Periodontitis

When a tooth is removed, the bone and gum often shrink, making it harder to place a dental implant later. This study tests a new magnesium membrane that is placed over a bone graft in the socket. Unlike standard membranes, it is rigid enough to protect the graft but dissolves on …

This study looks at whether placing a calcium hydroxide paste inside a tooth between root canal appointments helps infected teeth heal better. About 110 adults with painful tooth infections will receive standard root canal treatment over multiple visits. One group gets the extra …

This study tests a minimally-invasive non-surgical therapy (MINST) for treating gum disease-related bone defects. The approach uses small instruments and magnification to clean deep gum pockets with less tissue damage than traditional surgery. Researchers will measure bone healin…

This study looks at whether a special dental sealer (bioceramic) helps heal infections and reduces pain after a repeat root canal done in one visit. About 70 adults with failed root canals and silent infections in their back teeth will take part. They will get the new sealer or a…

This study compares two ways to remove infection at the tip of a tooth root: using a rotary bur (a small drill) or a piezoelectric unit (a vibrating tool). 124 adults with root infections will have surgery and then be followed for 12 months to see which method leads to better bon…

This study tests whether adding a special nano-gel (nano-hydroxyapatite) to a deep-cleaning gum treatment helps heal deep gum pockets better than cleaning alone. About 28 adults with advanced gum disease will be randomly assigned to get either the cleaning plus gel or just the cl…

This study tests whether adding nano-hyaluronic acid gel to a non-surgical deep cleaning procedure helps heal gum pockets better than cleaning alone. About 28 adults with moderate to severe gum disease will be randomly assigned to receive either the gel plus cleaning or just clea…

This trial tests four methods of activating the cleaning liquid during root canal treatment in adults aged 20 to 40 with an infected lower first molar. The goal is to see which method helps the infection at the root tip heal best after 12 months. Participants receive one-visit ro…

This study tests whether a patient's own stored tooth can be used as a graft to preserve jawbone after tooth extraction. About 21 adults needing at least two teeth pulled will receive this treatment. The goal is to maintain bone width and height for better future dental implant p…

This study looked at whether adding a diode laser to standard deep-cleaning treatment helps people with gum disease (periodontitis). Twenty-one adults in Yemen received the combined treatment, and researchers measured plaque, gum bleeding, pocket depth, and immune markers in gum …

This study tests whether adding a diode laser to standard deep cleaning helps people with gum disease. Forty adults with periodontitis will receive either standard cleaning alone or cleaning plus laser. Researchers will measure gum pocket depth and inflammatory markers in saliva …

This study tests whether personalized oral hygiene advice, delivered through an AI-powered mobile health app by trained volunteers, can improve gum health in older adults. Eighty-eight participants aged 60 and over from daycare centers in Hong Kong will receive bi-weekly advice b…

This study tests whether using a patient's own extracted tooth as a bone graft works as well as a traditional bone graft to repair bone damage from severe gum disease. Sixty adults with chronic periodontitis will receive one of the two graft types, both combined with a healing ge…

This study tests whether a new mouthwash that repairs enamel and fights bacteria works better than a standard chlorhexidine mouthwash for treating gum disease. About 40 adults with mild to moderate gum disease will use one of the mouthwashes along with deep cleaning. The goal is …

This study tests whether a blackberry extract mouthwash works as well as a standard antiseptic mouthwash (chlorhexidine) for treating gum disease. 48 adults with periodontitis will receive standard deep cleaning and then rinse with one of the mouthwashes or just plain water. Rese…

This study tests whether oleanolic acid, a natural plant compound, works better than standard medicines (calcium hydroxide and Ledermix) when placed inside a root canal. The goal is to reduce bacteria and inflammation in teeth with infection. Thirty-six adults with infected singl…

This study tests whether adding aspirin and omega-3 fatty acids to standard deep-cleaning gum treatment helps people with advanced gum disease (periodontitis). About 120 adults will be randomly assigned to get either standard cleaning alone, cleaning plus omega-3, or cleaning plu…

This study looks at whether adding hyaluronic acid gel or a special blood product (Alb-PRF) to standard deep-cleaning treatment helps people with advanced gum disease (periodontitis). 51 adults aged 30-60 with Stage III periodontitis will be randomly assigned to one of three grou…

