Heart conduction disease

This study tests two ways to treat a slow heart rate caused by overactive nerves, without using a permanent pacemaker. One method uses freezing (cryoablation) and the other uses burning (radiofrequency) to calm the nerves. Sixty adults aged 18 to 60 with symptoms like fainting or…

This study tests whether taking a daily fiber and magnesium supplement (WellBiome) for 6-8 weeks before heart surgery can improve recovery. Researchers will compare ICU time, complications, and hospital stay between 80 patients who get the supplement or a placebo. The goal is to …

This large phase 3 trial is testing whether adding vicadrostat to the existing drug empagliflozin can reduce the risk of heart problems in adults with type 2 diabetes, high blood pressure, and heart disease. About 11,800 participants will take either the combination or a placebo …

This study is testing a new, wire-free pacemaker called LivIQ in 325 people who need a pacemaker for a slow heartbeat. The goal is to see if it is safe and works well to keep the heart beating at the right pace. Participants will be followed for several months to check the device…

This study is testing a small, leadless pacemaker placed in the heart's upper chamber (atrium) for people with sinus node dysfunction, a condition where the heart's natural pacemaker doesn't work properly. Participants receive the Aveir AR pacemaker and a loop recorder to track h…

This study looks at the long-term safety of the drug pelacarsen in people with high lipoprotein(a) and heart disease. About 5,700 participants who finished a previous pelacarsen trial will receive the drug and be monitored for side effects and heart events. The goal is to see if …

This study is testing a pacemaker lead placed in a specific area of the heart called the left bundle branch area. The goal is to see if this placement is safe and helps the heart beat more naturally in people with slow heart rates. About 140 participants will get the lead and be …

This study tests a pre-set treatment plan for managing heart rhythm issues that can occur after transcatheter aortic valve replacement (TAVR). The goal is to reduce the number of patients who receive a permanent pacemaker while ensuring no one is put at risk of sudden cardiac dea…

This early-stage trial tests a single dose of SGT-501, a gene therapy given by IV, in 18 people with a rare inherited heart condition called CPVT that can cause dangerous fast heartbeats during exercise or stress. The main goal is to check safety and find the right dose in adults…

This study tests a newer pacing method called Conduction System Pacing (CSP) against standard right ventricular pacing in 1,260 adults with heart block. The goal is to see if CSP reduces heart failure events, hospitalizations, and need for additional procedures, while also improv…

This study is testing a digital app called VIRTUES that provides educational resources and treatment recommendations for heart conditions like atrial fibrillation and heart failure. Researchers will enroll 2000 patients across 11 modules to see if the app is easy to use and helps…

This study follows 1,805 people who already have an Aveir DR leadless pacemaker to see how safe it is over 5 years. The pacemaker helps control slow heart rhythms without wires. Researchers will track complications shortly after implant and for years afterward using real-world da…

This phase 3 trial is testing whether adding baxdrostat to the standard drug dapagliflozin can better prevent heart failure and cardiovascular death in people with type 2 diabetes who already have heart disease and high blood pressure. About 11,300 participants will receive eithe…

This study compares a new pacing method called conduction system pacing (CSP) to standard pacing for people with a slow heart rate and a wide QRS pattern on their ECG. The goal is to see if CSP better preserves the heart's pumping ability over one year. About 120 adults who need …

This study tests whether a special activity score, calculated from heart rate data, can help people who have completed cardiac rehab stick to exercise guidelines. About 318 participants will wear a smartwatch for 4 months and do an exercise test at the end. Researchers will compa…

This study compares two methods for closing the breastbone after open-heart surgery: rigid plate fixation (using a metal plate and screws) versus traditional wire cerclage (using stainless steel wires). The trial will enroll 250 adults at high risk for wound complications, such a…

This study tests whether text messages can help people who have finished cardiac rehab keep up healthy habits like weight management, physical activity, and taking medications. Researchers will enroll 400 people from groups often left out of heart research. The study compares dif…

