University Of California, San Francisco

This study tests a gene therapy for babies with Artemis-deficient severe combined immunodeficiency (ART-SCID), a life-threatening condition where the immune system doesn't work. Doctors take the baby's own blood stem cells, add a working copy of the faulty gene, and return them t…

This study tests whether a personalized deep brain stimulation (DBS) device can safely reduce cravings and opioid use in people with severe, long-term opioid addiction that hasn't improved with other treatments. Six adults aged 22-75 will undergo brain mapping to identify craving…

This study tests whether metformin, a common diabetes medicine, can help children and young adults with a rare brain tumor called PFA ependymoma that has come back or is growing. About 30 participants will receive metformin to see if it can slow tumor growth and change certain ma…

This study tests a laser treatment called LITT for children, teens, and young adults whose low-grade brain tumors have come back after prior therapy. About 40 participants will receive the laser procedure to heat and destroy tumor cells. The goal is to see if this approach can st…

This study looks at two ways to deliver cardiac rehabilitation—a program of exercise, education, and counseling for people with heart conditions. One method is in-person at a clinic, the other is done remotely via telehealth. The goal is to see if both approaches are equally effe…

This study tests a program to help people experiencing homelessness stop smoking. It combines coaching sessions with nicotine replacement therapy (like patches or gum). Researchers will check if participants attend sessions, use the therapy, and stay smoke-free at 3 and 6 months.…

This study tests whether a new genetic sequencing method can help doctors choose better treatments for people with drug-resistant tuberculosis (TB). About 2500 participants will be involved. The goal is to reduce time on ineffective drugs and improve cure rates.

This study tests whether adding urea to dialysis fluid can prevent dialysis disequilibrium syndrome (brain-related side effects like headache, confusion, or seizures) in patients with kidney failure who need urgent dialysis for dangerously high potassium or acid levels. About 20 …

This study tests a combination of two drugs (lenvatinib and pembrolizumab) in people with a rare, fast-growing type of neuroendocrine tumor called well-differentiated grade 3 (WD G3 NET). About 29 adults with advanced tumors that cannot be removed by surgery will receive the trea…

This early-phase study tests whether combining a targeted radiation drug (177Lu-PSMA-617) with liver-directed therapy is safe for men with metastatic castration-resistant prostate cancer that has spread to the liver. About 30 participants will receive the combination to check for…

This study is for people with advanced gastrointestinal cancers that are getting worse despite immunotherapy. It tests whether giving focused radiation to one tumor can help the immune system attack other tumors throughout the body. About 28 participants will receive radiation wh…

This early-stage trial tests whether bicalutamide, a drug that blocks male hormones, can reduce liver fat and stiffness in women with PCOS and nonalcoholic fatty liver disease (NAFLD). About 50 women aged 18-42 will receive either the drug or a placebo for a short time. The goal …

This study tests whether automated insulin delivery (AID) systems can safely manage blood sugar during labor and delivery for pregnant people with type 1 diabetes. About 150 participants will be randomly assigned to use their own AID system or standard intravenous insulin. The go…

This study tests whether clemastine fumarate, an old allergy medication, can help repair the protective coating around nerves in people with acute optic neuritis (inflammation of the optic nerve). About 90 participants will receive either clemastine or a placebo for 9 months. The…

This study looks at whether a specially designed cardiac rehabilitation program offered in a safety net clinic helps more people attend rehab compared to the usual referral to an outside program. About 100 adults who need heart rehab after a heart attack, surgery, or for heart fa…

This study tests a smartphone-based program that gives veterans small rewards for staying smoke-free before and after major elective surgery. Smoking raises the risk of problems like infections and longer hospital stays after surgery. The program uses breath tests to confirm abst…

This study tests whether a group program for newly married women, their husbands, and mothers-in-law can reduce anemia and improve nutrition. About 2,100 people in 140 villages will take part. The program includes education on nutrition and gender norms, plus micronutrient supple…

This study looks at whether giving a lower dose of radiation after a good response to initial chemotherapy is as effective as the standard higher dose for people with Epstein-Barr virus (EBV)-related nasopharyngeal cancer. The goal is to reduce long-term side effects like hearing…

This study tests a new way to provide HIV care for people who have trouble keeping regular doctor appointments. It offers drop-in visits and mobile care at convenient locations like a needle exchange site and community health centers. The goal is to help 400 participants stay in …

This study tests whether adding two experimental drugs, DB107-RRV and DB107-FC, to standard treatment (radiation and chemotherapy) helps people with newly diagnosed high grade glioma, a fast-growing brain tumor. About 70 adults aged 18-75 will receive the drugs during surgery and…

This study tests if a shorter, personalized treatment plan can work as well as the standard long treatment for a type of drug-resistant tuberculosis (TB). About 400 adults with this specific TB will be randomly assigned to different treatment lengths and combinations. The goal is…

This study tests a program called Mlambe for married couples in Malawi where one partner drinks heavily and at least one has HIV. The program combines savings accounts, financial training, and relationship skills to help couples reduce alcohol use and improve HIV management. Rese…

This study tests two insertable devices—a vaginal cup alone and a cup attached to a leg bag—to help women with obstetric fistula manage urine leakage without surgery. About 100 women who are waiting for fistula repair or whose surgery didn't work will try both devices to see whic…

