Can common drugs tame a racing heart when you stand?

NCT ID NCT00262470

Ongoing Symptom relief Sponsor: Satish R. Raj Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests several medications to see if they can control the rapid heart rate and symptoms that occur when people with chronic orthostatic intolerance stand up. Researchers will give single doses of drugs like acetazolamide, atomoxetine, clonidine, entacapone, and propranolol to 150 participants. The goal is to find which drug works best to improve daily life.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Acetazolamide, Atomoxetine, Clonidine, Entacapone, Propranolol
What this could lead to: If successful, this could identify which medications best control heart rate and relieve symptoms for people with orthostatic intolerance.
What could go wrong: This is an early-phase trial with single doses, so results may not reflect long-term use. The drugs may cause side effects or not work for everyone.

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Conditions

The condition(s) this trial relates to.

postural orthostatic tachycardia syndrome Tachycardia Tachycardia, Sinus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHRONIC ORTHOSTATIC INTOLERANCE TACHYCARDIA

Contacts and locations

Locations

Vanderbilt University Autonomic Dysfunction Center

Nashville, Tennessee, 37232-2195, United States

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