This study tests a device called Efferon LPS that filters harmful substances from the blood during and after heart surgery. The goal is to see if it can reduce the risk of multiple organ failure, a serious complication. Researchers will enroll 60 adults having heart surgery with …

This study tests a newer pacing method called left bundle branch area pacing against standard pacing in people who need a pacemaker after a TAVI procedure. About 266 participants will be enrolled to see if the new method reduces heart-related deaths, hospitalizations for heart fa…

This study tests whether genetic testing can help veterans at high risk for heart disease start and stick with statin medications. About 410 veterans aged 40-75 with diabetes or heart disease who are not currently taking statins will receive either a genetic report on their stati…

This study tests a new method called decrement evoked potential (DeEP) mapping to guide catheter ablation for ventricular tachycardia (VT) in people with structural heart disease. VT is a fast, dangerous heart rhythm that can cause sudden cardiac arrest. The standard ablation pro…

This study tests whether pregnant women at high risk for fetal heart block can use a home monitor to catch early signs of the condition. If detected, they receive steroids and IVIG to try to reverse the block before it becomes permanent. The goal is to prevent stillbirth and the …

This study tests whether adding digital coaching to home-based cardiac rehabilitation helps veterans complete more rehab sessions and improve their heart health. 150 veterans with heart disease will be randomly assigned to standard home rehab or home rehab plus a private social m…

This study compares two types of pacemaker settings in people who need a pacemaker after a TAVI procedure (a minimally invasive heart valve replacement). The two methods are 'physiological pacing' (which tries to mimic natural heart activation) and standard 'right ventricular pac…

This study looks at whether people at moderate risk for heart problems should continue or stop taking aspirin before a colonoscopy. About 2,500 participants will be randomly assigned to take either aspirin or a placebo for a few days around the procedure. The goal is to see which…

This study tests a noninvasive radiation treatment (SBRT) for people with ventricular tachycardia, a dangerous heart rhythm that can cause sudden death. The 12 participants have structural heart disease and have not been helped by standard treatments like drugs or catheter ablati…

This study compares a newer pacing method called left bundle branch pacing (LBBP) with standard right ventricular pacing in 1,300 people who need a pacemaker for heart block. Standard pacing can sometimes weaken the heart over time, leading to heart failure. LBBP tries to mimic t…

This study compares two ways of placing a pacemaker lead in people who need frequent pacing. One method (left bundle branch pacing) aims to activate the heart more naturally than the standard method. The goal is to see if it reduces the time the heart spends in fast, irregular rh…

This study compares a newer pacemaker method, left bundle branch area pacing (LBBAP), to the standard right ventricular pacing in 200 patients with heart block and normal heart function. The goal is to see if LBBAP better preserves the heart's pumping ability and reduces complica…

This study compares two ways to place a pacemaker in people with heart block (a condition where the heart's electrical signals slow or stop). One method uses standard right ventricular pacing, the other uses conduction system pacing (targeting the heart's natural electrical pathw…

This study tests an experimental drug called CRD-4730 in 12 adults with a rare inherited heart condition (CPVT) that can cause dangerous heart rhythms during exercise or stress. Participants will receive two different doses of the drug and a placebo in random order to see if it s…

This study compares a single dose of targeted radiation (SBRT) to the standard catheter ablation procedure for reducing dangerous heart rhythms in people with advanced heart disease. Sixty participants will be randomly assigned to one of the two treatments. The main goal is to se…

This study tests a program that uses an AI chatbot, health coach, and home monitoring devices to help 300 adults with heart disease, diabetes, or kidney disease manage their conditions. The goal is to see if this approach reduces hospital visits, complications, and deaths over 6 …

This study compares a new type of heart pacing (His-bundle pacing) to standard pacing in 120 adults with heart failure and right bundle-branch block. The goal is to see if the new method better improves the heart's pumping ability over 6 months. Participants will receive one of t…