This study tests whether Maraviroc, a drug already approved for HIV, can prevent a serious lung injury called primary graft dysfunction (PGD) that often happens right after a lung transplant. About 120 adults getting a double lung transplant will receive either Maraviroc or a pla…

This early-stage study tests whether giving enzyme replacement therapy to fetuses with certain genetic disorders (like MPS and Pompe disease) is safe and feasible. About 10 pregnant participants will receive the drug through the umbilical vein. The goal is to see if this approach…

This study looks at whether anti-IL1 medications (like anakinra or canakinumab) can reduce painful flare-ups and abnormal bone growth in people with fibrodysplasia ossificans progressiva (FOP), a rare genetic condition. About 11 participants with severe FOP will be tracked before…

This study is testing a new program for pregnant women with HIV and depression in Malawi. The program works with couples to improve communication and problem-solving, aiming to reduce depression and help women stick to their HIV medication to prevent passing the virus to their ba…

This study is for children and young adults with diffuse midline gliomas (DMGs), including DIPG, a rare and aggressive brain tumor. The trial tests whether combining the drug ONC201 with other new agents can help control the disease. About 360 participants will receive different …

This study tests whether adding cyclosporine A eye drops to the usual natamycin treatment can improve vision in people with fungal keratitis, a serious eye infection. About 150 adults with confirmed fungal infection will receive both drops. The main goal is to see if vision gets …

This study tests whether combining two drugs—glofitamab and pirtobrutinib—can safely shrink tumors in adults with mantle cell lymphoma that returned or didn't respond to prior treatment. About 30 participants will receive the combination and be monitored for side effects and canc…

This study tests two different approaches to prevent cytomegalovirus (CMV) infection in kidney transplant patients who are at high risk because the donor had CMV but the recipient did not. One group will take daily antiviral medicine for 200 days, while the other group will have …

This study tests a combination of two drugs (enfortumab vedotin and pembrolizumab) plus radiation therapy for people with muscle invasive bladder cancer. The goal is to kill the cancer while allowing patients to keep their bladder, avoiding the standard surgery to remove it. Abou…

This study tests a new radiation technique called hypofractionated stereotactic radiosurgery for people with grade II or recurrent grade I meningiomas after surgery. The treatment delivers higher doses of radiation over fewer sessions to kill remaining tumor cells while reducing …

This study tests whether combining two drugs, binimetinib and imatinib, can shrink tumors in people with advanced KIT-mutant melanoma that cannot be surgically removed. About 25 participants with stage III or IV melanoma will receive the drug combination. The goal is to see how m…

This study tests whether a special red-light device, used for 3 minutes twice a day, can slow the progression of nearsightedness (myopia) in children. Researchers will enroll 90 non-Chinese kids aged 8 to 13 with mild to moderate myopia. The goal is to see if this easy, at-home t…

This study is testing whether a higher-than-normal dose of metformin is acceptable and feasible for youth aged 10-21 with type 2 diabetes. Participants will take either the standard dose or a higher dose for 3 months. The goal is to see if the higher dose is well-tolerated and he…

This study looks at how two different types of bladder medication affect thinking, memory, and daily life in women aged 60 and older who have sudden, strong urges to urinate. Participants will be randomly assigned to take one of two drugs or a placebo for 6 months. The goal is to…

This study is a registry that collects information from adults with soft tissue tumors who receive histotripsy, a treatment that uses focused ultrasound to break down tumors without surgery. The goal is to confirm that histotripsy is safe and effective by tracking tumor response,…

This study looks at whether taking nisin, a natural food preservative, is safe and can improve mouth health in people with oral cavity squamous cell carcinoma. About 40 participants will take nisin before and after their standard surgery. The goal is to find the best dose and see…

This study tests whether giving the antibiotic azithromycin to children with severe acute malnutrition helps them gain weight and recover better than the current standard (amoxicillin) or a placebo. About 3,000 children aged 6-59 months in Burkina Faso will take part. The goal is…

This study tests whether giving pregnant women farming tools, seeds, and training can reduce food shortages and improve health for them and their babies. About 410 pregnant women in Kenya, half living with HIV, will either get the farming help right away or after the study ends. …

This study tests a remote program delivered via smartphone to help men living with HIV who use stimulants remember to take their HIV medication. The goal is to improve medication adherence and reduce the amount of virus in their blood (viral load). The program involves 270 partic…

This study is for children newly diagnosed with a very rare and aggressive brain tumor called ETMR. Researchers are testing whether a strong mix of chemotherapy drugs followed by high-dose chemo and focused radiation can help keep the tumor from growing back. About 70 children wi…

This study tests whether combining two drugs—pembrolizumab (an immunotherapy) and 177Lu-PSMA-617 (a targeted radiation therapy)—can slow the growth of advanced prostate cancer that has stopped responding to hormone treatments. About 48 men with metastatic castration-resistant pro…

This study tests a program called Smokefree Family Living (SFL) to help Chinese American smokers quit and reduce harmful smoke residue that lingers on surfaces like carpets and furniture. About 760 Chinese American smokers and their non-smoking family members will take part. The …

This study tests a program to help people with HIV and substance use stick to their HIV medications and stay engaged in care. The program focuses on coping skills, managing substance use, and improving HIV care habits. About 50 adults with HIV who have used substances like cannab…

