Childhood-onset epilepsy syndrome with developmental and/or epileptic encephalopathy

This study tests whether clemizole HCl (EPX-100) can safely reduce seizures when added to current treatments for Lennox-Gastaut syndrome, a severe form of epilepsy. About 260 children and adults aged 2 to 55 will receive either the drug or a placebo. The main goal is to measure c…

This Phase 3 trial tests a single inhaled dose of alprazolam (a fast-acting sedative) to stop prolonged seizures in people aged 12 and older. The goal is to see if it can end a seizure within 90 seconds and prevent it from coming back for at least 2 hours. About 350 participants …

This study tests an experimental drug called LP352 to see if it can safely reduce seizures in children and adults with developmental and epileptic encephalopathies (DEE), a group of severe epilepsy syndromes. About 320 participants will receive either LP352 or a placebo, and rese…

This study tests whether deep brain stimulation (DBS) can safely reduce seizures in children aged 5-14 with Lennox-Gastaut syndrome, a severe form of epilepsy. The trial uses a special device called Picostim to send electrical pulses to the brain. Researchers will track seizure f…

This pilot study tests whether a mild electrical current applied to the scalp (called tDCS) can reduce seizures in people with epilepsy. Thirty adults with hard-to-control epilepsy will use a head device for 30 minutes daily over two months. Researchers will track seizure counts …

This study investigates how rehearsal (repeating information) and sleep help solidify memories in people with epilepsy. Participants learn object-location pairs, with some pairs rehearsed and others not, and their memory is tested after a short delay and again after 12 hours—eith…

This study follows 2,300 children with epilepsy to see how their thinking and learning abilities change over many years. Researchers will track brain development, seizure control, and quality of life. The goal is to find early signs that predict how a child's cognitive skills wil…

This study looks at how sleep affects memory in children with certain types of epilepsy. Researchers will test memory before and after sleep in 95 children, comparing those with mild epilepsy, severe epilepsy, and no epilepsy. The goal is to see if epileptic brain activity during…

This study uses powerful MRI scanners to look at the brains and spinal cords of 700 people, including healthy volunteers and those with conditions like multiple sclerosis, Alzheimer's, and Parkinson's. The goal is to understand why some brains stay healthy while others decline. R…