OVARIAN CANCER

This early-phase study tested a vaccine called DCP-001 in 17 people with a serious type of ovarian cancer who had already completed standard treatment. The goal was to see if the vaccine is safe and can boost the immune system to recognize and fight cancer cells. Results will hel…

This study tested whether zafirlukast, an asthma drug, can control ovarian cancer that is only detected by rising CA-125 levels in the blood. Five women with this type of relapse took the drug to see if it could lower their CA-125 levels. The goal was to delay or prevent further …

This study tested a new drug called IMP4297 in 93 women with advanced ovarian cancer that has a BRCA1 or BRCA2 gene mutation and has not responded to at least two prior treatments. The goal was to see if the drug could shrink tumors or slow the cancer's growth. The drug is taken …

This early-stage study tested a new drug called CUE-102 in 42 adults with certain advanced cancers (colorectal, stomach, pancreatic, or ovarian) that had returned or spread and were no longer responding to standard treatments. The goal was to find a safe dose and see if the drug …

This study tested a drug called nirogacestat in 53 people with a rare type of ovarian cancer that had come back after treatment. The goal was to see if the drug could shrink tumors or stop them from growing. Researchers measured how many patients had their tumors shrink and how l…

This study tested a combination of two drugs, pamiparib and surufatinib, in 29 women with a tough-to-treat type of ovarian cancer that had stopped responding to platinum chemotherapy and a prior PARP inhibitor. The goal was to see if the combo could shrink tumors or slow cancer g…

This study tested a new drug called ZN-c3, alone or with another drug (niraparib), in 117 people with ovarian cancer that stopped responding to platinum-based chemotherapy. The goal was to see if the treatment is safe and can shrink tumors or slow the disease. This is not a cure,…

This early study tested a new radioactive treatment called Radspherin® in 21 people with ovarian cancer that came back and spread inside the belly. The treatment is given directly into the abdomen after surgery to remove visible tumors. The main goals were to find a safe dose and…

This study tested whether giving the immunotherapy drug nivolumab directly into the abdomen is safe after extensive surgery and heated chemotherapy for advanced ovarian cancer. 22 women with recurrent ovarian cancer took part. The goal was to find the highest safe dose and see if…

This study tested a combination of two drugs (NT-I7 and pembrolizumab) in 215 adults with advanced solid tumors that had come back or stopped responding to standard treatments. The goal was to find a safe dose and see if the combo could shrink tumors. The study also looked at imm…

This study tested a drug called mirvetuximab soravtansine in 79 adults with recurrent ovarian, peritoneal, or fallopian tube cancer that still responds to platinum chemotherapy and has high levels of a protein called folate receptor-alpha. The main goal was to see how many partic…

This early-phase study tested an experimental drug called VS-6766, given by mouth on different schedules, in 104 adults with advanced solid tumors or multiple myeloma. The goal was to find a safe and tolerable dose, both when used alone and when combined with another drug (everol…

This early-stage trial tested a new drug called SL-172154 combined with either standard chemotherapy or a targeted therapy in 86 people with ovarian cancer that stopped responding to platinum-based chemo. The main goals were to check safety and find the best dose. Researchers als…

This study tested a combination of two drugs, lenvatinib and pembrolizumab, in 611 people with advanced cancers that had stopped responding to standard treatments. The cancers included triple-negative breast, ovarian, gastric, colorectal, glioblastoma, biliary tract, and pancreat…

This early-stage study tested a new drug called COM902, alone or with another drug (COM701), in 94 people with advanced cancers like ovarian, lung, colon, and multiple myeloma. The main goal was to check safety and find the best dose. While not a cure, the approach aims to contro…

This study tested whether adding two drugs—pembrolizumab (an immunotherapy) and olaparib (a targeted therapy)—to standard chemotherapy could help women with advanced ovarian cancer live longer without their cancer growing. Over 1,300 women with a type of ovarian cancer that does …

