Epilepsy syndrome

This study tests brain surgery as a treatment for people whose epilepsy doesn't improve with medication. About 300 children and adults aged 8 and older will have surgery to remove or treat the part of the brain causing seizures. The goal is to stop or greatly reduce seizures, tho…

This study tests whether clemizole HCl (EPX-100) can safely reduce seizures when added to current treatments for Lennox-Gastaut syndrome, a severe form of epilepsy. About 260 children and adults aged 2 to 55 will receive either the drug or a placebo. The main goal is to measure c…

This Phase 3 study tests a drug called zorevunersen in 170 children aged 2 to 17 with Dravet syndrome, a severe form of epilepsy. The drug is given as an injection into the spine and compared to a sham procedure. The goal is to see if it reduces seizures and improves daily living…

This Phase 3 trial tests a single inhaled dose of alprazolam (a fast-acting sedative) to stop prolonged seizures in people aged 12 and older. The goal is to see if it can end a seizure within 90 seconds and prevent it from coming back for at least 2 hours. About 350 participants …

This early-stage trial tests a single dose of TSHA-105, a gene therapy injected into the spinal fluid, in 8 people aged 2 to 20 with SLC13A5 citrate transporter disorder. The goal is to see if it is safe and whether it can improve motor and thinking skills. Because the trial is v…

This study tests an experimental drug called EPX-100 (clemizole) in 150 children and adults with Dravet syndrome, a severe form of epilepsy. The goal is to see if adding EPX-100 to current treatments can safely reduce the number of motor seizures. Participants will be randomly as…

This early-stage trial tests a gene therapy called RC001 in children aged 2 to 18 with Dravet syndrome, a severe form of epilepsy caused by a genetic mutation. The therapy is given as a single injection into the spinal fluid. The main goal is to check safety and how the body proc…

This study tests a gene therapy called ETX101 for children with Dravet syndrome, a severe form of epilepsy caused by a genetic change. The treatment uses a harmless virus to deliver a working copy of the gene to help control seizures. The trial includes infants and children up to…

This study tests a new medicine called ION337 in children aged 2 to 12 with Dravet syndrome, a severe form of epilepsy. The main goal is to see if the drug is safe and tolerable when given as a spinal injection. Researchers will also measure how the drug moves through the body an…

This study looks at the long-term safety of the drug brivaracetam in children and teenagers with childhood absence epilepsy or juvenile absence epilepsy. About 120 participants who have already taken the drug in earlier studies will continue treatment and be monitored for side ef…

This study tests whether the drug LP352 can safely reduce seizures in children and adults with Dravet syndrome, a severe form of epilepsy. About 160 participants will receive either LP352 or a placebo, and researchers will track changes in seizure frequency over several months. T…

This study tests an experimental drug called LP352 to see if it can safely reduce seizures in children and adults with developmental and epileptic encephalopathies (DEE), a group of severe epilepsy syndromes. About 320 participants will receive either LP352 or a placebo, and rese…

This study tests a one-time injection of lab-grown nerve cells (NRTX-1001) into the brain for people with a specific type of epilepsy that doesn't respond to medication. The cells are designed to release a calming chemical called GABA to quiet overactive brain signals. Researcher…

This early-stage study tests a new gene therapy called AMT-260 in 12 adults with a severe form of epilepsy that doesn't respond to standard medications. The treatment is delivered directly into the brain using MRI guidance. The main goals are to check safety and see if it can red…

This study tests whether XEN1101, taken alongside current seizure medications, can reduce the number of generalized tonic-clonic seizures (convulsions affecting the whole body). About 160 people aged 12 and older with these seizures will receive either XEN1101 or a placebo for se…

This study is testing the safety of fenfluramine, a drug already approved for children 2 and older with Dravet syndrome, in younger children aged 12 to 23 months. Dravet syndrome is a severe genetic epilepsy that starts in the first year of life. The study will enroll 5 children …

This study tests an investigational drug called relutrigine in 160 children with a severe form of epilepsy called developmental and epileptic encephalopathy (DEE). The goal is to see if the drug can safely reduce monthly seizure frequency compared to a placebo. After the initial …

This study tests whether a modified Atkins diet (low carb, high fat) can control seizures in children aged 3-12 with newly diagnosed absence epilepsy, without using standard medications. Forty children will be enrolled and compared to a group whose parents chose medication instea…

This study tests a personalized deep brain stimulation (DBS) method for people with epilepsy that starts in the memory center of the brain. Eight participants will receive a device that sends low-frequency electrical pulses to specific brain networks, with the goal of reducing se…

This early-phase trial tests an injection of special brain cells (GABAergic interneuron progenitors) in 6 adults with drug-resistant mesial temporal lobe epilepsy. The goal is to see if the treatment is safe and can reduce seizure frequency. Participants will receive the cell the…

