University Of California, San Francisco

This study tests whether a trained friend, family member, or partner can safely give long-acting HIV injections at home. It involves 1,000 people with HIV who are already virally suppressed and have started the injectable treatment. The goal is to make HIV care more convenient an…

This study tests whether a special PET scan (PSMA PET) can help pick the right patients for radium-223 (Ra-223) radiation therapy. Ra-223 targets bone tumors in men with castration-resistant prostate cancer that has spread to the bones. The goal is to see if using the scan leads …

This study tests a program that combines weekly video chats with a counselor and a mobile app to help young adults (ages 18-29) with HIV keep the virus under control. Participants who are not yet virally suppressed will be randomly assigned to either the program or standard care.…

This early-phase study tests a daily injection called vosoritide in 6 children aged 5-10 with MPS IVA or VI, rare conditions that cause short stature and bone problems. The main goal is to see if the drug is safe and tolerable over 96 weeks. Researchers will also measure changes …

This study tests whether adding a light-activated dye (rose bengal) to standard antibiotic drops helps people with severe bacterial eye infections see better after 6 months. About 60 adults with moderate to severe vision loss from a corneal ulcer will receive either antibiotics p…

This study tests a combination of team-based clinic changes and a patient app to help more people complete a colonoscopy after an abnormal stool-based cancer screening. About 2,000 adults who speak English, Spanish, or Cantonese and had an abnormal FIT result will take part. The …

This study tests a new, less invasive surgical approach for people with persistent atrial fibrillation (a type of irregular heartbeat). The procedure combines two techniques to correct the heart's rhythm and reduce stroke risk. Researchers want to see if it is safe and effective,…

This study explores whether altering the gut microbiome can improve how people with Parkinson's disease respond to their medication. Researchers will first analyze gut bacteria patterns, then use antibiotics to reset the microbiome in a small group of participants. The goal is to…

This study looks at whether using a CPAP machine to treat obstructive sleep apnea can help women with Polycystic Ovary Syndrome (PCOS). The researchers want to see if better sleep can lower insulin resistance and improve hormone levels. The study involves 20 women aged 18-40 with…

This early-stage study tests a new drug (BGB-290) combined with chemotherapy (temozolomide) in adolescents and young adults with IDH1/2-mutant gliomas, a type of brain tumor. The goal is to find the safest dose and check for side effects. About 78 participants with newly diagnose…

This study aims to find out if 5 days of antibiotics works as well as 10 days for children hospitalized with pneumonia, skin infections, or urinary tract infections. About 1,200 children will be randomly assigned to either a 5-day or 10-day course, with some receiving a placebo a…

This study tests a stepped alcohol treatment program delivered via telemedicine for 180 adults with chronic liver disease and unhealthy alcohol use. Participants are randomly assigned to either the treatment program (motivational interviewing plus possible addiction medicine refe…

This early-stage trial tests the safety and best dose of two drugs, trametinib and everolimus, given together to children and young adults whose brain tumors (low- or high-grade gliomas) have returned after prior treatment. The drugs work by blocking different growth signals in t…

This study looks at different ways to help people from racially and ethnically diverse groups monitor their blood pressure at home. The goal is to see which methods work best to safely and fairly improve blood pressure control. About 330 adults with high blood pressure who get ca…

This study looks at whether giving a monthly food card to low-income adults with chronic conditions and food insecurity can improve their health and well-being. About 7,000 people in California's health insurance program will either get a monthly food benefit or a one-time lump s…

This study tests if a drug called Angiotensin II can help control blood pressure during liver transplant surgery, reducing the need for other blood pressure medications. It involves 50 adults with severe liver disease who are receiving a liver from a deceased donor. The goal is t…

This study tests whether certain FDA-approved drugs, used off-label, can improve recovery after a traumatic brain injury (TBI). Researchers will compare recovery in 672 adults who receive the experimental drug versus a placebo. The goal is to see if these drugs reduce brain damag…

This study tests whether giving the targeted drug osimertinib before surgery can shrink tumors in people with early-stage EGFR-mutant non-small cell lung cancer. About 27 adults with stage I to IIIA disease will receive the drug and then have surgery. The goal is to see how many …

