Scientists launch study to uncover what drives chronic fatigue syndrome
NCT ID NCT07227441
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study observes 200 people with and without ME/CFS to understand the long-term biological changes driving the condition. Researchers will collect samples and track participants over time, focusing on infections and inflammation. No treatments are tested; the goal is to gather knowledge to guide future research.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
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About 200 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Jan 2026
- Expected to finish
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Sep 2030
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
The investigators will enroll individuals with a diagnosis of ME/CFS across a wide spectrum of age, race, gender, and disease severity and will also enroll a subset of people without ME/CFS or other infection associated chronic conditions (healthy control)
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Willing and able to provide written informed consent * At least 18 years of age * Either: (1) a reported diagnosis of ME/CFS or (2) no history of ME/CFS or other infection-associated chronic conditions (healthy control) Exclusion Criteria: * Self reported or documented chronic anemia with hemoglobin \<9 g/dL * Known HIV, hepatitis B, or hepatitis C infection * Diagnosis of an infection-associated chronic condition other than ME/CFS or Long COVID (e.g. chronic Lyme disease, post-Ebola syndrome, etc.) * Serious medical or psychiatric illness that, in the opinion of the site investigator, would interfere with the ability to adhere to study requirements or to give informed consent * Active drug or alcohol use or dependence that, in the opinion of the PI, would interfere with adherence to study requirements or to give informed consent
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Zuckerberg San Francisco General Hospital
RECRUITINGSan Francisco, California, 94110, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- Could a High-Fat diet reset energy in long COVID?
- Scientists probe the mysterious crash that defines ME/CFS
- Brain retraining trial aims to ease chronic fatigue and long COVID symptoms
- Acupuncture needles aim to clear COVID brain fog in new trial
- Could a tiny dose of naltrexone ease ME/CFS fatigue?