This study tests the drug fenfluramine in 10 children aged 12 to 36 months whose infantile spasms did not get better with standard treatments. The children take fenfluramine for 21 days, and doctors check brain waves and seizure diaries to see if the spasms stop. If it helps, the…

This pilot study tests a device called NaviFUS that uses low-intensity focused ultrasound to calm overactive brain areas. It involves 16 adults with drug-resistant epilepsy who still have frequent seizures despite trying at least three medications. The goal is to see if the treat…

This study tests whether deep brain stimulation (DBS) can safely reduce seizures in children aged 5-14 with Lennox-Gastaut syndrome, a severe form of epilepsy. The trial uses a special device called Picostim to send electrical pulses to the brain. Researchers will track seizure f…

This pilot study tests whether a mild electrical current applied to the scalp (called tDCS) can reduce seizures in people with epilepsy. Thirty adults with hard-to-control epilepsy will use a head device for 30 minutes daily over two months. Researchers will track seizure counts …

This study tests a minimally invasive laser treatment for people with drug-resistant temporal lobe epilepsy. The procedure uses heat from a laser to destroy the small part of the brain causing seizures. Researchers will track whether patients become seizure-free and how their mem…

This early-stage trial tests a one-time injection of special nerve cells (NRTX-1001) into both sides of the brain in 10 adults with drug-resistant epilepsy. The cells are designed to calm overactive brain signals by releasing GABA. The main goal is safety, but researchers will al…

This study tests a new drug called ION283 in 10 people aged 10 to 18 with Lafora disease, a rare and severe form of epilepsy. The drug is given via a spinal injection to see if it is safe and can help control seizures and other symptoms. All participants will receive the same dos…

This study is testing a small device that fits in the ear to detect seizures by measuring brain waves. Researchers will first test it on 5 healthy people, then on 10 people with epilepsy who are already scheduled for a standard scalp EEG. The goal is to see if the in-ear device i…

This study is testing whether a high-resolution EEG (HR-EEG) can better predict which children with drug-resistant focal epilepsy will have successful surgery. About 120 children will have a painless HR-EEG recording before surgery. Researchers will compare the pattern of brain s…

This early-phase study tests whether a ketogenic (high-fat) diet can prevent epileptic spasms in infants with genetic epilepsy. Ten babies under 9 months old will receive the diet and be monitored with regular EEGs. The goal is to see if this approach is safe and feasible, potent…

This study tests if the drug levetiracetam can prevent epileptic seizures in 120 adults over 40 with Down syndrome and Alzheimer's disease. Participants will receive either the drug or a placebo for 96 weeks. The goal is to see if the drug can stop seizures and possibly slow brai…

This study tests a web-based program called Epilepsy Journey, which includes online modules and telehealth sessions with a therapist, to help teens with epilepsy improve their executive functioning skills like planning, organization, and emotional control. 310 teens aged 13-17 wi…

This pilot trial tests whether repeated sessions of pulsed low-intensity focused ultrasound can safely reduce seizures in people with drug-resistant temporal lobe epilepsy. Ten adults who still have seizures despite medication will receive the ultrasound treatment. Researchers wi…

This study tests whether an experimental drug called NPT 2042 can reduce the number and length of absence seizures (brief staring spells) in people aged 16-75 with genetic generalized epilepsy. Each participant will receive both the drug and a placebo in random order, with a two-…

This early study tests a device that uses low-intensity focused ultrasound to calm overactive brain areas in people with drug-resistant temporal lobe epilepsy. Eight adults will receive up to three 10-minute ultrasound sessions. Researchers will track side effects and check if se…

This study tracks the safety of Fycompa injection in people with epilepsy who have partial-onset seizures (age 4 and older) or primary generalized tonic-clonic seizures (age 12 and older). Researchers will record any side effects and measure drug levels in children aged 4 to 12. …

This study investigates how rehearsal (repeating information) and sleep help solidify memories in people with epilepsy. Participants learn object-location pairs, with some pairs rehearsed and others not, and their memory is tested after a short delay and again after 12 hours—eith…

This study is testing a digital platform called the Genetics Navigator to see if it can reduce distress for people undergoing genetic testing. The platform provides education, counseling, and management recommendations. Researchers will compare it to standard care in 170 adults a…

This study screens children and adults aged 8 and older with known or suspected epilepsy, especially those whose seizures are not controlled by medication. Participants undergo tests like EEG, MRI, and PET scans to characterize their epilepsy. The goal is to find suitable candida…

This study looks back at 483 patients who had small rectal neuroendocrine tumors (less than 2 cm) removed using one of two endoscopic techniques: endoscopic submucosal dissection (ESD) or endoscopic partial muscle resection (EPMR). The goal is to compare how often each method lea…

This study looks at how epileptic brain activity during sleep can cause awakenings and change dream recall or content. Researchers will use tiny electrical pulses in the brain during sleep to trigger mild epileptic activity and observe the effects. The goal is to better understan…