This study tests a program called CVD-FIT for African American adults who struggle to afford food and are at risk for heart disease. Participants get monthly income support, weekly incentives to buy healthy food, and phone-based education on heart health. The goal is to see if th…

This phase 2 trial tests whether a drug called 2-HOBA can reduce immune system overactivity in people with Long COVID who also have POTS (a condition causing rapid heart rate upon standing). The study will enroll 50 participants and randomly assign them to receive either 2-HOBA o…

This study is testing whether giving air conditioners and a $100 electricity subsidy to older adults in Boston neighborhoods can reduce heat stress, heat strain, and related health problems. One hundred participants aged 55-95 who don't have AC will be randomly assigned to receiv…

This study tests a new, smaller pacemaker called Micra AV2 in 150 adults with heart block (a condition where the heart's electrical signals are blocked). The pacemaker is designed to better match the heart's natural rhythm, especially during exercise, and lasts over 15 years. Res…

This study tests if a newer pacing method, left bundle branch area pacing, is better than standard right ventricular pacing for people who need a pacemaker. Researchers will compare outcomes like death, heart failure, and heart damage in 450 participants over two years. The goal …

This study compares two pacemaker strategies for people with sick sinus syndrome and AV conduction delay. Participants will be randomly assigned to receive either left bundle branch area pacing (LBBAP) or minimized ventricular pacing (MVP). The goal is to see which method leads t…

This study tests a new oral drug called AGP100 in people with a rare inherited heart condition (CPVT) that can cause dangerously fast heartbeats during stress or exercise. Ten adults aged 18-75 will take three different doses of AGP100 over six weeks while continuing their usual …

This study tests whether bempedoic acid, a cholesterol-lowering drug, can reduce artery inflammation and improve heart health in people with HIV. About 121 adults aged 40 and older with well-controlled HIV and at least one heart disease risk factor will receive either the drug or…

This study tests a newer heart pacing method (His or left bundle branch pacing) against the standard method (biventricular pacing) in over 2,000 adults with heart failure and a weak heart pump. The goal is to see which approach better improves quality of life, reduces hospital st…

This study tests a minimally invasive procedure to open narrowed veins above the heart in people with orthostatic hypotension or intolerance—conditions that cause dizziness, fainting, or fatigue when standing. 100 adults who haven't improved with standard treatments will receive …

This study is tracking 300 people under age 60 who faint frequently due to a condition called vasovagal syncope. Participants will receive either a nerve ablation procedure (which targets heart nerves) or a permanent pacemaker. The goal is to see which treatment better prevents f…

This study tests whether a newer pacing method called left bundle branch pacing (LBBP) works better than the standard biventricular pacing for people with chronic heart failure and reduced pumping ability. About 60 adults with heart failure and a specific electrical delay in the …

This study is testing whether a computer program (machine learning) can help doctors diagnose severe heart attacks in patients who have a heart condition called left bundle branch block (LBBB). LBBB can hide the usual signs of a heart attack on an ECG, making it hard to tell if a…

This study aims to develop a new clinical test to diagnose Calcium Release Deficiency Syndrome (CRDS), a rare inherited heart condition that increases the risk of sudden cardiac arrest. Researchers will use a pacing procedure to measure heart wave changes in 400 participants, inc…

This study explores whether a quick, painless cheek swab can spot protein changes linked to inherited heart conditions that cause sudden cardiac death in young people. Researchers will collect samples from 26 patients with arrhythmic disorders or family members at risk. If the te…

This study tests whether wearing a portable ECG monitor for 30 days after a heart valve replacement (TAVI) can detect dangerous heart rhythm problems better than the usual 1-2 days of hospital monitoring. 250 patients will be randomly assigned to either the extended monitoring gr…

This study is testing a special mattress that can measure heart rate, breathing, temperature, and body position without touching the patient. It is designed for people with heart disease who are in the hospital. The goal is to see if this wireless system works as well as standard…