This study tests whether clemastine fumarate, an allergy medicine, can help repair the protective coating (myelin) around nerve cells in people with multiple sclerosis (MS). About 74 adults with relapsing-remitting MS will receive either the drug or a placebo, and advanced MRI sc…

This early-stage trial tests a combination of two drugs, niraparib and irinotecan, in people with advanced solid tumors that have mutations in DNA repair genes like BRCA, ATM, or PALB2. The main goal is to find a safe dose and understand side effects. About 24 adults with cancers…

This study tests whether giving guaranteed income to people with HIV recently released from jail helps them stay in HIV care and keep the virus under control. 33 participants will receive money as a lump sum, monthly payments, or choose their preference. Researchers will measure …

This study tests a program to improve telehealth access for 600 low-income adults with diabetes or high blood pressure. Participants will get digital health coaching and clinic support. The goal is to see if this helps lower blood sugar levels and increase use of online patient p…

This study looks at whether people with a slow-growing brain tumor (low-grade glioma) that has a specific gene change (BRAF V600) can safely stop or lower their dose of two targeted drugs (dabrafenib and trametinib) after taking them for 12-24 months. About 96 participants will e…

This study tests a 10-week community-based pulmonary rehabilitation program (COPD Wellness) combined with social navigation (Health Advocates) to help vulnerable COPD patients improve their walking ability and quality of life. About 387 adults aged 40-90 with confirmed COPD who s…

This early study tests whether placing a deep brain stimulator in the cerebellum and using it to automatically adjust electrical pulses can safely improve movement and balance in people with spinocerebellar ataxia type 6. Five adults who still have some walking ability will recei…

This study tests whether using special cameras and eye pressure tests through telehealth can find glaucoma earlier in people at high risk (Black adults 50+, Hispanic adults 65+, and adults with diabetes 50+). About 2000 participants will either get the telehealth screening or jus…

This study tests a special MRI scan that uses an experimental contrast agent called hyperpolarized carbon-13 pyruvate. Unlike standard MRI, this scan shows how tumors process nutrients, which may help doctors predict whether pancreatic cancer treatments are working. The study inv…

This study will compare two hearing screening methods in about 14,000 preschool children to see which one is better at finding hearing loss. The goal is to identify hearing problems early so children can get help and avoid speech and language delays. Children will be tested using…

This study aims to find faster, simpler, and cheaper ways to diagnose tuberculosis (TB), a disease that kills over a million people each year. Researchers will test new diagnostic tools on over 26,000 adults in 10 countries who have a cough lasting two weeks or more, or who have …

This study aims to find faster, simpler, and cheaper ways to diagnose tuberculosis (TB) in children under 15. Every year, about 230,000 children die from TB, often because current tests are slow or hard to use. Researchers will enroll 2,100 children with TB symptoms to see how we…

This study tests new, faster, and cheaper ways to diagnose tuberculosis (TB) at the point of care. It will involve 1,350 adults with a cough or TB risk factors. The goal is to find better tests that can help identify the millions of people with TB who are currently missed.

This study is testing whether an artificial intelligence (AI) model called Mirai can accurately identify women at high risk for breast cancer. 400 women aged 40-89 who are flagged as high-risk by the AI will receive an additional MRI screening. The goal is to see if this approach…

This study aims to find low-cost, easy-to-use methods to encourage people at higher risk for HIV to get retested regularly. Researchers will test several behavioral nudges, like phone messages or reminders, in 40,000 adults in Kenya and Uganda. The goal is to see which approaches…

This study tests a program for low-income Latino families to prevent obesity in infants and toddlers. Half of the 576 participants will get coaching on healthy feeding, sleep, and screen time during doctor visits plus text tips. The other half will get safety and language advice.…

This study tests a program called Shamba Maisha that provides farming tools and training to households in Kenya. The goal is to see if reducing food insecurity and poverty can lower the risk of sexually transmitted infections (STIs) and HIV in 800 teenage girls aged 15-19. Partic…

This study compares two ways of screening for breast cancer: the usual annual mammogram versus a personalized schedule based on each woman's personal risk. Researchers will use family history, genetics, and breast density to tailor screening frequency. The goal is to see if perso…

This study compares two standard drugs, norepinephrine and phenylephrine, used to treat low blood pressure during major surgery. The goal is to see which one better prevents kidney injury after the operation. About 18,000 adults having non-cardiac surgery lasting at least two hou…

This study tests whether a monthly injection of naltrexone can prevent accidental fentanyl overdoses in people who use stimulants like cocaine or methamphetamine and are at risk for HIV. About 100 participants will either get the shot or standard harm reduction care for six month…

This study aims to increase RSV vaccination among Latino adults aged 50 and older in San Francisco. Researchers will test if counseling from community health workers and text message reminders help more people get the vaccine. The study also looks at whether younger adults can en…

This study tests whether giving antimalarial drugs to everyone living near a recent malaria case can stop the disease from spreading. Over 7,500 people in villages in Peru will take part. Half will get the extra drugs, and the other half will receive standard care like bed nets a…

This study looks at whether a brief alcohol counseling program can help heavy drinkers in Kenya and Uganda stay on HIV prevention medications like PrEP and PEP. About 400 adults who are at high risk for HIV and drink heavily will take part. The goal is to see if the counseling im…

