Chronic kidney disease

This study looks at how well the HPV9 vaccine (Gardasil 9) works in people who have had a kidney transplant. Researchers will measure antibody levels in 30 transplant recipients over 24 months and compare them to published data from healthy individuals. The goal is to see if the …

This study explores whether eating alkalizing fruits and vegetables, delivered to your home, can help manage metabolic acidosis in people with chronic kidney disease. The usual treatment, sodium bicarbonate, often causes side effects and doesn't always work. The trial will see if…

Researchers are following people with chronic kidney disease who received up to four injections of REACT, a therapy made from their own kidney cells, in earlier studies. The goal is to track long-term safety and see how long any effects on kidney function last. About 50 participa…

This phase II trial tests whether intensive blood pressure management (targeting systolic BP below 120 mmHg) is better than standard care (below 140 mmHg) for patients with advanced kidney or thyroid cancer starting anti-angiogenic TKI therapy. The study enrolls 61 participants a…

This study is testing a new dialysis system called Solv Multi-Pass for people with end-stage kidney disease. The device is designed to remove waste and extra fluid from the blood during in-center dialysis sessions. Researchers will check how safe it is and how well it works in 46…

This study tests a device that uses radiofrequency energy to calm overactive kidney nerves, which can drive high blood pressure. About 1,900 adults with uncontrolled hypertension will receive the procedure and be followed for years. The goal is to see if this approach safely and …

This study is testing whether taking aspirin can safely lower the risk of major heart problems, like heart attacks and strokes, in people with kidney failure who are on dialysis. About 9,000 adult dialysis patients will be randomly assigned to take aspirin or not, and researchers…

This study tests whether a newer type of dialysis filter (medium cut-off membrane) can better manage bone and mineral problems common in people with end-stage kidney disease. Thirty adults on maintenance dialysis will try both the new and standard filters for three months each. R…

This study tests whether a newer type of dialysis filter (medium cut-off membrane) can reduce inflammation and improve heart function better than the standard filter in people with end-stage kidney disease. Thirty adults on maintenance hemodialysis will use each filter for three …

This study was designed to test whether volenrelaxin could help adults with chronic kidney disease by reducing protein in the urine and preserving kidney function. It was a phase 2, placebo-controlled trial planned to last about 24 weeks. However, the study was withdrawn before e…

This trial tests whether an AI system that flags at-risk Medicare Advantage members and suggests care actions, reviewed by a nurse, can reduce overall healthcare spending over a year. About 9,900 participants in Utah are assigned to either this AI-supported navigation or usual ca…

This study tests whether the drug nicorandil can lower the risk of serious heart problems like heart attacks and strokes in people with coronary artery disease who are on kidney dialysis. Researchers are giving 15 mg of nicorandil daily to 268 participants and tracking heart-rela…

This study tests a program to help Black adults with chronic kidney disease (CKD) reduce their daily sitting time. Half of the 40 participants will receive support to sit less, while the other half will get general CKD education. The goal is to see if cutting down on sitting can …

This study tests a drug called pegcetacoplan in 320 adults who are getting a kidney transplant from a deceased donor and are at high risk for delayed graft function (when the kidney takes a while to start working). The goal is to see if the drug helps the kidney work sooner and r…

This Phase 2 study tests whether a combination of two drugs, zibotentan and dapagliflozin, works better than dapagliflozin alone at reducing protein leakage in urine for adults with chronic kidney disease. About 224 participants will receive either the combo or the single drug. T…

This trial tests whether a new drug called BCD-131 can manage anemia in people with chronic kidney disease who are on dialysis. Anemia is a common complication where the body doesn't make enough red blood cells, causing fatigue and weakness. The study compares BCD-131, given once…

This study tests whether adding dapagliflozin to baxdrostat reduces protein in the urine (a sign of kidney damage) better than baxdrostat alone. About 218 adults with chronic kidney disease and high blood pressure will take either the combo or baxdrostat plus a placebo. The goal …

This trial tests whether a specially designed 4-week diet can improve mineral balance and reduce cardiovascular risk in people with end-stage kidney disease on dialysis. The diet aims to correct common problems like high phosphate levels and inflammation. Researchers will compare…

This trial tests a comprehensive approach to improve kidney care and increase transplant rates. It combines provider training, digital dashboards, and a mobile health app to educate patients and help them find living donors. The study includes 5,000 adults with advanced chronic k…

This study tests whether adding finerenone to standard blood pressure medicines can reduce protein in the urine of children with chronic kidney disease. About 219 children aged 6 months to under 18 years will take either finerenone or a placebo for 6 months. The main goal is to s…

This study tests whether a 16-week program of group diet coaching and hands-on cooking classes can help Black Americans at risk for chronic kidney disease stick to the low-sodium DASH diet. The program involves 48 participants who either get the coaching and classes right away or…

This phase 3 trial is testing whether the drug retatrutide can lower the chance of serious heart problems (like heart attacks and strokes) and slow kidney disease in 10,000 overweight adults who already have heart or kidney disease. Participants receive either retatrutide or a pl…

This study tests whether a standardized care plan can help chronic kidney disease patients better control high potassium levels while optimizing their RAASi medications. About 1,000 participants will receive the care plan, which includes doctor training and patient education. The…