This early-phase trial tests whether calcium silicate and pectin, placed inside the tooth, can kill bacteria better than standard calcium hydroxide in root canals of dead teeth with abscesses. 63 adults with a single infected premolar will receive one of the three medications. Th…

This study looks at whether deep cleaning for gum disease can lower a key heart failure marker in the blood. About 80 adults with or without heart failure will receive dental scaling and root planing. Researchers will track changes in NT-proBNP levels and gum health over 6 months…

This study tests whether a protein from camel milk, made into tiny nanoparticles, can help repair bone damage caused by severe gum disease. About 44 adults with deep gum pockets and bone loss will receive the treatment during surgery. The goal is to see if the camel protein helps…

This study tests whether a gel made from ferulic acid, a natural antioxidant, can improve the results of deep cleaning for gum disease. Researchers will compare three groups: cleaning plus the gel, cleaning plus a placebo gel, and cleaning alone. The goal is to see if the gel hel…

This early-stage trial tests whether injecting resveratrol nanoparticles into the gums can improve treatment for stage III periodontitis. 48 adults will receive either the resveratrol gel, a placebo, or standard deep cleaning alone. Researchers will measure gum attachment levels …

This study compares two methods to clean infected root canals during a single dental visit: laser-activated irrigation and sonic-activated irrigation. Sixty adults with chronic apical periodontitis (a tooth infection) will receive one of the two treatments. Researchers will measu…

This study tested whether adding injectable Platelet-Rich Fibrin (i-PRF), a natural concentrate from a patient's own blood, to standard deep cleaning improves gum disease outcomes. In 13 adults with moderate to severe periodontitis, one side of the mouth received the combined tre…

This study compares two types of minimally invasive gum surgery for treating deep pockets caused by periodontitis. Fifty adults with advanced gum disease will be randomly assigned to receive either a single-flap or double-flap procedure. Researchers will measure how well each tec…

This study tests whether a melatonin-loaded gel, made from your own blood, can improve gum health in people with stage II periodontitis. About 60 adults with mild to moderate gum disease will receive the treatment. The main goal is to see if it helps reattach gums to teeth.

This study tests whether a pharmacist-led program can help people reduce their risk of heart disease. Over 1,000 adults with conditions like diabetes, high blood pressure, or obesity are taking part. Pharmacists use a step-by-step guide to assess risk and support lifestyle change…

This study compares a new calcium silicate-based sealer to the standard resin-based sealer for root canals in molar teeth. About 136 adults aged 18-65 with infected molars will receive one of the two sealers. The goal is to see which material leads to better healing and fewer sym…

This study reviews past dental records to see how effective scaling and root planing (a deep cleaning procedure) is for treating gum pockets that are 5 to 8 millimeters deep. Researchers will analyze data from 110 patients treated by dental students over two years. The goal is to…

This study tests whether adding a concentrate from the patient's own blood (injectable platelet rich fibrin, or I-PRF) to a standard bone graft helps repair bone defects caused by advanced gum disease. Twenty adults with stage III periodontitis and deep gum pockets will receive e…

This study compares two materials used to seal the tip of a tooth root during surgery for persistent infections after root canal treatment. About 110 adults will receive either MTA or TotalFill BC-RRM Fast Set Putty. Researchers will check healing with 3D X-rays after one year to…

This study compares two types of dental sealers used during root canal treatment: TotalFill (a bioceramic sealer) and AH Plus. The goal is to see which one leads to better healing of infections at the tooth root tip. 170 teeth from adults at a dental clinic in Singapore are being…

This study tests whether treating severe gum disease can slow down Alzheimer's disease. Researchers will give 26 people with both conditions deep dental cleaning, extractions if needed, and oral hygiene training. Over 24 months, they will track memory, thinking skills, and brain …

This study looks at two ways to treat severe gum disease that has reached the area where the roots of back teeth split. One approach uses non-surgical cleaning and maintenance, while the other involves surgery to reshape or rebuild bone. The goal is to see which method helps keep…

This study is testing whether artificial intelligence (AI) can accurately diagnose periodontitis (severe gum disease) and monitor gum inflammation using dental records and X-rays. Researchers will develop and validate AI models using data from 900 patients across multiple hospita…

