University Of California, San Francisco

This study is testing whether a surgical procedure called expansile duraplasty helps adults recover better after a recent traumatic spinal cord injury. Researchers will compare recovery in people who receive the procedure during their standard surgery to those who do not. The mai…

This study is testing if adding a blood test that shows recent alcohol use to a standard counseling session helps people with HIV drink less. 80 adults in Uganda with unhealthy alcohol use will be randomly assigned to receive either the standard counseling alone or the counseling…

This study is testing whether a combination of a digital exercise and nutrition coaching app, plus creatine and whey protein supplements, can help maintain muscle strength and reduce frailty in people with advanced liver disease (cirrhosis). It will involve 100 participants who w…

This study aims to find the best way to start buprenorphine treatment for adults with opioid addiction who use fentanyl. Researchers will compare two different starting methods to see which one helps people stay in treatment longer and feel better during the first week. Fifty par…

This study is testing a special pain management program to see if it can help prevent long-term pain and reduce the need for opioid painkillers after surgery. Researchers will use a computer tool to identify patients at higher risk for lasting pain and then offer half of them ext…

This study is testing a new approach to deep brain stimulation for Parkinson's disease. Researchers will implant devices that can sense brain signals through less invasive electrodes under the scalp, then use those signals to automatically adjust stimulation levels based on a pat…

This study is testing whether a probiotic supplement can treat anal precancerous lesions and clear the HPV infection that causes them in people living with HIV. The goal is to prevent these lesions from developing into anal cancer. About 90 participants will take either the probi…

This study tests whether a 90-day 'Health Advocate' program can help families facing financial hardship after their child's liver transplant. The advocate helps families find community resources and navigate the healthcare system. Researchers want to see if this support helps pre…

This study is testing a patient navigation program designed to help people who visit the emergency room for kidney stones actually attend their follow-up doctor's appointments. Researchers will identify 31 patients at high risk of missing their follow-up and pair them with a trai…

This study aims to find out if a shorter, 5-day course of antibiotics works just as well as a standard 10-day course for children hospitalized with common infections like pneumonia, skin infections, or urinary tract infections. About 1,200 children will be randomly assigned to re…

This study is testing whether a new support program called 'Mittin' helps women in Ethiopia better manage their birth control in line with their personal preferences. It will compare women at health centers using the Mittin program to those receiving standard care. The goal is to…

This study is testing whether giving targeted radiation treatment much sooner after spine cancer surgery—within days instead of weeks—is safe and helps control tumors better. It will involve 50 patients who have had surgery for cancer that has spread to the spine. The main goal i…

This study is testing whether providing different amounts of monthly grocery money helps low-income people with diabetes or high blood pressure better manage their health. About 4,450 participants will be randomly assigned to receive either an $80 or $120 monthly food card for on…

This study is testing whether following a low-sodium diet can help improve the severity of eczema (atopic dermatitis). Researchers will have 40 adults follow a low-salt diet for 24 weeks and will also give them salt tablets or a placebo at different times to see how changing salt…

This study aims to see if a non-invasive electrical stimulation treatment, delivered through the skin over the spine, is safe to start just 3 days after a traumatic spinal cord injury. It will involve 15 patients in the ICU to check for safety issues and gather early signs on whe…

This study is testing if an existing allergy medication, clemastine fumarate, can help repair the protective coating (myelin) around nerves in the brain for people with multiple sclerosis (MS). It will involve 44 adults with MS who have recently active brain lesions. Researchers …

This early-stage study is testing the safety of combining two treatments for advanced prostate cancer that has spread to the liver. It will give a radioactive drug that targets prostate cancer cells, along with a separate treatment focused directly on the liver tumors. The goal i…

This study is testing a targeted radiation treatment for people with early-stage liver cancer that cannot be removed by surgery. Doctors will inject tiny radioactive beads directly into the blood vessels feeding the tumor to deliver a high dose of radiation. The main goals are to…

This study offers low-dose chest CT scans to 1,200 California firefighters to check for early signs of lung cancer and other work-related lung diseases. Firefighters face higher cancer risks from smoke and chemical exposure, but current screening guidelines don't fully account fo…

This study aims to find a sustainable way for private pharmacies and drug shops in sub-Saharan Africa to keep providing free HIV self-test kits to adolescent girls and young women. Researchers will test different support systems, like subsidies and motivational tools, for shopkee…

This study is testing if giving preventive malaria medicine to school children every two months can reduce malaria for everyone in surrounding communities. It will involve about 4,800 children in areas with high malaria rates in Africa. Researchers believe treating children, who …

This study offers free dental check-ups, cleanings, and supplies to pregnant women to help them take better care of their teeth and gums. Researchers want to see if this support improves oral health during pregnancy and leads to better birth outcomes. The study will compare two d…