This study tests whether a program led by peers (trained community members) can help women at high risk for HIV use prevention methods like PrEP more consistently. About 60 HIV-negative women in Uganda will receive the program and be followed for 6 months. The goal is to see if t…

This study compares three ways to manage pain in the mouth after a surgery that uses a graft from the cheek to fix a narrowed urethra. Sixty men will be randomly assigned to one of three anesthetic methods. The goal is to find which approach reduces pain and the need for strong p…

This study is testing a mobile health program to reduce stress for parents of justice-involved youth (ages 12-17) who have substance use issues. The goal is to help parents feel more mindful and confident, so their teens are more likely to engage in treatment. About 60 caregivers…

This study tests whether group-based pain management can help low-income adults with chronic pain feel better and more supported. About 360 participants will join group sessions that address pain, stigma, and social isolation. The goal is to reduce pain's impact on daily life and…

This study tests a personalized digital meditation program (MediTrain) in 90 older adults aged 60-85 with mild cognitive impairment (MCI). The goal is to see if it improves sleep quality, reduces stress, and boosts cognitive abilities compared to healthy older adults. Participant…

This study aims to find the most effective dose of epidural medicine to relieve labor pain within 30 minutes. Researchers will test a combination of ropivacaine and fentanyl in 50 women in active labor. They will also monitor side effects and patient satisfaction to improve the c…

This study tests whether a home-based, virtually-supervised exercise program combining high-intensity endurance and resistance training is safe and feasible for people with Parkinson's disease. It also looks at how exercise affects thinking skills and related biological markers. …

This study tests whether a special injection called an erector spinae plane block (ESPB) can reduce pain and the need for strong pain medicines in children having scoliosis surgery. About 42 children with adolescent idiopathic or neuromuscular scoliosis will either get the block …

This study tests whether adding passive body heating (using a sauna blanket) to an online insomnia therapy program helps people sleep better. 40 adults with insomnia will receive the online therapy, and half will also use the sauna blanket for 15 minutes before bed. The goal is t…

This study tests whether taking placebo pills alongside standard pain medication can reduce opioid use and pain after hip surgery. Sixty-four teens and young adults undergoing a specific hip procedure will be randomly assigned to receive either placebo pills plus usual care or us…

This study tests whether a remote, video-based pelvic floor yoga program can reduce pain in women with chronic pelvic pain syndrome. 220 women will be randomly assigned to either yoga or a physical conditioning program. The goal is to see which approach better lowers pain intensi…

This study tests a social media-based program called the Quit the Hit Toolkit to help teens and young adults stop vaping. Researchers will train coaches to lead 5-week online support groups for participants aged 13-21 who vape regularly. The goal is to see if the program is pract…

This study tests whether a personalized digital exercise program and virtual support group can help gynecologic cancer patients feel better during treatment. About 60 women receiving chemotherapy or surgery will participate. The goal is to see if the program is practical and help…

This study tests a device worn on the forehead during sleep that gently stimulates a nerve. Researchers want to see if it reduces ADHD symptoms like inattention and hyperactivity in 60 autistic children aged 6-12. The study lasts 8-12 weeks and involves nightly use of the device …

This study tests a new approach to treat Parkinson's disease by using electrodes placed under the scalp to collect brain signals. Researchers want to see if these signals can help tailor deep brain stimulation to reduce bothersome movement and sleep episodes. About 24 adults with…

This study is testing a new chatbot that uses motivational interviewing to help people stop smoking. The chatbot will provide education, support, and a personalized quit plan. The study will enroll 440 adult smokers who are patients at a primary care clinic and follow them for 6 …

This study is testing whether giving a drug called tranexamic acid (TXA) during gender affirming mastectomy (top surgery) can lower the risk of bleeding and fluid buildup. About 150 adults having top surgery at UCSF will be randomly assigned to receive TXA or not. The goal is to …

This study tests whether applying mild electrical stimulation to the skin starting just 3 days after a spinal cord injury is safe and can help patients regain movement. Researchers will monitor 15 participants in the hospital, comparing active stimulation to a sham treatment. The…

This study tests a non-invasive device that sends electrical stimulation through the skin to the spinal cord, aiming to reduce chronic low back pain and improve movement. About 50 adults with low back pain who can stand up from a chair without help will receive the stimulation in…

This study compares a targeted nerve block injection to standard pain treatment for people with sudden sciatica in the emergency room. About 100 adults with severe leg and back pain will be randomly assigned to get either the injection or usual care. Researchers will measure pain…

This study explores whether a six-week creative writing program can help teens and young adults (ages 16-25) with anorexia nervosa express themselves and build emotional strength. Participants will read stories, write, and share in small groups. The goal is to see if this approac…

This study tests whether atropine eyedrops help reduce pain and inflammation after vitrectomy, a type of eye surgery. About 62 adults having vitrectomy will receive atropine or a placebo. Researchers will measure pain scores and signs of eye inflammation to see if atropine provid…

This study looks at whether moderate exercise training can improve symptoms and heart function in people with hypertrophic cardiomyopathy (HCM), a condition where the heart muscle is thickened. About 70 adults aged 18 to 80 with HCM will be randomly assigned to either a moderate …

