Gum disease treatment may alter Bone-Related markers, study finds
NCT ID NCT07475013
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study looks at how a standard deep-cleaning procedure called scaling and root planing affects certain proteins in the blood and gum fluid of people with advanced gum disease. Researchers will compare 28 patients with stage 3 periodontitis to 28 healthy individuals, measuring markers like GPNMB, TGF-β1, RANKL, and osteoprotegerin before and after treatment. The goal is to understand how these markers change and what they might mean for bone health and healing.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Scaling and Root Planing (SRP)
- What this could lead to
- If successful, this study could reveal how standard gum treatment affects key markers linked to bone health and healing, potentially guiding future therapies for periodontitis.
- What could go wrong
- This is a small, early-stage observational study with only 56 participants. It measures biological markers, not direct health outcomes, so results may not lead to new treatments.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Sağlık Bilimleri Üniversitesi Gülhane Diş Hekimliği Fakültesi
Ankara, 06010, Turkey (Türkiye)
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Other studies related to the condition(s) this trial covers.
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