Childhood-onset epilepsy syndrome with developmental and/or epileptic encephalopathy
MONDO:0800500A childhood-onset epilepsy syndrome where the onset of the condition includes manifestations of cognitive, neurological, or psychiatric impairment, stagnation, or regression, due directly to the underlying etiology. In contrast, an epileptic encephalopathy (EE) is present when the encephalopathy is caused by the epileptic activity. The term developmental and epileptic encephalopathy (DEE) is used when both factors contribute to the patient’s condition.
33 clinical trials for this condition and its sub-types.
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Broader categories
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New epilepsy drug shows promise in long-term safety trial
Disease control CompletedThis study tested the long-term safety of a drug called LP352 (bexicaserin) in 41 people aged 12 to 65 with severe epilepsy syndromes like Dravet or Lennox-Gastaut. Participants took the drug three times daily for up to 52 weeks. The main goal was to check for side effects, while…
Phase: PHASE2 • Sponsor: Longboard Pharmaceuticals • Aim: Disease control
Last updated Jun 27, 2026 08:01 UTC
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New hope for rare seizure patients: Long-Term drug safety confirmed
Disease control CompletedThis study looked at the long-term safety of a drug called fenfluramine (ZX008) for people with rare seizure disorders like Dravet syndrome and Lennox-Gastaut syndrome. A total of 412 participants who had completed earlier studies took the drug and were monitored for side effects…
Phase: PHASE3 • Sponsor: Zogenix, Inc. • Aim: Disease control
Last updated Jun 27, 2026 07:58 UTC
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New hope for kids with rare sleep epilepsy?
Disease control CompletedThis study tested a drug called NBI-827104 in 24 children with a rare epilepsy that causes constant brain spikes during sleep. The drug is a calcium channel blocker given daily for 13 weeks. The main goal was to see if it reduces abnormal brain activity measured by EEG.
Phase: PHASE2 • Sponsor: Neurocrine Biosciences • Aim: Disease control
Last updated Jun 26, 2026 13:48 UTC
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Could a magnetic helmet calm Seizure-Like brain waves in sleeping children?
Symptom relief CompletedThis study tested a wearable device that uses magnetic pulses to stimulate the brain in 10 children with a rare epilepsy called CSWS, where abnormal brain activity occurs during sleep. The device was applied for just 10 minutes to the area causing the seizures. Researchers measur…
Phase: NA • Sponsor: Children's Mercy Hospital Kansas City • Aim: Symptom relief
Last updated Jun 27, 2026 12:30 UTC
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Rare Epilepsy's toll on Kids' learning examined in small study
Knowledge-focused CompletedThis study looked at how Doose syndrome, a rare form of epilepsy, affects children's ability to learn and develop. Researchers followed 9 children and asked their parents about the disease's impact on school and daily life. The goal was to better understand the link between seizu…
Sponsor: Centre Hospitalier Universitaire, Amiens • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:06 UTC