Can a simple aspirin save dialysis patients from heart attacks?
NCT ID NCT04381143
First seen Jun 27, 2026 · Last updated Sep 15, 2026 · Updated 2 times
Summary
This study is testing whether taking aspirin can safely lower the risk of major heart problems, like heart attacks and strokes, in people with kidney failure who are on dialysis. About 9,000 adult dialysis patients will be randomly assigned to take aspirin or not, and researchers will track their heart health over time. The goal is to find out if aspirin's benefits outweigh its bleeding risks in this high-risk group.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 4
Runs after approval, following long-term safety and how well the treatment works in everyday use.
- Participants
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9,082 people
The number who actually took part.
- Started
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Jul 2020
- Expected to finish
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Dec 2026
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Incident or prevalent adults (≥18 years old) dialysis patients are included in the Dialysis Registry. * Commenced on dialysis with the expectation of ongoing maintenance dialysis requirement. * Willing and able to provide informed consent for this study. Exclusion Criteria: * Requirement for any form of antiplatelet agent (aspirin, glycoprotein IIb/IIIa inhibitors etc), or oral anticoagulation (warfarin, NOACs), in the view of the treating physician. * Contraindication to aspirin, in the view of the treating physician. * Dialysis requirement due to acute kidney injure with expectation of kidney function recovery. * History of haemorrhagic stroke or intracranial bleed within 12 months of screening. * Coagulopathy from any cause. * Unable to provide informed consent.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Anshun People Hospital
Anshun, Guizhou, 561099, China
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Anshun Xixiu District People's Hispital
Anshun, Guizhou, 561000, China
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Central People's Hospital of Zhanjiang
Zhanjiang, Guangdong, China
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China Guihang 302 Hospital
Anshun, Guizhou, 561000, China
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Dongguan Donghua Hospital
Dongguan, Guangdong, 523413, China
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Dongguan Eighth People's Hospital
Dongguan, Guangdong, China
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Dongguan Hospital of Integrative Traditional Chinese and Western Medicine
Dongguan, Guangdong, 523819, China
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Dongguan Houjie Hospital
Dongguan, Guangdong, 523955, China
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Dongguan Marina Bay Center Hospital
Dongguan, Guangdong, China
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Dongguan People's Hospital
Dongguan, Guangdong, China
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Fengqing People's Hospital of Yunnan Province
Lincang, Yunnan, China
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Fogang People Hospital
Qingyuan, Guangdong, 511600, China
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Foshan Gaoming District People's Hospital
Foshan, Guangdong, 528000, China
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Foshan Nanhai District People's Hospital
Foshan, Guangdong, China
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Foshan No.1 people's hospital
Foshan, Guangdong, China
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Foshan Sanshui People's Hospital
Foshan, Guangdong, China
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Foshan Second People's Hospital
Foshan, Guangdong, China
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Ganzhou Municiple Hospital
Ganzhou, Jiangxi, 341000, China
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Ganzhou People's Hospital
Ganzhou, Jiangxi, China
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General Hospital of Ningxia Medical University
Yinchuan, Ningxia, China
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Guangdong Agricultural Reclamation Central Hospital
Guangzhou, Guangdong, China
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Guangdong Cliffod Hospital
Guangzhou, Guangdong, China
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Guangdong Provincial Hospital of Integrative Medicine
Foshan, Guangdong, China
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Guangdong Provincial Hospital of Traditional Chinese Medicine Fangcun Branch (Guangzhou Charity Hospital)
Guangzhou, Guangdong, 510370, China
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Guangdong Provincial Peoples Hospital
Guangzhou, Guangdong, China
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Guangzhou First People's Hospital
Guangzhou, Guangdong, China
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Guangzhou Redcross Hospital
Guangzhou, Guangdong, 510240, China
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Hainan Provincial People's Hospital
Haikou, Hainan, China
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Heyuan People's Hospital
Heyuan, Guangdong, China
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Hua Du District People's Hospital of Guangzhou
Guangzhou, Guangdong, China
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Huangshi Central Hospital
Huangshi, Hubei, 435000, China
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Huizhou Central People's Hospital
Huizhou, Guangdong, China
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Huizhou First People Hospital
Huizhou, Guangdong, 516001, China
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Hunan Provincial People's Hospital
Changsha, Hunan, China