This trial is testing whether an artificial intelligence-enhanced electrocardiogram (AI-ECG) can better identify patients who need a cardiac implantable electronic device (like a pacemaker or defibrillator) compared to standard care. Over 11,000 participants will be randomly assi…

This study checks if a quick, non-invasive finger test (QuantaFlo HD) can detect early signs of heart dysfunction. Researchers will compare the finger test results with standard heart ultrasound measurements in 600 adults who have risk factors like high blood pressure or diabetes…

This study is testing whether a machine learning algorithm can accurately detect heart murmurs that point to structural heart disease. Researchers will record heart sounds from 125 adults using two different digital stethoscopes and compare the algorithm's findings to standard ec…

This study tests whether a newer pacemaker method (conduction system pacing) can better prevent heart muscle weakening compared to the standard method. Researchers will enroll 200 adults who need a pacemaker for a slow heart rhythm. The goal is to see which approach reduces the r…

This study compares two ways to dilute the numbing drug bupivacaine for a nerve block used during arm surgery. Researchers want to see if using sugar water (5% dextrose) instead of salt water (0.9% saline) affects how well and how long the block works. About 90 adults having elec…

This study tests a smartphone app designed to help people prepare for heart surgery through exercise, nutrition tips, and telehealth check-ins. About 40 adults awaiting surgery will either use the app or receive standard care. Researchers want to see if the app is easy to use, ac…

This study tests a 6-session program called BE-FIT that helps cardiac rehabilitation patients reduce anxiety about exercise. The program uses gradual exposure to feared sensations, prevents safety behaviors, and uses activity monitors for feedback. Researchers will enroll 146 adu…

This study tests whether diaphragmatic breathing exercises can reduce heart rate, blood pressure, and dizziness in pregnant women with Postural Orthostatic Tachycardia Syndrome (POTS). 44 pregnant women will be split into two groups: one doing breathing exercises, the other recei…

This study looks at whether eating more salt can help people with POTS, a condition that causes a fast heart rate and dizziness when standing. Researchers will compare a high-salt diet to a normal-salt diet over 3 months in 50 adults. The goal is to see if extra salt lowers heart…

This study looks at whether wearing compression garments (like tight waist-high stockings or abdominal shapewear) can help adults with POTS feel better and lower their heart rate during normal daily activities. About 30 participants will wear the garments at home and have their h…

This study looks at whether a large IV bag of saline (salt water) can improve thinking problems like brain fog in people with Long COVID or a condition called POTS. About 100 adults will receive either a full or tiny dose of saline to compare effects on reaction time and memory. …

This study tests whether a daily movement program led by a kinesiologist can reduce frailty in 60 hospitalized heart patients. Frailty makes people weaker and more likely to have longer hospital stays or be readmitted. The program encourages simple activities like standing, walki…

This study tests whether simple physical maneuvers like leg crossing, bending, or arm tensing can prevent fainting in children aged 6 to 18. Participants who visit the emergency department after a fainting episode will either receive standard care or learn these counterpressure m…

This study tests whether whole-body electrical muscle stimulation (WB-EMS) can help adults with neuromuscular diseases like ALS, SMA, and muscular dystrophy exercise safely. Because these conditions weaken the nerves that control muscles, traditional exercise is often too hard. W…

This study tests whether adding a program that targets sleep and stress (called RESST) to standard cardiac rehabilitation helps heart patients recover better. About 200 adults with heart conditions who also have poor sleep or high stress will take part. Researchers will measure s…

This phase 2 trial tests whether pyridostigmine, a drug that affects nerve signals, can reduce symptoms of postural tachycardia syndrome (POTS) like rapid heartbeat and dizziness. Fifty adults with POTS will take either pyridostigmine or a placebo for three days. The study aims t…

