Engineered immune cells take on recurrent ovarian cancer in new trial

NCT ID NCT05601752

First seen Mar 01, 2026 · Last updated May 16, 2026 · Updated 8 times

Summary

This phase 2 study tests a personalized cell therapy (ADP-A2M4CD8) alone or with another drug (nivolumab) in 66 people with recurrent ovarian cancer. Only patients with certain genetic markers (HLA-A*02 and MAGE-A4) can join. The goal is to see if the treatment shrinks tumors and is safe.

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Contacts and locations

Locations

  • Augusta University

    Augusta, Georgia, 30912, United States

  • Avera Cancer Institute

    Sioux Falls, South Dakota, 57105, United States

  • Centre Leon-Berard

    Lyon, 69008, France

  • Centro Oncologico Clara Campal

    Madrid, 28050, Spain

  • City of Hope

    Duarte, California, 91010, United States

  • Cleveland Clinic Foundation

    Cleveland, Ohio, 44195, United States

  • Clinica Universidad de Navarra

    Madrid, 28027, Spain

  • Honor Health

    Scottsdale, Arizona, 85258, United States

  • Hospital Universitario 12 de Octubre

    Madrid, 28041, Spain

  • Hospital Universitario Fundación Jiménez Díaz

    Madrid, 28040, Spain

  • Hospital Universitario Ramón y Cajal

    Madrid, 28034, Spain

  • Hospotal Clinico Universitario de Valencia

    Valencia, 46010, Spain

  • Institut Gustave Roussy

    Villejuif, 94805, France

  • Institut de Cancerologie de Strasbourg

    Strasbourg, 67200, France

  • Institut de Cancerologie des Hospices Civils de Lyon

    Pierre-Bénite, Lyon, 69310, France

  • Karmanos Cancer Institute

    Detroit, Michigan, 48201, United States

  • Rutgers Cancer Institute of NJ

    New Brunswick, New Jersey, 08901, United States

  • Swedish Cancer Institute

    Seattle, Washington, 98104, United States

  • The Christie Hospital

    Manchester, M20 4GJ, United Kingdom

  • University College of London Hospital

    London, NW1 2PG, United Kingdom

  • University Health Network (Princess Margaret Cancer Center)

    Toronto, Ontario, M5G 2M9, Canada

  • University of Oklahoma Health Sciences Center

    Oklahoma City, Oklahoma, 73104, United States

  • Vall d'Hebron Unversity Hospital

    Barcelona, 08035, Spain

Conditions

Explore the condition pages connected to this study.