Could antibodies be the key to understanding POTS?

NCT ID NCT02196376

Ongoing Knowledge-focused Sponsor: Vanderbilt University Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study compares blood samples from 212 people with and without Postural Orthostatic Tachycardia Syndrome (POTS) to see if those with POTS have higher levels of certain antibodies. Researchers also want to know if these antibodies are more common in people whose POTS started after a viral infection. Participants will have a medical history, physical exam, and blood draw. The goal is to better understand what causes POTS, not to test a new treatment.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this study could help explain what causes POTS in some people, possibly pointing toward new ways to diagnose or treat it.
What could go wrong: This is an early, observational study—it is not testing a treatment. It may not find clear differences between groups, and results may not lead to any direct medical changes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Orthostatic Intolerance postural orthostatic tachycardia syndrome primary dysautonomia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

POSTURAL ORTHOSTATIC TACHYCARDIA SYNDROME

Contacts and locations

Locations

Vanderbilt University Medical Center

Nashville, Tennessee, 37232, United States

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