Centre Hospitalier Le Mans

After an out-of-hospital cardiac arrest, doctors often aim to keep mean arterial pressure at or above 65 mmHg, but no one knows the best target. The METAPHORE trial compares a standard target of 65 mmHg with a higher target of 90 mmHg for the first 24 hours, using norepinephrine …

This study tests whether a carefully controlled low protein diet (about 0.6 grams of protein per kilogram of body weight each day) can help people with advanced chronic kidney disease delay the need for dialysis or a kidney transplant. The study enrolls adults with stage 4-5 or f…

This study tests whether the HAR score, a simple tool based on history, age, and risk factors, can help emergency dispatchers decide how urgently to respond to chest pain calls. Researchers will follow about 800 adults who call emergency services with non-traumatic chest pain in …

Ventilated patients in intensive care often need a gastric tube for feeding or drainage. Doctors usually insert the tube through the nose or the mouth, but they do not know which route is safer. This trial compares the two placement sites in 2,400 intubated adults to see whether …

This study investigates whether wearing a virtual reality headset during epidural injections can lower pain and anxiety in people with nerve root pain (radiculopathy). Participants receive two injections, each with the headset, and researchers measure anxiety levels and pain scor…

This study tests whether a personalized exercise program—focusing on the specific leg muscles affected by blocked arteries—can help people with peripheral arterial disease walk longer distances without pain. Participants are randomly assigned to either a tailored muscle-strengthe…

This study tracks how fast the 'halo sign' — a key ultrasound marker of inflamed arteries — disappears after starting steroid treatment in people with giant cell arteritis, a rare disease that can cause blindness. Researchers will scan the temporal arteries of 64 newly diagnosed …

About 1 in 4 women have their water break before labour starts. Most go into labour within 48 hours, but some need to be induced. This study tests whether deliberately breaking the leftover membrane when a woman is admitted to the hospital can shorten the time to labour and reduc…