University Of California, San Francisco

This study compares two types of noninvasive dental care for 160 pregnant people with gum disease. Participants get free dental check-ups, cleanings, and supplies. The goal is to see which approach better reduces gum inflammation and improves oral health habits and birth outcomes…

This study tests whether the oral drug upadacitinib can safely treat adults hospitalized with a severe flare of ulcerative colitis, potentially avoiding the need for steroids or surgery. Fifty participants will take the pill daily while in the hospital and be monitored for up to …

This study tests whether taking an antibiotic called TMP-SMX for an extra 6 months after a kidney transplant can prevent urinary tract infections (UTIs) in children and young adults. About 50 participants will either receive the antibiotic or a placebo daily for 6 months. Researc…

This study looks at whether a health advocate can help families of children who recently had a liver transplant. The advocate will help find community resources, solve problems, and coordinate doctor visits. The goal is to see if this support reduces the risk of organ rejection o…

This study compares two methods for starting buprenorphine treatment in adults with opioid use disorder who use fentanyl. Participants will be randomly assigned to either a low-dose or direct-to-inject approach and will track their symptoms for 90 days. The goal is to see which m…

This study compares two antiviral treatments—oral valganciclovir and ganciclovir eye drops—against a placebo for cytomegalovirus (CMV) anterior uveitis, a viral infection that causes inflammation inside the front of the eye. About 117 adults with active eye inflammation will rece…

This study tests whether probiotics (good bacteria) can treat anal precancerous lesions (HSIL) and reduce high-risk HPV infection in 90 people living with HIV. Participants will take probiotics or a placebo to see if the lesions shrink or disappear. The goal is to prevent anal ca…

This study tests a radiation treatment called Yttrium-90 for people with liver cancer that cannot be surgically removed. About 64 adults with one or two small tumors will receive this treatment through a tiny tube into the liver's blood vessels. The goal is to see how well it shr…

This study will enroll 1,500 pregnant women with HIV in Uganda to find the best way to screen for tuberculosis (TB) and decide when to start TB prevention medicine. Researchers will compare symptom-based screening with a blood test and test starting prevention during pregnancy ve…

This study tests giving radiation therapy (SBRT) soon after spine surgery, while patients are still in the hospital, instead of waiting 2-4 weeks. The goal is to see if this faster approach reduces wound problems and helps control tumor growth. About 50 adults with cancer that sp…

This study will give 4,450 low-income adults with diabetes or hypertension a monthly food card benefit of either $80 or $120. Researchers want to see if the extra grocery support helps reduce food insecurity and improves key health measures like blood sugar and blood pressure. Pa…

This study tests whether a program called "Mittin" helps women aged 15-49 in Addis Ababa, Ethiopia, use birth control that matches their personal preferences. About 2,715 women using hormonal contraceptives or IUDs will be split into two groups: one receiving standard care and th…

This study tests a drug called emapalumab in 40 adults who had a lung transplant and are now experiencing a sudden drop in lung function (acute lung allograft dysfunction). The goal is to see if the drug can help their lungs recover to near-normal function within 90 days. Partici…

This study tests whether clemastine fumarate, an allergy medicine, can repair damaged myelin (the protective coating around nerves) in people with multiple sclerosis. About 44 adults with relapsing-remitting MS will receive either the drug or a placebo, and advanced MRI scans wil…

This study tests whether personalized dietary counseling through video visits can help people who have had kidney stones reduce their salt intake. Researchers will compare the results of virtual home visits with standard advice, measuring changes in urine sodium over 24 weeks. Th…

This study tests whether giving school children preventive malaria medicine can lower malaria cases in the entire community. Since school-aged children often carry the malaria parasite without symptoms, treating them may reduce transmission to others. The trial will involve about…

This study looks at new ways to get free HIV self-test kits to adolescent girls and young women in sub-Saharan Africa. Researchers will work with local drug shops and pharmacies, testing different support methods to encourage shopkeepers to give out the kits for free. The goal is…

This study aims to prevent noise-induced hearing loss in Native American adults by using a culturally relevant Talking Circles program. About 400 tribal members aged 18 and older will take part, completing hearing tests and questionnaires over 12 months. The program teaches heari…

This study compares a new 7-day pack of a nutrient supplement (SQ-LNS) to the usual daily packets for preventing malnutrition in children aged 6-22 months in Ethiopia. Researchers want to see if families use the weekly pack correctly and if it is as safe and easy to use. The goal…

This study looks at whether a single session of audio-based therapy can reduce anxiety in adults with psoriasis. About 120 people will listen to a 23-30 minute audio program at home and report their anxiety levels before and after. The goal is to find an easy, accessible way to h…

This study tests whether a digital prehabilitation app (HEAL-ME) combined with creatine and whey protein supplements can help maintain muscle health and reduce frailty in 100 adults with cirrhosis. Participants will use the app and take supplements for at least 3 months. The goal…

This study tests a special pain management program called a Transitional Pain Service for adults at high risk of long-term pain after surgery. About 126 participants will either get usual care or extra support before and after surgery to improve pain control and reduce opioid use…

This study tests a new, gentle brain stimulation technique called kTMP to help people who had a stroke and still have arm weakness. Researchers will measure if this method improves arm and hand movement. The study plans to enroll 100 adults aged 18-80 who have had a stroke.

