University Of California, San Francisco

This study tests giving radiation therapy (SBRT) to the spine soon after surgery, while patients are still in the hospital, instead of waiting 2-4 weeks. The goal is to see if this faster approach is safe and helps control cancer growth in the spine. About 50 adults with cancer t…

This study looks at two different approaches to help pregnant people with gum disease get better dental care. Participants will receive free dental check-ups, cleanings, and supplies. The goal is to see which method reduces gum inflammation and improves oral health habits, and wh…

This trial tests a six-session peer-led program called Gwan Enjoy Life for sexual minority men living with HIV in Jamaica. The program aims to reduce depression, anxiety, and loneliness while helping participants stay engaged in HIV care and take their medications. Sixty men will…

This study tests whether oral valganciclovir or ganciclovir eye drops can reduce the virus causing eye inflammation and prevent flare-ups. About 117 adults with CMV anterior uveitis will receive either antiviral treatment or placebo for 7 days, then some continue for 12 months. T…

This trial tests a medical device that has not yet been approved by the U.S. FDA. The goal is to see if it can help control a specific disease. Participants will use the device as directed, and researchers will monitor its effects on symptoms and disease progression.

This trial tests whether a community-based program called I-CAN can improve how well women's contraceptive use matches their personal preferences. In rural Uganda, lay women are trained as peer mentors to provide support and information to other women of reproductive age. Village…

This study tests a package of care for pregnant women at high risk of complications in rural Nepal. The bundle includes identifying high-risk pregnancies, teleconsultations with experts, weekly calls from a patient navigator, training for local health providers, and regular teleh…

This study compares two methods of helping families of hospitalized children connect with social and economic resources. One group receives a list of local services (passive referral), while the other also gets help from trained navigators who assist with applications and follow-…

This pilot study tests a behavioral program called CBITS-RTM, adapted for teens in juvenile detention. The program combines group and individual therapy to address post-traumatic stress and includes a module on racial trauma. Researchers want to see if it reduces PTSD symptoms an…

This trial tests a treatment called Yttrium-90 radiation segmentectomy for people with liver cancer that can't be removed by surgery. Tiny radioactive beads are injected into the blood supply of the tumor to deliver targeted radiation. The study will enroll 64 participants to see…

This study tests a one-time infusion of emapalumab in 40 adults who had a lung transplant and now have a sudden drop in lung function (acute lung allograft dysfunction). The goal is to see if the drug can help their lungs recover to near-normal function within 90 days. Emapalumab…

This study tests whether the oral medication upadacitinib can safely treat acute severe ulcerative colitis in hospitalized adults without using steroids. Fifty participants will take upadacitinib daily during their hospital stay and be monitored for up to a year. The goal is to s…

This study tests two methods for starting buprenorphine treatment in adults with opioid use disorder who use fentanyl. Participants will be randomly assigned to either a low-dose start or a direct injection approach. The goal is to see which method helps people stay in treatment …

This study tests whether clemastine fumarate, an over-the-counter allergy medication, can repair damaged nerve insulation (myelin) in people with multiple sclerosis. About 44 adults with relapsing-remitting MS will receive either the drug or a placebo for 3 months, then all will …

This study will test two ways to find TB in pregnant women with HIV: using symptoms or a blood test. It will also compare starting TB prevention medicine right away versus after giving birth. The goal is to reduce harm to mothers and babies. About 1,500 pregnant women in Uganda w…

This study explores whether certain molecules in the blood, called RNA biomarkers, are different in people with cervical spondylotic myelopathy (CSM) compared to healthy individuals. Researchers will see if these markers relate to the severity of the condition and how patients re…

This study tests whether giving malaria medicine to school-age children can lower malaria cases in the entire community. School children often carry the malaria parasite without symptoms and spread it to others. The trial will involve about 4,800 children in The Gambia and measur…

This study looks at whether taking the antibiotic TMP-SMX for a full year after a kidney transplant can prevent urinary tract infections (UTIs) better than stopping after 6 months. Fifty children and young adults who recently had a kidney transplant will either keep taking TMP-SM…

This study looks at how to keep HIV self-test kits available for adolescent girls and young women in sub-Saharan Africa. Researchers will test two subsidy levels (high and low) for shopkeepers, with decreasing support over time. The goal is to find a sustainable way for private d…

