Heart conduction disease

This study compares a newer pacemaker method, left bundle branch area pacing (LBBAP), to the standard right ventricular pacing in 200 patients with heart block and normal heart function. The goal is to see if LBBAP better preserves the heart's pumping ability and reduces complica…

This study compares a newer pacing method called left bundle branch area pacing (LBBAP) with standard right ventricular pacing in 100 adults who need a pacemaker but have normal heart function. The goal is to see if LBBAP better prevents the decline in heart pumping ability that …

This pilot study investigates whether stimulating a nerve in the earlobe (vagal nerve stimulation), alone or combined with two medications (galantamine and pyridostigmine), can help control heart rate and reduce symptoms in women with Postural Tachycardia Syndrome (POTS). Partici…

This study tests if a newer pacing method called left bundle branch pacing (LBBP) is better than standard right ventricular pacing (RVP) at preserving heart function in 683 adults with atrioventricular block (a type of heart block). Participants will be randomly assigned to one o…

This study tests whether a special heart pacing technique (left bundle branch pacing) combined with standard heart failure drugs can improve heart function better than drugs alone. It includes 50 adults with non-ischemic heart failure and a specific heart block. The main goal is …

This study is testing whether a special pacemaker (cardiac resynchronization therapy, or CRT) can improve heart function and symptoms in people with mild heart failure and a specific type of heart block called left bundle-branch block. About 21 participants will receive a CRT dev…

This study compares a new leadless pacemaker (Micra AV) to a standard dual-chamber pacemaker in 100 patients aged 70 and older with heart block. The goal is to see if the leadless version works just as well for exercise capacity. Participants are randomly assigned to receive one …

This study tests whether a new leadless pacemaker (Micra AV) is better than a traditional wired pacemaker for people aged 75 and older with heart block. The goal is to see if the leadless device improves quality of life, patient acceptance, and exercise ability. Eighty participan…

This study tests the safety and performance of a new pacemaker system (Amvia pacemaker and Solia CSP S lead) for people who need help with their heart's electrical system. The device is designed to pace a specific part of the heart's natural wiring to improve efficiency. 152 part…

This study tests a new, non-invasive ultrasound method called electromechanical wave imaging (EWI) to see if it can more accurately locate and diagnose heart rhythm problems compared to standard tests. About 322 adults already scheduled for a heart procedure will get an EWI scan …

This study aims to validate a blood test that measures NET mRNA levels as a simpler way to assess norepinephrine transporter function in people with Postural Tachycardia Syndrome (POTS). Researchers will compare these levels with traditional measures in 200 participants, includin…

This study investigates whether a 16-week individually tailored exercise program, guided by a physiotherapist, can help adults with post-COVID POTS (postural orthostatic tachycardia syndrome) spend more time upright and feel better. Participants are randomly assigned to either th…

This study tests whether a mild electrical current applied to the skin of the ear can help people with Postural Orthostatic Tachycardia Syndrome (POTS). POTS causes a rapid heart rate and symptoms like light-headedness and fatigue when standing. The treatment aims to stimulate th…

This study tests whether moxonidine, a blood pressure medication that lowers sympathetic nerve activity, can reduce symptoms like rapid heartbeat and lightheadedness in people with Postural Tachycardia Syndrome (POTS). About 48 participants will take either moxonidine or a placeb…

This study tests whether breathing through a special resistance device can help people with Postural Orthostatic Tachycardia Syndrome (POTS) stand up longer and reduce the rapid heart rate that happens when they stand. Researchers will measure heart rate changes and symptom relie…

This study tests whether a simple IV infusion of saline (salt water) given a few hours before exercise can improve how long and how hard people with postural tachycardia syndrome (POTS) can exercise. Forty adults with POTS will exercise after receiving either saline or a placebo …

This study tests several medications to see if they can control the rapid heart rate and symptoms that occur when people with chronic orthostatic intolerance stand up. Researchers will give single doses of drugs like acetazolamide, atomoxetine, clonidine, entacapone, and proprano…

This study looks at why some people develop POTS (a condition causing rapid heartbeat and dizziness) after COVID-19. Researchers think a part of the nervous system that normally fights inflammation may not work well in these patients. They will compare 150 adults with and without…

This study looks at why some people develop a fast heart rate and dizziness months after COVID-19, a condition called post-COVID tachycardia syndrome. Researchers will measure immune markers and nerve activity in 60 participants to see if ongoing inflammation and reduced vagal ne…

