Childhood-onset idiopathic generalized epilepsy syndrome

This Phase 3 trial tests a single inhaled dose of alprazolam (a fast-acting sedative) to stop prolonged seizures in people aged 12 and older. The goal is to see if it can end a seizure within 90 seconds and prevent it from coming back for at least 2 hours. About 350 participants …

This study looks at the long-term safety of the drug brivaracetam in children and teenagers with childhood absence epilepsy or juvenile absence epilepsy. About 120 participants who have already taken the drug in earlier studies will continue treatment and be monitored for side ef…

This study tests whether a modified Atkins diet (low carb, high fat) can control seizures in children aged 3-12 with newly diagnosed absence epilepsy, without using standard medications. Forty children will be enrolled and compared to a group whose parents chose medication instea…

This study tests whether an experimental drug called NPT 2042 can reduce the number and length of absence seizures (brief staring spells) in people aged 16-75 with genetic generalized epilepsy. Each participant will receive both the drug and a placebo in random order, with a two-…

This study investigates how rehearsal (repeating information) and sleep help solidify memories in people with epilepsy. Participants learn object-location pairs, with some pairs rehearsed and others not, and their memory is tested after a short delay and again after 12 hours—eith…

This study follows 2,300 children with epilepsy to see how their thinking and learning abilities change over many years. Researchers will track brain development, seizure control, and quality of life. The goal is to find early signs that predict how a child's cognitive skills wil…

This study uses powerful MRI scanners to look at the brains and spinal cords of 700 people, including healthy volunteers and those with conditions like multiple sclerosis, Alzheimer's, and Parkinson's. The goal is to understand why some brains stay healthy while others decline. R…