This study is testing whether a small, battery-powered device worn on the ear can reduce gastrointestinal symptoms in children aged 10-18 with hypermobile Ehlers-Danlos syndrome (hEDS) and related autonomic nervous system problems. The device, called IB-Stim, delivers gentle elec…

This study tests a web-based app called IAMABLE that provides evidence-based rehabilitation strategies for people with chronic conditions like heart disease, arthritis, or neurological disorders. Fifty adults aged 45 to 75 will use the app for 4 months to set goals and learn abou…

This study tests whether a type of talk therapy called Behavioral Activation, delivered via home-based telehealth, can improve social functioning and mood in veterans recently discharged from the hospital for a heart condition. About 132 veterans with depression will receive eith…

This study compares two types of nerve blocks—M-TAPA and TAP block—for pain relief after open inguinal hernia repair. Sixty adults undergoing elective surgery will receive one of the two blocks with the same numbing medicine. Researchers will measure pain scores and patient satis…

This pilot study tests whether giving intravenous iron to people with POTS who have low iron stores can increase their blood volume and reduce symptoms like rapid heart rate upon standing. The study will enroll 12 adults aged 18-45 with confirmed POTS and low ferritin levels. Par…

This study compares a women-only cardiac rehabilitation program to the standard mixed-gender program for women with heart disease. Sixty women aged 40-80 will attend 36 sessions over 12 weeks, with extra women-focused education. Researchers will measure attendance, completion rat…

This study tests a program called One-Mind One-Heart that combines mindfulness and behavior change skills to help older adults with HIV reduce stress and improve heart health. The program includes text messages and covers topics like physical activity, diet, and substance use. Th…

This study tests whether a standardized, step-by-step protocol for giving blood thinner injections (low-molecular-weight heparin) can reduce bruising and pain in heart patients. About 180 patients in cardiac care units will be randomly assigned to receive injections either by the…

This registry study will enroll 200,000 high-risk cardiac patients to see how well an AI platform called Willem can detect heart problems from standard ECGs. The AI's readings will be compared to expert cardiologist diagnoses, but the AI results won't be shared with doctors, so p…

This study aims to learn more about how diseases related to blood clots, the immune system, and blood vessels start and change over time. Researchers will enroll up to 1,000 people aged 5 and older, including those with these conditions, their healthy relatives, and healthy volun…

This study aims to learn more about heart and blood vessel diseases by observing people who have them or are at risk. Researchers will collect samples and perform tests like imaging and stress tests on up to 5,000 participants, including healthy volunteers and relatives of affect…

This study creates a large database of about 12,000 people with and without heart disease. Researchers collect medical information and blood samples to analyze factors that influence heart conditions like coronary artery disease, heart failure, and stroke. The goal is to better u…

This registry will follow 500 people with inappropriate sinus tachycardia (IST) or postural orthostatic tachycardia syndrome (POTS) who have had or will have a heart ablation procedure using AtriCure devices. The goal is to collect real-world data on how safe and effective the pr…

This study looks at medical records of 1,000 older heart patients in Russia to see if they were prescribed potentially harmful medications during the COVID-19 pandemic. Researchers will use a medical database to count how often these risky prescriptions happened and check for dan…

This study is creating a large collection of blood, urine, stool, and heart tissue samples from 10,000 people with and without heart or metabolic conditions. The goal is to store these samples along with medical information to speed up future research into what causes these disea…

This study aims to find how common the KIT D816V mutation is in people with suspected clonal mast cell disease. Researchers will collect blood samples from 450 participants and test them using two sensitive methods. The results may improve understanding and diagnosis of these rar…

This study is testing whether simple nutritional checks before heart surgery can predict how well patients recover. Researchers will give 250 patients questionnaires, blood and urine tests, and measure grip strength and body composition. They will then see if these measures are l…

This study looks at whether it is safe and possible to do a special exercise test (MRI combined with a bike workout) in 20 people who already have a specific type of pacemaker. The goal is to see how different pacemaker settings affect the heart's pumping ability during light exe…