This trial tests whether a peer-led program that lets women choose and switch HIV prevention methods can increase consistent use compared to standard care. The program includes peer mentor support, HIV testing, access to PEP, and STI care. It enrolls HIV-negative women at elevate…

This study tests a culturally tailored Talking Circles program to prevent noise-induced hearing loss in Native American adults. 400 tribal members will join group discussions and hearing tests over 12 months. The goal is to increase hearing protection use and knowledge through co…

This study tests whether a device called the Guardian spatial emanator, which releases mosquito-repelling ingredients into the air, can be effectively added to an existing program that distributes antibiotics to children in Niger. The goal is to see if this integrated approach ca…

This trial tests whether a single dose of rectal indomethacin, a common anti-inflammatory drug, can prevent pancreatitis in patients undergoing a bile duct procedure (ERCP) who have had a prior sphincterotomy. About 860 adults will be randomly assigned to receive the drug or no d…

This study in Ethiopia tests whether a new 7-day package of a nutritional supplement (SQ-LNS) works as well as the usual daily packets for preventing malnutrition in children aged 6-24 months. Researchers will compare how well families stick to using each package type over 8 week…

This study tests whether personalized dietary counseling through video visits can help people who have had kidney stones eat less salt. One hundred adults with a history of calcium-based kidney stones will receive either standard advice or virtual home coaching. The goal is to se…

Researchers are testing whether giving naloxone soon after resuscitation starts can help people whose hearts stop outside the hospital after an opioid overdose. The trial enrolls adults in out-of-hospital cardiac arrest who are at risk of opioid involvement and who have received …

This trial tests whether listening to a 15-minute relaxation audio during breastfeeding, twice daily for 12 weeks, can improve weight gain in low-birth-weight newborns and reduce maternal stress and anxiety. Mothers of stable infants born under 2500 grams will be randomly assigne…

This study explores whether a 6-week creative writing program can help 10 teens and young adults (ages 16-25) with anorexia nervosa express themselves, reflect on their experiences, and build resilience. Participants will attend weekly workshops involving reading, writing, and gr…

This study tests a special pain management program called a Transitional Pain Service for adults having planned surgery who are at higher risk for long-lasting pain. About 126 participants will either get usual care or extra support before and after surgery to improve pain contro…

This study tests whether isotretinoin or doxycycline works better for treating an acne-like rash that can appear in people taking certain cancer drugs. About 50 participants who already have a moderate to severe rash will receive one of the two medications. The goal is to see whi…

This study tests whether combining whole-body hyperthermia (a controlled rise in body temperature) with cognitive behavioral therapy (CBT) can help adults with major depressive disorder. Sixty participants will receive either CBT, heat sessions, both, or neither, to see if the co…

This study tests a new, non-invasive brain stimulation technique called kTMP to help improve arm and hand function in people who have had a stroke. One hundred adults with chronic stroke-related arm weakness will receive either active or sham stimulation over 18 weeks. The goal i…

This study will test whether 8 weeks of improvisation music therapy can improve mood and lower stress for people with mild Alzheimer's disease and their care partners. About 40 older adults and their caregivers will attend music sessions and fill out questionnaires before and aft…

Researchers at the University of California, San Francisco are studying how well a calibrated touch device measures sensation in the larynx and throat. The study includes adults with larynx or throat disorders, including those whose condition followed radiation or other cancer tr…

Researchers at the University of California, San Francisco are testing whether short bursts of high-intensity exercise control blood sugar as well as longer, moderate workouts. The study enrolls 12 non-diabetic or pre-diabetic adults who wear a continuous glucose monitor for 11 d…

Researchers at the University of California, San Francisco are following 100 adolescents and young adults, ages 12 to 21, who are starting GLP-1 weight-loss drugs like Ozempic, Wegovy, or Mounjaro. Over one year, participants answer online surveys about their eating behaviors and…

This pilot study tests a patient navigation program for people who visited the ER for kidney stones and are at risk of missing their follow-up urology appointment. About 31 participants will get a trained navigator who helps with scheduling, transportation, and other barriers for…

Rectal cancer treatment can involve chemotherapy, radiation, surgery, or watch-and-wait surveillance, and each can affect bowel, urinary, sexual, and stoma function. Most studies measure quality of life at a single point or after one type of treatment, leaving gaps in how patient…

