Childhood-onset epilepsy syndrome with developmental and/or epileptic encephalopathy
MONDO:0800500A childhood-onset epilepsy syndrome where the onset of the condition includes manifestations of cognitive, neurological, or psychiatric impairment, stagnation, or regression, due directly to the underlying etiology. In contrast, an epileptic encephalopathy (EE) is present when the encephalopathy is caused by the epileptic activity. The term developmental and epileptic encephalopathy (DEE) is used when both factors contribute to the patient’s condition.
33 clinical trials for this condition and its sub-types.
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Broader categories
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Can two arthritis drugs stop deadly brain seizures? major trial launches
Disease control Not yet recruitingThis Phase 3 trial tests two existing anti-inflammatory drugs, anakinra and tocilizumab, in 438 patients with NORSE, a rare condition causing continuous seizures that don't respond to standard treatments. Patients are randomly assigned to one drug within 7 days of illness, and re…
Phase: PHASE3 • Sponsor: Yale University • Aim: Disease control
Last updated Jun 27, 2026 12:32 UTC
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Smart brain pacemaker aims to stop seizures while you sleep
Disease control Not yet recruitingThis early study will test a new way to use deep brain stimulation (DBS) in 4 adults with Lennox-Gastaut syndrome, a severe form of epilepsy. The device will automatically adjust stimulation based on whether the person is awake or asleep. Researchers want to see if this personali…
Phase: NA • Sponsor: University of Minnesota • Aim: Disease control
Last updated Jun 27, 2026 12:30 UTC
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Study tests safer switch from street CBD to approved drug for kids with severe epilepsy
Disease control Not yet recruitingThis study looks at the best way to switch children with Dravet or Lennox-Gastaut syndrome from artisanal (non-pharmaceutical) cannabidiol to Epidiolex, an FDA-approved CBD medication. About 25 children aged 2 to 18 will gradually increase their Epidiolex dose while reducing thei…
Phase: PHASE4 • Sponsor: Elizabeth Donner • Aim: Disease control
Last updated Jun 27, 2026 11:02 UTC
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Could melatonin tame a devastating childhood epilepsy?
Symptom relief Not yet recruitingThis study tests whether high doses of melatonin, a natural sleep hormone, can safely reduce abnormal brain activity in children with DEE-SWAS, a rare epilepsy that causes skill loss. Only 3 children will participate, and researchers will monitor side effects and changes in brain…
Phase: PHASE2 • Sponsor: Hugo W. Moser Research Institute at Kennedy Krieger, Inc. • Aim: Symptom relief
Last updated Jun 27, 2026 07:56 UTC
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Wearable EEG gadget aims to perfect seizure drug dosing at home
Knowledge-focused Not yet recruitingThis study tests whether a wearable device that records brain waves, heart rate, and movement at home can help doctors better adjust the dose of the seizure drug fenfluramine for people with Dravet syndrome or Lennox-Gastaut syndrome. Twenty patients will wear the device for 3-7 …
Phase: NA • Sponsor: Byteflies • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:56 UTC