OVARIAN CANCER

This study is testing whether adding two newer drugs (an immunotherapy and a vaccine) to a standard maintenance pill can better control recurrent ovarian cancer. It involves 188 women whose cancer has returned but responded to platinum chemotherapy and who do not have specific BR…

This study aims to monitor side effects in ovarian cancer patients taking the maintenance drug niraparib (Zedula). It will follow 354 participants for one year after they start treatment, tracking specific safety concerns like blood cell problems and high blood pressure. The stud…

This is the first human study testing the safety and early effects of an experimental drug called BL-M17D1 in people with advanced cancers that have a specific marker called HER2. The trial will enroll 120 adults with various hard-to-treat cancers, including breast, lung, and sto…

This study is testing whether combining two existing cancer drugs can help control advanced cancers that usually don't respond to standard immunotherapy. The trial is for adults with specific advanced cancers, like certain types of pancreatic, breast, and prostate cancer, who hav…

This study is testing whether the drug bevacizumab (Avastin) can help control ovarian, fallopian tube, or primary peritoneal cancer that was discovered during a second surgery after initial treatment. The research involves 35 participants who have completed standard chemotherapy …

This study is testing whether a drug called BGB-290 (pamiparib) can help keep ovarian cancer from coming back in patients whose cancer returned but then responded well to platinum-based chemotherapy. It compares the drug to a placebo (inactive pill) as a long-term maintenance tre…

This is the first human study testing the safety of an experimental drug called AB598 in people with advanced cancers. The trial will enroll 40 participants with various cancers including lung, stomach, bladder, and breast cancer to determine safe dosage levels and monitor side e…

This large, late-stage trial is testing whether adding a special heated chemotherapy wash to standard surgery helps people with advanced ovarian cancer stay cancer-free for longer. The study compares two groups: one receives the heated chemo during their tumor-removal surgery, an…

This study is testing whether adding Juice Plus+ nutritional supplements to the diet helps ovarian cancer patients in remission have better outcomes compared to patients who only receive dietary counseling. About 75 patients will be randomly assigned to either take the supplement…

This is a first-in-human study to find a safe dose and see how the body processes a new oral drug called ATV-1601. It is being tested in adults with advanced solid tumors, including certain breast cancers, that have a specific genetic change called an AKT1 E17K mutation. The main…

This study is testing an experimental drug called CYH33 for women with a specific type of recurrent ovarian cancer (clear cell carcinoma) that has a particular genetic change (PIK3CA mutation). It is for patients whose cancer has come back or persisted after standard chemotherapy…

This early-stage trial is testing the safety of a new treatment called ADP-A2M4CD8, which uses a patient's own modified immune cells to fight cancer. The study will enroll 120 adults with one of nine advanced cancers who have specific genetic markers. Researchers will give the ce…

This large, late-stage study is testing whether adding the immunotherapy drug pembrolizumab to standard chemotherapy (with or without bevacizumab) works better than chemotherapy alone for women with recurrent ovarian cancer that has stopped responding to platinum-based drugs. The…

This study is testing a pill called IMP4297 to see if it can help keep ovarian cancer from returning after patients finish their first round of chemotherapy. It involves 404 women with advanced ovarian cancer who responded well to initial chemo. Participants are randomly assigned…

This study aims to find the best way to give high-dose radiation to control cancer that has spread to bones, the spine, soft tissue, or lymph nodes. It compares giving all the radiation in one day versus spreading it over three days, using precise imaging to target the tumor and …

This study is testing several personalized treatments for women whose rare types of ovarian cancer have persisted or returned after prior therapy. Doctors will use specific markers found in a patient's tumor to match them to one of the investigational treatments. The main goal is…

This study tested whether adding a drug called olaparib to standard chemotherapy (paclitaxel and carboplatin) works better than chemotherapy alone for controlling advanced ovarian cancer that had previously responded to platinum drugs. It involved 162 patients whose cancer had re…