This study follows over 3,400 people who have already received the Aveir VR leadless pacemaker, a small device placed directly in the heart to treat slow heart rhythms. Researchers are using real-world medical records to check for complications up to 10 years after implantation. …

This study watches 40 adults who need a leadless pacemaker to see if where the device sits inside the heart changes heart rhythm or pumping strength. Researchers will use CT scans and ECGs to check heart function and valve leakage. The goal is to find the best spot for the pacema…

This study was designed to compare a newer pacing method (left bundle branch area pacing) with the standard method (right ventricular pacing) in patients who developed heart block after TAVR valve replacement. The goal was to see which method better preserves heart function and r…

This small pilot study is testing whether a gentle, non-invasive electrical stimulation on the ear (auricular vagus nerve stimulation) can change how the heart's electrical system works. Ten people who are already scheduled for a heart procedure will receive the stimulation while…

This pilot study looks at whether light, self-paced swimming is a tolerable activity for people with ME/CFS and related conditions like Long COVID and fibromyalgia. Participants will swim for 15-30 minutes at their own pace and track symptoms and heart rate variability using an a…

This early-phase study tests whether a single dose of moxonidine, a blood pressure medication that lowers sympathetic nerve activity, can reduce symptoms like rapid heartbeat and lightheadedness in people with postural tachycardia syndrome (POTS). The trial enrolls 48 adults aged…

This study looks at whether a substance called YKL-40 in the blood can help predict how well heart failure patients will respond to cardiac resynchronization therapy (CRT), a special pacemaker. About 51 adults with severe heart failure will have blood samples taken during their r…

This study looks at what happens in the body to cause POTS and dysautonomia after viral infections, including COVID-19. About 100 women will give a blood sample and share medical records. Researchers will study immune system markers to find clues that could lead to better diagnos…

This study looks at whether people with Postural Orthostatic Tachycardia Syndrome (POTS) might also have a rare condition called acute hepatic porphyria (AHP), which can cause similar symptoms like rapid heart rate and abdominal pain. Researchers will test 70 adults with POTS usi…

This study collects blood or skin samples from 100 adults with inherited heart rhythm disorders (like Long QT Syndrome or Brugada Syndrome) and healthy volunteers. Researchers will turn these samples into stem cells and then into heart cells to study how these diseases work and t…

This early-phase study tests whether a single dose of modafinil, a drug that promotes wakefulness, can improve concentration and mental clarity in people with Postural Tachycardia Syndrome (POTS). About 20 adults diagnosed with POTS will take the drug and then complete computer-b…

This study screens people with suspected Postural Tachycardia Syndrome (POTS) and healthy volunteers to see how their bodies handle sodium and the hormone aldosterone. Participants undergo autonomic function tests and blood volume measurements. The goal is to understand if a high…

This study is a nationwide registry in Taiwan that will follow 300 people who have or will receive a leadless pacemaker. The goal is to track how well the device works and any complications that may occur during or after the procedure. The study does not test a new treatment but …

This study at Vanderbilt University Medical Center is looking at whether people with postural tachycardia syndrome (POTS) have higher levels of certain immune proteins that might affect their symptoms. Researchers will measure these proteins in blood samples and test how the hear…

This study looks at whether drinking 16 ounces of water raises blood pressure more in the morning or the afternoon in people with orthostatic hypotension (a condition where blood pressure drops when standing). Twenty participants will drink water at two different times of day, an…

This study compares blood samples from 212 people with and without Postural Orthostatic Tachycardia Syndrome (POTS) to see if those with POTS have higher levels of certain antibodies. Researchers also want to know if these antibodies are more common in people whose POTS started a…

This study looks at why some people, especially young women, feel dizzy, tired, or have a racing heart when they stand up—a condition called orthostatic intolerance. Researchers will measure things like blood volume, sweat response, and heart rate in 260 participants to better un…

This study compares how the kidneys handle salt in people with postural orthostatic tachycardia syndrome (POTS) versus healthy volunteers. Researchers give a liter of saline intravenously and measure how much sodium is excreted in urine. The goal is to see if POTS patients have t…

This study uses a wrist-worn activity watch to measure sleep quality in people with orthostatic intolerance (a condition where standing causes dizziness) compared to healthy volunteers. Researchers want to see if these patients have worse sleep, like taking longer to fall asleep.…

This study looks at why people with Postural Tachycardia Syndrome (POTS) often have trouble thinking clearly, known as 'brain fog.' Researchers will compare brain scans of 21 POTS patients and healthy volunteers while they do mental tasks, both sitting and under simulated standin…