University Of California, San Francisco

This study is testing whether a combination of vaccines, immune-boosting drugs, and lab-made antibodies can help people with HIV control the virus on their own, without needing daily antiretroviral therapy (ART). Eleven participants on stable ART will receive the experimental reg…

This study is testing different support methods to help people from diverse backgrounds monitor their high blood pressure at home. Researchers will compare basic training with more comprehensive support that addresses digital literacy and social factors. The goal is to find the m…

This study examines whether starting the medication ocrelizumab very early after a first MS symptom changes markers of inflammation in the spinal fluid. It involves 30 newly diagnosed adults who will receive the drug every 6 months for 3 years. The goal is to see if early, strong…

This study is testing a new, quick urine test designed to help people living with HIV. The test gives clinic staff immediate information about whether a person has recently taken their key HIV medication. Researchers want to see if using this test helps identify people who are st…

This large study in Ethiopia is testing whether more frequent, targeted antibiotic treatments can eliminate the eye infection trachoma better than the current standard of annual treatment for everyone. Researchers are comparing four different antibiotic distribution strategies ac…

This study is investigating whether treating sleep apnea with CPAP therapy can improve metabolic and hormonal health in women with Polycystic Ovary Syndrome (PCOS). Researchers are enrolling 20 women with both PCOS and moderate-to-severe sleep apnea to test if using a CPAP machin…

This study is testing a new way to help people with HIV get their long-acting treatment injections. It will train a friend, family member, or partner to safely give the monthly or every-other-month shots at home instead of at a clinic. The goal is to make treatment more convenien…

This study is testing a smartphone app called MS CATCH, which helps people with MS track their mood symptoms. The app shares this information with their neurologist, who can then monitor changes and provide timely support. The goal is to improve how depression is reported, screen…

This study is testing whether a technology-based support program can help young adults (18-29) living with HIV better control their virus. The program combines weekly video chats with a counselor and a smartphone app to help with medication reminders, mental health, and social co…

This early-stage study is testing whether daily injections of a medication called vosoritide can safely help children with rare genetic disorders (MPS IVA and MPS VI) grow taller. Six children aged 5-10 will receive the injections for nearly two years while researchers monitor sa…

This study is testing a new system of visual guides, called pathways, to help doctors and nurses in community hospitals follow the best-known treatment steps for children hospitalized with common breathing illnesses like asthma, pneumonia, or bronchiolitis. It involves nearly 4,0…

This study is testing whether a special telehealth program can help people with advanced liver disease drink less alcohol. About 180 participants will be randomly assigned to either receive several motivational phone counseling sessions or to continue with their usual medical car…

This study aimed to see if safely removing thick mucus plugs from the airways of people with asthma could help them breathe better. Researchers planned to test this by performing a bronchoscopy procedure and measuring lung function before and after. The trial was withdrawn before…

This study explores whether changing the gut bacteria in people with Parkinson's disease can improve their symptoms and make their medication work better. Researchers will first examine how gut bacteria relate to symptoms, then test if using antibiotics to reset gut bacteria help…

This study is testing if adding a special light treatment to standard antibiotic and steroid eye drops leads to better long-term vision for people with severe bacterial eye ulcers. It is comparing two groups: one receives the real light treatment, and the other receives a sham (f…

This study is testing whether matching depression treatments to a person's specific symptoms works better than standard care. Researchers will first sort 150 adults with major depression into one of five subtypes, like trouble feeling pleasure or high anxiety. Then, half will get…

This study compares two feeding approaches for hospitalized teens and young adults (ages 12-24) with atypical anorexia nervosa. Researchers want to see if an individualized calorie plan helps restore medical stability faster than the current standard approach, while remaining saf…

This study aims to help more people complete a necessary colonoscopy after an abnormal stool test for colorectal cancer. It tests a two-part program: training clinic teams in best practices and providing patients with tech tools for instructions and scheduling help. The goal is t…

This study is testing whether certain already-approved medications can help people recover better after a traumatic brain injury (TBI). It will involve about 670 adults who recently suffered a moderate TBI. Researchers will compare recovery in people who receive the study drugs t…

This study is testing whether providing a monthly food card to low-income adults who have a chronic health condition and struggle to afford food can improve their health. Nearly 7,000 participants were randomly assigned to receive either a monthly food card or a single payment at…

This study aimed to see if communities with low levels of the eye infection trachoma could safely stop their yearly antibiotic treatments without the disease coming back. It planned to compare villages that stopped treatment to those that continued for three more years. The trial…

This study is testing different remote monitoring strategies to help people with high blood pressure better manage their condition. Researchers will enroll 2,500 English- and Spanish-speaking adults with hypertension to compare patient-focused and clinic-focused approaches. The g…

This study aims to find the best timing for steroid treatment in children who have had a stroke caused by a rare, aggressive artery inflammation. It will compare starting steroids immediately versus waiting to see if the artery damage gets worse. The goal is to control the diseas…