This early-stage study tested a new drug called RP903 in 69 people with advanced solid tumors (like ovarian, breast, or cervical cancer) who had no other treatment options. The main goal was to check the drug's safety and find the right dose, not to cure the cancer. While some pa…

This study tested whether adding the drug BD0801 to chemotherapy helps people with ovarian cancer that no longer responds to platinum-based treatments. The trial included 421 women with recurrent, platinum-resistant ovarian, fallopian tube, or primary peritoneal cancer. The goal …

This study looked at 120 women over 70 with advanced ovarian cancer who were considered vulnerable due to age and health. It compared three chemotherapy plans: standard two-drug therapy, a single drug, or a weekly low-dose combination. The goal was to see which plan allowed patie…

This study tested a combination of two drugs, apatinib and etoposide, in 35 women with ovarian cancer that no longer responded to platinum-based chemotherapy. The goal was to see if the combination could shrink tumors or slow the cancer's growth. The results help doctors understa…

This study tested a new drug (TJ004309) combined with an approved immunotherapy (atezolizumab) in 25 people with advanced ovarian, head and neck, lung, gastrointestinal, or triple-negative breast cancers. The goal was to see if the combination could shrink tumors. Participants ha…

This study tested whether adding two immunotherapy drugs (durvalumab and tremelimumab) to standard chemotherapy before surgery is safe and feasible for people with advanced ovarian, fallopian tube, or primary peritoneal cancer. The trial enrolled 69 participants and primarily mea…

This study allowed people with certain cancers (ovarian, basal cell, or colorectal) who had already shown benefit from the drug vismodegib in an earlier study to keep receiving it. The main goal was to track side effects and see how many people had to stop treatment due to them. …

This early-phase study tested a new drug called SNB-101 in 21 people with advanced solid tumors (like colorectal, breast, or lung cancer) that had stopped responding to standard treatments. The drug is a nanoparticle version of SN-38, a chemotherapy agent, given by IV on days 1 a…

This early-phase trial tested an experimental immunotherapy called ELI-002 in 25 people with KRAS-mutated pancreatic, colorectal, lung, ovarian, or bile duct cancers who had minimal residual disease (small amounts of cancer left after standard treatment). The goal was to see if t…

This study looked at whether a care plan led by a geriatrician and a nurse could help older adults (70+) with cancer live longer and feel better. It included 792 people with different cancers like breast, lung, or prostate. The approach was compared to usual cancer care to see if…

This study tested a new, non-invasive method called Raman spectroscopy to detect ovarian cancer. Researchers analyzed blood and tissue samples from 160 women with symptoms or undergoing treatment. The goal was to see if this light-based technique can identify cancer earlier and d…

This study looked at 221 women having surgery for an ovarian cyst that was thought to be non-cancerous. Researchers tested two blood markers (CA125 and HE4) and two scoring methods (ROMA and RMI) to see if they could better tell apart benign and malignant tumors. The goal was to …

This study looked at whether fluid collected from behind the vagina (culdocentesis) can help diagnose ovarian cancer. Researchers measured tumor markers CA-125 and HE4 in the fluid of 52 women scheduled for ovarian surgery. They also checked urine for estrogen ratios. The goal wa…

This study looked at two ways to manage ovarian cancer risk in 40 women with BRCA gene mutations or strong family history. One group had preventive surgery to remove ovaries and fallopian tubes, while the other group had regular CA-125 blood tests to catch cancer early. Researche…

This study looked at whether adding the drug aprepitant to the usual two anti-nausea medicines can better prevent nausea and vomiting caused by chemotherapy in people with gynecologic cancers like ovarian, cervical, and endometrial cancer. 143 patients took part. The goal was to …

This study tested whether giving a low dose of esketamine during ovarian cancer surgery could prevent depressive symptoms afterward. Over 500 women undergoing cytoreductive surgery received either esketamine or a placebo. The goal was to see if the drug reduced depression and sle…

