New hope for kids with severe epilepsy: drug trial targets seizures

NCT ID NCT06872125

Recruiting now Disease control Sponsor: Stoke Therapeutics, Inc Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Aug 06, 2026 · Updated 5 times

Summary

This Phase 3 study tests a drug called zorevunersen in 170 children aged 2 to 17 with Dravet syndrome, a severe form of epilepsy. The drug is given as an injection into the spine and compared to a sham procedure. The goal is to see if it reduces seizures and improves daily living skills.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: zorevunersen (STK-001)
What this could lead to: If successful, this could provide a new treatment option to reduce seizures and improve quality of life for children with Dravet syndrome.
What could go wrong: This is an early-stage Phase 3 trial with 170 participants, so results may not apply to all patients. The drug is given via spinal injection, which carries risks like headache or infection.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Dravet syndrome Epilepsies, Myoclonic

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DRAVET SYNDROME

Contacts and locations

Show contact details

Study contacts

Contact

Email: •••••@•••••

Locations

Advent Health Neuroscience Research Institute
ACTIVE_NOT_RECRUITING

Orlando, Florida, 32804, United States
Ann & Robert H. Lurie Children's Hospital of Chicago
ACTIVE_NOT_RECRUITING

Chicago, Illinois, 60611, United States
Arkansas Children's Hospital
ACTIVE_NOT_RECRUITING

Little Rock, Arkansas, 72202, United States
Azienda Ospedaliero Universitaria Ospedale Pediatrico Meyer
RECRUITING

Florence, Italy
Boston Children's Hospital
ACTIVE_NOT_RECRUITING

Boston, Massachusetts, 02115, United States
CS Mott Children's Hospital
ACTIVE_NOT_RECRUITING

Ann Arbor, Michigan, 48109, United States
Cedars Sinai Medical Center
ACTIVE_NOT_RECRUITING

Los Angeles, California, 90048, United States
Charité - Campus Virchow-Klinikum
RECRUITING

Berlin, Germany
Children's Hospital Colorado
ACTIVE_NOT_RECRUITING

Aurora, Colorado, 80045, United States
Children's Hospital of Orange County
ACTIVE_NOT_RECRUITING

Orange, California, 92868, United States
Children's National Medical Center
ACTIVE_NOT_RECRUITING

Washington D.C., District of Columbia, 20010, United States
Cleveland Clinic
ACTIVE_NOT_RECRUITING

Cleveland, Ohio, 44195, United States
Clinica Universidad de Navarra
RECRUITING

Pamplona, Spain
Cook Children's Medical Center
ACTIVE_NOT_RECRUITING

Fort Worth, Texas, 76104, United States
Duke University Health System
ACTIVE_NOT_RECRUITING

Durham, North Carolina, 27705, United States
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
RECRUITING

Roma, Italy
Fukuoka Children's Hospital
ACTIVE_NOT_RECRUITING

Fukuoka, Japan
Great Ormond Street Hospital for Children
ACTIVE_NOT_RECRUITING

London, WC1N 3JH, United Kingdom
Hokkaido University Hospital
ACTIVE_NOT_RECRUITING

Hokkaido, Japan
Hospital Blua Sanitas Valdebebas
RECRUITING

Madrid, Spain
Hospital Ruber Internacional
RECRUITING

Madrid, Spain
Hôpital Necker - Enfants Malades
RECRUITING

Paris, France
Hôpital Robert Debré - Paris
RECRUITING

Paris, France
Hôpital de la Timone
RECRUITING

Marseille, France
Integriertes Sozialpaediatrisches Zentrum
RECRUITING

München, Germany
Istituto Giannina Gaslini-Ospedale Pediatrico IRCCS
RECRUITING

Genova, Italy
Jichi Medical University Hospital
ACTIVE_NOT_RECRUITING

Shimotsuke, Japan
Kyoto University Hospital
ACTIVE_NOT_RECRUITING

Kyoto, Japan
LeBonheur Children's Hospital
ACTIVE_NOT_RECRUITING

Memphis, Tennessee, 38103, United States
Massachusetts General Hospital
ACTIVE_NOT_RECRUITING

Boston, Massachusetts, 02114, United States
Mayo Clinic
ACTIVE_NOT_RECRUITING

Rochester, Minnesota, 55905, United States
NHO Shizuoka
ACTIVE_NOT_RECRUITING

Shizuoka, Japan
NYU Langone Health
ACTIVE_NOT_RECRUITING

New York, New York, 10016, United States
Nagoya University Hospital
ACTIVE_NOT_RECRUITING

Nagoya, Japan
National Center of Neurology and Psychiatry
ACTIVE_NOT_RECRUITING

Tokyo, Japan
National Hospital Organization Nishi Niigata Central Hospital
ACTIVE_NOT_RECRUITING

Niigata, Japan
Nationwide Children's Hospital
ACTIVE_NOT_RECRUITING

Columbus, Ohio, 43205, United States
Nemours Children's Health
ACTIVE_NOT_RECRUITING

Jacksonville, Florida, 32207, United States
Nicklaus Children's Hospital
ACTIVE_NOT_RECRUITING

Miami, Florida, 33155, United States
Okayama University Hospital
ACTIVE_NOT_RECRUITING

Okayama, Japan
Oregon Health & Science University (OHSU)
ACTIVE_NOT_RECRUITING

Portland, Oregon, 97239, United States
Osaka City General Hospital
ACTIVE_NOT_RECRUITING

Osaka, Japan
Ospedale Pediatrico Bambino Gesù
RECRUITING

Roma, Italy
Peking University First Hospital
RECRUITING

Beijing, China
Phoenix Children's Hospital
ACTIVE_NOT_RECRUITING

Phoenix, Arizona, 85016, United States
Royal Hospital for Children
ACTIVE_NOT_RECRUITING

Glasgow, G51 4TF, United Kingdom
Sheffield Children's Hospital
ACTIVE_NOT_RECRUITING

Sheffield, S10 2TH, United Kingdom
Texas Children's Hospital
ACTIVE_NOT_RECRUITING

Houston, Texas, 77030, United States
The Second Affiliated Hospital of Guangzhou Medical university
RECRUITING

Guangzhou, China
USCF Medical Center
ACTIVE_NOT_RECRUITING

San Francisco, California, 94158, United States
UVA Health
ACTIVE_NOT_RECRUITING

Charlottesville, Virginia, 22903, United States
Universitaetsklinikum Bonn AoeR
RECRUITING

Bonn, Germany
Universitaetsklinikum Frankfurt Goethe-Universitaet
RECRUITING

Frankfurt, Germany
Universitaetsklinikum Freiburg
RECRUITING

Friedberg, Germany
Universitaetsklinikum Heidelberg
RECRUITING

Heidelberg, Germany
University of North Carolina at Chapel Hill
ACTIVE_NOT_RECRUITING

Chapel Hill, North Carolina, 27514, United States
University of Rochester Medical Center
ACTIVE_NOT_RECRUITING

Rochester, New York, 14642, United States
University of Utah Primary Children's Hospital
ACTIVE_NOT_RECRUITING

Salt Lake City, Utah, 84113, United States
Weill Cornell Medicine
ACTIVE_NOT_RECRUITING

New York, New York, 10021, United States
Wuhan Children's Hospital
RECRUITING

Wuhan, China
Yokohama City University Medical Center
ACTIVE_NOT_RECRUITING

Yokohama, Japan

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