Indiana University

This study tests if giving surfactant (a lung medicine) through a less invasive method helps premature babies with breathing problems survive. About 1,500 babies weighing 750–2000 grams will receive this treatment in African hospitals without ventilators. Researchers will track s…

This study looks at whether giving people with high blood pressure and food insecurity free healthy food and kitchen skills training can improve their blood pressure and overall health. About 200 adults aged 35-75 will either get the food and lessons or standard care. Researchers…

This study tests a new way to give radiation for prostate cancer that is harder to treat. It combines two types of radiation: one from outside the body and one from inside. The goal is to see if this approach is safe and tolerable for patients. About 31 men with unfavorable or hi…

This study looks at how to best help teens with mild alcohol problems during regular doctor visits. About 615 teens aged 12-17 will get a short counseling session, and researchers will test whether adding a caregiver session or an online program works better than no caregiver inv…

This study tests a two-drug maintenance therapy (zanzalintinib and oral etoposide) for people with relapsed germ-cell tumors that have not responded to standard treatments. After high-dose chemotherapy and a stem cell transplant, participants take these pills to try to prevent th…

This study looks at whether a special heart scan (CCTA) can help doctors find hidden heart artery plaque in prostate cancer patients who are on or about to start hormone therapy. About 100 participants will either get the scan or standard care. The goal is to see if the scan lead…

This study tests a small, handheld device that doctors can use at the bedside to check brain and nerve activity. The goal is to see if it can give quick and accurate information about where a problem is in the brain or spine, and what might be causing it (like a stroke or bleedin…

This study tests whether an internet-based cognitive behavioral therapy program, Good Days Ahead, can reduce depression and slow memory decline in older adults who survived an ICU stay. About 300 people aged 50 and older with depressive symptoms will be randomly assigned to recei…

This study tests a new virtual therapy called Smart Virtual Reminiscence (SVR) for older adults with mild cognitive impairment or early Alzheimer's. The therapy uses an AI-powered virtual coach to help people recall positive memories, aiming to reduce behavioral symptoms like agi…

This study looks at whether computerized cognitive training and Tai Chi-Qi Gong exercises can help people with early-onset Alzheimer's disease. About 60 participants will be assigned to either the training program or a control group. Researchers will measure memory, thinking skil…

This study tests whether a gel called PuraGel can help the nose heal faster and with less pain after skull base surgery. About 30 adults having this surgery will receive the gel on one side of their nose. Doctors will check healing and pain levels for up to 12 weeks after surgery…

This study follows 35 adults with chronic pancreatitis who receive a nerve-block procedure (EUS-CPN) to ease their pain. Researchers will track pain levels and pain medication use weekly for 24 weeks after the procedure to see if it helps reduce pain and the need for painkillers.

This study looks at whether spiritual care can improve emotional well-being and reduce anxiety and depression in people with stage IV lung or gastrointestinal cancer. About 36 adults will receive either spiritual support sessions or general information. The goal is to see if this…

This study looks at whether doing high-intensity walking training more often (high frequency) or less often (low frequency) helps people who had a stroke more than 6 months ago improve their walking. About 40 adults aged 18-85 who can walk a little but need help will participate.…

This study compares two standard pain relief methods—intrathecal morphine and intravenous methadone—for men undergoing surgery for testicular cancer. The goal is to see which approach provides better pain control after the operation. About 142 participants will be enrolled to mea…

This study is testing whether using the Replexa+ device twice daily for 3 months can improve blood flow in the lower legs and feet of veterans with peripheral artery disease and nerve pain. Ten participants will have their blood flow measured before and after treatment. The goal …

This small pilot study tests whether using a hand-held vibration device for just 3 minutes each day can safely reduce nerve pain and numbness caused by chemotherapy. Sixteen adults who completed chemo at least 60 days ago will try the therapy at home. The main goals are to see if…

This study looks at whether taking a supplement called 5HTP can improve breathing and reduce anxiety in children aged 8-18 with mild to moderate asthma and allergies. About 20 participants will be randomly assigned to receive either 5HTP or a placebo, then switch groups later. Th…

This study tests a program called the Green Activity Program, designed for people with mild memory problems or early Alzheimer's. The program encourages enjoyable outdoor activities like walking, gardening, or yoga with a friend or pet. Researchers want to see if the program is e…

This study tests whether daily leg heat therapy can improve walking ability and quality of life in people with peripheral artery disease (PAD). About 106 adults over age 50 with PAD will use heated trousers at home for 90 minutes each day. The main goal is to see if this treatmen…

This study tests a painless, non-surgical brain stimulation method called temporal interference (TI) to see if it can reduce nicotine cravings and vaping. 120 adults who vape heavily will receive either real TI to a deep brain area or a fake (sham) treatment during a single sessi…

