Could a hidden liver condition cause POTS? new study aims to find out
NCT ID NCT05344599
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looks at whether people with Postural Orthostatic Tachycardia Syndrome (POTS) might also have a rare condition called acute hepatic porphyria (AHP), which can cause similar symptoms like rapid heart rate and abdominal pain. Researchers will test 70 adults with POTS using genetic tests, urine tests, and autonomic function tests to see how common AHP is in this group. The goal is to identify which POTS patients might benefit from AHP screening and treatment.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
What this could lead to
If this study finds a link, it could lead to routine screening for acute hepatic porphyria in POTS patients, enabling earlier treatment.
What could go wrong
This is a small, observational study with only 70 participants, so results may not apply to all POTS patients. It does not test any new treatment.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Vanderbilt University Medical Center
Nashville, Tennessee, 37232, United States