This study tests a structured program to help adolescents with epilepsy transition from pediatric to adult healthcare. Researchers will compare how many patients attend their first adult clinic appointment and whether they return to pediatric care. The goal is to improve self-man…

This study follows 2,300 children with epilepsy to see how their thinking and learning abilities change over many years. Researchers will track brain development, seizure control, and quality of life. The goal is to find early signs that predict how a child's cognitive skills wil…

This study explores how the brain recognizes and remembers places, using virtual tours and brain recordings in people with epilepsy. Researchers aim to map the brain regions critical for spatial memory, so surgeons can avoid them during epilepsy surgery. Over 600 participants, in…

This study uses PET and MRI scans to look at serotonin pathways in the brainstem of adults with Dravet syndrome, a severe form of epilepsy. Researchers want to see if these pathways are different in Dravet patients compared to those with other drug-resistant epilepsy and healthy …

This study tests a special MRI method using ferumoxytol, an iron-based contrast agent, to get clearer images of tiny blood vessels in the brain's memory center (hippocampus) in people with temporal lobe epilepsy. Researchers aim to see if these images can help predict who will be…

This study looks at how a focal seizure (a seizure starting in one part of the brain) temporarily changes a person's ability to pay attention. Researchers will test 100 adults with epilepsy before and after a seizure using attention tasks and brain wave recordings. The goal is to…

This study aims to find new genetic causes of epilepsy in infants whose seizures start before 12 months of age. Researchers will analyze the DNA of 600 babies to see if a genetic diagnosis can be made and how that affects medical care and family well-being. The goal is to shorten…

This study aims to find genetic mutations in the brain that cause drug-resistant epilepsy in children. Researchers will compare DNA from blood and brain tissue, including samples from special electrodes placed in the brain. The goal is to better understand the root causes of thes…

This study is following 200 people with a confirmed genetic diagnosis of EPM1, a rare and progressive epilepsy disorder. Researchers will collect clinical data and biological samples (blood and urine) over time to understand how the disease progresses. The goal is to identify bio…

This study is creating a shared database of children who have received deep brain stimulation (DBS) for movement disorders like dystonia, epilepsy, or Tourette syndrome. By pooling data from multiple hospitals, researchers hope to answer key questions about who benefits most and …

This study collects information from 500 children worldwide who have both epilepsy and movement disorders caused by specific gene changes. Researchers will analyze medical records to find patterns linking symptoms to genetics. The goal is to create a shared database that helps do…

This study follows 1,000 children and teens with rare epilepsies (like West and Dravet syndromes) to see how different treatments affect their seizures and thinking skills. Researchers will compare care across hospitals to find what works best. The goal is to give families cleare…

This study combines advanced MRI scans with intracranial EEG recordings to map brain networks in people with drug-resistant epilepsy. Researchers aim to develop noninvasive imaging biomarkers that predict where seizures start and how they spread. The goal is to improve surgical o…

This study follows 50 children and young adults with Dravet syndrome caused by SCN1A gene mutations over four years. Researchers will use standard tests to measure changes in thinking, movement, and daily skills. They will also look for chemical markers in the blood that might re…

This study is creating a large registry and tissue bank for people with mitochondrial disorders. Researchers will collect medical information and samples from up to 1,000 participants, including those diagnosed with or suspected to have a mitochondrial disease. The goal is to gat…

This study is developing a platform called CAMERA that uses wristband sensors and smartphone data to predict anxiety and memory states in people with epilepsy. Researchers will monitor 40 patients in the hospital to see how brain, body, and behavior signals relate. The goal is to…

This study is collecting blood, tissue, and medical information from up to 1,000 people with RASopathies—a group of genetic conditions that affect development and raise cancer risk. Researchers will store these samples and data in a database for future studies. The goal is to lea…

This study looks at how sleep affects memory in children with certain types of epilepsy. Researchers will test memory before and after sleep in 95 children, comparing those with mild epilepsy, severe epilepsy, and no epilepsy. The goal is to see if epileptic brain activity during…

This study is observing 600 people of any age with STXBP1 or SYNGAP1 gene mutations to better understand how these disorders affect development, seizures, and quality of life. No treatment is given; instead, researchers will collect data from routine clinical assessments over tim…

This study uses powerful MRI scanners to look at the brains and spinal cords of 700 people, including healthy volunteers and those with conditions like multiple sclerosis, Alzheimer's, and Parkinson's. The goal is to understand why some brains stay healthy while others decline. R…

This study looks at how epilepsy affects a child's ability to understand others' thoughts and feelings, known as social cognition. Researchers will compare 96 children aged 6-12 with epilepsy to healthy children of the same age. They will use tests of memory, attention, language,…

This study aims to find the genetic causes of juvenile myoclonic epilepsy (JME) by collecting blood samples from over 1,000 people with JME across the UK, Europe, and North America. Researchers will compare their DNA to samples from 2,000 healthy controls. The goal is to improve …