This study tested a mobile app that lets ovarian cancer patients report their symptoms and well-being to their care team. The goal was to help doctors make better decisions and improve patients' quality of life. Ten women with advanced ovarian, fallopian tube, or primary peritone…

This study looked at whether acupressure, a technique where you apply gentle pressure to specific spots on the body, can help reduce severe tiredness in women who have had ovarian cancer. 171 survivors took part, and researchers measured their fatigue and quality of life over 24 …

This study tested a home-based brain training program for 60 women who had finished chemotherapy for gynecologic cancers (like ovarian or uterine cancer) and were experiencing memory or thinking problems. Participants used a computer program called BrainHQ for 10 weeks. The goal …

This study tested a digital tool (a chatbot) to help cancer survivors learn about genetic testing for hereditary cancer risk. 50 adults who had certain cancers (like breast, ovarian, or prostate) took part. The goal was to see if the chatbot was easy to use and if it helped more …

This study looked at whether a special website or coaching phone calls could help more people with a personal or family history of certain cancers get genetic testing. Over 800 participants were randomly assigned to use a mobile website, receive two motivational coaching calls, o…

This study tested a new follow-up approach for people who finished treatment for gynecologic cancers like ovarian, endometrial, cervical, or vulvar cancer. Instead of seeing a doctor every time, patients met with a nurse at every other visit and used a smartphone app to learn sel…

This study tested whether a green dye called ICG can help surgeons find the first lymph nodes that ovarian cancer might spread to. 48 women having ovary surgery took part. The goal was to see if the dye works well enough to guide safer, more precise surgery in the future.

This study tracked the safety of the drug olaparib in over 1,000 Chinese patients with ovarian or prostate cancer. Researchers recorded side effects and how doctors managed them in everyday practice. The goal was to better understand the drug's real-world safety profile in this p…

This study looked at how well the drug T-DXd works compared to usual treatments for people with several types of advanced cancers that have high levels of a protein called HER2. Researchers used existing data from earlier trials and real-world medical records to compare outcomes.…

This study looked at 386 women with cervical, uterine, or ovarian cancer to compare complication rates between standard keyhole surgery (laparoscopy) and robot-assisted keyhole surgery. The goal was to see which approach leads to fewer problems within the first six months after t…

This study tested a new automated method to grow cancer cells from patients with metastatic cancers (like prostate, breast, lung) inside chicken eggs. The goal was to see if this system could successfully grow tumors from patient samples, which could help doctors study cancer and…

This study reviewed medical records of 509 adults in Taiwan with advanced endometrial, ovarian, or cervical cancer. Researchers wanted to find out how many of these cancers have high levels of a protein called HER2 (IHC 3+). This information could help doctors identify patients w…

This study looked at whether following national guidelines for ovarian cancer surgery is cost-effective. Researchers measured the cost per year of good-quality life (QALY) for 200 women with advanced ovarian cancer. The goal was to see if sticking to guidelines provides better va…

This study checked if the drug olaparib, used for advanced ovarian or breast cancer, leads to low folate (folic acid) levels in the blood. Ten postmenopausal women were followed to see how many developed folate deficiency and when it happened. The goal was to understand a possibl…

This study looked at how completely surgeons remove the fallopian tubes when women have surgery to remove an ovary and tube. Researchers checked if any tube tissue was left behind and looked for factors that might cause incomplete removal. The goal was to create a training video …

This study followed 354 people with ovarian cancer who were taking niraparib (Zedula) capsules daily as part of their normal care. The main goal was to watch for side effects like low blood cell counts, high blood pressure, and other serious issues over one year. Researchers did …

This study looked at tumor cells found in the blood of 30 people with advanced ovarian cancer. Researchers counted these cells and studied their features to see if they relate to how the disease progresses. The goal is to develop a simple blood test to help monitor the cancer and…

This study tested different methods to encourage more people to get genetic testing for hereditary breast and ovarian cancer risk. Researchers used electronic health records to find over 1,300 eligible patients at Penn Medicine gynecology clinics. They tried sending messages dire…