This study tests a trilingual mobile app and telehealth coaching program to help people with chronic pain manage their symptoms without medication. Researchers will enroll 586 adults from Black, Chinese, and Latinx communities in the San Francisco Bay Area. Participants will be r…

This study tests whether low-intensity focused ultrasound (LIFU) — gentle sound waves — can temporarily reduce tremors in people with essential tremor. Researchers will target specific brain areas and measure changes in tremor and brain activity. The goal is to understand brain c…

This study tests a device that sends mild shockwaves to the penis to improve erections in men with erectile dysfunction (ED). Researchers will track 157 men to see who gets the most benefit. The goal is to help doctors decide which patients should try this treatment and which sho…

This study tests a special sticky pad called Brijjit® to see if it can stop raised scars (hypertrophic scars) after gender-affirming mastectomy (top surgery). About 78 adults will take part, and each person will have the pad on one side of their chest while the other side gets no…

This study looks at whether special brain exercises can help adults with low-grade glioma improve memory, attention, and thinking skills that often get worse after surgery, radiation, or chemo. About 97 participants will try one of three rehab methods (in-person, app-based, or te…

This study tests whether giving fruit and vegetable vouchers to families with food insecurity can help children with fatty liver disease (MASLD). About 48 kids aged 6 to 17 will receive vouchers for 6 months, and researchers will track changes in their diet, liver inflammation, a…

This study tests whether practicing yoga for 12 weeks can reduce symptoms of mild-to-moderate depression without using antidepressant medication. Researchers will compare a group doing yoga to a group receiving education about holistic health. The trial involves 180 adults with d…

This study tests whether a special fruit cube (miracle fruit) can improve taste problems in people with head and neck cancer who are getting radiation therapy. About 40 participants will receive either the fruit cube or a placebo to see if it helps them taste food better and eat …

This pilot study tests whether weekly sauna visits can help reduce loneliness in adults aged 19-22. Participants will visit a sauna in San Francisco once a week for 2 hours over 8 weeks, either alone or with a friend, and complete online surveys. The goal is to see if the study d…

This study looks at whether giving children a placebo pill, along with their usual pain treatment, can reduce the amount of opioids they need after scoliosis surgery. About 64 teenagers will be split into two groups: one gets the placebo plus standard care, the other gets standar…

This study tests whether letrozole, a drug currently used for breast cancer, can reduce symptoms like heavy bleeding and pelvic pain caused by uterine fibroids. About 140 premenopausal women will receive either letrozole or a placebo for 12 weeks. The goal is to see if the drug i…

This study looks at whether giving fluoride varnish during regular cancer follow-up visits can help improve oral health for head and neck cancer patients who have had radiation and lack easy access to dental care. About 120 uninsured or underinsured adults will take part. Researc…

This study tests whether low-intensity focused ultrasound (LIFU) can change brain activity linked to alcohol cravings in 25 adults with alcohol use disorder. Participants will receive LIFU and have brain scans to see if it reduces their response to alcohol-related cues. The goal …

This study tests whether a liquid called PILP is safe to use when treating cavities in adults. 30 adults with at least one cavity will get either PILP or a placebo before a filling. Researchers will check tooth health, pain, and gum condition over six months to see if PILP is a s…

This study follows 1,125 adults who have had or will have a procedure called catheter ablation for atrial fibrillation (an irregular heartbeat). Over one year, participants use a smartphone app to answer surveys about their lifestyle, symptoms, and quality of life. The goal is to…

This study looks at how telehealth abortion services compare to in-person care, focusing on timing, costs, and follow-up needs. Researchers will survey 2,000 patients seeking medication abortion either in-person or via telehealth. The goal is to learn how to improve telehealth fo…

This study looks at how oxidative stress (a type of cell damage) in both women and men affects the success of in vitro fertilization (IVF). Researchers will measure stress levels in fluid from the ovaries and in sperm, then track whether embryos implant and lead to pregnancy. The…

This observational study tests whether a daily ketone ester drink for 7 days can improve the gut microbiome in 20 healthy adults aged 18-40. Participants collect stool samples before, during, and after the study to track changes in gut bacteria. The goal is to see if ketones redu…

This study is testing whether people with dry eye disease can complete surveys and collect eye fluid samples from home, instead of visiting a doctor's office. The goal is to see if this remote approach works well for future, larger studies. About 90 adults with evaporative dry ey…

This study looks at how androgens (a type of sex hormone) might influence fatty liver disease in young women. Researchers will compare women with and without PCOS, a condition linked to high androgen levels and liver fat. The goal is to understand how liver health changes over ti…

This study looks at whether drinking alcohol increases the chance of atrial fibrillation (AFib) episodes in people with a type of AFib that comes and goes. One hundred participants will be randomly assigned to drink or avoid alcohol on different days while wearing heart monitors …

This study is testing a digital meditation program to see if it can improve thinking and reduce stress in older adults. Researchers will enroll 4,000 people aged 60 and older who own a smartphone or tablet. The goal is to find the best amount of meditation needed to help with mem…

This study looks at whether traditional healers in rural Uganda can offer HIV tests to children ages 18 months to 5 years. Researchers want to see if caregivers accept testing from a healer versus going to a health center. About 400 children will take part, and the goal is to fin…

This study aims to see if giving women who strongly want to avoid pregnancy easy-to-understand information about tubal sterilization versus long-acting reversible contraceptives (like IUDs) helps them feel they have better access to birth control. About 650 English- or Spanish-sp…