This Phase 3 trial tests whether adding zibotentan to the standard drug dapagliflozin can better protect kidney function in people with chronic kidney disease and high proteinuria. About 1,800 adults are taking either the combo or dapagliflozin alone. The main goal is to see if t…

This study aims to find better ways to treat depression in people with chronic kidney disease (CKD). About 201 adults with advanced CKD and major depression will receive either behavioral activation teletherapy plus a non-SSRI antidepressant, or the antidepressant plus teletherap…

This Phase 3 trial tests whether a cell therapy called REACT (rilparencel) can slow kidney decline in 685 adults with type 2 diabetes and chronic kidney disease. Participants receive either two injections of their own kidney cells or sham procedures. The study measures changes in…

This study compares two methods for creating an arteriovenous fistula (AVF) in people with end-stage kidney disease who need dialysis. The newer endovascular method uses a needle through the skin, while the traditional surgical method requires an incision. Researchers will enroll…

This study tests whether taking potassium supplements can slow down kidney function loss in people with moderate-to-severe chronic kidney disease (CKD) and high blood pressure. About 532 adults with CKD stage 3b or 4 will receive potassium or a placebo. The goal is to see if pota…

This trial tests whether a procedure called renal denervation can safely lower blood pressure in people with chronic kidney disease (stage 3) whose hypertension is not controlled by medication. The procedure uses ultrasound energy to calm overactive nerves in the kidney that may …

This study is testing a new type of graft (called aXess) for people with end-stage kidney disease who need hemodialysis but can't have a standard fistula. The graft is made of a biodegradable material that may help reduce complications. About 140 adults will be enrolled to see if…

This clinical trial tests an experimental drug called SAL0120 in people with chronic kidney disease (CKD). The study aims to see if different doses of SAL0120 can reduce protein in the urine, a key marker of kidney damage. Participants are randomly assigned to receive either SAL0…

This study tests whether taking a 7-day course of oral antibiotics after hip or knee replacement surgery can prevent joint infections in patients at higher risk due to conditions like obesity, diabetes, or autoimmune disease. About 4,600 participants will receive one of three ant…

This study tests the safety and how the body processes migalastat in 14 adults with Fabry disease who have severe kidney impairment or are on dialysis. Participants take migalastat capsules, and researchers measure drug levels in blood and dialysate. The goal is to ensure proper …

This study tests whether a structured health coaching program can help people on maintenance hemodialysis better manage their own health. Participants receive one-on-one coaching during dialysis sessions plus follow-up support through a messaging app. The goal is to improve self-…

This phase 2 trial tests whether dapagliflozin, a drug already used for diabetes and chronic kidney disease, can slow kidney damage in people with lupus nephritis. Lupus nephritis is a serious complication of lupus that causes kidney inflammation and can lead to chronic kidney di…

This study tests a drug called belantamab mafodotin in people with multiple myeloma that has come back or stopped responding to treatment, and who also have kidney problems—from mild impairment to end-stage disease requiring dialysis. The drug is an antibody-drug conjugate that t…

This Phase 3 trial tests a lab-grown blood vessel (ATEV) against the standard surgically created fistula in 121 women with end-stage kidney disease who need dialysis. The goal is to see if the ATEV allows more days without a catheter and reduces infections over 12 months. If succ…

This phase 3 study tests whether adding baxdrostat to the standard drug dapagliflozin can better slow chronic kidney disease (CKD) progression in adults with CKD and high blood pressure. About 2,500 participants will receive either the combination or dapagliflozin alone for 24 mo…

This study compares two types of dialysis in 64 adults with end-stage kidney disease. One group gets standard hemodialysis, the other gets hemodiafiltration, which uses both diffusion and convection to remove waste. The main goal is to see if hemodiafiltration leads to less weigh…

This study tests whether a natural supplement called nicotinamide riboside can improve artery stiffness and lower blood pressure in people with moderate to severe chronic kidney disease. About 118 adults aged 35-80 will take either the supplement or a placebo for 3 months. The go…

This study compares two types of surgery to create dialysis access in older adults (60+) with end-stage kidney disease. One method connects a vein directly to an artery (fistula), the other uses a synthetic tube (graft). The goal is to see which leads to fewer infections and more…

This study tests a drug called vonsetamig in 43 people with chronic kidney disease who are on dialysis and have very high levels of anti-HLA antibodies, making it nearly impossible to find a matching kidney donor. The drug aims to safely lower these antibodies so that a kidney tr…

This study looks at whether switching to a plant-based diet can improve heart health and reduce inflammation in people who have had a kidney transplant. Twenty-five participants who are at least three months post-transplant will follow a plant-based diet for 16 weeks after a two-…

This Phase 3 trial tests whether dapagliflozin (Forxiga), a drug originally for diabetes, can reduce the risk of death, kidney failure, and heart failure hospitalization in 1750 people with severe chronic kidney disease. Unlike earlier studies, this trial includes patients on dia…

This study tests whether a short course of two drugs, dasatinib and quercetin, can clear senescent (aging) cells in people with chronic kidney disease. The goal is to see if this reduces frailty and improves stem cell function. Thirty participants aged 40-80 with moderate-to-seve…