This study tests giving a single dose of radiation directly to the area where a breast tumor was removed, right during surgery. It involves about 1,259 people with early-stage breast cancer. The goal is to see if this one-time treatment works as well as standard radiation and has…

This study looks at whether giving steroids early can help children who had a stroke due to a condition called focal cerebral arteriopathy (FCA). About 80 kids will be split into two groups: one gets steroids right away, the other gets them only if the disease gets worse. All chi…

This study was designed to see if it is safe to stop yearly mass antibiotic treatments in communities where trachoma is now rare. Researchers planned to compare communities that stop treatment with those that continue for three more years. The goal was to find out if stopping lea…

This study compares different strategies to help people with high blood pressure get their numbers under control. Researchers will test patient-focused and clinic-focused approaches using remote monitoring. About 2,500 English- and Spanish-speaking adults with hypertension will t…

This study looks at how the drug guselkumab affects immune cells in people with two types of psoriasis: plaque and guttate. Researchers will measure changes in skin cells that produce a protein called IL-17. The goal is to better understand how the drug works in these conditions.…

This early-stage trial tests a new treatment for people with a rare, aggressive brain tumor called H3.3K27M-mutated diffuse midline glioma. The treatment uses the patient's own immune cells, which are modified in a lab to better recognize and attack the tumor. The main goals are …

This study tests whether an FDA-approved drug, used off-label, can improve recovery in adults with severe traumatic brain injury (TBI). 26 participants will receive either the drug or a placebo within 24 hours of injury. The main goal is to see if the drug improves daily function…

This study tests if adding a procedure called expansile duraplasty to standard spinal cord injury surgery can improve recovery. Researchers will compare strength, movement, and independence in 66 adults who recently had a spinal cord injury. Half will get the extra procedure, hal…

This study tests whether giving antibiotics more often to entire communities can eliminate trachoma, an eye infection that can cause blindness. Over 300,000 people in Ethiopia are taking part. The goal is to see if this intensive approach works better than the current yearly trea…

This study tests whether a mix of a DNA vaccine, a booster vaccine, an immune stimulant, and special antibodies can help people with HIV control the virus after stopping their daily antiretroviral therapy. About 11 participants will receive the combination and then pause their re…

This study looks at whether using a special blood pressure monitor at home can find atrial fibrillation (an irregular heartbeat) sooner in older adults with high blood pressure. About 1,900 people aged 60 and older will take daily readings and answer app surveys for up to 18 mont…

This study in Burkina Faso tests whether adding a nutritional supplement (SQ-LNS) to the monthly malaria prevention medicine given to children during rainy season can reduce both malaria and malnutrition. About 438 children aged 6-59 months will take part. The goal is to see if c…

This study compares two online sleep programs in 456 pregnant people with insomnia to see if one can prevent depression during and after pregnancy. Participants receive either digital cognitive behavioral therapy for insomnia or sleep hygiene education over six weeks. The goal is…

This study aimed to see if an enhanced method of finding malaria cases in high-risk villages and among forest workers could reduce the spread of two types of malaria in southern Laos. The approach involved testing people who live or work in these areas more thoroughly. However, t…

This study looks at whether women in Uganda can prevent cervical cancer by using a self-administered HPV test at home or in community health campaigns. The test checks for the virus that can lead to cervical cancer, allowing early treatment. Over 2,500 women aged 25-49 are taking…

This study looks at whether two different health programs are practical and liked by breast cancer survivors. About 106 people who finished treatment for early-stage breast cancer will try either an Ayurveda program (with diet, yoga, and touch therapy) or a health education progr…

This study tests a portable cooling cap worn during chemotherapy to prevent hair loss in women with early-stage breast cancer. The cap cools the scalp to reduce damage to hair follicles from chemo drugs. The study involves 40 women and measures how well the cap works and any side…

This study is testing a smartphone app called MS Falls Insight Track (MS FIT) that helps people with multiple sclerosis log their falls and near-falls, view their health data, and share it with their care team. The goal is to see if using the app can help patients and doctors wor…