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Jiangmen Center hospital
Jiangmen, Guangdong, China
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Jiangxi Province Peple's Hospital
Nanchang, Jiangxi, China
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Jiashi County People's Hospital
Kashgar, Xinjiang, 844399, China
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Jieyang People's Hospital
Jieyang, Guangdong, China
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Jingmen Central Hospital
Jingmen, Hubei, 448001, China
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Jingzhou Central Hospital
Jingzhou, Hubei, 434020, China
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Jinwan Center Hospital of Zhuhai
Zhuhai, Guangdong, China
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Jiujiang No.1people's Hospital
Jiujiang, Jiangxi, China
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Kaiping Center Hospital
Kaiping, Guangdong, China
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Lianjiang People's Hospital
Lianjiang, Guangdong, China
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Lianping County People's Hospital
Lianping, Guangdong, 517100, China
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Lishui City Center Hospital
Lishui, Zhejiang, 323020, China
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Maoming Hospital of Traditional Chinese Medicine
Maoming, Guangdong, China
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Maoming People's Hospital
Maoming, Guangdong, China
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Meizhou People's Hospital
Meizhou, Guangdong, 514011, China
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Nantong Haimen People's Hospital
Nantong, Jiangsu, 226199, China
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Nanxiong People Hospital
Xiongzhou, Guangdong, 512499, China
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Panyu District people's hospital of Guangzhou
Guangzhou, Guangdong, China
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Peking University Shenzhen Hospital
Shenzhen, Guangdong, 518036, China
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People Hospital of Yingde City Guangdong Province
Yingcheng, Guangdong, China
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People's Hospital of Yangdong District Yangjiang City
Yangjiang, Guangdong, 529900, China
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Puning People's Hospital
Puning, Guangdong, China
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Qingyuan Hospital of Traditional Chinese Medicine
Qingyuan, Guangdong, China
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Qingyuan People's Hospital
Qingyuan, Guangdong, 511518, China
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Shache County People's Hospital
Kashgar, Xinjiang, 844700, China
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Shanghang County Hospital
Longyan, Fujian, 364299, China
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Shantou Central Hospital
Shantou, Guanggong, 515100, China
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Shantou Chaonan Minsheng Hospital
Shantou, Guangdong, 515144, China
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Shanwei People's Hospital
Shanwei, Guangdong, China
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Shaoguan First People's Hospital
Shaoguan, Guangdong, China
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Shenshan Medical Center, Memorial Hospital of Sun Yat-sen University
Shanwei, Guangdong, China
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Shenzhen Baoan People's Hospital
Shenzhen, Guangdong, China
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Shenzhen Hospital of Southern Medical University
Shenzhen, Guangdong, China
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Shenzhen Longhua District People's Hospital
Shenzhen, Guangdong, China
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Shenzhen No.2 people's hospital
Shenzhen, Guangdong, China
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ShunDe Hospital Guangzhou University of Chinese Medicine
Shunde, Guangdong, China
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Sichuan Province People's Hospital
Chengdu, Sichuan, China
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Subei People's Hospital
Yangzhou, Jiangsu, 225001, China
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Sun Yat-sen Memorial Hospital
Guangzhou, Guangdong, 510235, China
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The Affiliated Hospital of Guangdong Medical University
Zhanjiang, Guangdong, 524000, China
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The Affiliated Hospital of Youjiang Ethnic Medicine College
Baise City, Guangxi, China
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The Central Hospital of Wuhan
Wuhan, Hubei, China
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The Eighth Affiliated Hospital of Southern Medical University, The First People's Hospital of Shunde
Shunde, Guangdong, China
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The Eighth Affiliated Hospital of Sun Yat-sen University (Futian, Shenzhen)
Shenzhen, Guangdong, China
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The Fifth Affiliated Hospital of Guangzhou Medical University
Guangzhou, Guangdong, China
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The Fifth Affiliated Hospital of Southern Medical University
Guangzhou, Guangdong, 510900, China
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The First Affiliated Hospital of Fujian Medical University
Fuzhou, Fujian, China
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The First Affiliated Hospital of Guangdong Medical University
Guangzhou, Guangdong, 510120, China