This study is testing whether eating Brazil nuts can reduce inflammation and oxidative stress in people with chronic kidney disease. Fifty patients will take Brazil nut supplements for six months while researchers measure changes in blood and gut bacteria. It is a small, early-st…

This study looks at whether a combination of nurse health coaching, doctor training, and subsidies for a kidney-protecting drug can help slow the worsening of chronic kidney disease. About 724 adults with moderate-to-severe kidney disease in Singapore will be randomly assigned to…

This study looks at whether taking cinnamon supplements for three months can lower inflammation and improve gut health in people with chronic kidney disease. Thirty patients will take either cinnamon capsules or a placebo. Researchers will measure markers of inflammation and oxid…

This study tests a new device called STARgraft-3, a tube used for dialysis in people with end-stage kidney disease. The goal is to see if it stays open longer and resists infection better than standard grafts. About 21 adults will be followed for up to a year to check how well th…

This study tests a special dialysis fluid containing amino acids (protein building blocks) to see if it can improve the nutritional status of adults with end-stage kidney disease who are on peritoneal dialysis. About 50 participants will replace one daily dialysis bag with this s…

This study looks at whether adding more magnesium to the fluid used during dialysis can help people with kidney failure live longer and have fewer heart-related hospital stays. Many dialysis patients have low magnesium, which can lead to muscle cramps and heart issues. The trial …

This study tests whether the drug finerenone can lower protein levels in the urine of people with chronic kidney disease who are not taking certain blood pressure medications. About 180 adults will receive either finerenone or a placebo for 6 months. The goal is to see if fineren…

This study looks at whether drinking nitrate-rich beetroot juice every day for three months can improve blood vessel health, movement, and thinking in people with chronic kidney disease. About 92 participants with moderate kidney disease will receive either the active beetroot ju…

This study tests whether adding a special filter (hemoperfusion) to regular dialysis can better remove waste products like beta-2 microglobulin, parathyroid hormone, and C-reactive protein from the blood. About 410 adults with end-stage kidney disease on maintenance dialysis will…

This study looks at whether people with ANCA vasculitis who have reached end-stage kidney disease can safely stop taking immunosuppressive medications. The goal is to see if stopping these drugs lowers the risk of serious infections and other side effects without causing dangerou…

This study is tracking over 1,000 Japanese patients with chronic kidney disease who are taking JARDIANCE® (empagliflozin) daily for a long period. Researchers are monitoring side effects and whether the drug helps slow kidney decline in real-world conditions. The goal is to see i…

This study tests whether a nurse practitioner-led team can improve care for adults with two or more chronic conditions like heart failure, diabetes, or kidney disease. Participants are randomly assigned to either the nurse-led team or usual care. The team reviews medications to e…

This study tests whether giving a special nutrient mixture (Olimel N12) during hemodialysis can help prevent muscle loss and improve quality of life in people with end-stage kidney disease. About 166 patients will receive either the nutrient infusion or a simple glucose solution …

This study tests a special device that uses radiofrequency energy to calm overactive kidney nerves, which can help lower blood pressure. It is for adults aged 18-65 with uncontrolled high blood pressure and chronic kidney disease who are already on at least two blood pressure med…

This study is testing the drug dapagliflozin in 731 Chinese adults with chronic kidney disease. The goal is to see if the drug can slow kidney decline and is safe. Participants take the drug by mouth, and researchers track kidney function and side effects over time.

This study looks at whether a natural substance called fisetin can help people with advanced chronic kidney disease. Researchers will measure changes in inflammation, stem cell health, and physical frailty after 14 days of treatment. The study involves 30 adults aged 40-80 with m…

This phase 3 trial tests whether finerenone can reduce protein in the urine (proteinuria) of people who have had a kidney transplant. Proteinuria is a sign of kidney damage. The study compares finerenone plus standard care to dapagliflozin plus standard care in 54 adult patients.…

This study tests a 1-month course of three medicines (isoniazid, rifapentine, and vitamin B6) to treat latent tuberculosis in 25 adults with end-stage kidney disease who are candidates for a kidney transplant. The goal is to see if this shorter treatment is safe and easy to compl…

This study compares two types of peritoneal dialysis—standard and incremental—in 100 adults starting dialysis. The goal is to see if using less dialysis solution (incremental) helps preserve remaining kidney function and reduces cell damage compared to the standard approach. Part…

This study tests whether a pharmacist-led program can help people reduce their risk of heart disease. Over 1,000 adults with conditions like diabetes, high blood pressure, or obesity are taking part. Pharmacists use a step-by-step guide to assess risk and support lifestyle change…

This early-stage trial tests whether a patient's own fat-derived stem cells, applied during surgery, can prevent dialysis fistulas from failing. About 74 adults with advanced kidney disease will receive either stem cells or a placebo. The goal is to see if the treatment improves …

This study tests whether delivering specially designed meals can improve nutrition in elderly, low-income patients with end-stage kidney disease who are on dialysis. Twenty-five participants will first eat their usual diet for 4 weeks, then receive personalized meals for another …

This study looks at whether giving testosterone to men with low testosterone and kidney failure can help them recover better after a kidney transplant. About 50 men will receive testosterone before and after their transplant, and their safety and recovery will be compared to a si…