This study explores whether making music together can improve social attention and feelings of closeness between people with mild to moderate frontotemporal dementia or Alzheimer's disease and their caregivers. About 80 patient-caregiver pairs will take part in rhythmic musical a…

This study tests whether repeated magnetic pulses to the brain (rTMS) can reduce chronic nerve pain that hasn't responded to other treatments. About 32 adults with conditions like post-stroke pain or nerve injury will receive rTMS daily for two weeks. The goal is to see if this n…

This study tests whether combining a gentle, noninvasive brain stimulation technique (tACS) with a digital meditation program can improve thinking skills and well-being in adults aged 60-85 with mild cognitive impairment (MCI). About 90 participants will use a meditation app whil…

This study tests whether using a wearable bladder device along with pelvic floor therapy at home can help people with multiple sclerosis manage overactive bladder symptoms. About 20 women with MS and mild to moderate bladder problems will try the treatment for three months. The m…

This small study tests whether using inflatable cuffs on the legs during low-intensity stepping exercises can improve mobility and quality of life in people with advanced Parkinson's disease. Four participants will train twice a week for 8 weeks on a Nu-Step machine while wearing…

This study tests whether a behavioral sleep treatment can improve sleep and reduce other symptoms of Gulf War Illness (GWI) in veterans. About 80 Gulf War veterans aged 48-80 will take part. The goal is to see if treating sleep problems like apnea and insomnia can help with fatig…

This study tests whether a smartphone app called MS CATCH can improve depression care for people with multiple sclerosis (MS). Participants use the app to regularly report their mood, and their neurologist can see this information and get alerts if there are concerns. The goal is…

This small study tests whether a yoga program led by a Black or African American trainer can improve quality of life and reduce symptoms in Black cancer survivors. About 13 participants will attend yoga sessions and report how they feel. The goal is to see if this culturally tail…

This study looks at two different ways of feeding teens and young adults (ages 12-24) hospitalized with atypical anorexia nervosa. One method is a personalized calorie plan, the other is a higher-calorie standard approach. The goal is to see which helps patients become medically …

This study tests a new program that combines mindful eating with motivational interviewing to help people with overweight reduce binge eating. About 100 adults will either receive the new program plus daily meditation, or just meditation alone. Researchers will measure how accept…

This study tests a new, low-cost device to help people who have trouble opening their mouth fully after radiation treatment for head and neck cancer. The device is a jaw stretcher with sensors that measure pressure and how wide the mouth opens, giving real-time feedback. About 35…

This study looks at how different doses of the antibiotic doxycycline affect antibiotic resistance and the balance of bacteria in the eyes and gut of people with ocular rosacea, a chronic eye condition. About 50 adults with ocular rosacea will receive either a low anti-inflammato…

This study is testing whether giving families who are homeless or at risk of homelessness $1,000 per month for two years can help them find stable housing and improve their health and well-being. About 300 families in Santa Clara County, California, will take part. The study comp…

This study collects tissue and blood samples from 156 people with advanced prostate, kidney, or bladder cancer to find genetic markers that predict how well different treatments will work. Participants give a biopsy of a growing tumor before starting their planned therapy, which …

This study looks at how lying flat or sitting upright in a rescue litter affects lung function. Researchers will measure breathing in 12 healthy volunteers weighing 130-310 pounds. The goal is to find out if a vertical position is better for patients with breathing problems durin…

This study looks at whether young adults (ages 21-25) who regularly use high-potency cannabis concentrates can improve their memory, attention, and other thinking skills by switching to less potent products. Researchers will track participants' cannabis use, collect blood and uri…

This study looks at four different tools to help people who have had cancer improve their diet and physical activity. About 353 cancer survivors will try these tools to see which ones work best. The goal is to find simple ways to help survivors follow healthy lifestyle guidelines…

This study looks at how a meditation program called TARA changes brain connections in teens aged 14 to 18 with mild or moderate depression. Researchers use MRI scans to measure changes in a brain area called the putamen and track depression symptoms using a questionnaire. The goa…