This study looks at whether people with type 2 diabetes, COPD, or heart disease who join a health program in Halsnaes Municipality improve their physical function and well-being. About 194 adults will be tracked before and after the program using tests and questionnaires. The goa…

This study looks at how people with ME/CFS (chronic fatigue syndrome) and people with heart conditions feel after a bike exercise test. Researchers want to see if the type and timing of symptoms after exercise are different between the two groups. 80 adults will take part, and th…

This study follows 300 people who had hospital-acquired pneumonia to see how it affects their heart and lungs over 18 months. Researchers will take blood samples, swabs, and perform heart and lung tests to understand the link between pneumonia and later cardiovascular problems li…

This study is testing a comprehensive MRI scan to see if it can better diagnose different heart conditions. Researchers will scan 2,000 adults with suspected or confirmed heart disease. The goal is to create a standard imaging method that improves early detection and risk predict…

This study is observing 150 people who have a pacemaker with a special setting called Closed Loop Stimulation (CLS) combined with left bundle branch area pacing. The goal is to see if this setting reduces the occurrence of atrial fibrillation over two years. Participants have sin…

This study is testing whether artificial intelligence can predict if someone will develop one of five common diseases: diabetes, heart disease, breast cancer, back pain, or arthritis. Researchers will collect health data from 1,000 adults aged 30 to 60, including medical records,…

This study uses advanced heart MRI to see how bariatric surgery and cardiac rehabilitation change the heart's structure and function. Researchers will scan 150 adults before and 6-12 months after these metabolic treatments. The goal is to understand how the heart adapts to these …

This study is building a registry of 1,211 people in Brazil who have inherited heart conditions like cardiomyopathy, arrhythmias, and Marfan syndrome. Researchers will collect DNA samples and medical information to discover which genes are most commonly affected and how often the…

This study looks at whether raising carbon dioxide levels in the blood can lower heart rate and reduce symptoms in people with Postural Orthostatic Tachycardia Syndrome (POTS) when they stand up. Researchers will test different CO2 levels in 26 adults with POTS during a tilt-tabl…

This study will use a new type of cardiac MRI to look at the heart's microscopic structure in 1,000 people—both healthy volunteers and those with various heart conditions. The goal is to see if this advanced imaging can detect early signs of heart damage better than standard test…

This study is looking at whether people with postural tachycardia syndrome (POTS) have certain antibodies that might be causing their symptoms. Researchers will compare 125 adults with and without POTS, using small doses of two drugs to see how their bodies respond. The goal is t…

This study looks at how the heart and blood vessels communicate when blood pressure drops, like when standing up quickly. Researchers will test young and older men and women using a vacuum chamber around the legs to safely mimic low blood pressure. They will also see if squeezing…

This study is building a huge database of up to 800,000 Korean patients with heart or brain vascular disease. By tracking their health over many years, researchers hope to understand the unique patterns and risk factors in this population. The goal is to create a platform that ca…

This study is creating a large biobank of blood, DNA, plasma, and tissue samples from 15,000 people with and without heart and aortic diseases. Researchers will use this information to better understand conditions like aortic aneurysm, heart failure, and bicuspid aortic valve. Th…

This study aims to develop better MRI methods for imaging the heart and brain, and to describe heart diseases using these new techniques. It will also investigate whether gadolinium, a common MRI contrast agent, stays in the body long after use. Up to 5,000 healthy volunteers and…

This study looks at how the brains of young people with Postural Tachycardia Syndrome (POTS) process what they see. Researchers will use brain scans to compare brain activity in teens with POTS and healthy teens. The goal is to learn more about how different parts of the brain co…

This study tests whether a machine-learning model can predict serious heart events in children admitted to the hospital. The model alerts doctors when a child may need a palliative care consultation. Researchers will compare outcomes before and after the model is used, involving …

