Indiana University

This pilot study will test whether breathing controlled amounts of carbon dioxide (CO2) can help doctors see blood flow in the heart using MRI, without needing standard contrast dyes. Thirty adults with known or suspected coronary artery disease will take part. The goal is to che…

This study tests a new, non-invasive method to detect coronary artery disease using a computer-controlled gas challenge. Researchers will monitor how 80 healthy adults aged 45 and older respond to changes in oxygen and carbon dioxide levels. The goal is to see if this breathing t…

This study will test a new, non-invasive device that measures blood flow and oxygen levels in the brains of newborn babies. Researchers will compare babies who were exposed to opioids before birth with those who were not. The goal is to see if the device can detect signs of opioi…

This study tests a new, gentle device called Boppli that continuously measures blood pressure in newborn babies in the NICU. Researchers will compare it to the standard blood pressure cuff to see if it works better at finding high blood pressure. The study includes 30 infants at …

This study continues a community project in rural Kenya to prevent cervical cancer. It offers the 9-valent HPV vaccine to 2000 adolescent girls and tests self-collected swabs for high-risk HPV in adult women. Researchers will also study why some families do not participate and wh…

This study tests whether a more intensive diet and activity counseling program can help high-risk pregnant women keep their blood sugar in a healthy range and lower their chances of developing gestational diabetes. About 100 women early in pregnancy (16 weeks or less) who have ri…

This study compares a new suction-based cervical stabilizer (Carevix) to the standard clamp (tenaculum) for IUD insertion. 100 women will be randomly assigned to one device, and they will report their pain on a 0-10 scale. The goal is to see if the new device causes less pain and…

This study tests whether a single dose of psilocybin (the active ingredient in magic mushrooms) combined with psychotherapy is safe and can reduce depression and substance use in veterans and first responders who haven't responded to standard treatments. Fifty participants will r…

This study tests whether a slow-release form of the hormone DHEA can help control asthma symptoms in adults. Asthma treatments like glucocorticoids can lower DHEA levels, so researchers want to see if adding DHEA improves asthma control scores. The trial will involve 30 adults ag…

This study tests whether structured spiritual care from a chaplain can reduce anxiety and improve well-being for family members of ICU patients who cannot make decisions for themselves. The chaplain will meet with the family surrogate several times and stay in touch weekly. The t…

This study tests a portable exercise bike that clamps to hospital beds, allowing patients to pedal their arms and legs while lying down. The goal is to see if using the bike for at least 15 minutes a day can help prevent muscle loss, weakness, and other problems like blood clots …

This study aims to see if using a standard method for cervical ripening (softening the cervix before labor) increases the chance of a vaginal delivery. About 1,158 pregnant women scheduled for labor induction will be randomly assigned to one of two standard approaches. The goal i…

This study tests if a gentle electrical stimulation on the outer ear can activate the vagus nerve and reduce nausea, vomiting, and stomach discomfort in people with diabetes and gastroparesis. Sixty adults with both conditions will receive the treatment and report symptom changes…

This study looks at whether high-intensity walking training can help people with cerebellar damage walk better. Researchers will compare this training to standard therapy in 20 adults aged 18-85. The goal is to see if the training is practical and effective for improving mobility…

This study tests two ways to deliver a group training program for caregivers of children with autism in low-resource areas. The program aims to reduce caregiver stress and improve the child's communication and behavior. About 320 caregivers of children aged 2 to 8 will take part.…

This study tests a new virtual reality walking program for people with traumatic brain injury. Participants will use VR goggles while walking overground, and their progress will be compared to standard treadmill-based VR therapy. The goal is to see if this approach improves walki…

This study tests whether using the Replexa+ device twice daily for 3 months can improve blood flow in the lower legs and feet of veterans with peripheral artery disease (PAD) and peripheral neuropathy. Ten participants will have their blood flow measured before and after treatmen…

This study tests a program that offers mental health screening, therapy, and follow-up to pregnant women who are in the hospital for medical complications. About 50 participants will receive brief counseling and symptom tracking during their stay and for three months after. The g…

This study will test whether immunotherapy drugs (immune checkpoint inhibitors) change how the liver processes other medications. About 80 adults with various cancers who are starting immunotherapy will take a low-dose cocktail of 7 common drugs. Researchers will measure drug lev…

This study looks at whether using growth charts made specifically for twins can help doctors better track baby growth during twin pregnancies. About 150 pregnant people with twins will be randomly assigned to have their care guided by either a standard chart or a twin-specific ch…

This study looks at how being in hot or cold environments changes how hard it feels to breathe and how well you think when breathing is difficult. Fifteen healthy adults will do breathing tasks in different temperatures. The goal is to understand, not to treat or cure any conditi…

This study looks at whether changing the sound of a person's breathing can help them feel less breathless and think more clearly when breathing is hard. Researchers will have 15 healthy adults breathe through a mask that makes it harder to breathe, while playing back their breath…

This study looks at using simple, low-cost communication tools like picture boards and gestures for children with autism who have trouble speaking. It involves 500 children and their caregivers in rural Virginia and western Kenya. The goal is to find better ways to match each chi…

This study will collect blood samples from 100 adults with cancer who are starting immunotherapy. Researchers will analyze the samples to find patterns in immune cells and molecules that might predict how well the treatment works or if it causes side effects. The goal is to bette…

This study looks at whether chemicals and other substances in a mother's body during pregnancy can help predict if her child will develop autism. Researchers will use stored urine and cord blood samples from 600 first-time mothers. The goal is to build a model that could estimate…

This study tests a special monitor that tracks sleep without touching the person. It will be used for 100 people with Alzheimer's or related dementias living in long-term care facilities. The goal is to see if sharing sleep data with staff helps them find and treat sleep problems…

This study explores whether pregnancy complications like gestational diabetes or high blood pressure can speed up ovarian aging, which is linked to higher risks for heart disease and bone loss. Researchers will follow 655 women over time, measuring hormones and health markers. Th…

This study aims to find out how often primary ciliary dyskinesia (PCD) goes undiagnosed in adults with bronchiectasis. Researchers will use two non-invasive tests—a nasal nitric oxide measurement and high-speed video microscopy—to screen 60 participants. The goal is to improve de…

This study looks at two different methods to help people who have had a traumatic brain injury (TBI) feel more in control of their health. About 142 adults who are at least one year past their injury and see a brain injury doctor will take part. They will have one virtual session…

This study tests a special PET scan called [18F]-AraG to see how well standard chemoradiotherapy is working in people with advanced head and neck cancer. The scan looks at immune cells in the tumor to help doctors understand treatment response. Only 5 adults with stage III or IV …

This study looks at whether a 6-month or 12-month follow-up colonoscopy is better for people who had a large colon polyp (20-50 mm) removed that was not cancerous. About 546 adults will be assigned to one of the two follow-up schedules. The goal is to see which timing finds any r…

The goal of this clinical trial is to understand how many individuals who previously participated in the Indiana Biobank will return a type 1 diabetes home screening kit based upon different methods of recruitment communication. The main question it aims to answer is: What form …