This study follows 578 women with uterine fibroids who choose either radiofrequency ablation (Acessa) or myomectomy. Researchers track symptom changes, quality of life, and need for repeat treatment over three years. The goal is to understand long-term safety and effectiveness of…

This study follows 1,500 adults aged 65 and older who have had a traumatic brain injury (TBI), along with similar healthy participants, for 12 months. Researchers will use brain scans, blood tests, and health history to better understand how recovery happens and to create tools t…

This study tests a new MRI technique that tracks how the brain uses a special form of sugar (deuterated glucose). It includes 80 healthy adults and people with a type of brain tumor called glioma. The goal is to see if this method can detect differences in brain metabolism, which…

This study looks at which combination of tests works best to find early signs of cancer in the cervix or anus of people living with HIV. About 1,586 participants in Mexico and Puerto Rico will be tested using different methods, including HPV testing and cell analysis. The goal is…

This study aims to build a large online registry of adults interested in brain research. Participants complete questionnaires and cognitive tests from home to help scientists understand brain aging and diseases like Alzheimer's. Anyone over 18 can join by visiting the study websi…

This study looks at 500 pregnant women whose fetuses have structural problems not explained by standard genetic tests. Researchers will use advanced DNA sequencing to find hidden genetic causes. The goal is to learn more about these conditions and how families use this informatio…

This study aims to uncover the genetic reasons behind non-immune hydrops fetalis, a rare condition where abnormal fluid builds up in a fetus. Researchers will use advanced DNA and RNA sequencing on 500 affected pregnancies and their parents. The goal is to improve diagnosis, coun…

This study works with about 30 family child care home directors in California to help them lower their exposure to pesticides. Experts provide education, collect carpet dust samples to test for pesticides, and offer monthly advice for 7 months. The goal is to reduce health risks …

This study follows 1,436 women in Nepal who sought pregnancy termination services. Researchers track their physical and mental health, their children's development, and family well-being over three years. The goal is to understand the health consequences of unwanted pregnancy and…

This study tests whether virtual peer groups can help Latinx teenagers (ages 13-17) with type 1 diabetes use insulin pumps and continuous glucose monitors more often. The program, called DREAM, was developed with input from teens, families, and doctors. Researchers will check if …

This study looks at whether it's practical and okay to ask families about social needs (like food, housing, or money) when their child is in the hospital. About 50 caregivers of hospitalized children will take part. The goal is to see if this screening can be done smoothly and if…

This study looks at how well the MS medication ocrelizumab removes B cells from lymph nodes, not just from blood. Researchers will analyze lymph node samples from 5 people with relapsing-remitting MS who are starting ocrelizumab. The goal is to understand why some immune cells re…

This study looks at brain networks that may cause compulsive behaviors in people with anorexia nervosa. Researchers will use brain scans and a non-invasive technique called TMS to see if stimulating a specific brain area can help. The goal is to understand the brain patterns behi…

This study follows about 300 children who had seizures shortly after birth, along with their parents, to see if genes affect the risk of developing epilepsy later in childhood. Researchers will use medical records, brain scans, and genetic tests to create a tool that predicts low…

This study planned to test a program that would identify heart patients with social challenges (like trouble getting food or housing) and connect them to community resources to prevent hospital readmissions. It was designed for adults with heart failure or coronary artery disease…

This study aimed to see if removing mucus plugs from the airways using a scope (bronchoscopy) is safe and improves lung function in people with asthma. It planned to enroll adults aged 18-70 with asthma and low lung function. However, the study was withdrawn before any participan…

This study looks at how things like family income, education, and social support affect the health of children after a liver transplant. Researchers will survey 500 families and interview some of them to understand the challenges they face. The goal is to find ways to help all ch…

This study aims to understand how the brain processes spoken language by recording brain activity in people with epilepsy or brain tumors who already have electrodes implanted for medical reasons. Researchers will compare brain signals from English, Spanish, and Mandarin speakers…

This study looks at how often fatty liver disease occurs in people living with HIV. Researchers will use a special ultrasound scan to measure liver fat in 1,250 adults with HIV who are on stable treatment. The goal is to fill a knowledge gap, since past studies on fatty liver hav…