This study is testing whether adding a blood pressure medication called Angiotensin II to standard care helps during liver transplant surgery. It aims to see if the drug helps control dangerously low blood pressure more effectively and reduces the need for other strong medication…

This study is collecting information on a one-time radiation treatment given right during breast cancer surgery. It aims to see if this single dose, delivered to the area where the tumor was removed, works as well as the standard several-weeks course of radiation for early-stage …

This study is testing whether an existing, FDA-approved drug can help people recover better from a severe traumatic brain injury (TBI). The drug is being used 'off-label,' meaning it's not yet approved for TBI. Researchers will compare recovery in a small group of 26 adults who r…

This study is testing if a non-invasive brain stimulation technique, similar to one used for OCD, can help people with anorexia nervosa. Researchers will give 20 participants magnetic pulses to a specific brain area to see if it reduces compulsive thoughts about food and weight a…

This study is testing whether a special type of imaging scan (PSMA PET) can help doctors better select patients for a targeted radiation treatment called Ra-223. The treatment is for men whose prostate cancer has become resistant to hormone therapy and has spread to their bones. …

This early-stage study is testing a new two-drug combination (BGB-290 and temozolomide) for adolescents and young adults with specific types of brain tumors that have returned or are newly diagnosed. The main goal is to find the safest dose and understand the side effects. Resear…

This nationwide study follows women for three years after they receive treatment for uterine fibroids. Researchers are comparing two procedures—radiofrequency ablation (a less invasive heat treatment) and traditional surgery—to see which provides better long-term relief from symp…

This study is testing different combinations of screening tests to find the best way to detect early, pre-cancerous changes in the cervix and anus of people living with HIV. People with HIV are at higher risk for cancers caused by HPV. The research involves over 1,500 adults in M…

This study tests whether adding a nutritional supplement to an existing malaria prevention program can better protect young children in Burkina Faso. During the rainy season when malaria risk is high and food is scarce, researchers are giving some children a peanut-based nutritio…

This study is testing if a specific online sleep therapy program can prevent depression in pregnant people who have trouble sleeping. It compares two different six-week digital sleep programs to see which one is better at reducing the risk of developing depression during pregnanc…

This study aimed to test a new support program for adults hospitalized with heart disease. The program would automatically screen patients for social needs like food or housing insecurity and connect them electronically to local community resources. The goal was to see if address…

This study is testing whether a meditation app can improve emotional well-being in lonely adults aged 60 and older. Researchers will use brain scans (fMRI and EEG) and surveys to see how the app affects feelings of loneliness, stress, and mood. The goal is to understand if a simp…

This study is testing a new program that combines mindful eating techniques with motivational counseling to help people reduce binge eating. Researchers are enrolling 100 adults with overweight and binge eating to see if the program is practical and acceptable to participants. Th…

This study is testing whether a specific mindfulness meditation program can help reduce depression symptoms in teenagers. Researchers are enrolling 120 teens aged 14-18 with mild to moderate depression to participate in meditation training. They will use brain scans (MRI) to see …

This study is testing a new program called 'Meet Me on the Pitch' that uses soccer to help improve mental health and school engagement in young people aged 14-21. The program combines regular soccer activities with lessons on managing emotions and seeking help. Researchers will c…

This study is testing whether a behavioral sleep treatment can improve sleep and reduce other symptoms for Gulf War Veterans suffering from Gulf War Illness. The treatment is delivered remotely via video or phone to 80 veterans who have both sleep apnea and insomnia. Researchers …

This study is testing a non-invasive brain stimulation treatment called rTMS to see if it can reduce chronic nerve pain. It will involve 32 adults with long-term pain from conditions like nerve injuries or post-stroke pain. Participants will receive magnetic pulses to specific br…

This study is testing a new, low-cost device designed to help people who have trouble opening their mouth after radiation treatment for head and neck cancer. The device is like a jaw-stretching tool with sensors that give feedback, aiming to make exercises more effective. Researc…

This pilot study is testing whether combining a gentle, non-invasive brain stimulation technique with a digital meditation program can improve thinking skills and well-being in older adults with mild cognitive impairment (MCI). Researchers will measure changes in attention, react…

This study is testing a smartphone app called MS Falls Insight Track that helps people with multiple sclerosis monitor and prevent falls. The app connects patients' health data with information from wearable devices like Fitbits to track falls in real time. Researchers are checki…

This small, early-stage study is testing a new exercise method for people with advanced Parkinson's disease. Four participants will do light leg-stepping exercises while wearing special cuffs on their thighs that gently reduce blood flow. Researchers want to see if this 8-week pr…

This study explores whether doing rhythmic music activities together can improve social attention and feelings of connection for people with mild to moderate frontotemporal dementia or Alzheimer's disease and their caregivers. Researchers will compare groups doing synchronized mu…

This study is testing whether adding new 'wearable for the bladder' devices to standard pelvic floor physical therapy helps people with multiple sclerosis (MS) manage overactive bladder symptoms. Researchers want to see if using these devices at home for three months is practical…