This study tests whether a 16-week virtual exercise program (aerobic and strength training) can improve fitness, muscle mass, and quality of life in 100 adults with stable metastatic breast cancer. Participants must have had no cancer growth in the past year and not be on strong …

This study tests whether a telephone counseling program can help people with advanced gastrointestinal cancer and their family caregivers feel better. The program teaches strategies to manage stress and symptoms, and is compared to a standard education and support program. About …

This study looks at how the COVID-19 pandemic may have changed people's physical activity, sleep, blood pressure, and mental stress. Researchers will track 100 adults aged 18-75 using wearable devices, fitness tests, and health questionnaires over two visits. The goal is to bette…

This study looks at whether taking a dietary nitrate supplement (found in beets and leafy greens) can prevent muscle loss and weakness when a leg is immobilized in a brace for 14 days. Researchers will measure muscle function and energy use in 24 healthy young men. The goal is to…

This study tests whether a mild electrical current applied to the scalp (tDCS) can improve how quickly people learn a complex hand-coordination video game. Fifty-two healthy adults aged 18 to 45 will play Guitar Hero while receiving either real or fake stimulation. Researchers wi…

This study tests whether a mild electrical pulse behind the ear (taVNS) can change insulin, C-peptide, and blood sugar levels in 30 healthy adults aged 18-70. Researchers will compare active stimulation to a control group and measure heart rate changes. The goal is to learn how t…

This study looks at how well a new bedside test (TEG 6s) measures blood clotting in healthy children. About 125 kids having planned surgery will give a small blood sample. The goal is to find normal values for children and see if they match published ranges. This is an observatio…

This study aims to find out if children with primary ciliary dyskinesia (PCD) also have a condition called bronchial hyperresponsiveness, which makes airways overly sensitive. Researchers will compare 40 participants (those with PCD and healthy volunteers) using breathing tests. …

This study collects blood or brain tissue from families with two or more members diagnosed with Alzheimer's or dementia. Researchers will use the samples to find genes linked to the disease. The goal is to help future studies develop new treatments. Participants will not receive …

This study looks at how much a person's own kidney function recovers after getting a simultaneous liver and kidney transplant. Researchers will follow 15 adults with kidney problems who are already listed for this transplant but not yet on dialysis. They will use special scans an…

This small pilot study will test whether proton pump inhibitors (PPIs) improve the flexibility of the esophagus in 10 people with eosinophilic esophagitis (EoE). Researchers will use a special balloon device to measure stiffness in both the upper and lower esophagus before and af…

This study tests a new ankle brace with built-in motion sensors to see if it can accurately measure how people walk and balance. About 60 healthy adults will wear the brace while doing activities like walking, running, and jumping. The goal is to check if the brace works as well …

This study tests a decision support tool called Periviable GOALS for parents facing the threat of an extremely early delivery (between 22 and 25 weeks of pregnancy). The tool provides clear information about outcomes and helps parents clarify their values. About 216 pregnant adul…

This study looks at whether a common vitamin (niacin, or vitamin B3) can get into the brain fluid of people with mild-to-moderate Alzheimer's. Researchers will give 30 volunteers a single 500 mg dose of extended-release niacin and measure its levels in blood and spinal fluid. The…

This study tests a smartphone app called SuperAssist that helps mental health providers and their supervisors improve how they work together. The goal is to see if the app makes providers feel more supported, clear about their role, and better able to help clients. About 180 beha…

This study looks at why Black Americans often report higher levels of paranoia than White Americans, even without a mental health diagnosis. Researchers will ask 480 Black American adults to imagine stressful situations related to race and then measure their feelings of suspicion…

This study looks at whether a program called ADAPT, where nurses and social workers call people with heart failure weekly to help manage symptoms and provide emotional support, can work outside of a research setting. The goal is to see if community clinics can use this program to…

This study compares three ways to check for fluid overload (too much fluid in the body) in people on home dialysis: a symptom questionnaire, a physical exam, and a lung ultrasound. Fluid overload often leads to hospital visits, so finding the best detection method is important. R…

This study aims to better understand a condition called Exercise-Induced Laryngeal Obstruction (EILO), where the vocal cords close during exercise, making it hard to breathe. Researchers will use a small, wearable device on the neck and MRI scans to measure breathing patterns and…

This study looks at whether brain activity related to learning can predict how well teens respond to a program aimed at reducing cannabis use. Teens aged 14-17 get a brain scan, then attend 10 weekly virtual sessions where they report use and take drug tests. They can earn prizes…

This study looks at how older adults with and without vision problems step over obstacles of different heights and contrasts. Researchers want to understand how vision and eye movements affect walking and fall risk. The goal is to create better fall-prevention strategies for peop…

This study tests a new non-invasive method called temporal interference (TI) to stimulate deep brain regions using harmless electrical currents. Researchers will scan the brains of 30 healthy adults aged 18-50 to see if TI can safely activate deep areas without affecting the oute…