This study looks at whether simple leg movements, like crossing legs or tensing buttock muscles, can raise blood pressure in children aged 6-18 who faint often. Researchers will measure heart and blood flow responses during these movements in 30 children. The goal is to understan…

This study will use advanced heart MRI scans on up to 100,000 people with known or suspected heart disease. The goal is to learn how these scans can help doctors better understand, diagnose, and treat different heart conditions. Researchers will track participants' health over ti…

This study creates a large collection of blood, tissue, and medical information from up to 5,000 people with or at risk for pediatric heart disease. Researchers will use these samples to better understand the disease and find new ways to diagnose or treat it in the future. Partic…

This study measures how hard children with conditions like neuromuscular disease, scoliosis, or heart problems work to breathe. Researchers use a thin tube placed through the nose into the esophagus to measure breathing muscle strength and effort. The goal is to better understand…

This registry is collecting information from 8,000 people undergoing heart or chest surgery. The goal is to see how factors before and during surgery relate to serious complications like death, shock, or infection. By analyzing this data, researchers hope to find ways to improve …

This study is testing a tool called B-COMPASS that uses a 22-question survey to predict whether people will follow their prescribed treatments. Researchers will enroll 3100 adults with cardiovascular, endocrine, immune, nerve, cancer, or rare diseases across Europe. The goal is t…

This study is testing whether giving probiotics after heart surgery can improve recovery by changing the bacteria in the gut. Researchers will measure certain chemicals in the blood that come from gut bacteria. The trial involves 30 adults scheduled for heart surgery, who will re…

This study looks at how the brain, nerves, and blood vessels interact in 80 adults having heart surgery. Researchers will measure brain activity, blood flow, and heart reflexes to better understand the link between heart disease and depression. The goal is to develop new tools fo…

This study collects blood samples from 1500 adults at risk for heart disease to discover new biomarkers that can predict future heart attacks, strokes, or blocked leg arteries. Participants are seen at a specialized prevention center and provide samples and health data at the sta…

This study tests whether a single PET tracer (FDG) can measure both blood flow and sugar use in the heart, instead of needing two separate tracers. Researchers will compare results from FDG with a dedicated flow tracer in 60 healthy adults and people with heart disease. The goal …

This study is testing a new, non-invasive monitor (fetal magnetocardiography) to detect hidden heart problems in high-risk pregnancies that might lead to fetal death. Researchers will study 30 pregnant women with conditions like congenital heart disease or twin pregnancy. The goa…

This study tests a program called Heart-to-Heart, where community health workers help low-income patients make informed choices about cardiac rehab after a heart event. About 50 adults from Johns Hopkins Hospital will take part. The goal is to see if the program is practical and …

This study will enroll 5,000 adults with chronic heart conditions like heart failure, high blood pressure, or aortic stenosis. Participants will wear a Prolaio digital health patch that monitors heart rate, breathing, and other vital signs. The goal is to observe how these condit…

This study collects small heart tissue samples from 400 adults undergoing heart procedures. Researchers will analyze these samples to find new markers that could help diagnose heart diseases earlier and better understand how the heart works in health and disease. The goal is to i…

This study looks at 200 adults with sick sinus syndrome who need a pacemaker. Researchers will compare two places to put the pacing wire—Bachmann's bundle or the right atrial appendage—to see which one better prevents heart damage. The goal is to learn which site leads to healthi…

This study looks at why some people develop a fast heart rate and dizziness months after COVID-19, a condition called post-COVID tachycardia syndrome. Researchers will measure immune markers and nerve activity in 60 participants to see if ongoing inflammation and reduced vagal ne…

This research study collects health information from 10,000 people with brain inflammation conditions like Long COVID, ME/CFS, and autoimmune diseases. Participants use a smartphone app to share symptoms, health history, and wearable data. The goal is to find disease subtypes and…