This study looks at lymph node tissue from people with HIV to learn how the virus stays in the body even when medicines are working. Researchers will remove small lymph nodes from the groin area and measure how much HIV is there and how damaged the tissue is. The goal is to bette…

This study looks at how social, genetic, and environmental factors affect the health of people with meningioma, the most common type of brain tumor. Researchers will survey 3,000 adults to understand why some groups have worse outcomes. The goal is to find ways to improve care fo…

This study aims to check how accurate pulse oximeters are when oxygen levels drop to mild, moderate, and severe low levels. Researchers will compare the device's reading with a precise blood test. The study involves 10,000 healthy adults aged 18-50 and will also look at how skin …

This study is testing two different daily doses of zinc (25 mg and 40 mg) in 34 people with sickle cell disease, aged 15 to 40. The goal is to find out which dose is best at improving bone health markers and is safe to take. Results will help design a larger future study on zinc'…

This study looks at whether doing a detailed genetic test (genomic sequencing) on fluid from the womb can find important genetic changes in fetuses that appear normal on ultrasound. Researchers will test 1,000 pregnant people who are already having standard genetic tests for othe…

This study collects health information from up to 250 people with lysosomal storage diseases, including pregnant women whose fetus has a diagnosis. Researchers will track symptoms, lab results, and development over time to better understand how these rare conditions progress. The…

This study aims to find biological markers in the brain that can help diagnose major depression and predict how well a person will respond to treatment. Researchers will use MRI and EEG scans to monitor changes in the brain during transcranial magnetic stimulation (TMS) therapy. …

This study is building a large registry of people who have had a stroke and still have symptoms. The goal is to connect them with researchers working on new ways to improve recovery. No treatment is given; participation simply involves joining the registry.

This study is testing a smartphone app called Empower My Congenital Health (EmpowerMyCH) designed to help adults with congenital heart disease feel more confident managing their own healthcare. The app includes a digital medical passport, educational information, community suppor…

This study is testing whether step counts from a wearable device can help predict when cancer patients undergoing radiation therapy might need to go to the emergency room or be hospitalized. Researchers will collect activity data from 260 adults with cancer to see if changes in w…

This study is tracking 100 people with HER2-negative metastatic breast cancer who are receiving antibody-drug conjugates (ADCs) as part of their normal care. Researchers want to see how long these drugs control the cancer in real-world settings. The goal is to gather information …

This study looks at whether giving patients and their kidney doctors extra information about remaining kidney function after a hospital stay can improve recovery. About 40 adults who still need dialysis after leaving the hospital will collect a timed urine sample before discharge…

This study is testing whether a blood test that looks for tumor DNA can find signs of cancer left behind after treatment for head and neck cancer. Researchers will follow 250 adults who have finished curative treatment to see if the test results match up with whether the cancer c…

This study looks at whether packing a skin abscess after draining it is really needed. About 196 adults will be checked to see if skipping packing leads to more infections or extra doctor visits. The goal is to reduce pain and unnecessary procedures.

This study is creating and testing a simple, patient-friendly tool to help Black or African American men with metastatic prostate cancer understand genetic testing for their tumors. Researchers will interview participants to see if the tool is clear and helpful, and then measure …

This study looks at why some prostate cancers stop responding to a type of targeted radiation therapy called PSMA radioligand therapy. Researchers will use scans and tumor biopsies from 125 people to measure how much radiation the tumors get and check for gene patterns linked to …

This study aims to understand how to improve smoking cessation support for pregnant women who have experienced trauma. Researchers will interview both pregnant women and healthcare providers to gather ideas. The goal is to create a program that combines trauma-informed care with …

This study collects large amounts of white blood cells from people with HIV using a process called leukapheresis. Researchers want to understand why the virus can stay hidden even with treatment and how inflammation affects the body. About 100 HIV-positive adults will take part, …

This study looks at whether menopause and HIV together raise the risk of heart disease in women. Researchers will examine inflammation and body changes using MRI scans and blood tests. The goal is to understand why heart risks increase in menopausal women with HIV. About 90 women…

This study looks at whether a night of poor sleep can increase abnormal heartbeats in people with obstructive sleep apnea. Researchers will ask 100 adults to wear a heart monitor for 14 days and sometimes skip using their sleep device. The goal is to understand the short-term lin…

This study looks at whether using common moisturizers like Vaseline or CeraVe can lower inflammation in adults aged 70 and older with dry skin. Participants will apply a moisturizer daily for 4 weeks and then stop for 4 weeks, acting as their own control. The main goal is to see …

This study explores whether playing a navigation-based digital game can improve long-term memory in healthy older adults and those with mild cognitive impairment. Participants will play the game at home for up to 8 weeks and complete memory tests before, after, and 6 months later…

This study tests whether training mothers to measure their child's upper arm with a simple tape can catch malnutrition early and prevent relapse. About 2,400 children who recovered from severe acute malnutrition will take part. Some mothers will check their child weekly and follo…

This study looks at whether short selfie videos taken on a smartphone can accurately measure walking and speech changes in people with multiple sclerosis (MS). About 300 adults with MS will record 5 videos every 3 months for a year and also visit the clinic for standard tests. Th…