This study is testing a drug called entrectinib for people with advanced solid tumors that have specific genetic changes (NTRK, ROS1, or ALK gene rearrangements). It's a 'basket trial,' meaning it groups patients by their tumor's genetic type rather than where the cancer started …

This study aims to find out which treatment sequence helps women with advanced ovarian cancer live longer. It compares having major surgery immediately versus starting with three cycles of chemotherapy followed by surgery and more chemo. The trial enrolled 797 women to determine …

This study is testing if a simple electronic reminder for doctors can help more patients with a suspicious ovarian mass get quickly referred to a specialized cancer surgeon. The goal is to see if this 'nudge' improves the speed and rate of referrals, especially for patients from …

This large, late-stage trial is testing whether a drug called olaparib can help keep advanced ovarian cancer from coming back after successful initial chemotherapy. It involves 366 women whose cancer responded well to chemo but who do not have specific BRCA gene mutations. The st…

This study is testing a new oral drug called AZD5305 to see if it is safe and can help control advanced cancers. It is being tested alone and in combination with other cancer medicines in over 700 patients with various hard-to-treat solid tumors. The main goals are to find the ri…

This study is testing a new three-drug combination for women with recurrent ovarian cancer that has stopped responding to platinum-based chemotherapy. The goal is to see if adding an experimental drug called ALX148 to two existing treatments (liposomal doxorubicin and pembrolizum…

This is a first-in-human study testing a new type of cancer treatment called P-MUC1C-ALLO1 in adults with advanced solid tumors that have spread or cannot be removed by surgery. The main goals are to find a safe dose and see how well the body tolerates this 'off-the-shelf' CAR-T …

This early-stage study is testing a new drug called BT5528 in people with advanced solid tumors that have spread or returned. The main goals are to find a safe dose, understand the side effects, and see if the drug shows early signs of helping to control cancers like ovarian, lun…

This study is testing whether a three-drug combination can help the body's immune system fight advanced ovarian, fallopian tube, or primary peritoneal cancer that has returned after initial treatment. The treatment includes an immunotherapy drug (pembrolizumab), an investigationa…

This study is testing whether two immunotherapy drugs, nivolumab alone or combined with ipilimumab, can help control recurrent clear cell ovarian, fallopian tube, and related cancers. It will enroll 46 patients whose cancer has returned after standard chemotherapy. The main goal …

This early-stage trial is testing the safety and finding the right dose of a two-drug combination (naptumomab estafenatox and durvalumab) for people with advanced or metastatic solid tumors. It will enroll about 120 adults with one of many eligible cancer types, including breast,…

This study is testing whether a personalized vaccine called Vigil can help women with advanced ovarian cancer stay cancer-free longer after their initial surgery and chemotherapy. The vaccine is made from each patient's own tumor cells and is given as a series of injections. Rese…

This study is testing two new drug combinations for women with advanced ovarian cancer whose tumors grew while on a common type of maintenance therapy called a PARP inhibitor. It aims to see if adding a new drug called tuvusertib to either niraparib or lartesertib can shrink tumo…

This early-stage study is testing the safety of a new, personalized cell therapy for people with advanced solid tumors that have stopped responding to standard treatments. Doctors collect a patient's own immune cells, genetically modify them to better recognize and attack their s…

This early-stage study tests a personalized cell therapy for people with advanced solid tumors. Doctors collect a patient's own immune cells, genetically modify them in a lab to better recognize and attack cancer, then infuse them back into the patient. The main goals are to chec…

This large, late-stage study is testing whether adding two newer drugs—an immunotherapy (pembrolizumab) and a maintenance therapy (olaparib)—to standard chemotherapy can help women with advanced ovarian, fallopian tube, or peritoneal cancer live longer without their cancer gettin…

This study is testing a new personalized treatment for ovarian cancer that has come back. Doctors take a patient's own immune cells, modify them in a lab to better target the cancer, and then infuse them back. The trial is seeing if these modified cells work better alone or when …

