OVARIAN CANCER

This study tests a new drug called JPI-547 combined with bevacizumab in people whose ovarian cancer has returned after prior treatment with platinum chemotherapy and PARP inhibitors. About 81 participants will receive either the new drug combination or standard care to see if it …

This early-stage study tests a new cell therapy called KT032 in 24 people with advanced solid tumors (like ovarian, colon, or mesothelioma) that have spread to the belly lining. The main goal is to check safety and find the right dose. Participants must have tried standard treatm…

This study tests a combination of three drugs (Benmelstobart, Anlotinib, and Cyclophosphamide) in 40 adults with recurrent ovarian, fallopian tube, or primary peritoneal cancer. The goal is to see if this treatment can control the disease and improve survival. Participants must h…

This study tests a drug called sacituzumab in 22 people with a rare and aggressive ovarian cancer (clear cell carcinoma) whose tumors grew after immunotherapy. The drug targets cancer cells and delivers chemotherapy directly to them. The main goal is to see if it can shrink tumor…

This study tests a new drug, azenosertib, against standard chemotherapy in people with ovarian cancer that no longer responds to platinum-based treatments. The trial includes 420 adults whose tumors have a specific protein called cyclin E1. The goal is to see if azenosertib can s…

This study tests two new drug combinations given before surgery for people with advanced ovarian cancer that cannot be fully removed right away. The goal is to shrink the tumor enough to allow successful surgery. About 104 participants with a specific type of ovarian cancer (BRCA…

This early-phase study tests a new treatment for people with advanced ovarian cancer or other solid tumors that have not responded to standard therapies. The treatment uses the patient's own immune cells, which are genetically modified to better recognize and attack cancer cells,…

This study tests a combination of three drugs (liposomal irinotecan, sintilimab, and anlotinib) in 36 people with a rare type of ovarian cancer that has come back after treatment. The goal is to see if the combo can shrink tumors and how safe it is. Participants must have had at …

This study looks at women with advanced ovarian cancer who first receive three rounds of chemotherapy. A special score called KELIM helps doctors decide whether to do surgery right away or after more chemo. The goal is to see if this personalized timing can help patients live lon…

This study tests whether a combination of two drugs, fluzoparib and famitinib, can help keep advanced ovarian cancer from returning after initial chemotherapy. About 43 women with stage III or IV ovarian cancer who responded well to chemo will take these pills daily for up to 2 y…

This study compares two chemotherapy approaches for women with advanced ovarian cancer that has a high level of the PARK2 gene. One group gets the standard two-drug combo (paclitaxel plus carboplatin), while the other gets only paclitaxel. The goal is to see if the single drug wo…

This study tests a new cell therapy called SL-28 for people with advanced solid tumors that have not responded to standard treatments. The therapy uses donor immune cells to attack the cancer. The goal is to see if it is safe and can shrink tumors in up to 60 participants with va…

This study tests a new drug called Rina-S (with or without bevacizumab) against standard platinum-based chemotherapy for people with ovarian cancer that has come back but still responds to platinum treatments. About 688 participants will be randomly assigned to receive either the…

This early-stage study tests two versions of a drug (CKD-215 and D215) in 24 adults with advanced BRCA-mutated ovarian, fallopian tube, or primary peritoneal cancer. The goal is to see how the body processes each drug and check for side effects. Participants will receive both dru…

This study tests a new drug called QLS5132, given with other cancer treatments, for people with advanced solid tumors like stomach, lung, ovarian, or endometrial cancer. The goal is to find safe doses and see if the combination shrinks tumors. About 626 participants will receive …

This study is testing a new medical device that gently collects cells from the vagina to look for signs of ovarian and endometrial cancer. The goal is to see if this less invasive method can detect cancer-related markers as well as or better than current tests. About 300 women, s…

This study tests a new blood test (OCS) that uses exosome technology to monitor for ovarian cancer recurrence in patients whose CA125 levels were normal before their first treatment. About 32 women with stage I-IV ovarian cancer will provide blood samples after initial surgery an…

This study tests whether giving a special dye (Cytalux) several days before surgery works as well as giving it closer to the operation. The dye makes tumors glow under a special camera, helping surgeons see and remove them. About 106 adults having surgery for suspected lung cance…

This study tests whether a supplement called N-Acetyl-Cysteine (NAC) can reduce memory and thinking problems caused by chemotherapy in ovarian cancer patients. About 102 women with advanced ovarian cancer will receive NAC alongside their standard platinum-based chemo. The goal is…

This study looks at whether hand and foot exercises can reduce nerve pain (like numbness and tingling) caused by chemotherapy in older adults with gynecological cancer. About 74 people aged 65 and older will take part. The goal is to see if these exercises improve their quality o…

This study is for young adults (ages 21-45) who had certain cancers as teens or young adults. Researchers are adapting a program that helps survivors manage their health and find the right follow-up care. The goal is to see if this program improves how confident and capable survi…

This study looks at whether a blood test that counts and analyzes circulating tumor cells can predict how well certain cancer drugs (PARP inhibitors) work in people with advanced breast, prostate, pancreatic, or ovarian cancer. Researchers will collect blood samples from 300 adul…

This study checks if surgeons can tell key details about ovarian cancer by looking at images from a camera inside the belly. About 70-80 surgeons will review pictures from 50 patients and guess the cancer type and growth pattern. The goal is to see if visual clues can help choose…

This study checks if a newer, cheaper DNA sequencing machine (MGI) works as well as the current standard (Illumina) for finding gene changes linked to hereditary cancers like breast, ovarian, and Lynch syndrome. Researchers will compare results from 248 stored DNA samples using b…

This study uses a special 3D ultrasound to look at blood flow in the cervix and ovaries of women with cervical cancer, precancerous changes, or ovarian cancer. Researchers want to see if blood flow patterns can help tell these conditions apart or predict how well patients will do…

This study looks at whether a low-carbohydrate diet helps women with advanced ovarian cancer who are taking a type of maintenance therapy called PARP inhibitors. Researchers will review medical records and ask about eating habits from 600 women across 14 hospitals in China. The g…

This study looks at whether watching an educational video changes what cancer patients know and think about genetic testing. About 200 people with certain cancers will take a survey, watch the video, and then take another survey. The goal is to see if the video helps them make a …

This study looks at how well different labs agree when testing for a protein called FRa in stored tissue samples from people with ovarian cancer. About 1,000 women will have their old biopsy samples tested again. No new treatments or visits are needed. The goal is to improve futu…

This study tests a new questionnaire (the QLQ-OV39) to see if it accurately measures quality of life in people with ovarian cancer. About 50 adults with early or advanced ovarian cancer will fill out the questionnaire and give feedback. The goal is to improve how doctors and rese…

This study tests whether artificial intelligence (AI) can accurately predict the type of ovarian cancer and how well surgery will go by analyzing videos from a routine diagnostic procedure called laparoscopy. Researchers will enroll 100 adults with advanced ovarian cancer to see …