This study aims to discover how the human brain understands speech across different languages like English, Spanish, and Mandarin. Researchers will record brain activity directly from the surface of the brain in patients already undergoing surgery for epilepsy or brain tumors. Th…

This study aimed to learn more about mucus plugs in people with asthma. Researchers planned to use a guided camera (bronchoscopy) to collect small samples from the airways of people with asthma—both with and without visible mucus plugs—and from healthy volunteers. By comparing th…

This study aims to understand how social and economic factors—like family finances, neighborhood conditions, and access to care—affect children's health outcomes after liver transplantation. Researchers will survey and interview 500 caregivers of children receiving liver transpla…

This study aims to understand how common fatty liver disease is in people living with HIV. Researchers will enroll 1,250 participants to measure liver fat and identify factors that increase risk, such as genetics, diet, and HIV treatment history. The goal is to fill a critical kn…

This study follows 300 children who had seizures as newborns to understand how their genes might affect their risk of developing epilepsy later in childhood. Researchers are collecting genetic information along with brain scan and medical history data to try to build better tools…

This study aims to better understand blood sugar patterns in women with Polycystic Ovary Syndrome (PCOS) using a wearable glucose monitor. Researchers will first track glucose levels in women with and without PCOS. Then, they will test if using the monitor for 90 days, along with…

This study aims to understand if a common low-dose pill for eye rosacea (40mg doxycycline) actually changes the bacteria in the gut and eye or increases antibiotic resistance, even though it's not officially classified as an antibiotic. Researchers will compare 50 adults with ocu…

This study aims to understand how a part of the brain called the cerebellum helps us control and learn speech. Researchers will compare people with a movement disorder called cerebellar ataxia to healthy volunteers. They will use brain scans, speaking tasks, and a non-invasive br…

This study is testing a new brain imaging method that uses a special form of sugar to see how glioma brain tumors use energy. Researchers will scan 80 participants—including healthy people and those with glioma—to develop better imaging techniques. The goal is to understand tumor…

This study aims to see if a simple blood test can predict which prostate cancer patients will experience memory and thinking problems when they start hormone therapy (ADT). Researchers will follow 32 men to check if changes in a specific blood protein are linked to cognitive decl…

This study aims to find out if a person's breathing is better when they are secured in a rescue litter that is vertical (upright) versus horizontal (lying flat). Researchers will measure lung function in 12 healthy volunteers placed in different litter positions. The goal is to g…

This study aims to learn if giving families experiencing homelessness $1,000 per month for two years helps them find and keep stable housing and improves their health and well-being. Researchers will enroll 300 families in Santa Clara County, California, and randomly assign half …

This study is testing whether taking music improvisation classes can help improve thinking skills and self-control in older adults. Researchers want to see if this fun, creative training can help people stay mentally engaged, especially those with mild memory concerns. The study …

This national study aims to discover the genetic causes of non-immune hydrops fetalis (NIHF) and other birth defects, conditions where excess fluid builds up in a fetus. Researchers are enrolling 500 families where a pregnancy is affected by these conditions to perform advanced g…

This study is testing if improvisation training can help surgical residents manage stress, feel more connected to their team, and make better clinical decisions. Ten residents at one university will either take improv classes or continue their standard training. The goal is to le…

This study aims to better understand and predict recovery for adults 65 and older who suffer a traumatic brain injury (TBI). Researchers will follow 1500 older adults who come to the emergency department with a head injury, along with some healthy comparison participants, for one…

This study is building a large online registry of people interested in brain research. Participants answer health and lifestyle questionnaires and take online memory tests over time. The goal is to help scientists understand brain health and find people for future research studie…

This study aims to understand why some cancer treatments work for certain patients but not others. Researchers will collect tumor tissue and blood samples from 156 people with advanced prostate, kidney, or bladder cancer who are about to start a new treatment. By analyzing the ge…

This study is testing whether young people with type 2 diabetes will use a continuous glucose monitor (CGM) and if having this real-time data changes their behavior. About 30 participants, aged 8-20, will be split into two groups: one uses the CGM for 6 months, and the other uses…

This study aims to create a detailed database of adult asthma patients to help recruit participants for future research. Researchers will collect medical histories, lung function tests, and sputum samples to better understand the different types and severities of asthma. The goal…

This study aims to understand the long-term health and social consequences for women and their children when a pregnancy is unwanted and legal abortion services are denied. Researchers are following over 1,400 women in Nepal who sought pregnancy termination, checking in every six…

This study aims to find brain activity patterns that could help doctors better understand and diagnose chronic pain. Researchers will use a special helmet that gently stimulates the brain and records its electrical response in 100 adults with long-term pain. The goal is to see if…

This study aims to find out why people of South Asian descent have higher rates of heart disease and stroke, even when typical risk factors are accounted for. Researchers are following over 2,300 South Asian adults in the US for several years to identify new causes. The goal is t…