This study allows ovarian and breast cancer patients who were benefiting from olaparib treatment in a previous clinical trial to continue receiving the medication. The program provides ongoing access to the drug for 185 patients who show continued clinical improvement. Participan…

This study is testing the safety and effectiveness of two oral drugs, avutometinib and defactinib, given together to Japanese patients with a specific type of recurrent ovarian cancer. The goal is to see if this combination can shrink tumors and control the cancer in patients who…

This large study is testing whether removing the fallopian tubes during a routine hysterectomy for non-cancerous reasons can safely reduce the risk of developing ovarian cancer later in life. It involves 4,400 women under 55 who are having a hysterectomy. Researchers will compare…

This small pilot study is testing whether a special support program is practical and helpful for women with advanced ovarian cancer. The program includes exercise, nutrition, and stress management, and is given alongside chemotherapy before major surgery. The goal is to see if th…

This study is testing an online program called 'Journey Ahead' designed to help women with gynecologic cancers (like ovarian, cervical, or uterine cancer) develop better coping and communication skills. The program aims to reduce distress, improve emotional acceptance, and enhanc…

This study aims to find a quick way to spot depression in women with ovarian, peritoneal, or fallopian tube cancer. It also compares a 10-week phone counseling program with standard care to see which better improves patients' quality of life. Participants answer questionnaires an…

This study aims to combine information from PET/MRI scans with blood and tissue tests to create detailed profiles of high-grade serous ovarian cancer. Researchers will use computer analysis to examine imaging results alongside genetic and immune system data from tumor samples. Th…

This study aims to understand the full impact of advanced, treatment-resistant ovarian cancer on patients and their caregivers in Canada. Researchers will survey 150 patients and their caregivers about their quality of life, symptoms, work challenges, and treatment preferences. T…

This study aims to understand how much time people with advanced breast or ovarian cancer spend on treatment-related tasks like appointments, travel, and home care. Participants will use a smartphone app for 28 days to track their activities and complete daily surveys about their…

This study is testing whether a simple blood test, called a liquid biopsy, can be used to understand how ovarian cancer changes over time and predict if it will come back or progress. It involves 20 newly diagnosed patients who will give blood samples during their standard treatm…

This study aims to understand how women with BRCA gene mutations think about new tools for assessing their ovarian cancer risk. Researchers are interviewing 24 women to learn how they might use genetic risk scores and early detection blood tests when deciding whether to have prev…

This study aims to identify molecular patterns in tissue samples that might predict how gynecological cancers behave. Researchers will collect samples from 300 women with suspected ovarian, cervical, or endometrial cancer. The goal is to link these molecular findings to the patie…

This study aims to understand the lifestyle, emotional, and social factors in the lives of women who have survived advanced ovarian cancer for at least seven years. Researchers will collect information through questionnaires and interviews about diet, exercise, stress, and social…

This study aims to test a new type of MRI scan that uses a special contrast agent to see if it can measure how aggressive an ovarian cancer might be before surgery. It will involve 30 participants, including people at high risk for ovarian cancer and those already suspected of ha…

This study aims to understand why some ovarian cancers become resistant to initial treatment. Researchers will examine 10 patients with advanced ovarian cancer who undergo a follow-up surgical procedure after completing chemotherapy. The study will compare outcomes between patien…

This study aims to create a collection, or biobank, of biological samples from people with breast, ovarian, or uterine cancers, as well as from some of their close relatives. Researchers will collect samples like blood, urine, and leftover tumor tissue to store for future researc…

This study is testing a different way to provide genetic testing to cancer patients. Instead of referring patients to a genetic counselor, doctors themselves order the tests, and counselors then give results by phone. Researchers are measuring how this change affects patient dist…

This study is observing 100 women with breast or gynecological cancers to see if their diet in the month before starting chemotherapy is linked to levels of a blood protein called hepcidin. Researchers will then check if hepcidin levels are connected to how well patients can stic…