This study compares robot-assisted kidney transplant to the standard open surgery in 106 adults with end-stage kidney disease. The goal is to see if the robotic approach reduces serious complications like bleeding or blood clots within 30 days after surgery. Participants are rand…

This early-stage study tests a conditioning regimen to make the recipient's immune system accept a donor kidney without needing lifelong anti-rejection medication. About 20 adults with kidney failure receiving their first transplant from a living donor will participate. The main …

This study is testing a new drug called tegoprubart (AT-1501) to see if it is safe and effective for preventing kidney transplant rejection over several years. About 132 people who have already received a kidney transplant will receive either tegoprubart or the standard drug tacr…

This study tests a new surgical method called RADAR for creating blood vessel connections needed for dialysis in 200 people with end-stage kidney disease. The goal is to see if this technique leads to fewer blockages and better long-term function compared to the standard approach…

This study follows 11 kidney transplant patients who received an experimental cell therapy called TX200-TR101 in an earlier trial. Researchers will monitor them for up to 15 years to check for long-term side effects and how well their transplanted kidney is doing. The goal is to …

This early study tests whether the drug belumosudil, given with donor stem cells, can help the body accept a new kidney without needing strong anti-rejection drugs for life. Sixteen adults with end-stage kidney disease will receive a living donor kidney and stem cell transplant, …

This study looks at how well a new robotic surgery system (Medtronic Hugo) works for urologic procedures like removing prostate, bladder, or kidney tumors. About 144 adults will have surgery with the robot, and doctors will check if the surgery is completed without switching to a…

This phase 4 study tested whether a once-monthly injection of darbepoetin alfa works as well as the standard every-2-week schedule for maintaining healthy hemoglobin levels in people with advanced chronic kidney disease who are not on dialysis. Forty Korean adults completed the 1…

Researchers are building deep learning models that analyze digital images of kidney biopsy tissue to classify kidney diseases such as IgA nephropathy and membranous nephropathy. The study uses pathology images and clinical data from thousands of patients who had kidney biopsies a…

This study tests a new ultrasound technique called super-resolution ultrasound imaging (SRUI) to see tiny blood vessels in the kidneys. Researchers will give an FDA-approved contrast agent called Definity to healthy volunteers and people with chronic kidney disease (CKD) who need…

This trial tests whether a blood-based test called KidneyIntelX can help doctors better manage patients with type 2 diabetes and early-stage chronic kidney disease. The test estimates the risk of rapid kidney function decline over five years. Researchers will see if using this te…

This trial tests whether a blood-based test called KidneyIntelX can help doctors better manage type 2 diabetes patients with early to moderate chronic kidney disease. The test estimates the risk of rapid kidney function decline over five years. Researchers will see if using this …

This study tests a new PET/CT imaging method that uses a special dye to spot kidney scarring (fibrosis) in people with chronic kidney disease. The goal is to see if this scan can accurately measure fibrosis without needing a needle biopsy. 150 patients will be scanned, and the re…

This study tests whether portable ultrasound and blood glucose monitors can help doctors catch chronic conditions like diabetes, heart disease, and kidney disease earlier than usual. About 200 adults will use these devices or receive standard care for 6 months. The goal is to see…

This trial investigates whether a daily effervescent supplement containing calcium, magnesium, and citrate can prevent bone loss, magnesium deficiency, and kidney damage in adults who take proton pump inhibitors (PPIs) long-term for conditions like heartburn or GERD. Participants…

This study aimed to see if hydroxychloroquine could prevent COVID-19 hospitalizations in adults on dialysis for kidney failure. It was designed as a randomized trial but was withdrawn before enrolling any participants. No results are available.

People on hemodialysis receive needle sticks through a fistula or graft several times a week, and the pain and anxiety can build over time. This trial tests whether slow, deep breathing combined with lemongrass aromatherapy reduces pain and anxiety during needle insertion. Resear…

Researchers are testing whether dapagliflozin, a daily oral drug, helps people with refractory heart failure who are on peritoneal dialysis remove more salt and fluid. The trial compares two 12-week periods: one with dapagliflozin added to usual care and one without. About 31 adu…

This pilot study will test whether a short eye-exercise program done during dialysis sessions can improve physical function, balance, and fear of falling in people with kidney failure. Thirty adults on maintenance hemodialysis will be randomly assigned to do the exercises or rece…

This study tests whether wearing bright light glasses during dialysis can reduce severe fatigue in people with end-stage kidney disease. Sixty adults on hemodialysis will use the glasses for one hour, three times a week, for four weeks. The goal is to see if this simple, non-drug…

This trial tests whether exercise done during dialysis sessions can help people with end-stage kidney disease think more clearly and feel better day-to-day. Participants will be randomly assigned to standard care alone or to one of three exercise programs—aerobic, resistance, or …

This study tests whether an artificial intelligence-supported education program can help reduce itching in people with chronic kidney disease who are on hemodialysis. The program teaches patients about causes of itching, skin care, diet, and self-management strategies through an …

This pilot study tests a 16-week physical activity and power training program for up to 30 older Veterans with advanced chronic kidney disease. The main goal is to see if the program is doable and well-tolerated. Participants will be pre-frail or have difficulty walking, and the …