This study follows 200 adults with stage 4 breast cancer that has spread to the brain or spinal lining. Participants fill out questionnaires about their symptoms, thinking abilities, and physical function over time. The goal is to track how symptoms change and how treatments affe…

This study will follow 40 adults with brain tumors who are scheduled for standard brain radiotherapy. Researchers will collect blood samples, perform brain scans, and give thinking and quality-of-life tests before and after treatment. The goal is to identify biological markers th…

This study looks at whether music therapy can reduce painful mouth sores (oral mucositis) in children with cancer. Researchers will interview 50 families online to learn about their experiences with music therapy. The goal is to find patterns that could lead to better, drug-free …

This study will give a single dose of oral methamphetamine to 20 people with HIV who are on effective antiretroviral therapy and have undetectable virus levels. The goal is to see if the drug can temporarily wake up dormant HIV hiding in cells, which could help researchers find n…

This study looks at whether extra phone calls and text messages can help patients who are likely to miss their urology procedures. About 68 adults at high risk of no-showing will be split into two groups: one gets standard care, the other gets extra reminders. The goal is to see …

This study tests whether 3D infrared body scanning can better assess malnutrition in adolescents and young adults hospitalized with anorexia nervosa. Researchers will measure body composition and track how organ and tissue stores relate to medical stability, nutritional needs, an…

This study tests whether showing patients with diabetes short animated videos (in English or Spanish) about diabetic eye disease can improve their understanding and increase how often they return for follow-up eye exams. About 150 patients at Zuckerberg San Francisco General Hosp…

This study tests a 6-week group bootcamp for caregivers of infants (3-15 months old) diagnosed with or at high risk for cerebral palsy. The program teaches parents how to better interact with and support their baby through physical and occupational therapy techniques. The goal is…

This study explores whether a special imaging technique called parenchymal blood volume (PBV) imaging can detect changes in blood flow within liver tumors after giving a drug called nitroglycerin. The drug is commonly used for heart conditions but may temporarily increase blood f…

This study will see if setting up vision centers in rural South Asian communities helps more people get the eye care they need. Researchers will compare communities that get a vision center right away with those that wait. They will check if more people get glasses and if their e…

This study tests whether people with fibrotic interstitial lung disease can use home monitoring devices—like a spirometer, pulse oximeter, and scale—to help detect serious lung events such as flare-ups or hospitalizations. About 200 participants will use these devices connected t…

This study looks at how different ways of packaging a person in a rescue litter affect their breathing. Researchers will measure lung function in 24 healthy adults while lying down, on their side, and upright in a vacuum mattress. The goal is to find the best position to keep air…

This pilot study tests a one-time 'booster' session for people who inject drugs and their injecting partners, given right after finishing hepatitis C treatment. The session helps them set health goals, identify barriers, and improve communication to stay engaged in ongoing health…

This study tests a tiny microdevice, about the size of a grain of rice, that holds up to 20 different FDA-approved skin medications. Placed directly on the skin, it releases very small amounts of each drug to see how the skin reacts. The goal is to find out if this device can saf…

This study tests whether a machine-learning tool built into electronic health records can help doctors reduce kidney injury after surgery. Over 25,000 adults having non-emergency surgery will take part. Doctors are randomly assigned to see the tool's risk prediction, see it with …

This study looks at whether sharing results from a blood test that shows recent alcohol use can help people with HIV drink less. Researchers will enroll 80 people in Uganda who drink heavily. Half will get standard counseling plus their blood test results, and half will get couns…

This study will test a new program designed to help people who have been hospitalized for a physical injury. The program connects survivors with resources to meet their medical and social needs. Researchers will interview 25 participants and track which resources they use to see …

This study tests whether an AI-powered app called HeartBot II can improve women's awareness of heart attack symptoms. About 200 women will be randomly assigned to use the app right away or wait 12 weeks. Participants complete surveys about their knowledge and confidence in recogn…

This study will test whether an AI-powered 'digital twin' can accurately predict how type 2 diabetes progresses in young people aged 10-21. Researchers will create a virtual model of each participant using their health data, then compare predicted changes in blood sugar (HbA1C) t…