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Miracle fruit tested as taste saver for head and neck cancer patients

NCT ID NCT05273307

Symptom relief Sponsor: University of California, San Francisco Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Aug 12, 2026 · Updated 3 times

Summary

This phase 3 trial tests whether a 'miracle fruit' cube (miraculin) can improve taste loss in head and neck cancer patients undergoing radiation therapy. Taste problems are common and hard to treat during radiation. The study will compare the fruit cube to a placebo in 40 patients, measuring changes in taste perception and diet over time.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
miraculin (miracle fruit cube)
What this could lead to
If it works, this could offer a simple, natural way to help cancer patients enjoy food again during radiation treatment.
What could go wrong
This is a small, early-stage trial with only 40 participants, so results may not apply to everyone. The effect may be modest and temporary.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

40 people

The number who actually took part.

Started

Mar 2022

Expected to finish

Nov 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Participants must have documentation of histologically or cytologically confirmed head and neck cancer diagnosis including primary tumors of the following sites: oropharynx, nasopharynx, oral cavity, nasal cavity, paranasal sinus, salivary gland, unknown primary origin in the head and neck, or cutaneous squamous cell carcinoma having had a surgery including neck dissection. 2. Treatment plan includes curative-intent (including post-operative) radiation therapy with or without concurrent chemotherapy 3. Age \>=18 years at screening visit. 4. Eastern Cooperative Oncology Group (ECOG) performance status \<= 2 (Karnofsky \>= 60%) 5. Ability to understand a written informed consent document, and the willingness to sign it Exclusion Criteria: 1. Patient-reported pre-existing dysgeusia prior to beginning radiation therapy. 2. Receiving nutrition through tube feeds or intravenously prior to beginning radiation therapy. 3. Inability to complete patient-reported outcomes (PROs) and quality of life questionnaires in English. 4. Known allergy to berries.

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Conditions

The condition(s) this trial relates to.

head and neck cancer Head and Neck Neoplasms Taste Disorders

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Head and neck cancer Taste dysfunction

Contacts and locations

Locations

  • University of California, San Francisco

    San Francisco, California, 94143, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.