This study uses a special eye scan called OCTA to measure the density of tiny blood vessels in the retina. Researchers will compare results from 64 people—half with cardiovascular disease and half healthy—to see if the scan can reliably detect vessel changes linked to heart probl…

This study is testing whether adding genetic and imaging information to standard risk assessments can better predict heart disease in 30,000 healthy Italian adults aged 40-80. Participants will have their risk calculated using traditional methods and then again with the added dat…

This study aims to measure how often a heart valve leak (tricuspid regurgitation) develops or worsens after getting a pacemaker or defibrillator with a lead that crosses the valve. About 200 adults who need their first device will have heart ultrasounds before and after the proce…

This study is testing a virtual patient navigation program for 260 English, Chinese, or Spanish speakers with breast cancer or heart disease. The goal is to see if a phone-based portal can help underserved people get the support they need, even though it won't fully replace in-pe…

This study looks at how a special pacing method called His bundle pacing affects the heart's electrical activity in 80 people with bradycardia (slow heart rate) or heart failure. Researchers will take extra measurements during standard pacemaker implantation to see if this techni…

This study follows over 10,000 Moroccan adults for 10 years after a heart screening. Researchers will track heart attacks, strokes, and heart-related deaths to build a risk score tailored to the Moroccan population. The goal is to better predict and prevent heart disease in Moroc…

This study is building a biobank of blood and tissue samples from 500 patients undergoing cardiac surgery. Researchers will analyze these samples to better understand the causes and progression of heart disease. The goal is to improve future diagnosis and treatment, but no new th…

This study looks at why some people develop POTS (a condition causing rapid heartbeat and dizziness) after COVID-19. Researchers think a part of the nervous system that normally fights inflammation may not work well in these patients. They will compare 150 adults with and without…

This study uses 3D mapping to explore the electrical and structural features of a specific area in the heart called the left bundle branch area. The goal is to improve how pacemaker leads are placed in that region. Researchers will review data from 30 patients, ages 18 to 88, who…

This study looks at why eating carbohydrates makes symptoms worse for people with Postural Tachycardia Syndrome (POTS), a condition that causes dizziness and rapid heartbeat upon standing. Researchers will measure blood flow changes in the abdomen after a sugary drink in 50 parti…

This study tracks 150 adults in cardiac rehab to see if men and women differ in how much they move during and up to 6 months after the program. Participants wear activity trackers and complete fitness tests at three visits over 10 months. The goal is to understand barriers to sta…

This study aims to see if voice recordings from a smartphone can help detect heart disease. Researchers will collect voice samples and health data from up to 1 million adults using the Mayo Clinic app. No treatment is given; the goal is to gather information for future AI tools.

This study collects medical records, circumstances, and DNA from children who died suddenly and unexpectedly between ages 11 months and 18 years. Researchers will analyze this information to find risk factors and causes, with the goal of preventing future deaths. Families of affe…

This study is a registry that collects information from 1,000 adults who have conditions like fainting, rapid heartbeat, or low blood pressure and have received a procedure that adjusts nerve signals to the heart. Researchers will track whether symptoms return within a year. The …

This study looks at how the brain works in 120 adolescents with POTS, a condition causing rapid heart rate and dizziness when standing. Researchers will use brain scans and questionnaires to see if a problem in the brain's threat-detection system explains symptoms. The goal is to…

This study is testing whether a smartwatch, combined with artificial intelligence and remote doctor check-ins, can help detect heart issues like atrial fibrillation and unstable angina earlier than usual. Researchers at the University of Sao Paulo will enroll 520 adults with hear…

This study is observing 900 adults in Greece who have both chronic obstructive pulmonary disease (COPD) and at least one heart condition. Researchers will track their health for two years, recording lung flare-ups, heart complications, hospital visits, and quality of life. The go…

This study collects blood and tissue samples from 2,000 people with or without heart rhythm problems. Researchers will analyze the samples to find genetic differences linked to arrhythmias. The goal is to better understand the causes of these conditions, not to test a new treatme…