University Of California, San Francisco

This early-phase trial tests a new treatment for children and young adults with a rare, aggressive brain tumor called H3.3K27M-mutated diffuse midline glioma. The treatment involves taking a patient's own immune cells (T cells), genetically modifying them in the lab to recognize …

This study tests whether taking propranolol, a beta blocker, before and after surgery can reduce complications like delirium, kidney problems, and pain in people with post-traumatic stress disorder (PTSD). Participants are veterans scheduled for certain surgeries and will take th…

This trial compares two approaches to antibiotic use after appendix removal surgery: a restrictive course (none or up to 24 hours) versus a liberal course (24 hours to 4 days). The goal is to see if the shorter course is just as safe and effective, while reducing side effects and…

This study compared two antiviral medicines (oral valganciclovir and topical ganciclovir 2%) against a placebo for treating CMV-related inflammation in the front of the eye. The goal was to see which approach better controls the infection and reduces complications like pain, glau…

This pilot study tested three common blood pressure medications—amlodipine, chlorthalidone, and losartan—in 36 young adults aged 18-40 with hypertension. Participants took the drugs at home and monitored their blood pressure regularly. The goal was to see which drug works best an…

This study looked at whether giving the immunotherapy drug pembrolizumab (with or without axitinib) before surgery could help control advanced kidney cancer. Only 6 people took part before the study was stopped early. The goal was to see if the treatment boosted immune cells in t…

This study tested a program called Malkia Klabu ("Queen Club") in Tanzania. The program made local drug shops more welcoming for adolescent girls and young women, so they could easily get HIV prevention services and contraception. Researchers looked at whether this approach incre…

This study tests a sticky pad called Brijjit® to see if it can prevent thick, raised scars (hypertrophic scars) after gender-affirming mastectomy (top surgery). About 78 people will take part, and each person will have the device on one side of their chest while the other side ge…

This trial tests different settings of a gentle electrical stimulation device, placed on the skin of the affected arm, to see which ones best improve hand function in people who have had a stroke. Participants will receive varying durations and strengths of stimulation, and resea…

This trial tests whether a structured cardiac rehabilitation program can improve exercise capacity and heart rate response in people with Long COVID. Participants have persistent symptoms and reduced exercise tolerance after a confirmed COVID-19 infection. The program includes pe…

This study tests whether a breathing-based meditation practice called SKY can reduce symptoms of depression and anxiety in adolescents aged 16 to 24. Participants with mild-to-moderate depression will practice the breathing techniques for 8 weeks, while researchers track mood, st…

This study tests whether placebo pills taken knowingly — called open-label placebo — can reduce depression symptoms in unmedicated teens aged 13–18 with mild to moderate depression. Participants take placebo pills for two weeks while researchers use brain scans to see if the trea…

This small study tested whether adding n-acetylcysteine (NAC) to albuterol could improve lung function and reduce mucus plugs in people with moderate-to-severe asthma. Only 4 participants were enrolled before the trial was terminated early. The crossover design gave each person t…

This study tested whether Acthar gel could improve symptoms and lung function in people with sarcoidosis, a disease that causes inflammation in the lungs. Researchers also checked if a blood marker called CXCL9 could predict how well the treatment works. Only 2 people joined befo…

This study tested whether a device called Nanodropper, which makes smaller eye drops, works as well as standard eye drops for lowering eye pressure in people with glaucoma or ocular hypertension. The study enrolled 16 adults who already used a common glaucoma drop. The goal was t…

This study looked at whether adding blood flow restriction training to standard physical therapy helps people regain knee strength and muscle size after meniscus repair surgery. About 15 participants were split into two groups: one did standard rehab, the other added the special …

This study tested how acceptable it is to use misoprostol alone to start a late period. It included 17 adults whose period was up to 14 days late. The goal was to see if people were satisfied with this approach and if it worked to bring on their period.

This study tested a behavioral program using bright light therapy and sleep coaching to improve sleep and thinking in older adults with mild cognitive impairment or mild Alzheimer's. Only 15 people were enrolled before the study was stopped early. The goal was to see if the progr…

This study tested whether applying tranexamic acid (TXA) directly to the surgical wound during breast removal and reconstruction can reduce bleeding (hematoma) and fluid collections (seroma). These complications can delay healing and cancer treatments. The trial enrolled 23 women…

Researchers at the University of California, San Francisco are studying whether stimulating the vagus nerve through the ear during a nap can improve memory. The trial enrolls healthy adults aged 18 to 64 who nap regularly. Participants receive either active stimulation or a sham …

This study aimed to see if a sedative called dexmedetomidine produces sleep more like natural sleep than another sedative, propofol. Researchers planned to measure brain activity in 3 healthy volunteers during drug-induced and natural sleep. The trial was terminated early, so onl…

This study aimed to see if a simple blood test could predict memory and thinking problems in men with prostate cancer receiving hormone therapy (ADT). Researchers planned to follow 32 men over time, comparing those on ADT to those not on it. The study was stopped early, so result…

This study aimed to uncover hidden causes of asthma attacks and how inhaled steroids work. Researchers planned to analyze sputum from 67 adults with severe asthma. However, the study was terminated early, so results are limited.

This pilot study tested several low-cost behavioral nudges, like videos and text messages, to encourage HIV retesting among 98 adults at higher risk of HIV in rural Kenya and Uganda. The goal was to see which approaches were acceptable and feasible, so the best ones could be used…

The DREAM study is an observational research project that enrolled over 1,500 pregnant women and their children to understand how exposure to environmental chemicals—like those in consumer products, air, and water—might influence cancer risk. Researchers collected blood, urine, a…