This study tests a digital mindfulness app called Calm Health in 26 adults with chronic kidney disease. Participants use the app for 6 weeks while wearing a wrist sensor to track sleep, activity, and heart rate. The goal is to see if the app is easy to use and if it helps reduce …

People on hemodialysis need their fistula punctured with a needle three times a week, which can be painful and anxiety-provoking. This trial compares three approaches: usual care, applying an ice pack to a specific point on the hand before the needle, and using a numbing gel. Res…

This pilot study tests a 13-week Dialectical Behavioural Therapy (DBT) skills training program for Canadians who have recently started or will soon start facility-based hemodialysis. The goal is to see if the program is feasible and helpful for improving mental health and reducin…

This study tests whether a 9-week tele-nursing program—including education, phone or online check-ins, and counseling—can improve quality of life and health outcomes for people with stage 3 or 4 chronic kidney disease who are not yet on dialysis. Researchers will compare 66 parti…

This study tests a small, battery-powered headband that delivers a gentle electrical pulse to the scalp to help reduce chronic pain in people with end-stage kidney disease who are on dialysis. About 125 adults will use the device at home and report their pain levels. The goal is …

This study tests whether adding mindfulness (guided meditation) to a group exercise program during dialysis can improve safety, adherence, and quality of life for people with chronic kidney disease. Thirty participants will be split into two groups: one doing exercise plus mindfu…

This study tests whether a 6-month program of aerobic and resistance exercises, done during dialysis sessions, can improve body composition, muscle oxygen levels, and physical function in 40 adults with chronic kidney disease. Participants are randomly assigned to either the exer…

This study tests whether a 5-week virtual reality program that teaches positive thinking skills can help reduce depression and improve quality of life in people on hemodialysis. Sixty-one adults with end-stage kidney disease and mild-to-moderate depressive symptoms will either re…

This study tests whether adding a structured exercise program during dialysis sessions can improve strength, walking ability, and quality of life for people with end-stage kidney disease. About 800 patients will be randomly assigned to either dialysis plus exercise or dialysis al…

This study tests if anakinra is better than prednisone for treating gout flares in people with advanced chronic kidney disease or who have had a kidney transplant. Gout causes sudden, severe joint pain. Standard treatments can be risky for these patients. The study measures pain …

This study tests a virtual reality platform designed for people on hemodialysis. The platform includes games to encourage exercise, plus nutritional advice and psychological support. Researchers hope it will improve patients' walking ability, quality of life, and overall well-bei…

This study tests whether a group exercise program shown on TVs during hemodialysis is safe and doable for people with chronic kidney failure. About 45 adults will follow along with exercise videos while receiving dialysis. The goal is to see if this approach can help fight muscle…

This study compares continuous spinal anesthesia to general anesthesia for people receiving a kidney transplant. The goal is to see if the spinal method keeps blood pressure more stable and reduces pain. Sixty adults with end-stage kidney disease are taking part.

This study tests two numbing medicines, ropivacaine and lidocaine, in 40 adults with end-stage kidney disease who need surgery to create a blood vessel connection (fistula) for dialysis. Patients are randomly assigned to receive one of the two drugs during surgery, and neither th…

This study looks at whether SGLT2 inhibitors, a type of diabetes drug, can help prevent or manage anemia in people with chronic kidney disease. Researchers will analyze data from 15,000 patients in Japan to see how these drugs affect anemia rates, treatments, and costs. The goal …

This study tests a special education program for veterans with advanced chronic kidney disease. The goal is to help them understand their condition and choose the best type of dialysis, especially home dialysis. About 656 veterans will take part to see if this program improves th…

Researchers are examining health records to see whether older adults with advanced chronic kidney disease who start domperidone at 30 mg per day or more face a higher 30-day risk of hospitalization, emergency visits, or death compared with those taking lower doses. The study draw…

This completed study looked at nearly 7,000 older adults (65+) with low kidney function who started taking the antidepressant sertraline. Researchers compared the safety of a 50 mg daily dose versus a 25 mg daily dose, tracking hospital visits, emergency department visits, or dea…

This completed study looked at 1,100 older adults (65+) with advanced chronic kidney disease who started taking pramipexole, a drug for restless legs or Parkinson's. Researchers compared a very low starting dose (0.125 mg/day) to slightly higher doses (0.25 or 0.375 mg/day) to se…

This study looked at over 7,000 older adults (65+) with reduced kidney function who started taking the antidepressant citalopram. Researchers compared a 20 mg/day dose to a 10 mg/day dose to see if the higher dose increased the risk of serious events like hospitalization, emergen…

This completed study looked at 5000 older adults (66+) with low kidney function who started taking the antidepressant nortriptyline. Researchers compared those taking more than 10 mg per day to those taking exactly 10 mg per day to see if higher doses increased the chance of an e…

This completed study looked at over 12,000 older adults (66+) with low kidney function who started taking lorazepam. Researchers compared higher doses (1-4 mg/day) to lower doses (0.5-1 mg/day) to see if there was a greater risk of hospitalization, emergency visits, or death with…

Researchers at University Hospital Freiburg are studying how blood levels of hsCRP and Lp(a), two markers linked to heart disease, change over time in patients who have had these tests more than once. The study asks whether a high result on a first test often returns to normal la…

