLOT followed by CROSS or CROSS followed by FLOT. The goal is to see if this intensive approach improves how long patients live without the cancer coming back.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
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Locations
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Amsterdam UMC
NOT_YET_RECRUITINGAmsterdam, North Holland, Netherlands
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Antoni van Leeuwenhoek/Nederlands Kanker Instituut
NOT_YET_RECRUITINGAmsterdam, Netherlands
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Catharina Ziekenhuis
NOT_YET_RECRUITINGEindhoven, North Brabant, Netherlands
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Elisabeth Tweesteden Ziekenhuis
NOT_YET_RECRUITINGTilburg, North Brabant, Netherlands
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Erasmus Medical Centre
RECRUITINGRotterdam, South Holland, Netherlands
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Frisius medisch centrum
NOT_YET_RECRUITINGLeeuwarden, North Brabant, Netherlands
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Gelre ziekenhuis
NOT_YET_RECRUITINGApeldoorn, Netherlands
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Leids Universitair Medisch Centrum
NOT_YET_RECRUITINGLeiden, Netherlands
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Radboud Universitair Medisch Centrum
NOT_YET_RECRUITINGNijmegen, Netherlands
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Ziekenhuisgroep Twente
NOT_YET_RECRUITINGAlmelo, Netherlands
Contact Phone: •••-•••-•••• Email: •••••@•••••
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.