Epilepsy syndrome

This study tests whether cenobamate, an experimental anti-epileptic drug, can safely reduce primary generalized tonic-clonic (PGTC) seizures when added to a person's usual seizure medications. Adults and adolescents aged 12 and older with PGTC seizures are randomly assigned to re…

This study tested a brain implant (RNS System) that delivers targeted electrical stimulation to the thalamus to reduce seizures in people aged 12 and older with drug-resistant idiopathic generalized epilepsy. The goal was to see if the device is safe and effective at cutting down…

This study tested a new drug called OMT-28 in 28 people with primary mitochondrial disease, a condition that affects how cells produce energy. Participants took the drug once daily for 6 months, and researchers measured safety, blood markers of inflammation, and symptoms like fat…

This phase 3 trial tested whether giving two anti-seizure drugs together (levetiracetam plus clonazepam) works better than clonazepam alone for stopping prolonged seizures in the ambulance or at home. 203 adults with generalized tonic-clonic status epilepticus took part. The main…

This study looked at the safety of vatiquinone in 101 people with inherited mitochondrial disease who had already taken the drug in a previous study or treatment plan. The goal was to track any side effects until the drug became commercially available or the program ended. Partic…

This study tested the long-term safety of a drug called LP352 (bexicaserin) in 41 people aged 12 to 65 with severe epilepsy syndromes like Dravet or Lennox-Gastaut. Participants took the drug three times daily for up to 52 weeks. The main goal was to check for side effects, while…

This study looked at the long-term safety of a drug called fenfluramine (ZX008) for people with rare seizure disorders like Dravet syndrome and Lennox-Gastaut syndrome. A total of 412 participants who had completed earlier studies took the drug and were monitored for side effects…

This study looked at the long-term safety and tolerability of the drug brivaracetam in 84 children and young adults (ages 2 to 26) with childhood or juvenile absence epilepsy. Participants who had already been in a previous study were given brivaracetam and monitored for side eff…

This study reviewed medical records of 66 adults in intensive care who received the anesthetic gas isoflurane for severe seizures that didn't respond to standard treatments. Researchers wanted to see how often isoflurane stopped the seizures or led to full awakening. The goal is …

This study tested a drug called NBI-827104 in 24 children with a rare epilepsy that causes constant brain spikes during sleep. The drug is a calcium channel blocker given daily for 13 weeks. The main goal was to see if it reduces abnormal brain activity measured by EEG.

This study tested whether a powerful genetic test called exome sequencing can find the cause of severe epilepsy in children when standard tests fail. Researchers studied 15 children with epileptic encephalopathy of unknown genetic origin. The goal was to see if this test could im…

This study tested a smartphone app that guides children through deep breathing (hyperventilation) and records their face and sounds to detect absence seizures. 65 children with and without seizure history participated. The app's accuracy was compared to standard EEG monitoring. T…

This study tested whether a simple eye-tracking system can identify children with childhood absence epilepsy and related thinking problems. Researchers compared eye movement recordings from 60 participants (kids with epilepsy and healthy controls) to standard tests. The goal is t…

This study tested whether giving midazolam in the mouth (buccal) works as well as a shot in the thigh (intramuscular) to stop seizures in children aged 6 months to 12 years. 90 children were randomly assigned to one of the two methods. The main goal was to see if seizures stopped…

This study tested whether remote occupational therapy could help children and teens (ages 7-18) with Dravet syndrome improve their daily living skills and satisfaction. 14 families participated in online sessions where a therapist coached the child or parent. The goal was to see …

This study tested a wearable device that uses magnetic pulses to stimulate the brain in 10 children with a rare epilepsy called CSWS, where abnormal brain activity occurs during sleep. The device was applied for just 10 minutes to the area causing the seizures. Researchers measur…

This study tested whether daily 20-minute warm baths could safely reduce seizures in 8 children (ages 6 months to 6 years) with CDKL5 deficiency, a rare genetic disorder causing hard-to-control seizures. The treatment was added to their usual medications for 12 weeks. The goal wa…

This study tested a device that sends a very mild electrical current to the brain (tDCS) to see if it can safely reduce seizures in people with epilepsy that doesn't respond to medication. 127 participants aged 9 and older received either real or fake (sham) stimulation for 10 se…

This study tested whether stimulating a deep brain area (the central thalamus) could help people with temporal lobe epilepsy stay conscious during seizures. Five participants received implanted electrodes that delivered stimulation when a seizure was detected. The goal was not to…

This completed study looked at how people learn and remember associations, like names or where you met someone. Researchers compared healthy young and older adults with patients who have memory problems from Alzheimer's or semantic dementia. They used memory tests and brain scans…

This study looked at how Doose syndrome, a rare form of epilepsy, affects children's ability to learn and develop. Researchers followed 9 children and asked their parents about the disease's impact on school and daily life. The goal was to better understand the link between seizu…

This study uses a non-invasive light-based technique called near-infrared spectroscopy (NIRS) combined with EEG to measure blood flow changes in the brains of children aged 3 to 6 years during infantile epilepsy spasms. The goal is to better understand what happens in the brain b…

This study looked at how people with temporal lobe epilepsy (TLE) remember spatial information, like directions, compared to healthy volunteers. Researchers tested memory right after a navigation task and again six weeks later. They wanted to see if people with TLE forget spatial…

Infantile spasms are a type of seizure that can harm development if not treated quickly, but they are often mistaken for normal movements. This study tested a computer program that learns from parent-recorded videos to tell the difference between these seizures and harmless movem…

This study looked at how fever changes seizure patterns in people with CDKL5 deficiency disorder, a rare genetic condition that causes hard-to-control seizures. Researchers surveyed parents of 131 affected individuals to collect information on fever history and seizure frequency.…

This study tested whether adding Nutri-score labels (A to E ratings) to restaurant menus, alongside calorie information, helps people pick healthier meals. Over 600 adults in Liverpool ordered from a menu with either calorie info alone or calorie info plus Nutri-score labels. Res…

This study tested a mobile app designed to educate parents and caregivers of children with epilepsy. The app provides information about the condition, tracks symptoms, and helps manage appointments. Researchers wanted to see if using the app for one month would increase parents' …

This study tested two versions of the seizure medication stiripentol (Diacomit®) in 24 healthy adults: a capsule and a liquid suspension. The goal was to see if the liquid form is absorbed by the body in a similar way to the capsule. If so, it could provide a more convenient opti…

This study tested whether a non-invasive brain stimulation technique called repetitive transcranial magnetic stimulation (rTMS) can reduce abnormal brain activity and improve language in children with benign epilepsy with centrotemporal spikes (BECTS). Twenty-two children receive…