This study tests a special MRI scan that uses a natural substance (hyperpolarized pyruvate) to see how active prostate cancer cells are. It involves 60 men with low- to intermediate-risk prostate cancer who are not receiving treatment but are being watched closely (active surveil…

This study looks at how to help veterans with advanced prostate cancer make informed choices about precision oncology tests, which use genetic information to guide treatment. Researchers will develop and test a decision-support tool to address gaps in understanding and reduce rac…

This study looks at how antibiotics change the bacteria in the gut and breast after mastectomy with implant reconstruction. Researchers want to see if certain bacteria make infections more likely. About 200 women with breast cancer or a strong genetic risk will provide tissue and…

This study looks at whether short-term changes in the immune system can alter how people with PTSD process fear. About 288 adults who have experienced trauma will receive either a typhoid vaccine or a placebo. Researchers will measure their physical responses to sounds and use qu…

This study tests if a culturally-tailored mobile app with education and support groups can improve health for 2100 new mothers in India. The app provides information and social support to supplement standard care. Researchers will measure breastfeeding rates, postpartum depressio…

This study tests whether platelet-rich plasma (PRP) injections into the knee change certain proteins in the blood of people with knee osteoarthritis. About 60 participants, ages 18 to 70, will receive either PRP or a saltwater placebo injection, and researchers will compare prote…

This study looks at what happens in the body when people with HIV temporarily stop their medication. Volunteers pause antiretroviral therapy (ART) and have frequent check-ups. Most restart treatment within three weeks, even if the virus doesn't come back. The goal is to learn mor…

This study looks at whether special planning sessions help formerly homeless older adults make decisions about their future medical care. Researchers will compare group sessions versus one-on-one coaching in 650 people living in supportive housing. The goal is to help ensure thei…

This study is creating tools to predict how sarcoidosis will affect the lungs over time. Researchers will collect clinical data and blood markers from 200 adults with sarcoidosis during routine clinic visits. The goal is to help doctors better forecast lung function changes, impr…

This study is observing 200 people with and without ME/CFS (chronic fatigue syndrome) to learn what biological changes drive the condition. Researchers will collect samples and track participants over time to understand long-term inflammation and infections. The goal is to uncove…

This study aims to understand how asthma works by comparing cells from the airways of people with and without asthma. Researchers will look at the genetic activity in these cells to learn more about mucus production. The study involves 24 adults and uses a bronchoscopy to collect…

This study explores whether wearable bladder devices can help track and improve bladder function in people undergoing pelvic health physical therapy. Researchers will test the devices in 25 adults, including postpartum women and men after prostate surgery. The goal is to see if t…

This study looks at the forces placed on the tongue and throat during laryngeal surgery and whether they cause pain, numbness, or other problems. Researchers will measure these forces in 100 adults having throat surgery. In the first 50 patients, surgeons won't see the measuremen…

This study follows 500 adults with newly diagnosed gynecologic cancer to understand how frailty—being more vulnerable to stress from illness—affects their recovery and quality of life. Researchers will measure physical signs like weight loss, weakness, and slow walking. No new tr…

This study tests a new approach for children and young adults whose medulloblastoma or ependymoma has come back. Doctors will analyze the tumor's genes and test drugs on it in real time to create a personalized treatment plan. The goal is to see if this can be done quickly enough…

This study collects blood samples from people with and without HIV to help researchers study the virus. No treatment or medication is given. Up to 2,000 adults with good vein access can join. The goal is to provide samples for future scientific studies.

This study aims to learn more about a rare condition called SPLIS, caused by a genetic enzyme deficiency. Researchers will collect medical records, genetic information, and samples like blood and urine from up to 120 participants of all ages. No treatments are given; the goal is …

This study looks at how the body handles synthetic nicotine compared to natural nicotine from tobacco. About 18 experienced e-cigarette users will try three types of nicotine liquid and have their blood, heart rate, and cravings measured. The goal is to understand if synthetic ni…

This study looks at whether short educational videos can help people with diabetes better understand their eye disease and show up for follow-up appointments. About 150 patients at Zuckerberg San Francisco General Hospital will watch videos and answer questions. The goal is to se…

This study looks at whether a tablet-based test called TabCAT can help primary care doctors find early signs of memory loss or dementia in older adults. The test is quick, scores itself, and links to the patient's medical record. Researchers will compare detection rates in 26 Kai…

This study looks at whether an educational video shown to patients after HoLEP prostate surgery can reduce the number of follow-up calls, messages, and visits to the hospital. About 114 adults scheduled for the procedure will be randomly assigned to either watch the video or not.…

This study tests whether a drug called colesevelam, which binds to bile acids, can help lower levels of PFAS (often called 'forever chemicals') in the blood of 50 male firefighters who have high exposure. Participants will take the drug or a placebo for several weeks, then switch…

This study is gathering information from 1,000 people with hidradenitis suppurativa (HS), a painful and poorly understood skin condition. Researchers will track symptoms, genetics, and other health data to create a better classification system and identify potential new treatment…

This study aims to adapt alcohol and drug treatment to better fit the experiences of Black teenagers on probation. Researchers will interview teens and hold group discussions with parents and community advocates to understand how racial discrimination affects substance use. The g…

