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Heated chemotherapy during surgery may delay ovarian cancer return

NCT ID NCT03842982

Ongoing Disease control Sponsor: Centre Oscar Lambret Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This phase 3 trial tests whether giving heated chemotherapy directly into the abdomen during surgery can help people with advanced ovarian cancer live longer without the disease coming back. About 362 participants will either receive standard surgery alone or surgery plus the heated chemotherapy. The study is active but no longer recruiting, and results are awaited.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Cisplatin (heated chemotherapy given directly into the abdomen during surgery)
What this could lead to
If successful, this could offer a way to delay ovarian cancer recurrence after surgery, giving patients more time without the disease progressing.
What could go wrong
This is a phase 3 trial, but results are not yet final. The heated chemotherapy adds complexity and risk of side effects, and it may not improve survival for all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

fallopian tube carcinoma ovarian cancer ovarian carcinoma ovarian neoplasm peritoneal carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OVARIAN CANCER OVARIAN CARCINOMA OVARY NEOPLASMS

Contacts and locations

Locations

  • Centre François Baclesse

    Caen, 14076, France

  • Centre Henri Becquerel

    Rouen, France

  • Centre Hospitalier Lyon Sud

    Pierre-Bénite, 69495, France

  • Centre Jean Perrin

    Clermont-Ferrand, 63011, France

  • Centre Oscar Lambret

    Lille, 59020, France

  • Clinique Mathilde

    Rouen, 76100, France

  • Cliniques universitaires St-Luc, Institut Roi Albert II

    Brussels, 1200, Belgium

  • Hôpital Européen Georges Pompidou

    Paris, 75008, France

  • Hôpital Jeanne de Flandre

    Lille, 59037, France

  • Hôpital de Hautepierre

    Strasbourg, France

  • ICM-Val d'Aurelle

    Montpellier, 34298, France

  • Institut Bergonié

    Bordeaux, 33076, France

  • Institut Gustave Roussy

    Villejuif, 94805, France

  • Institut Jules Bordet

    Brussels, 1070, Belgium

  • Institut Paoli Calmettes

    Marseille, 13273, France

  • Institut de Cancérologie de Lorraine

    Vandœuvre-lès-Nancy, 54519, France

  • Institut de Cancérologie de l'Ouest

    Angers, 49055, France

  • Institut de Cancérologie de l'Ouest

    Saint-Herblain, 44800, France

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