This study is testing whether a combination of whole-body hyperthermia (a treatment that raises your body temperature) and cognitive behavioral therapy (a type of talk therapy) can help ease symptoms of major depression. The study will include 60 adults with depression who will r…

This study tests whether adding hormone replacement therapy (HRT) to standard care can improve frozen shoulder symptoms in women going through menopause. Sixty women will be randomly assigned to receive either HRT plus standard care or standard care alone. The main goals are to m…

This study looks at whether cutting back on salt can make eczema less severe. Forty adults will follow a low-salt diet for 24 weeks and take either salt tablets or a placebo to see how sodium affects their skin. Researchers will measure eczema severity, skin sodium levels, and re…

This early study tests the safety of using short electric pulses to destroy soft tissue tumors near the skin in people with metastatic breast cancer. About 20 adults will receive the treatment under image guidance. The main goal is to see if the procedure is safe and to measure a…

This study will test whether 8 weeks of improvisation music therapy can improve mood and lower stress for people with mild Alzheimer's disease and their care partners. About 40 older adults and their caregivers will attend music sessions and fill out questionnaires before and aft…

This study tests whether an app called HeartBot II, which uses an AI chatbot, can improve women's awareness and knowledge of heart attack symptoms. About 200 women will be randomly assigned to use the app right away or wait 12 weeks. Participants complete surveys at the start, 12…

This study looks at whether showing AI predictions in a special way (using Bayesian updates and uncertainty ranges) helps doctors diagnose chest pain or shortness of breath more accurately. About 100 healthcare professionals will review simulated patient cases and give their diag…

This study tests whether showing anesthesiologists a computer-calculated risk score for acute kidney injury (AKI) helps them take steps to prevent it. About 25,500 adults having non-emergency surgery will take part. Doctors will either see the risk score alone, the score plus an …

This study tests a grain-of-rice-sized microdevice that places tiny amounts of approved drugs directly into patches of psoriasis or eczema. The goal is to see if the device can safely predict how a person's skin will respond to standard treatments. Ten adults with these skin cond…

This study will gather genetic data and biological samples from up to 10,000 people with genetic or suspected genetic conditions. Researchers will analyze this information in computers and in lab-grown cells to better understand how specific gene changes cause disease and to test…

This study looks at whether changing how much salt you eat can affect the amount of sodium in your skin and the severity of eczema or psoriasis. Fifty adults will follow a low-salt diet for 13 weeks and take either sodium tablets or placebo pills for 5 weeks each. Researchers wil…

This study will test a new program designed to help people who have been hospitalized for a physical injury. Researchers want to see if the program is practical and helpful for meeting both medical and social needs. About 25 adult injury survivors from Zuckerberg San Francisco Ge…

This study will collect tumor samples and health information from up to 50,000 adults with hereditary cancers. Researchers will use these samples to create lab models of the tumors, which can help them understand how these cancers grow and test new treatments. The goal is to spee…

This study looks at whether written materials, videos, or a combination of both help women feel more knowledgeable, confident, and less anxious when deciding about breast reconstruction after mastectomy. About 100 adults considering mastectomy will be randomly assigned to receive…

This study tests a 6-week group bootcamp for caregivers of infants with or at high risk for cerebral palsy. The program teaches parents how to better support their child's development through physical and occupational therapy techniques. The goal is to improve caregiver knowledge…

This study will test a new artificial intelligence (AI) tool that helps breast cancer patients learn about their condition and treatment. About 35 adults with breast cancer will use the AI to ask questions and get answers. Doctors will check if the information is safe, accurate, …

This study looks at how substance use may cause scarring and inflammation in the hearts of people with HIV. Researchers will use a special heart MRI to take detailed pictures of the heart. The study involves one visit and will include 400 adults from existing HIV study groups.

This study aims to build an AI-powered 'digital twin' for 50 young people (ages 10-21) with type 2 diabetes. The digital twin will simulate how their disease might progress and how they might respond to treatments. Researchers will then test whether sharing these predictions with…

This study will see if setting up vision centers in rural South Asia helps more people get glasses and eye care. About 40,000 people will take part, with some communities getting a vision center right away and others waiting. Researchers will check if these centers improve vision…

This study looks at how short-term methamphetamine use affects the hidden HIV virus in people who are already on effective HIV treatment. About 20 adults with well-controlled HIV will take oral methamphetamine under medical supervision. Researchers will measure changes in virus a…

This study tests a program where a trained navigator helps kidney stone patients attend their follow-up urology appointments after an ER visit. About 31 adults at high risk of missing appointments will receive support for 12 weeks. The goal is to see if this approach is feasible …

This study looks at two different FDA-approved machines that create platelet-rich plasma (PRP) for people with knee osteoarthritis. PRP is made from your own blood and may help with joint pain and stiffness. The researchers will check if the PRP from each machine has different am…

This study looks at whether sharing results from a blood test that measures recent alcohol use (called PEth) during counseling helps people with HIV who drink too much cut back. About 80 adults in Uganda will take part. Half will get standard counseling plus their PEth results, a…

This study looks at how standard brain radiation therapy affects thinking and memory in 40 adults with brain tumors (primary or metastatic). Researchers will measure specific proteins in the blood and use brain scans to understand the biological changes behind cognitive decline. …