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Why kidney patients feel so tired: muscle fatigue under the microscope

NCT ID NCT03998917

Knowledge-focused Sponsor: Centre Hospitalier le Mans Source: ClinicalTrials.gov ↗

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled This study
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
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Expanded access (paused)
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Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
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Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 01, 2026 · Last updated Jul 02, 2026 · Updated 1 time

Summary

This study investigates why people with advanced chronic kidney disease (not yet on dialysis) often feel deep fatigue. Researchers will measure muscle strength and fatigue using simple tests like hand grip and walking speed. The goal is to understand how kidney disease affects neuromuscular function, which could help design safe exercise programs for these patients.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could point toward tailored exercise programs to reduce fatigue and improve muscle function in pre-dialysis kidney patients.
What could go wrong
This is an observational study with a small scope, so it may not lead to direct treatments. Results may not apply to all kidney patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Expected to start

Sep 2019

An estimate. Start dates often move.

Expected to finish

Dec 2020

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Chronic Kidney Disease (CKD) group: Patients with chronic kidney disease and a glomerular filtration rate less than 60 ml/min of creatinine. Control group: The control group will consist of a group of people from the same age group as the CKD group but without chronic kidney disease. The exclusion criteria apply to this group. They will be selected from the spouses and other volunteers.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adult patients (Age\> 18 years) who have signed the informed consent form * Social security coverage * For patients in the Chronic Kidney Disease group: Glomerular filtration rate less than 60 ml/min of creatinine for more than three months Exclusion Criteria: * Dermatological conditions of the upper limbs which would contra-indicate Electromyographic electrodes being positioned * Gestating women * Patients with known neuromuscular conditions * Patients with dementia * Patients with acute heart failure * Patients with a history of surgery of the evaluated limb * Patients included in an interventional study involving administration of treatments other than routine care * For the patients in the Chronic Kidney Disease group: patients currently undergoing dialysis or in a pre-dialysis program (e.g. with a dialysis fistula already in place).

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Conditions

The condition(s) this trial relates to.

chronic kidney disease chronic renal failure syndrome end stage renal failure Fatigue

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Chronic kidney disease stage 5 Chronic kidney disease STAGE3 Chronic kidney disease, stage 4 (severe) Chronic kidney failure Fatigue

Contacts and locations

Locations

  • Centre Hospitalier Le Mans

    Le Mans, 72000, France

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