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Asthma mucus plug removal study halted before it began

NCT ID NCT05748912

Knowledge-focused Sponsor: University of California, San Francisco Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled This study
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study aimed to see if removing mucus plugs from the airways of people with asthma is safe and could improve lung function. Researchers planned to use a thin tube with a camera (bronchoscopy) to remove the plugs and then check breathing tests one week and six months later. However, the study was withdrawn before enrolling any participants, so no results are available.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Started

Jan 2022

Finished

Mar 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 80 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Protocol A: Inclusion Criteria: * Males or females between the ages 18 to 70 at the time of visit 1. * Clinical history of asthma per patient report or medical record. * Pre-bronchodilator FEV1 \< 80% predicted and ≥ 35% predicted * CT mucus plug score \> 5. * Written informed consent obtained from subject and ability for subject to comply with the requirements of the study. Exclusion Criteria: * Smoking of tobacco or other recreational inhalants in the last month and/or \>10 pack-year smoking history. * History of other pulmonary disorders including cystic fibrosis and COPD (Chronic Obstructive Pulmonary Disease). * History of unstable cardiovascular disease. * BMI \> 45 * Current use of anticoagulant medications. * Upper Respiratory Infection (URI) within the previous 6 weeks * Currently pregnant and/or unwillingness to practice medically acceptable birth control or complete abstinence during the study * History of COVID-19 (coronavirus disease) in the past 6 months. Protocol B: Inclusion Criteria: * Males or females between the ages 18 to 80 at the time of visit 1. * Undergoing clinically indicated bronchoscopy for removal of mucus plugs. * Clinical history of airway disease (including asthma, COPD and bronchiectasis) per patient report or medical record. * Written informed consent obtained from subject. Exclusion Criteria: * Upper Respiratory Infection (URI) in the past 30 days. * History of COVID-19 in the past 30 days. * Currently pregnant during the study.

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Conditions

The condition(s) this trial relates to.

asthma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Asthma

Contacts and locations

Locations

  • UCSF Airway Clinical Research Center

    San Francisco, California, 94143, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.