This study gives improvisation training to ear, nose, and throat surgical residents to see if it improves their sense of connection, stress levels, and mood. A control group continues standard education without improv. The goal is to understand whether this creative approach can …

This study aims to uncover the genetic reasons behind non-immune hydrops fetalis (a severe fetal condition) and other birth defects. Researchers will use advanced genetic testing (exome sequencing) on 500 affected fetuses or newborns to find hidden genetic causes. The goal is to …

This study follows about 2,000 women aged 15-34 who are not pregnant at the start. Researchers track their pregnancy preferences over a year and, if they become pregnant, follow their decision-making and health outcomes. The goal is to understand how unintended pregnancy impacts …

This study follows 500 adults who need surgery for a paralyzed or weakened vocal cord. Researchers will track voice quality, complications, and recovery for two years after surgery. The goal is to learn which surgical methods work best for different patients.

This study tests whether choosing depression treatments based on a person's specific symptoms (like loss of pleasure or anxiety) works better than usual care. Researchers will enroll 150 adults with major depressive disorder. The goal is to see if this personalized approach leads…

This study looks at how the drug ocrelizumab changes certain markers in the spinal fluid of people newly diagnosed with relapsing multiple sclerosis (MS) or a high-risk first episode. The goal is to see if early treatment can reduce signs of chronic inflammation in the brain. Abo…

This study looks at adults with asthma to learn more about their condition, including how severe it is and what factors affect it. Researchers will collect medical history and do lung function tests. The goal is to build a database that helps with future asthma research. About 25…

This study uses a small device called a continuous glucose monitor (CGM) to track blood sugar levels in women with PCOS over 10 days. Researchers want to see how blood sugar patterns differ in PCOS and whether using the CGM can help improve metabolic and reproductive health. Abou…

This study looks at whether young people (ages 8-20) with type 2 diabetes will wear and use a continuous glucose monitor (CGM) and if it helps them manage their blood sugar. About 30 participants will either use the CGM or receive standard care for 6 months. The goal is to see if…

This study looks at how the cerebellum, a part of the brain, helps us learn and adjust our speech over time and in the moment. Researchers will study people with cerebellar ataxia (a condition that affects coordination) and healthy volunteers. They will use speaking tasks, brain …

This study looks at how a meditation app affects emotional well-being in lonely adults aged 60 and older. Researchers use brain scans and heart monitors to see what changes in the brain. The goal is to understand the effects, not to test a treatment.

This study planned to give low-dose CT scans to firefighters aged 35 and older to check for lung cancer and other lung diseases caused by job-related smoke and chemical exposure. It aimed to see if screening based on occupation, not just smoking history, could catch cancers earli…

This study aims to find brain-based markers that could help doctors better diagnose chronic pain and predict which treatments will work best. Researchers will use a device that gently stimulates the brain with magnetic pulses and records the brain's electrical responses in 100 ad…

This study follows 2,314 South Asian adults (ages 40-84) in the US to uncover why they have high rates of heart disease and stroke, even without typical risk factors. Researchers measure artery calcium, diabetes, and other markers over time. The goal is to identify unique causes …

This study tests a program called Meet Me on the Pitch that combines soccer with mental health support for teens ages 14-21. The goal is to see if it helps with emotional well-being, confidence, and school performance. About 480 youth who already play with Soccer Without Borders …

This study looks at a school-based program called VOCES-NUEVAS designed to help newcomer girls from Latin America feel better mentally and emotionally. About 24 students from four school health centers will take short surveys before and after the program and share their thoughts.…

This study aimed to understand why some people with asthma develop mucus plugs in their airways. Researchers planned to use a thin, camera-guided tube to collect samples from the lungs of 60 adults—some with asthma and mucus plugs, some with asthma but no plugs, and healthy volun…

This study looks at whether learning music improvisation can help older adults (60+) better regulate their thoughts and actions. Researchers will compare participants who take improvisation training to those who don't, measuring changes in cognitive skills and brain activity. The…