This study compares four different rinsing tools used after root canal treatment to see which one reduces pain the most. Fifty-two adults with an infected lower back tooth will be randomly assigned to one of four groups. They will rate their pain at several times over two days an…

This study tests a numbing method called intraseptal anesthesia for gum surgery. Sixty adults with gum disease will receive a small amount of articaine to see if it effectively blocks pain during the procedure. The goal is to find a less painful alternative to standard numbing te…

This study compares two treatments for severe tooth pain: vital pulp therapy, which tries to save the tooth's nerve, and standard root canal treatment, which removes it. Researchers will measure pain after 24 hours and one week, and check healing at 6 and 12 months using AI to re…

This study looks at two ways to clean root canals (rotary vs. reciprocating files) and whether rinsing with very cold saline (cryotherapy) reduces pain after the procedure. Sixty adults with infected but painless teeth will be randomly assigned to one of four groups. Patients wil…

This study tests two ways to clean a tooth during a root canal: laser-activated irrigation and passive ultrasonic irrigation. Researchers want to see which method leads to less pain and better quality of life afterward. 90 adults with infected or damaged permanent teeth are takin…

This study looks at two different cleaning solutions used during root canal treatment for teeth with long-term infection. The goal is to see which method helps the infection heal better and causes less pain afterward. 63 healthy adults with infected front or premolar teeth will b…

This study tests a less invasive surgical approach for treating persistent tooth infections. Instead of removing all infected tissue and using stitches, surgeons remove only part of the tissue and seal the area with a medical glue. The goal is to see if this method reduces pain, …

This study tests whether adding N-acetylcysteine (NAC) to standard root canal treatment can reduce pain and improve healing in people with infected, dead teeth. Forty adults with mature teeth and signs of infection around the root tip will receive either NAC or standard medicatio…

This study looks at two different materials used to fill root canals after infection. 64 adults with infected but painless teeth will get one of the two sealers. Researchers will track pain for a week and check healing with X-rays over time to see which works better.

This study tests whether adding a common mouthwash ingredient (chlorhexidine) to a standard root canal medicine (calcium hydroxide) helps reduce pain after treatment. 80 adults with infected front teeth will receive one of two mixtures. Pain levels are checked at 12, 24, and 48 h…

This study tests two different pastes placed inside the tooth between root canal visits to see which one reduces pain and helps the bone heal better. Eighty adults with infected but painless front teeth will receive either Bio-C Temp or Metapaste. Pain is tracked for a week, and …

This study looks at three different methods to activate cleaning fluids during root canal retreatment: ultrasonic, sonic, and laser. The goal is to see which one causes the least pain and helps the infection heal best. Seventy-five adults with previously treated teeth that still …

This study follows up to 500 people with acute or chronic inflammatory disorders, such as infections or immune problems, over time. Researchers will monitor participants with standard tests and may screen them for other studies. The goal is to better understand these conditions a…

This study looked at whether having more frequent contact with a clinician (at least once a week) improves satisfaction for people with long-lasting musculoskeletal conditions. Participants were split into two groups: one with standard contact and one with extra check-ins via tex…

This study collects blood, urine, and tissue samples from 330 adults with advanced lung or head and neck cancer to improve precision medicine. Researchers will analyze genetic changes in these samples and grow some tumors in mice to compare DNA. The goal is to refine liquid biops…

This study follows 200 adults with high blood pressure and gum disease to see how gum health affects blood pressure and cholesterol levels over 6 to 12 months. Researchers will measure triglycerides and LDL cholesterol to understand the link. The goal is to learn whether treating…

This study looks at tissue samples taken from deep gum pockets in people with periodontitis who have already completed initial treatment. Researchers want to describe the tissue features and see if they relate to how well the gums heal. The goal is to better understand healing pa…

This study compares the levels of two bacteria, E. saphenum and P. gingivalis, in 148 adults over age 30—111 with gum disease (periodontitis) and 37 with healthy gums. Researchers collect plaque samples and use advanced lab tests to measure bacterial levels. The goal is to better…

This study looks at whether routine blood sugar testing during dental checkups can help find hidden high blood sugar in people with advanced gum disease. About 300 adults with severe gum disease will get a simple finger-prick blood test during their dental visit. The goal is to s…

