Can common drugs tame a racing heart when you stand?
NCT ID NCT00262470
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests several medications to see if they can control the rapid heart rate and symptoms that occur when people with chronic orthostatic intolerance stand up. Researchers will give single doses of drugs like acetazolamide, atomoxetine, clonidine, entacapone, and propranolol to 150 participants. The goal is to find which drug works best to improve daily life.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Acetazolamide, Atomoxetine, Clonidine, Entacapone, Propranolol
What this could lead to
If successful, this could identify which medications best control heart rate and relieve symptoms for people with orthostatic intolerance.
What could go wrong
This is an early-phase trial with single doses, so results may not reflect long-term use. The drugs may cause side effects or not work for everyone.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Vanderbilt University Autonomic Dysfunction Center
Nashville, Tennessee, 37232-2195, United States