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Laser zaps tooth infections better than sonic cleaners?

NCT ID NCT07387809

Disease control Sponsor: University of Zagreb Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study compares two methods to clean infected root canals during a single dental visit: laser-activated irrigation and sonic-activated irrigation. Sixty adults with chronic apical periodontitis (a tooth infection) will receive one of the two treatments. Researchers will measure pain levels over a week, check bacteria removal, and use 3D scans to see if the infection heals after one year. The goal is to find out if the laser method reduces pain and improves healing more than the sonic method.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Laser-activated irrigation (Er:YAG laser) and sonic-activated irrigation (polymer tip device)
What this could lead to
If successful, this could show that laser-activated irrigation is a more effective way to clean infected root canals, reducing pain and improving healing after a single dental visit.
What could go wrong
This is a small, early-stage study with only 60 participants, so results may not apply to everyone. The laser device is already used in dentistry, so the main question is whether it works better than existing methods.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 60 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jan 2024

Expected to finish

Feb 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

Children (under 18), adults (18 to 64) and older adults (65 and over)

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * teeth tender to percussion, palpation * teeth that have a sinus tract and swelling * a chronic periapical lesion greater than 5 mm in diameter based on the initial X-ray * previous endodontic treatment and root canal filling that is inadequate according to clinical criteria (filling, overfilling, non-homogeneous root canal filling, unfilled root canals) Exclusion Criteria: * immunocompromised patients * pregnant women * teeth with a periodontal pocket depth greater than 3 mm * teeth with signs and symptoms of vertical fracture * teeth that cannot be restored or prosthetically provided after endodontic treatment * use of antibiotic therapy within the last month * diagnosis of acute apical abscess

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Conditions

The condition(s) this trial relates to.

chronic apical periodontitis periapical periodontitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Apical periodontitis

Contacts and locations

Locations

  • School of Dental Medicine, University of Zagreb

    Zagreb, 10 000, Croatia

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