New triple therapy takes on hard-to-treat ovarian cancer
NCT ID NCT07239622
First seen Nov 20, 2025 · Last updated Jun 23, 2026 · Updated 36 times
Summary
This phase 2 trial tests a combination of three drugs—liposomal irinotecan, sintilimab, and anlotinib—in 36 people with recurrent or persistent ovarian clear cell carcinoma. The goal is to see if the treatment can shrink tumors and control the disease. Participants must have already tried platinum-based chemotherapy.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
liposomal irinotecan, sintilimab, and anlotinib
What this could lead to
If successful, this combination could offer a new treatment option for people with recurrent ovarian clear cell carcinoma, potentially shrinking tumors and delaying disease progression.
What could go wrong
This is a small, early-phase trial with only 36 participants and no comparison group. The combination may cause significant side effects, and results may not apply to all patients.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.