This study looks at how different types of dialysis affect heart health, bone metabolism, inflammation, and quality of life in people with end-stage kidney disease. Researchers will compare patients on hemodialysis, continuous ambulatory peritoneal dialysis, and automated periton…

This study looked at over 12,000 older adults (age 66+) with low kidney function who started taking the antidepressant escitalopram. Researchers compared the safety of a 10 mg daily dose versus a 5 mg daily dose. The goal was to see if the higher dose led to more hospital visits,…

This study looked at 14,000 older adults (66+) with advanced chronic kidney disease who started taking tamsulosin. Researchers compared those on a higher dose (0.8 mg/day) to those on a lower dose (0.4 mg/day) to see if the higher dose led to more hospital visits or deaths within…

This pilot study tests a program that screens older dialysis patients for common age-related problems like falls, memory trouble, and medication issues. A geriatrics team then gives personalized recommendations to the dialysis clinic. The goal is to see if this approach is practi…

This study looks at how common kidney injury is in newborns in intensive care and what factors increase the risk. Researchers will review medical records of about 4,000 babies from hospitals around the world. The goal is to better understand short- and long-term kidney health, bu…

This study monitors heart rate variability in 150 adults with type 2 diabetes who also have heart failure, chronic kidney disease, or both. Participants will wear a 24-hour heart monitor before and after starting a standard SGLT2 inhibitor medication. The goal is to understand ho…

This study re-analyzes data from a previous trial of 343 heart surgery patients who received a blood purification device (oXiris) connected to the heart-lung machine. The original trial found a 12% reduction in acute kidney injury within 7 days. Now researchers will examine how t…

This study looks back at dental implant cases to see if bone-related conditions—like vitamin D deficiency, calcium problems, or kidney disease—make implant failure more likely. Researchers will compare 192 failed implants with successful ones from similar patients. The goal is to…

This study examined whether starting a higher dose of two common antidepressants (venlafaxine and duloxetine) increases the risk of emergency visits, hospital stays, or death within 30 days in older adults with chronic kidney disease. Researchers analyzed health records from over…

This study tests whether a ring-shaped, cuffless device called CART BP Pro can accurately measure blood pressure in people receiving maintenance hemodialysis. Participants will wear the device on their finger for about 48 hours, and its readings will be compared with standard blo…

This study looks at how the drug eloralintide enters the bloodstream and leaves the body in people with severe kidney disease or kidney failure, compared to healthy volunteers. About 28 participants will receive a single shot under the skin. The study lasts about 14 weeks and doe…

This study is creating a registry of 5,000 adults with chronic kidney disease (CKD) to collect information on their health, treatments, and outcomes. Researchers aim to understand how the disease progresses, identify risk factors, and see how well current treatments match guideli…

This study investigates whether people with type 2 diabetes who have or are at risk for chronic kidney disease produce too much aldosterone, a hormone that regulates salt and blood pressure. Participants undergo several suppression tests—including oral sodium, saline infusion, an…

This study aims to develop an artificial intelligence-based model to predict serious outcomes in people with chronic kidney disease (CKD), such as disease progression, kidney failure, or death. Researchers will follow over 1,100 adults with moderate CKD in Vietnam for two years, …

This study looks at how dapagliflozin, a diabetes drug, affects heart function and metabolism in people with chronic kidney disease. Researchers will measure heart strain, oxygen use during exercise, and blood chemicals in 60 adults. The goal is to understand how the drug works b…

This study reviews medical records of 1200 Indian adults with chronic kidney disease and type 2 diabetes who started finerenone between August 2022 and April 2024. Researchers will analyze how doctors prescribed the drug, dose changes, and lab results like kidney function and pot…

This study tests whether a tele-health navigator program can help more kidney transplant candidates find living donors. About 347 adults with end-stage kidney disease will either get the navigator support or standard care. The goal is to see if remote guidance increases donor scr…

This study tests a new tool that personalizes lab results for older adults (65+) with chronic kidney disease. Researchers want to see if the new reports help patients better understand their results and feel less anxious. About 255 participants will review different report design…

This trial investigates whether kidney transplant candidates on dialysis can safely skip routine heart screening after being placed on the waiting list. Participants are randomly assigned to either no further screening or regular annual screening for hidden coronary artery diseas…

This study tests whether the type of filter (membrane) used during hemodialysis changes how immune cells and clotting factors react. Ten adults on long-term dialysis will try three different membranes over one week, with blood samples taken during each session. The goal is to see…

This study follows about 793 people with chronic kidney disease who previously took part in a program designed to help them talk to doctors and family about kidney transplants. Researchers want to see if the program's effects last over time, including whether patients start trans…

This study investigates why people with advanced chronic kidney disease (not yet on dialysis) often feel deep fatigue. Researchers will measure muscle strength and fatigue using simple tests like hand grip and walking speed. The goal is to understand how kidney disease affects ne…

This observational study follows 150,000 people with chronic kidney disease and type 2 diabetes to see how finerenone (Kerendia) works in everyday medical care. Researchers will compare those taking finerenone to those not taking it, looking at rates of heart attacks and heart fa…

This study examines health data from about 800,000 Korean adults to see how often conditions like obesity, type 2 diabetes, heart disease, chronic kidney disease, and fatty liver occur together. Researchers will analyze national survey and insurance records from 2013 to 2023. No …