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The First Affiliated Hospital of Guangzhou University of Chinese Medicine
Guangzhou, Guangdong, China
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The First Affiliated Hospital of Hainan Medical University
Haikou, Hainan, 570105, China
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The First Affiliated Hospital of Jinan University
Guangzhou, Guangdong, 510630, China
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The First Affiliated Hospital of Nanchang University
Nanchang, Jiangxi, China
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The First Affiliated Hospital of Shihezi University Medical College
Shihezi, Xinjiang, China
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The First Affiliated Hospital of Sun Yat-sen University
Guanzhou, Guangdong, China
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The First Affiliated Hospital, Zhejiang University
Hangzhou, Zhejiang, China
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The First Hospital of Lanzhou University
Lanzhou, Gansu, China
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The First People's Hospital of Jiangxia District, Wuhan City
Wuhan, Hubei, 430200, China
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The First People's Hospital of Kashi Prefecture
Kashgar, Xinjiang, China
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The First People's Hospital of Shaoguan
Shaoguan, Guangdong, China
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The Fourth Affiliated Hospital of Guangzhou Medical University
Licheng, Guangdong, China
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The People's Hospital of Jiangmen
Jiangmen, Guangdong, 529000, China
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The Second Affiliated Hospital of Xi'an Jiaotong University (Xibei Hospital)
Xi’an, Shanxi, 710004, China
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The Second People Hospital of Foshan Nanhai
Foshan, Guangdong, 528251, China
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The Second People's Hospital of Kashi Prefecture
Kashgar, Xinjiang, China
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The Seventh Affiliated Hospital of Sun Yat-sen
Shenzhen, Guangdong, 510275, China
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The Sixth Affiliated Hospital of Sun yat-sen University
Guangzhou, Guangdong, China
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The Third Affiliated Hospital of Southern Medical University
Guangzhou, Guangdong, 225200, China
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The Third Affiliated Hospital of Sun Yat-sen University
Guangzhou, Guangdong, China
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The Third Affiliated Hospital of Sun Yat-sen University Yuedong Hospital
Meizhou, Guangdong, 514799, China
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The Third Affiliated Hospital of Sun Yat-sen University Zhaoqing Hospital
Zhaoqing, Guangdong, 526070, China
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The Union Hospital Affiliated to Tongji Medical College of Huazhong University of Science and Technology
Wuhan, Hubei, China
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The fifth affiliated hospital of sun yat-sen university
Zhuhai, Guangdong, China
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The first Affiliated Hospital of Shantou Medical University
Shantou, Guangdong, 515041, China
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The first affiliated hospital of Guangxi Medical University
Nanning, Guangxi, China
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The third Xiangya Hospital of Central South University
Changsha, Hunan, China
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Tongji Hospital, Tongji Medical College of Huazhong Science and Technology University
Wuhan, Hubei, China
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Wengyuan People Hospital
Shaoguan, Guangdong, 512600, China
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Wuhan No.1 People's Hospital
Wuhan, Hubei, China
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Wuhan Puren Hospital
Wuhan, Hubei, 430012, China
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Xiangya Hospital Central South University
Changsha, Hunan, China
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Xiangyang Central Hospital
Xiangyang, Hubei, 441021, China
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Xinyang Central Hospital
Xinyang, Henan, China
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Xuzhou Mining Group General Hospital
Xuzhou, Jiangsu, 221006, China
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Yangjiang Hospital of Traditional Chinese Medicine
Yangjiang, Guangdong, China
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Yangjiang People's Hospital
Yangjiang, Guangdong, China
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Yuebei People's Hospital
Shaoguan, Guangdong, China
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Yunfu People's Hospital
Yunfu, Guangdong, China
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Zhaoqing first people's hospital
Zhaoqing, Guangdong, China
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Zhongshan City People's Hospital
Zhongshan, Guangdong, China
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Zhongshan Xiaolan People's Hospital
Zhongshan, Guangdong, China
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Zhoushan Hospital
Zhoushan, Zhejiang, 316100, China
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Zhuhai People's Hospital
Zhuhai, Guangdong, China
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Zhujiang Hospital of Southern Medical University
Guangzhou, Guangdong, 510280, China
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