This study tests whether a Norwegian clinic (NSAC) helps people with common mental health issues or muscle pain return to work sooner. 2500 adults are split into three groups: one gets treatment quickly, one waits 10-14 weeks, and one gets a basic check-up. Researchers will track…

This study checks how many teeth remain functional 10 years after root canal treatment using a sealer called Endomethasone N. Researchers will review records from 179 adults who had the treatment at least 5 years ago. The goal is to understand the long-term success and safety of …

This study looks at how smoking changes the body's immune response in gum disease. Researchers compared smokers and non-smokers with healthy gums, gingivitis, or periodontitis. They measured specific proteins and genes in gum tissue to understand the link between smoking and infl…

This study looks at whether the Parkinson's drug Levodopa-Benserazide affects gum health and inflammation. Researchers will measure gum health and saliva markers in 136 people, including Parkinson's patients with and without gum disease, and healthy controls. The goal is to under…

This study looks at how a standard deep-cleaning procedure called scaling and root planing affects certain proteins in the blood and gum fluid of people with advanced gum disease. Researchers will compare 28 patients with stage 3 periodontitis to 28 healthy individuals, measuring…

This study looks at whether a person's genetic makeup influences how well a tooth infection heals after root canal treatment. Researchers will collect saliva samples from 96 adults with chronic apical periodontitis and analyze specific genes related to inflammation and bone repai…

This study examines how nicotine buildup in gum tissue influences the results of non-surgical periodontitis treatment. Researchers will measure nicotine and cotinine levels in the gums of 56 smokers and non-smokers with periodontitis. The goal is to understand if nicotine intoxic…

This study looks at how the severity of gum disease (periodontitis) impacts people's daily lives. Researchers examined 300 adults aged 18 to 65, measuring gum health through clinical exams and using two short questionnaires (OHIP-14 and OShip-14) to capture how oral health affect…

This study looks at how an acute tooth infection (apical periodontitis) affects the masseter muscle, a key jaw muscle used for chewing. Researchers will use ultrasound to measure muscle thickness and stiffness before and after dental treatment with calcium hydroxide. The goal is …

This study follows 60 adults with infected teeth who receive standard root canal treatment. Researchers collect fluid from around the tooth before and after treatment to see if certain proteins can predict whether the infection heals on X-rays after one year. The goal is to find …

This study looks back at the medical records of about 4 million people who had physical or occupational therapy for muscle and joint problems. Researchers want to see if different ways of giving therapy lead to different results. No new treatments are tested—the goal is to learn …

This study aimed to see if a mobile monitoring tool could accurately identify surgical site infections (SSIs) in orthopedic surgery patients, compared to the usual manual review. The study was withdrawn before enrolling any participants, so no results are available. It was design…

This study looks at whether non-surgical gum cleaning (scaling and root planing) can change levels of certain bone-related substances in the blood of people with advanced gum disease. Sixteen adults with stage III periodontitis will receive the treatment, and their blood will be …

This study looks at how different root canal cleaning methods—laser and ultrasound—affect the immune response in people with and without type 2 diabetes who have a tooth infection called apical periodontitis. Researchers will measure certain immune markers in fluid from around th…

This study looks at 50 people with gum disease—25 smokers and 25 non-smokers—to see if a protein in saliva called histatin-1 is linked to healing after standard non-surgical gum treatment. Researchers measure the protein and gum health at the start, one month, and three months af…

This study looks at two genetic markers (Cofilin-2 and Lactoferrin) in 84 adults with gum disease, some of whom also have coronary heart disease. Researchers measure changes in these markers and gum health after a standard deep-cleaning dental treatment. The goal is to better und…

This study follows 30 adults who had surgery for advanced gum disease (periodontitis). Researchers want to see if the surgery keeps teeth healthy and how long the benefits last. Participants are checked at regular visits with exams and X-rays. This is an observational study, mean…

This study looks at whether taking antidepressants can reduce gum inflammation in people with chronic periodontitis (gum disease) and depression. Researchers will collect gum fluid and plaque samples from 92 patients during routine dental procedures. The goal is to see if depress…

This study tests whether using ozone water during root canal treatment can reduce oxidative stress (a sign of inflammation) in the jawbone. Sixty adults with a single-rooted tooth and a silent infection will be randomly assigned to receive either ozone water or salt water as a fi…