This observational study follows over 4,600 adults with chronic kidney disease and type 2 diabetes who are starting finerenone, a drug that helps slow kidney damage. Researchers will collect data from routine doctor visits over 12 months to understand why doctors prescribe it, ho…

This long-term study follows over 5,000 people with chronic kidney disease to learn how the condition affects the heart and blood vessels. Researchers are tracking kidney function, heart events like heart attacks and strokes, and various risk factors. The goal is to find better w…

This study was designed to see how a low dose of bevacizumab (Avastin) behaves in the body and whether it safely lowers a certain protein (VEGF-A) in people with kidney failure on dialysis. The goal was to gather information for a future trial on preventing dialysis access failur…

This study investigates whether a single infusion of L-arginine, an amino acid, can reduce abnormally high sympathetic nerve activity in people with chronic kidney disease (CKD). High nerve activity is linked to increased cardiovascular risk in CKD patients. Researchers will meas…

This study observes 69 adults with chronic kidney disease who are on hemodialysis. Researchers want to find the best way to diagnose malnutrition using the GLIM criteria and other tools. The goal is to see which methods best predict declines in quality of life, muscle strength, a…

This study was designed to see how accurately patients report their own medication and healthcare use in diaries compared to official health insurance records. It planned to include people with diabetes, arthritis, kidney disease, or prostate cancer. However, the study was withdr…

This study tests two ways to help older adults with kidney failure make informed choices about their care. One approach offers education and decision aids; the other adds a supportive care program for those who choose non-dialysis options. Researchers will compare how many patien…

This study aims to find the genetic causes of kidney diseases like FSGS and nephrotic syndrome. Researchers will collect saliva and urine samples from up to 2,050 participants, including patients and their family members, as well as healthy volunteers. The goal is to understand w…

This study tests a questionnaire called NECPAL to see if it can spot patients with serious long-term illnesses like cancer, heart failure, or kidney disease who might benefit from palliative care. Researchers will check 200 adults in the hospital or day clinic to see how many are…

The APOLLO study looks at how variations in the APOL1 gene, common in people of African ancestry, affect kidney transplant outcomes. Researchers are testing DNA from 5,000 kidney donors and recipients to see if certain gene variants lead to faster kidney failure or harm living do…

This early study is testing whether the diabetes and heart failure drug empagliflozin (Jardiance) is safe for people on dialysis for kidney failure. The drug is already approved for other uses but has not been studied in dialysis patients. Researchers will give 24 participants ei…

This study gives a single dose of bepirovirsen to 32 adults with hepatitis B, some with kidney disease and some healthy. Researchers measure how much drug gets into the blood and how long it stays. The goal is to see if kidney problems change drug levels, which could affect futur…

This study looks at whether low levels of pyrophosphate, a natural substance that prevents mineral buildup, can predict artery hardening in people with moderate chronic kidney disease. Researchers will measure pyrophosphate in blood samples from 242 patients and track artery chan…

This study follows 96 people with end-stage kidney disease who need a brachiocephalic fistula for dialysis. Researchers collect data from exams, blood tests, and imaging to track changes in the vein over time. The goal is to learn what causes cephalic arch stenosis, a common narr…

This study is testing whether a detailed MRI scan can provide better information about chronic kidney disease (CKD) than standard tests. Researchers will scan 486 adults with CKD and track their health over time to see if the MRI can predict which patients will get worse. The goa…

This study was designed to see how a new experimental drug for chronic kidney disease, nurandociguat, affects the way the body processes two common medicines: rosuvastatin (a cholesterol drug) and dabigatran (a blood thinner). Healthy adults would have taken these drugs alone and…

This study looks at how kidney dialysis affects brain blood flow in 37 adults with chronic kidney failure. Researchers use a special breathing device called RespirAct to measure the brain's response to carbon dioxide before and after dialysis sessions. The goal is to find ways to…

This study looks at over 10,000 adults in Ecuador to understand why some people with diabetes develop kidney disease. Researchers will collect health surveys, blood and urine samples, and kidney tissue to study social, environmental, and biological factors. The goal is to find ne…

This observational study follows 25 people with end-stage kidney disease who are receiving a living donor kidney transplant. Researchers want to see how protein in the urine (proteinuria) relates to blood flow in the native kidneys before and after transplant. They also check for…

This study uses a continuous glucose monitor (a small sensor) to track blood sugar levels in 40 adults with diabetes and end-stage kidney disease who are on dialysis. The goal is to see how glucose changes during and between dialysis sessions over two weeks, and whether those pat…

This study tests whether a Learning Health System (LHS) can improve care for people with high blood pressure, diabetes, and kidney disease in Thai primary care clinics. The LHS uses electronic health records to help healthcare teams identify patients who need more active manageme…

This study explores the experiences of young adults aged 16 to 30 who receive haemodialysis in a hospital or clinic. Researchers want to understand what makes social interaction difficult and how to reduce loneliness. Through surveys, interviews, and workshops, they aim to create…

This study screened over 16,600 adults aged 45-70 with at least one risk factor (like high blood pressure or smoking) but no known heart disease. Researchers used ultrasound and simple blood and urine tests to find hidden signs of atherosclerosis, pre-diabetes, and kidney disease…