This study aims to find the best methods to screen for tuberculosis (TB) and the safest time to give TB preventive medicine to pregnant women living with HIV in Uganda. It will compare different screening tests and whether to start preventive treatment during pregnancy or after b…

This study aims to see if personalized diet counseling delivered through video calls can help people who form kidney stones eat less salt, which may prevent new stones from forming. Researchers will work with 100 participants to compare this new telehealth approach to standard di…

This study aims to see if taking a common antibiotic for an extra six months helps prevent urinary tract infections in children and young adults who recently received a kidney transplant. Researchers will compare the antibiotic to a placebo pill in 50 participants to measure infe…

This study is testing if a targeted nerve-block injection in the hip provides better pain relief than standard care for adults coming to the emergency room with severe sciatica. Researchers will compare pain levels and walking ability between two groups: one receiving the nerve b…

This study is testing a new, non-invasive brain stimulation technique called KTMP to see if it can help improve arm and hand function in people who have long-term weakness from a stroke. Researchers will use a gentle magnetic device on the scalp to try to promote brain activity r…

This small pilot study is testing whether regular sauna visits can help reduce loneliness in young adults. Fifteen participants aged 19-22 will visit a San Francisco sauna once a week for eight weeks, either alone or with a friend. Researchers want to see if people find this appr…

This study is testing if a single 30-minute audio therapy session can help reduce anxiety in adults with psoriasis. Researchers will measure changes in anxiety, mood, and itch severity before and after participants listen to the audio at home. The goal is to see if this easy-to-a…

This study is testing whether adding hormone replacement therapy (HRT) to standard treatment helps women going through menopause who have a frozen shoulder. Sixty women will be randomly assigned to receive either standard care plus HRT or standard care alone. Researchers will che…

This study is testing whether 8 weeks of music therapy can help improve mood and reduce stress for people living with mild Alzheimer's disease and their family caregivers. Forty participants will attend music sessions and fill out questionnaires about their feelings and stress le…

This study aims to understand how social factors and personal risks affect outcomes for people with meningioma, a common type of brain tumor. Researchers will survey 3,000 adult patients and review their medical records to identify patterns. This is an observational study that co…

This study aims to find better ways to show artificial intelligence (AI) predictions to doctors to improve their diagnostic accuracy and trust in the technology. One hundred US-based clinicians will review eight simulated patient cases about chest pain or shortness of breath. Res…

This study is creating a large collection of biological samples from people with hereditary cancers or a family history of cancer. Researchers will use these samples to grow tumor models in the lab to better understand how hereditary cancers develop and respond to treatments. Par…

This study is building a large collection of genetic data and biological samples from people with genetic conditions. The goal is to better understand how specific gene mutations cause disease and to test, in the lab, which mutations might be correctable with future gene editing …

This study aims to see if two different, FDA-approved machines make platelet-rich plasma (PRP) of different quality for treating knee arthritis. Researchers will enroll 20 people with knee osteoarthritis to compare the PRP made by each machine. They will check the platelets in th…

This study is testing a tiny device, about the size of a grain of rice, that is placed on the skin. The device contains tiny amounts of approved medications for eczema (atopic dermatitis) and psoriasis. Researchers aim to see if the device's local skin reaction can safely and eff…

This study is testing whether a smartphone app called HeartBot II, which uses an AI chatbot, can help women learn to recognize heart attack symptoms and know how to respond. About 200 women will be randomly assigned to use the app right away or after a 12-week wait. Researchers w…

This study aims to understand why radiation therapy for brain tumors can affect patients' memory and thinking skills. Researchers will track 40 adults with brain tumors, taking blood tests and brain scans before and after their standard radiation treatment to look for biological …

This study aims to develop and test an artificial intelligence (AI) model, called a 'digital twin,' to predict how type 2 diabetes will progress in young people. Researchers will create these digital twins for 50 participants aged 10-21 and use them to simulate future blood sugar…

This study is testing a 6-week group training program for parents and caregivers of infants diagnosed with or at high risk for cerebral palsy. The program teaches practical skills and provides education about early intervention, aiming to boost caregivers' knowledge, comfort, and…

This study aims to understand how stimulant and multiple substance use affects heart inflammation and scarring in people living with HIV. Researchers will compare 400 participants with and without HIV using detailed heart MRI scans during a single visit. The goal is to gather kno…

This study aims to understand if going through menopause increases the risk of heart disease for women living with HIV. Researchers will analyze existing health data and use MRI scans from 90 women to look at inflammation and body composition. The goal is to fill a key knowledge …

This study aims to find out if establishing local vision centers in rural South Asia helps more people get eye care, glasses, and better vision. Researchers will compare communities that get a vision center right away with those that wait, tracking results over two years. The goa…