This study tests a computer program called CirrhosisRx that helps doctors make decisions for hospitalized patients with cirrhosis (liver scarring). About 2,100 adults with cirrhosis will be split into two groups: one where doctors use the tool and one where they follow usual care…

This study looks at how cannabis and tobacco affect the body when used together. Researchers will measure levels of THC and nicotine in the blood of 48 regular users who smoke or vape both substances. The goal is to understand the combined health risks and inform public health gu…

This study looks at how whole milk versus skim milk affects blood sugar and cholesterol in healthy adults. Researchers will ask 100 participants to drink only whole milk for a period, then switch to skim milk (or the other way around). The goal is to see if the fat content in mil…

This observational study looks at whether certain genetic elements, called transposable elements, can prematurely age the immune system of people with sepsis in the ICU. Researchers will collect blood samples from 116 adult patients to see if these elements are linked to higher d…

This study is for people diagnosed with pancreatic neuroendocrine tumors (PanNEN). Researchers want to learn how many people have inherited gene changes that may be linked to their cancer. About 300 participants will provide a blood or saliva sample for genetic testing. The goal …

This study enrolls 750 people who have finished standard TB treatment to see if new blood or sputum tests can predict whether their TB will come back within a year. Current methods for predicting TB recurrence are not very accurate, making it hard to test new treatments. By findi…

This study looks at why a medication called Doxy-PEP prevents bacterial STIs in some people but not in others. Researchers will measure drug levels in hair, blood, and urine from 48 volunteers who take the medication in different patterns. The goal is to develop better ways to tr…

This study tests whether playing an immersive virtual reality game can improve memory in 200 older adults with mild memory decline. Participants will undergo memory tests and brain scans to see if the training strengthens brain connections. The goal is to find a non-drug way to h…

This study tests whether a digital intervention can improve working memory and self-control in older adults, including those with mild cognitive impairment. Participants will complete cognitive tests and surveys before and after up to 8 weeks of at-home brain training, with a fol…

This study follows 4,000 adults with pancreatic cysts to learn which ones turn into cancer and which stay harmless. Participants provide health updates over time, but no treatment is given. The goal is to help doctors decide when surgery is needed and when it can be safely avoide…

This study is building a registry of people with metastatic lobular breast cancer, a less common type of breast cancer. Researchers will collect data from about 12 participants to create a new tool that better measures how well treatments are working. The goal is to improve survi…

This study is testing a program called CONNECTing to LungCare that helps smokers and their doctors have better conversations about quitting smoking and getting screened for lung cancer. The program provides education and a personalized summary to guide these discussions. Research…

This study aims to understand why African American men with prostate cancer often miss out on genetic testing and whether a community-based health coach can help. Researchers will provide culturally tailored education and track how many men choose to get tested. The goal is to le…

This study is creating a large registry of 3000 people with hidradenitis suppurativa (HS), a painful and poorly understood skin condition. Researchers will collect medical information and blood samples over time to learn what causes HS and how it progresses. The goal is to develo…

This study tests two imaging methods—central microperimetry and radial OCT—to see if they can more accurately measure the progression of geographic atrophy, a form of age-related macular degeneration that can lead to vision loss. Researchers will follow 80 participants aged 55 an…

This study compares a newer MRI-based scan (DWI) with the standard FDG PET scan to see how well each finds cancer spread in people with metastatic cancer. About 30 adults with cancer that has spread will get both scans, and researchers will compare the results. The goal is to see…

This study looks at how not having enough healthy food at home affects liver disease in children with MASLD (a fatty liver condition). Researchers will track 160 children from California liver and weight clinics to see if food insecurity leads to worse liver damage. The goal is t…

This study looks at whether different ways of holding your breath, with or without extra oxygen, can make MRI pictures of the liver clearer. Ten healthy adults ages 18 to 75 will have one MRI scan while trying two breath-hold methods. The goal is to reduce blurring caused by brea…

This study is testing a computer program that uses interactive stories and artificial intelligence to help teenagers aged 15-17 who already drink alcohol make healthier choices. About 200 teens will use the program during their regular clinic visits. The goal is to see if the pro…

This study follows 300 adults with stage IIB to IV melanoma who are receiving immune checkpoint inhibitors. Researchers will track 53 different symptoms over time to identify which are most common, severe, and distressing. The goal is to find risk factors linked to worse symptoms…

This study looks at how the drug aripiprazole affects brain activity in adults who stutter. Researchers will use brain scans to measure how the brain processes sound before and during speech. The goal is to better understand what causes stuttering, not to test a new treatment.

This study looks at why cancer patients feel very tired during chemotherapy and radiation. Researchers will collect blood and stool samples from 125 adults with different cancers before, during, and after treatment. They aim to find links between fatigue and changes in genes and …

This study is testing a virtual patient navigation program for 260 underserved adults who speak English, Chinese, or Spanish and have breast cancer or heart disease. The program uses a phone-based portal to connect patients with navigators who can help them manage their care. The…

This study looks at different ways to help people with age-related macular degeneration, diabetic retinopathy, or glaucoma get to their eye hospital appointment after a screening. About 3,000 participants will be split into three groups: some get text reminders, some get calls fr…

This study looks at whether measuring body fat before and after breast reconstruction surgery can help predict outcomes. About 40 women having a mastectomy followed by immediate reconstruction will take part. The goal is to see if these measurements are easy to collect and if the…