This study planned to use a machine learning algorithm to estimate blood potassium levels from a single-lead ECG in hospitalized patients. It was designed as a retrospective analysis of existing data from a home hospital program. However, the study was withdrawn before enrolling …

This study collects information from about 1000 critically ill infants who need a special type of dialysis (blood cleaning) using a new machine called CARPEDIEM. The goal is to learn why doctors start this treatment, how to best use it, and what happens to the babies afterward. T…

This study aimed to see if a computer could learn to predict how long a patient would stay in a home hospital program. Researchers planned to use data from past patients to train the computer. However, the study was withdrawn before any patients were enrolled, so no results are a…

This study follows 1,600 people with chronic kidney disease for 10 years to see how different types of exercise affect harmful toxins in the blood, physical fitness, and overall health. Participants include those in early stages, on dialysis, or with a kidney transplant. The goal…

This study tests whether a video decision aid helps older adults with advanced kidney disease plan their future medical care. About 456 patients aged 65 and older will watch a video explaining dialysis, non-dialysis management, and CPR, then record their preferences. The goal is …

This study examines how end-stage renal disease (ESRD) impacts recovery after pancreatic surgery. Researchers will review medical records of 100 patients to compare complication rates, hospital stays, and costs based on kidney function and dialysis use. The goal is to provide cle…

This study looks at whether vitamin D levels in the blood can help identify kidney injury in people who have had heart surgery. Researchers will compare vitamin D measurements with standard kidney function tests in 46 adults with different levels of kidney health. The goal is to …

This study uses advanced MRI techniques to measure changes in heart muscle tissue in 8,000 adults with heart failure, heart muscle disease, inflammation, coronary artery disease, or chronic kidney disease. The goal is to see if these measurements can help doctors better diagnose …

This study compares a new, less invasive needle-based method (endo-AVF) with traditional surgery for creating arteriovenous fistulas (AVFs) needed for dialysis. About 21 adults will be randomly assigned to one of the two techniques to see if a larger trial is feasible. The goal i…

This observational study plans to enroll 120,000 people with various chronic diseases like pancreatitis, diabetes, and arthritis. Researchers will collect blood samples and health data to study how genetics and lifestyle affect disease progression. The goal is to find common dise…

This study looks at how well muscle strength tests work for people with chronic kidney disease. It also tests if a supervised online exercise program is helpful and safe. 50 adults with kidney disease (on dialysis or with a transplant) will take part.

This study aimed to see if simple electronic reminders could help doctors reduce risky medication combinations in older patients. It planned to enroll primary care clinicians and use behavioral nudges in the electronic health record. However, the trial was withdrawn before any pa…

This study was designed to observe people with chronic kidney disease (CKD) and end-stage kidney disease (ESKD) to understand how the disease naturally progresses and how well current treatments work. It planned to enroll adults diagnosed with CKD or ESKD and follow their health …

This study aims to identify clinical, lifestyle, and genetic factors that affect blood sugar control and kidney complications in adults with type 2 diabetes in Mexico. Researchers will collect medical history, physical test results, and blood samples from 1,000 participants. The …

This study follows 1,800 adults with reduced kidney function (not on dialysis) to see how nutrition and lifestyle affect their health. Researchers will track changes in kidney function, heart health, bone health, and thinking skills over time. The goal is to find better ways to m…

This pilot study tests a new educational tool to help people with chronic kidney disease (CKD) make informed decisions about pregnancy and contraception. About 70 participants will receive a decision aid before a routine nephrology appointment and then complete a survey to measur…

This study follows 600 people with and without chronic kidney disease (CKD) for up to four years to compare how often memory loss, confusion, and daily activity problems occur. Researchers will also look for risk factors that make thinking and memory worse in CKD patients. Partic…

This study looks at how two drugs, Sacubitril/Valsartan (Entresto) and MANP, affect people with a type of heart failure called HFpEF, which also involves chronic kidney disease or shortness of breath during exercise. Researchers will measure changes in body chemicals and kidney f…

This study was designed to see how changing the amount of fluid, the time it stays in the belly, and the sugar level in the dialysis fluid affects how much fluid is removed during automated peritoneal dialysis. It was meant for adults with chronic kidney disease on dialysis for a…

This study looks at 120 adults on regular hemodialysis to see if a simple blood test called the neutrophil-to-lymphocyte ratio (NLR) can help detect peripheral artery disease (PAD). PAD is a common but often overlooked complication in kidney patients. The goal is to find a cheap,…

This study looks at how muscle loss (sarcopenia) affects people with chronic kidney disease (CKD) compared to healthy individuals. Researchers will measure body composition and muscle function in 80 participants. The goal is to better understand when and how muscle loss happens i…

This trial compares two ways to screen First Nations adults in Manitoba for chronic kidney disease. One group gets a letter and lab form in the mail; the other group's primary care network is also contacted. The goal is to see which method leads to more people getting screened, s…

This study follows 300 adults with chronic kidney disease who are already taking SGLT2 inhibitors. Researchers want to see if the amount of sugar in their urine is linked to changes in protein levels, a key marker of kidney damage. The goal is to find a simple way to tell if the …