OVARIAN CANCER

This study is testing whether paclitaxel chemotherapy alone works as well as the standard paclitaxel-carboplatin combination for advanced ovarian cancer patients with high levels of a specific gene called PARK2. Researchers want to see if using just one drug can reduce side effec…

This study is testing whether a combination of three drugs—benmelstobart, anlotinib, and cyclophosphamide—can help control recurrent ovarian, fallopian tube, or primary peritoneal cancer. It aims to see if this treatment can delay cancer progression and is safe for patients. The …

This study is testing whether taking two oral medications (fluzoparib and famitinib) as maintenance therapy can help delay the return of advanced ovarian cancer in women who responded well to their initial chemotherapy. The trial will enroll 43 women aged 18-75 who have advanced …

This study is testing an experimental drug called QLS5132, given by IV in combination with other cancer therapies, for people with advanced solid tumors like lung, stomach, ovarian, and endometrial cancer. The main goals are to find a safe and effective dose and to see how well t…

This study is testing a new combination of three drugs to see if it can shrink tumors and control a specific, hard-to-treat type of ovarian cancer that has come back or persisted after prior treatment. It will enroll 36 patients to evaluate how well the treatment works and how sa…

This study is testing an investigational pill called valemetostat for adults with advanced solid tumors that have stopped responding to standard treatments. It is specifically for people whose cancers have certain genetic changes affecting a cellular system called SWI/SNF. The go…

This study is testing a drug called sacituzumab for a specific, hard-to-treat type of ovarian cancer (clear cell carcinoma). It is for patients whose cancer has started growing again after treatment with immunotherapy. The goal is to see if this new drug can shrink tumors and con…

This study is testing two different drug combinations to shrink tumors in people with advanced ovarian cancer before they have surgery. It's for patients whose cancer can't be fully removed with initial surgery or who can't tolerate that surgery. Researchers will compare how well…

This early-stage study is testing a new cell-based treatment called SL-28 in adults with advanced solid tumors that have not responded to standard therapies. The main goals are to find the safest and most effective dose and to check for side effects. Participants will receive the…

This study is for people with recurrent ovarian cancer that has progressed after treatment with a specific type of maintenance therapy (PARP inhibitors). It aims to see if a newer, targeted drug called trastuzumab deruxtecan works better than standard chemotherapy. The drug speci…

This early-phase study is testing a new personalized treatment for adults with advanced ovarian cancer and other solid tumors that have come back or stopped responding to standard therapies. Doctors will modify a patient's own immune cells in a lab to better recognize and attack …

This study is creating and testing a patient navigation program to help young adults who have survived cancer. The program aims to guide survivors to get the recommended primary care and cancer check-ups they need. Researchers will first adapt an existing program for young surviv…

This study is testing a new drug combination (JPI-547 with bevacizumab) for ovarian cancer that has come back after previous treatments. It aims to see if this combination can help control the cancer longer and is safe for patients. The study is for people whose cancer responded …

This international study aims to improve treatment for advanced ovarian cancer by personalizing the timing of surgery. Patients first receive three cycles of chemotherapy. A special blood test score (KELIM) then determines their next steps: patients with a good score have surgery…

This is a very early study to first check if a new cell therapy called KT032 is safe and tolerable for people with advanced cancers like ovarian, mesothelioma, or colon cancer. It will involve about 24 adults whose cancer has progressed despite standard treatments. The main goal …

This study aims to see if giving a special fluorescent dye called Cytalux several days before surgery works as well as giving it right before surgery. It is for adults having surgery for suspected lung cancer or confirmed ovarian cancer. The dye helps surgeons see cancer cells mo…

This study is testing a new blood test called OCS, which looks for tiny particles called exosomes, to see if it can detect when ovarian cancer comes back. It focuses on patients whose standard blood marker (CA125) was low when they were first diagnosed. The goal is to find a more…

This study is testing a new, more comfortable vaginal swab device to see if it can detect early signs of ovarian and endometrial cancer. Researchers will collect samples from 300 women attending gynecology clinics, including some with cancer and some without, to look for biologic…

This study is testing a new artificial intelligence (AI) tool designed to help doctors make better decisions for ovarian cancer patients. The AI will analyze videos taken during a diagnostic procedure to try to predict the specific type of cancer and whether surgeons will likely …

This study is testing whether a simple hand and foot exercise program can help reduce nerve pain and improve quality of life for older women receiving chemotherapy for gynecologic cancers. Researchers will enroll 74 participants aged 65+ who are experiencing nerve pain from their…

This study compares two different DNA sequencing machines to see if they give similar results for genetic testing in cancer patients. Researchers will test the same patient samples on both the new MGI machine and the established Illumina machines. The goal is to determine if the …

This study aims to test and improve a questionnaire designed to measure quality of life for ovarian cancer patients. Researchers will ask 50 patients with ovarian cancer to complete the questionnaire and provide feedback through interviews. The goal is to create a better tool for…

This study is testing a digital app designed to help cancer patients understand their genetic test results. The goal is to see if using the app reduces patient distress and improves knowledge compared to receiving standard information from pamphlets or videos. The study will invo…

This study aims to understand whether surgeons can accurately identify specific features of advanced ovarian cancer just by looking at it during surgery. Researchers will ask 70-80 experienced ovarian cancer surgeons to review laparoscopic images from 19 patients and describe wha…

This study looks back at medical records to see if eating a low-carbohydrate diet is linked to better survival for women with a specific type of ovarian cancer who are on a standard maintenance therapy. Researchers will compare the outcomes of about 600 patients who had different…

This study aims to understand if measuring blood flow to tumors using a special 3D ultrasound can help doctors. It will look at women with cervical cancer, precancerous cervical changes, or ovarian cancer. The goal is to see if these blood flow measurements can predict how the di…

This study aims to understand if an educational video can improve cancer patients' knowledge about genetic testing and help them make informed choices about whether to pursue testing. Researchers will enroll 200 cancer patients who haven't had genetic testing before. Participants…