Could a hidden liver condition cause POTS? new study aims to find out

NCT ID NCT05344599

Ongoing Knowledge-focused Sponsor: Vanderbilt University Medical Center Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at whether people with Postural Orthostatic Tachycardia Syndrome (POTS) might also have a rare condition called acute hepatic porphyria (AHP), which can cause similar symptoms like rapid heart rate and abdominal pain. Researchers will test 70 adults with POTS using genetic tests, urine tests, and autonomic function tests to see how common AHP is in this group. The goal is to identify which POTS patients might benefit from AHP screening and treatment.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If this study finds a link, it could lead to routine screening for acute hepatic porphyria in POTS patients, enabling earlier treatment.
What could go wrong: This is a small, observational study with only 70 participants, so results may not apply to all POTS patients. It does not test any new treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

hepatic porphyria hereditary coproporphyria postural orthostatic tachycardia syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE HEPATIC PORPHYRIA POSTURAL ORTHOSTATIC TACHYCARDIA SYNDROME

Contacts and locations

Locations

Vanderbilt University Medical Center

Nashville, Tennessee, 37232, United States

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